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deferoxamine mesylate

The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41696&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41696&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C417″ NCI Thesaurus)
PDQ

The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome.
NCI

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bylinné čaje

An aqueous extract derived from parts of various plants, but excluding that made from the leaves of the real tea bush Camellia sinensis. The parts used can be fresh or dried leaves, roots, seeds and flowers.
NCI

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puerperium

A period after PARTURITION, from the time of giving BIRTH to the complete involution of the UTERUS to its pre-pregnant state. Puerperium generally lasts about six to eight weeks.
MSH

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arginin-tRNA-ligasa

An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.
MSH

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multienzymové komplexy

Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
MSH

systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates; may involve simply a transfer of water molecules of hydrogen atoms or be associated with large supramolecular structures such as mitochondria or ribosomes.
CSP

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aplikace místní

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
MSH

drug applied to a particular surface area, usually affecting only the area to which it is applied.
CSP

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demence multiinfarktová

Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)
MSH

dementia, due to significant cerebrovascular disease, with a stepwise deteriorating course and a `patchy` distribution of neurologic deficits.
CSP

A common form of dementia caused by multiple cortical or subcortical cerebral infarctions.
NCI

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heterocyklické sloučeniny

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

ring compounds having atoms other than carbon in their nuclei.
CSP

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pulzační průtok

Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
MSH

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arterioly

The smallest divisions of the arteries located between the muscular arteries and the capillaries.
MSH

smallest thin-walled divisions of the arteries located between the muscular arteries and the capillaries.
CSP

Subdivision of arterial tree (organ) which is directly continuous with capillary vessel.
UWDA

A small, terminal branch in the arterial system. Arterioles often connect to capillaries.
NCI

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svaly – relaxace

That phase of a muscle twitch during which a muscle returns to a resting position.
MSH

lessening of muscle tension.
CSP

A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. [GOC:rl, PMID:19996365]
GO

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alfa-2-adrenergní receptory

A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
MSH

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zubní cement (tkáň)

The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)
MSH

Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth.
UWDA

bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament.
CSP

Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth.
FMA

A bonelike substance covering the root of a tooth
CHV

Bone-like rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal. It serves as an attachment for the periodontal ligament, thus assisting in tooth support.
NCI

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kyseliny hexuronové

Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
MSH

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pyelitida

Inflammation of the KIDNEY PELVIS and KIDNEY CALICES where urine is collected before discharge, but does not involve the renal parenchyma (the NEPHRONS) where urine is processed.
MSH

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arylamin-N-acetyltransferasa

An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.
MSH

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Mycobacterium

genus of gram positive, aerobic bacteria; most species are free living in soil and water, but the major habitat for some is the diseased tissue of warm blooded hosts.
CSP

A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.
MSH

A genus of acid-fast Gram-positive, aerobic and nonmotile bacteria in the phylum Actinobacteria.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Mycobacterium genus level.
NCI

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syndrom přívodné kličky

A complication of gastrojejunostomy (BILLROTH II PROCEDURE), a reconstructive GASTROENTEROSTOMY. It is caused by acute (complete) or chronic (intermittent) obstruction of the afferent jejunal loop due to HERNIA, intussusception, kinking, VOLVULUS, etc. It is characterized by PAIN and VOMITING of BILE-stained fluid.
MSH

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zubní plak – index

An index which scores the degree of dental plaque accumulation.
MSH

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histamin – antagonisté

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
MSH

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pyridoxamin

The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.
MSH

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aspartátkarbamoyltransferasa

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
MSH

Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade.
NCI

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virus ptačí myeloblastózy

A species of ALPHARETROVIRUS causing anemia in fowl.
MSH

A retro-transcribing virus, of the genus Alpharetrovirus and the family Retroviridae, that causes anemia and malignant disease in wild and domestic fowl.
NCI

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aglutinace – testy

Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
MSH

mixing of antibodies with their corresponding antigens on the surface of large, easily sedimented particles such as animal cells, erythrocytes, or bacteria; the antibodies cross-link the particles, forming visible clumps.
CSP

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dentinogenesis

The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)
MSH

the formation of dentin; dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately; formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward; a layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes.
CSP

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histonkinasa

An aspect of protein kinase (EC 2.7.1.37) in which serine residues in protamines and histones are phosphorylated in the presence of ATP. EC 2.7.1.70.
MSH

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pyruvate dehydrogenase

a component of the multi-enzyme pyruvate dehydrogenase complex also another name for EC 4.1.1.1, PYRUVATE DECARBOXYLASE, do not confuse.
CSP

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adstringencia

Agents, usually topical, that cause the contraction of tissues for the control of bleeding or secretions.
MSH

With a binding, contracting action on mucous membranes, skin, and other tissues, Astringent substances reduce irritation and inflammation; create a barrier against infection; help wounds and burns to heal; arrest secretion; and control bleeding. (NCI04)
NCI

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myosin typ II

The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.
MSH

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letadla

A weight-carrying structure for navigation of the air that is supported either by its own buoyancy or by the dynamic action of the air against its surfaces. (Webster, 1973)
MSH

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