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spánek letní

In certain living species, a period of dormancy during the summer months marked by decreased metabolism.
MSH

Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season. [GOC:jl, http://www.wikipedia.org/Estivation, PMID:12443930]
GO

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sulfisoxazol

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
MSH

A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.
NCI

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endarteritida

Inflammation of the inner endothelial lining (TUNICA INTIMA) of an artery.
MSH

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pia mater

The innermost layer of the three meninges covering the brain and spinal cord. It is the fine vascular membrane that lies under the ARACHNOID and the DURA MATER.
MSH

innermost layer of the leptomeninges, which adheres to the brain and spinal cord and conforms to all the irregularities on their surfaces.
CSP

The delicate, highly vascular, innermost membrane encasing the brain and spinal cord.
NCI

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isoprotilátky

Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
MSH

antibodies produced by one individual that react with antigens of another individual of the same species.
CSP

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kalmodulin

A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
MSH

intracellular protein that mediates the calcium dependence of many enzymes and cell functions.
CSP

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ethchlorvynol

A sedative and hypnotic that has been used in the short-term management of INSOMNIA. Its use has been superseded by other drugs.
MSH

A member of the class of tertiary carbinols with sedative and hypnotic properties. Ethchlorvynol appears to depress the central nervous system by binding at a benzodiazepine-GABA-A-chloride ionophore receptor complex, located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.
NCI

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superfetace

The FERTILIZATION of an OVUM that takes place when a FETUS is already present in the UTERUS. Superfetation results in an unusual PREGNANCY with fetuses of different ages and sizes developing in utero simultaneously.
MSH

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endoribonukleasy

A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.
MSH

A hydrolase enzyme which makes oligonucleotides and polynucleotides by hydrolysing the interior bonds of ribonucleotides. (On-line Medical Dictionary)
NCI

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piperidine

saturated 6-membered ring structure with one nitrogen atom.
CSP

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izotachoforéza

A nonlinear electrophoretic technique used to separate a variety of ionic compounds, ranging from small metal ions to large molecules like proteins. Unlike “linear” zone electrophoresis in which separating solute bands continually spread by diffusion or dispersion, isotachophoresis forms self-sharpening, adjacent zones of substantially pure solute whose concentrations often exceed several mgs/ml. In isotachophoresis a multianalyte sample is introduced between the leading electrolyte and the terminating electrolyte where the sample ions have lower electrophoretic mobilities than the leading ion but larger than the terminating ion. (From “Isotachophoresis” on the AES Web Site [Internet]. Madison, WI: The American Electrophoresis Society; c2000-2008 [cited 2009 Aug 20]. Available from http://www.aesociety.org/areas/isotachophoresis.php)
MSH

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kandidóza chronická mukokutánní

A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
MSH

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ethosuximid

An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
MSH

A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures.
NCI

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kardiovaskulární chirurgické výkony

procedures performed on the cardiovascular system, used in the treatment of disease, injuries, or deformities; includes excision of portions of the cardiovascular system.
CSP

Surgery performed on the heart or blood vessels.
MSH

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enteritida přenosná krocanů

An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.
MSH

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pityriasis rubra pilaris

A chronic skin disease characterized by small follicular papules, disseminated reddish-brown scaly patches, and often, palmoplantar hyperkeratosis. The papules are about the size of a pin and topped by a horny plug.
MSH

A rare cutaneous disorder of unknown etiology characterized by the presence of reddish-orange scaly plaques, palmoplantar keratoderma, keratotic follicular papules, and confluent erythematous areas with areas of normal skin between the lesions.
NCI

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Svědkové Jehovovi

Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah`s Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
MSH

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tobolky

Hard or soft soluble containers used for the oral administration of medicine.
MSH

A solid pharmaceutical dosage form that contains medicinal agent within either a hard or soft soluble container or shell, usually used for the oral administration of medicine. The shells are made of a suitable form of gelatin or other substance. (NCI)
NCI

A solid contained within either a hard or soft soluble shell, usually prepared from gelatin.
NCI

A form for medicine that is taken by mouth. It usually has a shell made of gelatin with the medicine inside.
NCI

A drug packaging type usually in a cylindrical shape with rounded ends. Capsule shells may be made from gelatin, starch, or cellulose, or other suitable materials, may be soft or hard, and are filled with solid or liquid drug products.
NCI

A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or “shell” made from a suitable form of gelatin.


HL7V3.0

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etioporfyriny

Porphyrins with four methyl and four ethyl side chains attached to the pyrrole rings.
MSH

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přežití – analýza

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
MSH

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enzymy – indukce

An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
MSH

Enzyme Induction involves initiation of function of a biological molecule that possesses catalytic activity.
NCI

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rostliny

Multicellular, eukaryotic life forms of the kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
MSH

multicellular, autotrophic, photosynthetic organisms with multicellular haploid and diploid stages, gametes produced by mitosis; may be terrestrial or aquatic.
CSP

Any living organism that typically synthesizes its food from inorganic substances, possesses cellulose cell walls, responds slowly and often permanently to a stimulus, lacks specialized sense organs and nervous system, and has no powers of locomotion. (EPA Terminology Reference System)
NCI

A living subject from the order of plants.


HL7V3.0

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kalidin

A decapeptide bradykinin homolog cleaved from kininogen by kallikreins. It is a smooth-muscle stimulant and hypotensive agent that acts by vasodilatation.
MSH

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oxid uhelnatý

Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
MSH

colorless, odorless, poisonous gas produced by incomplete fossil fuel combustion.
CSP

An odorless, tasteless, poisonous gas, CO, that results from the incomplete combustion of carbon. Inhalation causes central nervous system damage and asphyxiation.
NCI

A poisonous gas that has no color or odor. It is given off by burning fuel (as in exhaust from cars or household heaters) and tobacco products. Carbon monoxide prevents red blood cells from carrying enough oxygen for cells and tissues to live.
NCI

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Exkoriace

A superficial traumatic injury to the skin caused most often by scratching, but also by abrasions or by a chemical or thermal burn.
NCI

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sympatolytika

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
MSH

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trombocyty – aktivace

A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
MSH

process by which platelets change shape, aggregate, adhere to vascular wall, and secrete cytokines during clotting; induced by a variety of agonists including thrombin, ADP, PAF, and epinephrine via a G protein/IP3 coupled receptor system.
CSP

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
GO

Platelet Activation involves initiation of a set of stimulated platelet activities involved in aggregation of platelets and fibrin during blood coagulation.
NCI

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keratokonjunktivitida infekční

Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.
MSH

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karcinom Walkerův 256

A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
MSH

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extracelulární matrix

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
MSH

meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface; it promotes cellular proliferation and provides a supporting structure.
CSP

Body substance which consists of ground substance and connective tissue fibers.
UWDA

A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). [GOC:mah]
GO

Body substance which consists of ground substance and connective tissue fibers.
FMA

The extracellular matrix is a network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
NCI

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