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ekkrinní žlázy

Simple sweat glands that secrete sweat directly onto the SKIN.
MSH

A type of simple sweat gland that is found in almost all regions of the skin. These glands produce sweat that reaches the surface of the skin by way of coiled ducts (tubes). The body is cooled as sweat evaporates from the skin.
NCI

An unbranched, coiled, tubular gland not associated with the hair follicle that promotes cooling by evaporation of its secretion. It is innervated by cholinergic nerve fibers.
NCI

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luteom

An ovarian neoplasm composed of LUTEAL CELLS derived from luteinized GRANULOSA CELLS and THECA CELLS. Luteomas respond to GONADOTROPINS, and vary in their hormone production (PROGESTERONE; ESTROGENS; or ANDROGENS). During PREGNANCY, a transient type of luteoma may develop due to an exaggerated LUTEINIZATION of the OVARY.
MSH

A benign ovarian stromal tumor in which more than 90% of the tumor cells resemble steroid hormone-secreting cells. Crystals of Reinke are not present. It occurs in post-menopausal women and it is usually associated with estrogenic effects.
NCI

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polygrafie

The aggregate enterprise of manufacturing and technically producing books. (From Random House Unabridged Dictionary, 2d ed)
MSH

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temporomandibulární kloub

An articulation between the condyle of the mandible and the articular tubercle of the temporal bone.
MSH

temporomandibular articulation: a bicondylar joint formed by the head of the mandible and the mandibular fossa, and the articular tubercle of the temporal bone.
CSP

The joint between the head of the lower mandible and the temporal bone. (NCI)
NCI

The joint between the head of the lower mandible and the temporal bone.
NCI

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galaktosylceramidasa

An enzyme that hydrolyzes galactose from ceramide monohexosides. Deficiency of this enzyme may cause globoid cell leukodystrophy (LEUKODYSTROPHY, GLOBOID CELL). EC 3.2.1.46.
MSH

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polymerázová řetězová reakce

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
MSH

method for reproducing specific DNA sequences based on elongation of complementary primers by DNA polymerase; primarily used to increase quantities for analytical detection of, e.g., virus genome.
CSP

A laboratory method used to make many copies of a specific DNA sequence.
NCI

laboratory procedure for producing large amounts of specific DNA or RNA fragments
CHV

Description:Polymerase Chain Reaction


HL7V3.0

A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample.
NCI

Molecular, Polymerase chain reaction


HL7V3.0

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ekonomická hodnota života

The evaluation of the monetary value of a life lost or a life saved.
MSH

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lymfocytární choriomeningitida

A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
MSH

benign viral infection of meninges and central nervous system producing an infiltration of lymphocytes in the choroid plexus.
CSP

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botulotoxiny

Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
MSH

toxins produced by Clostridium botulinum; there are at least seven different substances, most being proteins; they have neuro-, entero-, and hemotoxic properties, are immunogenic, and are among the most potent poisons known; used medically to block release of acetylcholine at cholinergic synapses.
CSP

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testis – nemoci

Pathological processes of the TESTIS.
MSH

deviation from or interruption of the normal structure or function of the testis.
CSP

Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It`s easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports.

You should examine your testicles monthly and seek medical attention for lumps, redness, pain or other changes. Testicles can get inflamed or infected. They can also develop cancer. Testicular cancer is rare and highly treatable. It usually happens between the ages of 15 and 40.


MEDLINEPLUS

A disorder characterized by involvement of the testis.
NCI

A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.
NCI

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gamma-Tubulin

Ubiquitous or widely expressed 51-kDa conserved Gamma-Tubulins (Tubulin Family) constitute a major essential component of microtubule organizing centers such as spindle poles or centrosomes that are likely involved in minus-end nucleation of microtubule assembly. (NCI)
NCI

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polytetrafluoroethylen

Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
MSH

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Educational aspects

Used for education, training programs, and courses in various fields and disciplines, and for training groups of persons.
MSH

The activities of educating or instructing or teaching; activities that impart knowledge or skill.
NCI

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lysin-tRNA-ligasa

An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
MSH

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Moraxella (Branhamella) catarrhalis

Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause MENINGITIS; BACTEREMIA; EMPYEMA; PERICARDITIS; and PNEUMONIA.
MSH

A species of gram-negative, aerobic, oxidase-positive diplococcus bacteria within the phylum Proteobacteria that causes upper respiratory tract infections, particularly in immunocompromised hosts.
NCI

Any bacterial organism that can be assigned to the species Moraxella catarrhalis.
NCI

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tetrahydrouridin

An inhibitor of nucleotide metabolism.
MSH

A substance that makes tumor cells more sensitive to radiation therapy and is being studied in the treatment of cancer. It belongs to the families of drugs called cytidine deaminase inhibitors, multidrug resistance modulators, and radiosensitizers.
NCI

A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2`-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2`-deoxycytidine monophosphate (CldCMP) to 5-chloro-2`-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2`-deoxyuridine). Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39710&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39710&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C868″ NCI Thesaurus)
PDQ

A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2`-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2`-deoxycytidine monophosphate (CldCMP) to 5-chloro-2`-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2`-deoxyuridine). (NCI04)
NCI

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žaludek – vyprazdňování

The evacuation of food from the stomach into the duodenum.
MSH

evacuation of food from the stomach into the duodenum.
CSP

The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. [GOC:cy, ISBN:9781416032458]
GO

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sviňuchy

Mammals of the family Phocoenidae comprising four genera found in the North Pacific Ocean and both sides of the North Atlantic Ocean and in various other seas. They differ from DOLPHINS in that porpoises have a blunt snout and a rather stocky body while dolphins have a beak-like snout and a slender, streamlined body. They usually travel in small groups. (From Walker`s Mammals of the World, 5th ed, pp1003-4)
MSH

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modifikátory efektu (epidemiologie)

Factors that modify the effect of the putative causal factor(s) under study.
MSH

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magnety

Objects that produce a magnetic field.
MSH

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brom – radioisotopy

Unstable isotopes of bromine that decay or disintegrate emitting radiation. Br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.
MSH

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tematická apercepce – test

A projective technique which focuses primarily on the dynamics of interpersonal relationships. It consists of a series of 31 pictures that depict various social situations and interpersonal relations. A subset is selected by the examiner and presented to the subject who is asked to tell a story about each picture. The stories are interpreted in terms of the subject`s relations to authority figures, to contemporaries of both sexes, and in terms of the compromises between external demands and the needs of the id, the ego, and the superego. (From Campbell, Psychiatric Dictionary, 1996)
MSH

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ventrikulografie radionuklidová rovnovážná

Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
MSH

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dvojchroman draselný

Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.
MSH

An orange to red colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Potassium dichromate is highly corrosive and is a strong oxidizing agent. This substance is used in wood preservatives, in the manufacture of pigments and in photomechanical processes, but is mainly replaced by sodium dichromate. Potassium dichromate primarily affects the respiratory tract causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
NCI

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elastin

collagen-like, elastic protein found in yellow connective tissue.
CSP

Elastin (786 aa, ~68 kDa) is encoded by the human ELN gene. This protein is involved in the elasticity of the extracellular matrix.
NCI

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katar maligní

A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte.
MSH

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bronchopulmonální sekvestrace

A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.
MSH

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thiaminpyrofosfokinasa

An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2.
MSH

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genové produkty rev

Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.
MSH

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preexcitační syndromy

A group of conditions in which HEART VENTRICLE activation by the atrial impulse is faster than the normal impulse conduction from the SINOATRIAL NODE. In these pre-excitation syndromes, atrial impulses often bypass the ATRIOVENTRICULAR NODE delay and travel via ACCESSORY CONDUCTING PATHWAYS connecting the atrium directly to the BUNDLE OF HIS.
MSH

A condition characterized by the activation of the whole or some part of the ventricle by the transmission of an atrial impulse along an accessory pathway rather than by way of the normal specific conduction system which includes a delay at the atrioventricular node. (NCI)
NCI

A syndrome characterized by premature contractions of the ventricles due to the presence of an accessory conductive pathway between the atria and the ventricles.
NCI

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