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hemoglobinopatie

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
MSH

group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
CSP

An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule.
NCI

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Ranidae

The family of true frogs of the order Anura. The family occurs worldwide except in Antarctica.
MSH

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Azotobacteraceae

A subfamily of motile, gram-negative bacteria found in SOIL and WATER and capable of fixing atmospheric nitrogen.
MSH

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morálka – vývoj

The process by which individuals internalize standards of right and wrong conduct.
MSH

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alternativní lékařství

diagnostic or therapeutic technique which is presently outside the field of conventional medical practice; for use as a `tag` term index at `T` emphasis level.
CSP

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Camuratiho-Engelmannův syndrom

An autosomal dominant form of dysplasia that is characterized by progressive thickening of diaphyseal cortex of long bones. Mutations in the gene that encodes TRANSFORMING GROWTH FACTOR BETA1 are one cause of this disorder.
MSH

An autosomal dominant skeletal disorder caused by mutations in the TGFB1 gene. It is characterized by thickening of the bones, particularly the long bones of the extremities. It is associated with muscle weakness and tiredness.
NCI

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hemostáza

The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
MSH

process of arresting blood flow or bleeding, either physiologically by vasoconstriction and coagulation or by mechanical or surgical means.
CSP

The arrest of bleeding, either by the natural processes of vasoconstriction and coagulation or by surgical means.
NCI

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

The arrest of bleeding, either by the physiological properties of vasoconstriction and coagulation or by surgical means.
NCI

body function that stops bleeding by coagulating blood and constricting blood vessel
CHV

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razoxan

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.
MSH

A bis-dioxopiperazine and a derivative of the chelating agent EDTA with antineoplastic activity. Razoxane inhibits the enzyme topoisomerase II without inducing DNA strand breaks, thereby inhibiting DNA synthesis and inducing cytotoxicity. Although its mechanism is unknown, this agent exhibits anti-angiogenic activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C801″ NCI Thesaurus)
PDQ

An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.
NCI

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bakteriální infekce

Infections by bacteria, general or unspecified.
MSH

infections and associated diseases caused by bacteria, general or unspecified.
CSP

Bacteria are living things that have only one cell. Under a microscope, they look like balls, rods or spirals. They are so small that a line of 1,000 could fit across a pencil eraser. Most bacteria won`t hurt you – less than 1 percent makes people sick. Many are helpful. Some bacteria help to digest food, destroy disease-causing cells and give the body needed vitamins. Bacteria are also used in making healthy foods like yogurt and cheese.

But infectious bacteria can make you ill. They reproduce quickly in your body. Many give off chemicals called toxins, which can damage tissue and make you sick. Examples of bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli.

Antibiotics are the usual treatment. When you take antibiotics, follow the directions carefully. Each time you take antibiotics, you increase the chances that bacteria in your body will learn to resist them. Later, you could get or spread an infection that those antibiotics cannot cure.

NIH: National Institute of Allergy and Infectious Diseases


MEDLINEPLUS

An infection caused by bacteria.
NCI

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kinetózy

Disorder caused by motion, as sea sickness, train sickness, car sickness, air sickness, or SPACE MOTION SICKNESS. It may include nausea, vomiting and dizziness.
MSH

Motion sickness is a common problem in people traveling by car, train, airplanes and especially boats. Motion sickness can start suddenly, with a queasy feeling and cold sweats. It can then lead to dizziness and nausea and vomiting.

Your brain senses movement by getting signals from your inner ears, eyes, muscles and joints. When it gets signals that do not match, you can get motion sickness. For example, down below on a boat, your inner ear senses motion, but your eyes cannot tell you are moving.

Where you sit can make a difference. The front seat of a car, forward cars of a train, upper deck on a boat or wing seats in a plane may give you a smoother ride. Looking out into the distance – instead of trying to read or look at something in the vehicle – can also help.

Centers for Disease Control and Prevention


MEDLINEPLUS

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Ambystomatidae

A family of the class Urodela which includes 4 living genera, about 33 species, and occurs only in North America. Adults are usually terrestrial, but the larval forms are aquatic.
MSH

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dichlorvos

An organophosphorus insecticide that inhibits acetylcholinesterase.
MSH

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virus hepatitidy kachen

Unassigned species, in the family PICORNAVIRIDAE, causing high mortality in ducklings 3 days to 3 weeks old.
MSH

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receptor epidermálního růstového faktoru

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
MSH

Epidermal growth factor receptor (1210 aa, 134 kD) is a cell adhesion process protein that is encoded by the human EGFR gene and has roles in cell-cell adhesion, cell migration, cell proliferation and signal transduction.
NCI

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bambermyciny

Antibiotic complex obtained from Streptomyces bambergiensis containing mainly Moenomycins A and C. They are used as feed additives and growth promoters for poultry, swine, and cattle.
MSH

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melanocyty stimulující hormony

peptide hormones secreted by the intermediate lobe of the pituitary that stimulate melanin release and dispersal; also found in the brain where they are presumed to play a signaling role.
CSP

Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS.
MSH

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Activation of Amino Acids

The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. [GOC:jl]
GO

A reaction that produces an “activated” amino acid derivative, such as amino acyl adenylate, or amino acylphosphorylate and provides energy for the amino acid to be incorporated into a peptide, protein, or other macromolecule.
MSH

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dieta makrobiotická

An approach to nutrition based on whole cereal grains, beans, cooked vegetables and the Chinese YIN-YANG principle. It advocates a diet consisting of organic and locally grown foods, seasonal vegetables, complex carbohydrates, and fewer fats, sugars, and chemically processed foods.
MSH

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HERNIA INGINALA

An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach`s triangle. The former type is commonly seen in children and young adults; the latter in adults.
MSH

The protrusion of a sac-like structure containing fibroadipose tissue through an abnormal opening in the inguinal region.
NCI

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receptory steroidů

Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
MSH

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arteria basilaris

The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
MSH

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mumie

Bodies preserved either by the ancient Egyptian technique or due to chance under favorable climatic conditions.
MSH

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5-aminolevulátsynthetasa

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
MSH

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digitalisové glykosidy

Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.
MSH

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heterozygot

An individual having different alleles at one or more loci regarding a specific character.
MSH

having different alleles at one or more loci in homologous chromosome segments.
CSP

Having two different allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
NCI

Occurs when the two alleles at a particular gene locus are different. A heterozygous genotype may include one normal allele and one mutation, or two different mutations. The latter is called a compound heterozygote.
NCI

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referenční knihy

Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
MSH

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poruchy chování

any of various conditions characterized by impairment of an individual`s normal behavioral functioning, and caused by social, psychological, biochemical, genetic, or other factors, such as infection or head trauma.
CSP

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nervus musculocutaneus

A major nerve of the upper extremity. The fibers of the musculocutaneous nerve originate in the lower cervical spinal cord (usually C5 to C7), travel via the lateral cord of the brachial plexus, and supply sensory and motor innervation to the upper arm, elbow, and forearm.
MSH

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amoxapin

The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both. It also blocks dopamine receptors.
MSH

A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
NCI

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dijodtyrosin

A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).
MSH

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