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antitumorózní látky

Substances that inhibit or prevent the proliferation of NEOPLASMS.
MSH

agent that inhibits or prevents the development or proliferation of neoplasms.
CSP

A drug used to treat cancer.
NCI

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000).
NDFRT

A substance that inhibits the maturation, growth or spread of tumor cells.
NCI

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omeprazol

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.
MSH

substituted benzimidazole used as a gastric acid secretion inhibitor.
CSP

A drug that inhibits gastric acid secretion.
NCI

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716″ NCI Thesaurus)
PDQ

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
NCI

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isoenzymy

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
MSH

different form of the same enzyme, such as from another tissue or species, membrane-bound vs. soluble, secreted vs. intracellular, or oligomerized to a different degree.
CSP

The term “isoenzyme” or “isozyme” refers to variants of the same enzyme which can be separated on special conducting media using electrophoresis. It should apply only to those multiple forms of enzymes arising from genetically determined differences in primary structure and not to those derived by modification of the same primary sequence.
NCI

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cytochemie

Branch of histochemistry associated with the localization of cellular components by specific staining methods, as for example the localization of acid phosphatases by the Gomori method.
NCI

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etika stomatologická

The principles of proper professional conduct concerning the rights and duties of the dentist, relations with patients and fellow practitioners, as well as actions of the dentist in patient care and interpersonal relations with patient families. (From Stedman, 25th ed)
MSH

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sarkoidóza

WHAT: Sarcoidosis:
AIR

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
MSH

inflammatory disease characterized by small lumps or granulomas in lymph nodes and other organs.
CSP

Sarcoidosis is an inflammatory disease. It starts as tiny, grain-like lumps called granulomas, which most often appear in your lungs or lymph nodes. They can clump together and form larger lumps that attack other organs. Sarcoidosis often affects your skin, eyes or liver.

Sarcoidosis may be mild, or it can be severe and do lasting damage. It does not always cause symptoms, so you can have it without knowing it. Symptoms vary, depending on which organs are affected.

No one is sure what causes sarcoidosis. It affects men and women of all ages and races worldwide. However, it occurs mostly in people ages 20 to 40, African Americans, especially women, and people of Asian, German, Irish, Puerto Rican and Scandinavian origin.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

a disease that produces messes especially in the liver, lungs, skin, and lymph nodes
CHV

An inflammatory disease marked by the formation of granulomas (small nodules of immune cells) in the lungs, lymph nodes, and other organs. Sarcoidosis may be acute and go away by itself, or it may be chronic and progressive.
NCI

An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.
NCI

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anus

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded.
NCI

The opening of the rectum to the outside of the body.
NCI

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded. (NCI)
NCI

The external outlet of the GASTROINTESTINAL TRACT.
MSH

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operon

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
MSH

group of contiguous genes coordinately regulated by a promoter and an operator element; found in prokaryotes.
CSP

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isoxsuprin

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
MSH

A benzyl alcohol derivative with vasodilator activity. The mechanism of action of isoxsuprine hydrochloride is controversial, because isoxsuprine has beta-adrenergic activities that could not be offset by beta-adrenergic blockers. Although stimulation of the beta adrenergic receptor increases blood flow to produce vasodilatation, this agent may also have direct effects on the contractility of smooth muscle. Additionally, isoxsuprine causes relaxation of uterine smooth muscle and may also produce positive inotropic and chronotropic effects on the myocardium.
NCI

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cytofotometrie

A method for the study of certain organic compounds within cells, in situ, by measuring the light intensities of the selectively stained areas of cytoplasm. The compounds studied and their locations in the cells are made to fluoresce and are observed under a microscope.
MSH

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ethylenchlorhydrin

Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.
MSH

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Schillingův test

A diagnostic test in which vitamin B12 is tagged with radioactive cobalt, taken orally, and gastrointestinal absorption is determined via measurement of the amount of radioactivity in a 24-hour urine collection.
MSH

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afakie po kataraktě

Absence of the crystalline lens resulting from cataract extraction.
MSH

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Optics

science that deals with the genesis and propagation of light, the changes that it undergoes and produces, and other phenomena closely associated with it.
CSP

The branch of physics that describes the behavior and properties of light and the interaction of light with matter.
NCI

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zaměstnání – žádost o místo

Process of applying for employment. It includes written application for employment or personal appearance.
MSH

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sběr dat

Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
MSH

gathering or assemblage of information (statistics or measurements) about a system, population, etc.; do not confuse with SAMPLE COLLECTION (PHYSICAL).
CSP

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eugenol

A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.
MSH

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školy zdravotnické

Schools which offer training in the area of health.
MSH

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schůzky a rozvrhy

The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.
MSH

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organizace – afiliace

Formal relationships established between otherwise independent organizations. These include affiliation agreements, interlocking boards, common controls, hospital medical school affiliations, etc.
MSH

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guma karaya

Polysaccharide gum from Sterculia urens (STERCULIA). It is used as a suspending or stabilizing agent in foods, cosmetics and pharmaceuticals; a bulk-forming laxative; a surgical lubricant and adhesive; and in the treatment of skin ulcers.
MSH

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decidua

The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
MSH

endometrium of the pregnant uterus; shed at parturition, except for the deepest layer.
CSP

The epithelial tissue of the endometrium.
NCI

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existencialismus

Philosophy based on the analysis of the individual`s existence in the world which holds that human existence cannot be completely described in scientific terms. Existentialism also stresses the freedom and responsibility of the individual as well as the uniqueness of religious and ethical experiences and the analysis of subjective phenomena such as anxiety, guilt, and suffering. (APA, Thesaurus of Psychological Index Terms, 8th ed.)
MSH

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skopolamin

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.
MSH

The hydrobromide salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. Structurally similar to acetylcholine, scopolamine antagonizes acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. The agent is used to cause mydriasis, cycloplegia, to control the secretion of saliva and gastric acid, to slow gut motility, and prevent vomiting.
NCI

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arbaprostil

A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors.
MSH

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orfenadrin

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
MSH

A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine receptors as well as N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS). This may interfere with the transmission of nerve impulses from the spinal cord to the muscles and may help relax muscles. In addition, orphenadrine exerts antagonistic effects on histamine H1 receptors.
NCI

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keratóza aktinická

A thick, scaly patch of skin that may become cancer. It usually forms on areas exposed to the sun, such as the face, scalp, back of the hands, or chest. It is most common in people with fair skin.
NCI

White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.
MSH

precancerous thick and scaly patches of skin
CHV

A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.
NCI

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kyselina dehydroaskorbová

The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.
MSH

The oxidized form of ascorbic acid; it can be readily reduced to ascorbic acid in vivo.
NCI

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extraorální trakční přístroje

Extraoral devices for applying force to the dentition in order to avoid some of the problems in anchorage control met with in intermaxillary traction and to apply force in directions not otherwise possible.
MSH

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Process of secretion

production of a hormone or other substance which will perform a specialized function outside the gland, cell or organ.
CSP

Used for the discharge across the cell membrane, into the extracellular space or ducts, of endogenous substances resulting from the activity of intact cells of glands, tissues, or organs.
MSH

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