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penicilamin

3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson`s disease.
MSH

beta dimethyl analog of cysteine; USP lists as a chelating agent.
CSP

A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.
NCI

A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C729″ NCI Thesaurus)
PDQ

A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
NCI

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enteropeptidasa

A specialized proteolytic enzyme secreted by intestinal cells. It converts TRYPSINOGEN into its active form TRYPSIN by removing the N-terminal peptide. EC 3.4.21.9.
MSH

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geny překrývající se

Genes whose nucleotide sequences overlap to some degree. The overlapped sequences may involve structural or regulatory genes of eukaryotic or prokaryotic cells.
MSH

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karbamoylfosfátsynthasa (hydrolyzující glutamin)

An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
MSH

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druhová specificita

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
MSH

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hnůj

Accumulations of solid or liquid animal excreta usually from stables and barnyards with or without litter material. Its chief application is as a fertilizer. (From Webster`s 3d ed)
MSH

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pentosafosfátová dráha

pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a pentose phosphate.
CSP

The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”, MetaCyc:PENTOSE-P-PWY]
GO

An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
MSH

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pohlavní orgány ženské – nádory

Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
MSH

new abnormal tissue of the female reproductive system that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

Cancer in the human female`s reproductive organs
NCI

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karboanhydrasa III

A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
MSH

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spermové banky

Centers for acquiring and storing semen.
MSH

Freezing sperm for use in the future. This procedure can allow men to father children after loss of fertility.
NCI

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davové chování

Collective behavior of an aggregate of individuals giving the appearance of unity of attitude, feeling, and motivation.
MSH

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Peptococcus

A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of the mouth, upper respiratory tract, and large intestine in humans. Its organisms cause infections of soft tissues and bacteremias.
MSH

A genus of anaerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Peptococcaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Peptococcus genus level.
NCI

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Německo

central European country bordering on the North and Baltic Seas, capital Berlin.
CSP

A country in Central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. (NCI)
NCI

Description:Realm code for use of Germany


HL7V3.0

A country in Central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. (CIA World Factbook 2002)
NCI

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karcinom bazoskvamózní

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
MSH

skin carcinoma that histologically exhibits both basal and squamous elements.
CSP

A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases.
NCI

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sfinkterotomie transhepatická

Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.
MSH

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správa materiálů v nemocnici

The management of all procurement, distribution, and storage of equipment and supplies, as well as logistics management including laundry, processing of reusables, etc.
MSH

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perikarditida konstriktivní

Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.
MSH

A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function.
NCI

A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action.
NCI

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dásně – hypertrofie

Abnormal enlargement or overgrowth of the gingivae brought about by enlargement of existing cells.
MSH

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kardiopulmonální bypass

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
MSH

A procedure to circulate and oxygenate the blood by a machine during heart surgery
CHV

diversion of the blood flow to the heart directly to the aorta, via a pump oxygenator, avoiding the heart and/or the lungs; a form of extracorporeal circulation used in heart surgery; see BLOOD OXYGENATOR for the portion that oxygenates the blood and EXTRACORPOREAL CIRCULATION for the portion that recirculates one`s blood.
CSP

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spiramycin

A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.
MSH

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maytansin

An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
MSH

An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39492&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39492&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C626″ NCI Thesaurus)
PDQ

An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)
NCI

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periflebitida

Periphlebitis is inflammation of the outer coat of a vein or of tissues surrounding the vein.
MSH

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glomerulární filtrace – hodnota

The volume of water filtered out of plasma through glomerular capillary walls into Bowman`s capsules per unit of time. It is considered to be equivalent to INULIN clearance.
MSH

rate at which plasma is filtered by the glomerular filtration membrane into Bowman`s space; determined by the permeabiliy of the membrane, hydrostatic pressure in the glomerular capillaries and Bowman`s space, and the colloid osmotic pressure exerted by the proteins of the capillary plasma.
CSP

A kidney function test that measures the fluid volume that is filtered from the kidney glomeruli to the Bowman`s capsule per unit of time.
NCI

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arteria carotis – stenóza

Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)
MSH

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spondylóza

A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
MSH

degeneration of the spinal bone where spinal columns are fused and immobilized
CHV

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lékařská podpora, oddíl 19

Federal program, created by Public Law 89-97, Title XIX, a 1965 amendment to the Social Security Act, administered by the states, that provides health care benefits to indigent and medically indigent persons.
MSH

A joint federal and state program that provides assistance with healthcare costs to people with low income and limited resources. Medicaid is run by state and local governments within federal guidelines. Healthcare bills are paid from federal, state and local tax funds. The eligibility for the program does not depend on a person`s age. Participating beneficiaries usually pay no part of costs for covered healthcare expenses except a small co-payment required in some cases.
NCI

Medicaid is government health insurance that helps many low-income people in the United States to pay their medical bills. Although the Federal government establishes general guidelines for the program, each state has its own rules. Your state might require you to pay a small part of the cost for some medical services.

You have to meet certain requirements to be eligible for Medicaid. These might involve

  • Your age
  • Whether you are pregnant, disabled or blind
  • Your income and resources
  • Whether or not you are a U.S. citizen or a lawfully admitted immigrant

Centers for Medicare and Medicaid Services


MEDLINEPLUS

A health insurance program for people who cannot afford regular medical care. The program is run by U.S. federal, state, and local governments. People who receive Medicaid may have to pay a small amount for the services they get.
NCI

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osobnostní dotazník

Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.
MSH

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glukosa – roztok hypertonický

Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.
MSH

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extrakce katarakty

The removal of a cataractous CRYSTALLINE LENS from the eye.
MSH

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stapes

One of the three ossicles of the middle ear. It transmits sound vibrations from the INCUS to the internal ear (Ear, Internal see LABYRINTH).
MSH

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