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kyselina eikosapentaenová

An essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes.
NCI

A class of polyunsaturated fatty acids with 20 carbons and 5 double bonds.
NCI

Polyunsaturated fatty acid with 20 carbons and 5 double bonds at the 3rd, 6th, 9th, 12th and 15th carbons from the methyl end.
NCI

A polyunsaturated long-chain fatty acid with a 20-carbon backbone and 5 double bonds, originating from the 3rd, 6th, 9th, 12th and 15th positions from the methyl end.
NCI

Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
MSH

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nalorfin

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
MSH

narcotic antagonist with some agonist properties; an antagonist at mu opioid receptors and an agonist at kappa opioid receptors.
CSP

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antituberkulotika

Drugs used in the treatment of tuberculosis. They are divided into two main classes: “first-line” agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and “second-line” drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
MSH

drug used in the treatment of tuberculosis.
CSP

Describes a drug or effect that works against tuberculosis (a contagious bacterial infection that usually affects the lungs).
NCI

Any agent that is active against Mycobacterium tuberculosis and can be used in the treatment of or in the prevention of tuberculosis.
NCI

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progestiny

class of drugs which mimic progesterone by promoting gestation.
CSP

a synthetic or natural hormone that mimics progesterone
CHV

Any natural or laboratory-made substance that has some or all of the biologic effects of progesterone, a female hormone.
NCI

Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
MSH

Substances that produce effects similar to those of progesterone, the only natural progestagen. All other progestogens are synthetic and are often referred to as progestins. All progestagens have antiestrogenic and antigonadotropic properties. (From Wikipedia)
NCI

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hospice

Facilities or services which are especially devoted to providing palliative and supportive care to the patient with a terminal illness and to the patient`s family.
MSH

facility that provides palliative and supportive care for terminally ill patients and their families.
CSP

An establishment that provides palliative and supportive care for terminally ill patients and their families via physical, psychological, social and other forms of care.
NCI

program that provides spiritual, emotional, and physical care to terminally ill patients and their family
CHV

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Cytolysins

group of substances elaborated by microorganisms, plants or animals that are specifically toxic to individual cells; they may be involved in immunity or may be contained in venoms.
CSP

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bolesti břicha

Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue injuries, or diseases.
MSH

Your abdomen extends from below your chest to your groin. Some people call it the stomach, but your abdomen contains many other important organs. Pain in the abdomen can come from any one of them. The pain may start somewhere else, such as your chest. Severe pain doesn`t always mean a serious problem. Nor does mild pain mean a problem is not serious.

Call your healthcare provider if mild pain lasts a week or more or if you have pain with other symptoms. Get medical help immediately if

  • You have abdominal pain that is sudden and sharp
  • You also have pain in your chest, neck or shoulder
  • You`re vomiting blood or have blood in your stool
  • Your abdomen is stiff, hard and tender to touch
  • You can`t move your bowels, especially if you`re also vomiting


MEDLINEPLUS

A disorder characterized by a sensation of marked discomfort in the abdominal region.
NCI

Painful sensation in the abdominal region.
NCI

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nos – polypy

Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
MSH

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aortografie

Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
MSH

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promyelocyty

A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes.
NCI

The cells in the granulocytic series that are derived from myeloblasts and that are the earliest cells of the myelocyte stage.
MSH

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nemocnice obecní

Hospitals controlled by the city government.
MSH

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nebezpečné chování

Actions which have a high risk of being harmful or injurious to oneself or others.
MSH

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absentérství

Chronic absence from work or other duty.
MSH

failure to appear, especially for work or school.
CSP

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Tobramycin Sulfate

The sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. In addition, this agent induces misreading of the mRNA template, which results in 1) detachment of the ribosomal complex and inhibition of protein elongation or 2) incorporation of the incorrect amino acids into the growing polypeptide chain and the production of abnormal or nonfunctional proteins. Altogether, cell permeability is altered and cell death ensues.
NCI

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APENDIZITISA

Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.
MSH

The appendix is a small, tube-like organ attached to the first part of the large intestine, also called the colon. It is located in the lower right area of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow and inflammation. If the blockage is not treated, the appendix can break open and leak infection into the body.

Symptoms may include

  • Pain and/or swelling in the abdomen
  • Loss of appetite
  • Nausea and vomiting
  • Constipation or diarrhea
  • Inability to pass gas
  • Low fever

Not everyone with appendicitis has all these symptoms.

Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis. It happens most often to people between the ages of 10 and 30.

National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

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propoxykain

A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)
MSH

A para-aminobenzoic acid ester with local anesthetic activity. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.
NCI

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lidský T-lymfotropní virus 1

strain of primate T lymphotropic virus 1 isolated from mature T4 cells in patients with T lymphoproliferation malignancies; causes adult T cell leukemia, T cell lymphoma, and is involved in mycosis fungoides, Sezary syndrome and tropical spastic paraparesis.
CSP

A type of virus that infects T cells (a type of white blood cell) and can cause leukemia and lymphoma. HTLV-1 is spread by sharing syringes or needles, through blood transfusions or sexual contact, and from mother to child during birth or breast-feeding.
NCI

A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).
MSH

A human immunodeficiency virus; a species of lentivirus causing leukemia and sometimes a mild immunodeficiency.
NCI

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debrisochin

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
MSH

3,4-dihydro-2(H)-isoquinolinecarboxamidine (sulfate); oxidative metabolism of this drug is used to assay and model drug metabolism in general, especially genetic, ethnic, and individual pharmacokinetic differences.
CSP

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účty splatné a pohledávky

Short-term debt obligations and assets occurring in the regular course of operational transactions.
MSH

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neodym

Neodymium. An element of the rare earth family of metals. It has the atomic symbol Nd, atomic number 60, and atomic weight 144.24, and is used in industrial applications.
MSH

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arachidonátlipoxygenasy

Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .
MSH

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prostaglandiny G

A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. Most frequently encountered member of this group is the prostaglandin G2.
MSH

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mola hydatidosa

Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
MSH

trophoblastic hyperplasia associated with normal gestation, or molar pregnancy; characterized by the swelling of the chorionic villi and elevated human chorionic gonadotropin; hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
CSP

A slow-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. A hydatidiform mole contains many cysts (sacs of fluid). It is usually benign (not cancer) but it may spread to nearby tissues (invasive mole). It may also become a malignant tumor called choriocarcinoma. Hydatidiform mole is the most common type of gestational trophoblastic tumor.
NCI

A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells. According to the amount of villous involvement, a hydatidiform mole is defined as complete or partial. Most molar pregnancies are complete and are characterized by generalized hydropic villous changes. Partial moles are characterized by a mixture of large hydropic villi and normal placenta tissue. Complete moles are usually diploid and typically present between the eleventh and twenty-fifth week of pregnancy, whereas partial moles are usually triploid and usually present around the nineteenth week of pregnancy. The incidence of choriocarcinoma is higher in patients with complete hydatidiform mole. When a hydatidiform mole invades the myometrium and broad ligament, or it is found in distant sites as vagina, vulva, and lung, it is referred as invasive mole.
NCI

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deferoxamine mesylate

The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41696&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41696&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C417″ NCI Thesaurus)
PDQ

The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome.
NCI

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acetyl-CoA-C-acetyltransferasa

An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE.
MSH

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nádory vyvolané zářením

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
MSH

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arginin-tRNA-ligasa

An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.
MSH

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proteinkinasy

A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
MSH

group of enzymes under review by NC-IUBMB include EC 2.7.1.38, EC 2.7.1.70, EC 2.7.1.99, EC 2.7.1.109, EC 2.7.1.110, EC 2.7.1.111, EC 2.7.1.115, EC 2.7. 1.116, EC 2.7.1.124, EC 2.7.1.135, and EC 2.7.1.141.
CSP

A class of phosphotransferase proteins that posttranslationally modify protein substrates through the addition of phosphate groups.
NCI

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hydrogenasa

An enzyme found in bacteria. It catalyzes the reduction of FERREDOXIN and other substances in the presence of molecular hydrogen and is involved in the electron transport of bacterial photosynthesis.
MSH

specific enzyme (EC 1.18.99.1) that catalyzes the conversion of H+ to hydrogen gas via oxidation of ferredoxin; do not use for general term to cover other hydrogenating enzymes.
CSP

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demence multiinfarktová

Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)
MSH

dementia, due to significant cerebrovascular disease, with a stepwise deteriorating course and a `patchy` distribution of neurologic deficits.
CSP

A common form of dementia caused by multiple cortical or subcortical cerebral infarctions.
NCI

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