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antitumorózní látky

Substances that inhibit or prevent the proliferation of NEOPLASMS.
MSH

agent that inhibits or prevents the development or proliferation of neoplasms.
CSP

A drug used to treat cancer.
NCI

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000).
NDFRT

A substance that inhibits the maturation, growth or spread of tumor cells.
NCI

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Salmonella arizonae

Gram-negative rods widely distributed in LIZARDS and SNAKES, and implicated in enteric, bone (BONE DISEASES), and joint infections (JOINT DISEASES) in humans.
MSH

A subspecies of aerobic, Gram negative, rod shaped bacteria assigned to the phylum Proteobacteria and the species Salmonella enterica. S. enterica subsp. arizonae is an inhabitant of the gut of reptiles and is pathogenic in humans, although is rarely isolated from clinical specimens.
NCI

Any bacterial organism that can be assigned to the species Salmonella enterica subspecies arizonae.
NCI

a kind of bacteria found it in some reptiles that causes bone and joint diseases in human
CHV

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asociace pro duševní zdraví

Voluntary organizations which support educational programs and research in psychiatry with the objective of the promotion of mental health. An early association in the United States was founded as the National Committee for Mental Hygiene in 1909, became the Mental Health Association in 1976 and later the National Mental Health Association in 1980. State and local mental health associations in this country are chartered by the national organization and affiliated with it.
MSH

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omeprazol

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.
MSH

substituted benzimidazole used as a gastric acid secretion inhibitor.
CSP

A drug that inhibits gastric acid secretion.
NCI

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716″ NCI Thesaurus)
PDQ

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
NCI

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cytochemie

Branch of histochemistry associated with the localization of cellular components by specific staining methods, as for example the localization of acid phosphatases by the Gomori method.
NCI

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vládní organizace

Administrative units of government responsible for policy making and management of governmental activities.
MSH

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anus

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded.
NCI

The opening of the rectum to the outside of the body.
NCI

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded. (NCI)
NCI

The external outlet of the GASTROINTESTINAL TRACT.
MSH

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sarkoidóza

WHAT: Sarcoidosis:
AIR

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
MSH

inflammatory disease characterized by small lumps or granulomas in lymph nodes and other organs.
CSP

Sarcoidosis is an inflammatory disease. It starts as tiny, grain-like lumps called granulomas, which most often appear in your lungs or lymph nodes. They can clump together and form larger lumps that attack other organs. Sarcoidosis often affects your skin, eyes or liver.

Sarcoidosis may be mild, or it can be severe and do lasting damage. It does not always cause symptoms, so you can have it without knowing it. Symptoms vary, depending on which organs are affected.

No one is sure what causes sarcoidosis. It affects men and women of all ages and races worldwide. However, it occurs mostly in people ages 20 to 40, African Americans, especially women, and people of Asian, German, Irish, Puerto Rican and Scandinavian origin.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

a disease that produces messes especially in the liver, lungs, skin, and lymph nodes
CHV

An inflammatory disease marked by the formation of granulomas (small nodules of immune cells) in the lungs, lymph nodes, and other organs. Sarcoidosis may be acute and go away by itself, or it may be chronic and progressive.
NCI

An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.
NCI

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mezenterium – cysta

A rare intra-abdominal tumor in the MESENTERY. Mesenteric cysts are usually benign and can be very large fluid-filled (2000 mL) lesions.
MSH

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operon

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
MSH

group of contiguous genes coordinately regulated by a promoter and an operator element; found in prokaryotes.
CSP

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cytofotometrie

A method for the study of certain organic compounds within cells, in situ, by measuring the light intensities of the selectively stained areas of cytoplasm. The compounds studied and their locations in the cells are made to fluoresce and are observed under a microscope.
MSH

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granulózobuněčný nádor

A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
MSH

A type of slow-growing, malignant tumor that usually affects the ovary.
NCI

A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms.
NCI

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afakie po kataraktě

Absence of the crystalline lens resulting from cataract extraction.
MSH

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Schillingův test

A diagnostic test in which vitamin B12 is tagged with radioactive cobalt, taken orally, and gastrointestinal absorption is determined via measurement of the amount of radioactivity in a 24-hour urine collection.
MSH

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hutnictví

The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)
MSH

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Optics

science that deals with the genesis and propagation of light, the changes that it undergoes and produces, and other phenomena closely associated with it.
CSP

The branch of physics that describes the behavior and properties of light and the interaction of light with matter.
NCI

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sběr dat

Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
MSH

gathering or assemblage of information (statistics or measurements) about a system, population, etc.; do not confuse with SAMPLE COLLECTION (PHYSICAL).
CSP

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GTP-fosfohydrolasy

nonEC; family of high energy phosphate hydrolases; unlike ATPases, which are mainly involved in bioenergetics, GTPases are mainly involved in biological signal transduction.
CSP

Enzymes that hydrolyze GTP to GDP. EC 3.6.1.-.
MSH

Proteins that hydrolyze guanine triphosphate to yield guanine diphosphate. This is a class of proteins that belongs to a family of high energy phosphate hydrolases. Members of this family play major roles in biological signal transduction pathways.
NCI

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schůzky a rozvrhy

The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.
MSH

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školy zdravotnické

Schools which offer training in the area of health.
MSH

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methansulfonáty

Organic salts or esters of methanesulfonic acid.
MSH

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organizace – afiliace

Formal relationships established between otherwise independent organizations. These include affiliation agreements, interlocking boards, common controls, hospital medical school affiliations, etc.
MSH

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decidua

The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.
MSH

endometrium of the pregnant uterus; shed at parturition, except for the deepest layer.
CSP

The epithelial tissue of the endometrium.
NCI

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Caviidae

Taxonomic family which includes Guinea pigs, wild cavies, and the capybara.
NCI

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arbaprostil

A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors.
MSH

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skopolamin

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.
MSH

The hydrobromide salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. Structurally similar to acetylcholine, scopolamine antagonizes acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. The agent is used to cause mydriasis, cycloplegia, to control the secretion of saliva and gastric acid, to slow gut motility, and prevent vomiting.
NCI

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methoxyfluran

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
MSH

highly potent inhalation anesthetic used primarily to produce analgesia during the first stage of labor; use limited by dose related nephrotoxicity.
CSP

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orfenadrin

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
MSH

A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine receptors as well as N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS). This may interfere with the transmission of nerve impulses from the spinal cord to the muscles and may help relax muscles. In addition, orphenadrine exerts antagonistic effects on histamine H1 receptors.
NCI

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kyselina dehydroaskorbová

The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.
MSH

The oxidized form of ascorbic acid; it can be readily reduced to ascorbic acid in vivo.
NCI

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vláskové buňky vnitřní

Auditory sensory cells of organ of Corti, usually placed in one row medially to the core of spongy bone (the modiolus). Inner hair cells are in fewer numbers than the OUTER AUDITORY HAIR CELLS, and their STEREOCILIA are approximately twice as thick as those of the outer hair cells.
MSH

A cell situated on the inner most layer of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and touch the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve.
NCI

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