Shopping Page. Buy or upgrade website.

6-merkaptopurin

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
MSH

A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.
NCI

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5`-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C195″ NCI Thesaurus)
PDQ

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5`-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
NCI

Price: $1.00

Loading Updating cart…

anorexia nervosa

An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
MSH

syndrome in which the primary features include excessive fear of becoming overweight, body image disturbance, significant weight loss, refusal to maintain minimal normal weight, and amenorrhea; disorder occurs most frequently in adolescent females.
CSP

An eating disorder marked by an intense fear of gaining weight, a refusal to maintain a healthy weight, and a distorted body image. People with anorexia nervosa have an abnormal loss of appetite for food, try to avoid eating, and eat as little as possible.
NCI

A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea.
NCI

Price: $1.00

Loading Updating cart…

programovací jazyk

Specific languages used to prepare computer programs.
MSH

A formal language in which computer programs are written. The definition of a particular language consists of both syntax (how the various symbols of the language may be combined) and semantics (the meaning of the language constructs). (Free On-Line Dictionary of Computing)
NCI

Price: $1.00

Loading Updating cart…

neurofibrily

The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the cytoplasm of the body of a neuron and extending from one dendrite into another or into the axon.
MSH

Price: $1.00

Loading Updating cart…

Cryptococcus neoformans

species of the fungus Cryptococcus, which causes cryptococcosis; its teleomorph is Filobasidiella neoformans.
CSP

A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
MSH

A species of the fungus cryptococcus, the causative agent of cryptococcosis.
NCI

Price: $1.00

Loading Updating cart…

hyperglykemické hyperosmolární neketotické kóma

A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.
MSH

Price: $1.00

Loading Updating cart…

slez

The fourth stomach of ruminating animals. It is also called the “true” stomach. It is an elongated pear-shaped sac lying on the floor of the abdomen, on the right-hand side, and roughly between the seventh and twelfth ribs. It leads to the beginning of the small intestine. (From Black`s Veterinary Dictionary, 17th ed)
MSH

Price: $1.00

Loading Updating cart…

antropometrie

The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
MSH

measurement of the physical dimensions of the human or other primate body characteristics such as size, breadth, girth, weight, proportion and distance between anatomical points; also includes segment masses, the centers of gravity of body segments, and the ranges of joint motion, which are used in biomechanical analyses of work postures; in anthropology it is used to refer to different body sizes and proportions of individuals belonging to different populations.
CSP

Price: $1.00

Loading Updating cart…

propanil

A chlorinated anilide that is used as an herbicide.
MSH

Price: $1.00

Loading Updating cart…

neurofarmakologie

The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system.
MSH

study of the origin, nature, properties, and actions of drugs and their effects on the nervous system; use this term mainly for intended, desired effects; for harmful or undesired effects, see NEUROTOXICOLOGY.
CSP

A branch of pharmacology concerned with the effects of drugs on the nervous system.
NCI

Price: $1.00

Loading Updating cart…

kyanidy

Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
MSH

class of compounds derived from HCN containing the -CN radical.
CSP

Price: $1.00

Loading Updating cart…

hypertenze maligní

A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
MSH

Price: $1.00

Loading Updating cart…

Acanthamoeba

facultative parasite of humans usually causes chronic infectin of the skin or central nervous system; causative agents of keratitis (corneal inflammation and opacity); most common ameba in fresh water and soil.
CSP

A genus of free-living soil amoebae that produces no flagellate stage. Its organisms are pathogens for several infections in humans and have been found in the eye, bone, brain, and respiratory tract.
MSH

Price: $1.00

Loading Updating cart…

protilátky – tvorba

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
MSH

synthesis of antibodies in response to B-cell activation by antigens; includes genetic regulation, recombination, all aspects of gene expression of the antibodies as well as the proliferation and differentiation of the B lymphocytes into plasma cells or memory cells.
CSP

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149 “Fundamental Immunology”]
GO

Price: $1.00

Loading Updating cart…

propylthiouracil

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
MSH

A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5`-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39288&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39288&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C781″ NCI Thesaurus)
PDQ

A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5`-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
NCI

Price: $1.00

Loading Updating cart…

Nová Guinea

Originally an island of the Malay Archipelago, the second largest island in the world. It divided, West New Guinea becoming part of Indonesia and East New Guinea becoming Papua New Guinea.
MSH

Price: $1.00

Loading Updating cart…

cykloserin

Antibiotic substance produced by Streptomyces garyphalus.
MSH

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.
NCI

Price: $1.00

Loading Updating cart…

hypoglyciny

Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
MSH

Price: $1.00

Loading Updating cart…

acetabulum

Two cup shaped areas, one each on the lateral side of the lower pelvis that house the head of the femur to form the ball and socket joint of the hip. (NCI)
NCI

Two cup shaped areas, one each on the lateral side of the lower pelvis that house the head of the femur to form the ball and socket joint of the hip.
NCI

Price: $1.00

Loading Updating cart…

antigeny diferenciační myelomonocytární

Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
MSH

Price: $1.00

Loading Updating cart…

protézy – design

The plan and delineation of prostheses in general or a specific prosthesis.
MSH

Price: $1.00

Loading Updating cart…

nifurtimox

A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.
MSH

A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.
NCI

Price: $1.00

Loading Updating cart…

cysteinové endopeptidasy

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
MSH

Price: $1.00

Loading Updating cart…

hypotonické roztoky

Solutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
MSH

Price: $1.00

Loading Updating cart…

acetylcholinesterasa

An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
MSH

an enzyme
CHV

Price: $1.00

Loading Updating cart…

antitumorózní látky fytogenní

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
MSH

Price: $1.00

Loading Updating cart…

proteiny

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
MSH

linear polymers of alpha-L-aminoacids ranging in size from a few thousand to over 1 million daltons, capable of oligomerization, with specific functions dictated by aminoacid sequence and encoded genetically.
CSP

A molecule made up of amino acids that are needed for the body to function properly. Proteins are the basis of body structures such as skin and hair and of substances such as enzymes, cytokines, and antibodies.
NCI

A group of complex organic macromolecules composed of one or more chains (linear polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few thousand to over 1 million Daltons. Proteins are fundamental genetically encoded components of living cells with specific structures and functions dictated by amino acid sequence.
NCI

Price: $1.00

Loading Updating cart…

nitroanisol-O-demethylasa

Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.
MSH

Price: $1.00

Loading Updating cart…

cytochromy b5

Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.
MSH

Price: $1.00

Loading Updating cart…

identifikace (psychologie)

A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others.
MSH

process by which an individual unconsciously endeavors to pattern himself after another; this process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others.
CSP

Price: $1.00

Loading Updating cart…

Comments are closed