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pyridoxamin

The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.
MSH

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aspartátkarbamoyltransferasa

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
MSH

Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade.
NCI

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falešně pozitivní reakce

Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
MSH

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agrafie

Loss or impairment of the ability to write (letters, syllables, words, or phrases) due to an injury to a specific cerebral area or occasionally due to emotional factors. This condition rarely occurs in isolation, and often accompanies APHASIA. (From Adams et al., Principles of Neurology, 6th ed, p485; APA, Thesaurus of Psychological Index Terms, 1994)
MSH

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zubní náhrady – identifikační značky

Any system of defining ownership of dentures or dental prostheses.
MSH

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L-laktátdehydrogenasa

do not confuse with EC 1.1.2.3, EC 1.1.2.4, or EC 1.1.2.5, lactate dehydrogenase (cytochrome).
CSP

One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. An increased amount of lactate dehydrogenase in the blood may be a sign of tissue damage and some types of cancer or other diseases.
NCI

A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
MSH

A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
NCI

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Q-třídění

A personality assessment technique in which the subject or observer indicates the degree to which a standardized set of descriptive statements actually describes the subject. The term reflects “sorting” procedures occasionally used with this technique.
MSH

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atetóza

A dyskinesia characterized by an inability to maintain the fingers, toes, tongue, or other body parts in a stable position, resulting in continuous slow, sinusoidal, and flowing involuntary movements. This condition is frequently accompanied by CHOREA, where it is referred to as choreoathetosis. Athetosis may occur as a manifestation of BASAL GANGLIA DISEASES or DRUG TOXICITY. (From Adams et al., Principles of Neurology, 6th ed, p76)
MSH

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kyseliny mastné omega-3

A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
MSH

group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon; they are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
CSP

A type of fat obtained in the diet and involved in immunity.
NCI

A class of dietary fatty acids with the first double bond at the 3rd carbon from the methyl end.
NCI

Any fatty acid that contains an unsaturated bond originating from the 3rd carbon from the methyl end. Omega-3 fatty acids do not occur naturally with chain lengths shorter than 16 carbon units.
NCI

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alaninracemasa

A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.
MSH

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deoxyribonukleasa I

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5`-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
MSH

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jazykové techniky

Skills in the use of language which lead to proficiency in written or spoken communication.
MSH

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paterčata

Five individuals derived from five FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
MSH

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atypické formy baktérií

Microorganisms that have undergone greater changes than normal in morphology, physiology, or cultural characteristics.
MSH

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arteria femoralis

The main artery of the thigh, a continuation of the external iliac artery.
MSH

An artery that starts within the inguinal region and extends to the lower extremities. (NCI)
NCI

An artery that starts within the inguinal region and extends to the lower extremities.
NCI

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aldehydoxidoreduktasy

Oxidoreductases that are specific for ALDEHYDES.
MSH

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dermatoglyfy

The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.
MSH

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laserová chirurgie

The use of a laser either to vaporize surface lesions or to make bloodless cuts in tissue. It does not include the coagulation of tissue by laser (LASER COAGULATION).
MSH

A surgical procedure that uses the cutting power of a laser beam to make bloodless cuts in tissue or to remove a surface lesion such as a tumor.
NCI

A type of operation using the cutting powers of laser beams from various sources. The use of a laser either to vaporize surface lesions or to make bloodless cuts in tissue. (from On-line Medical Dictionary)
NCI

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zubní kořen – cysta

Slow-growing fluid-filled epithelial sac at the apex of a tooth with a nonvital pulp or defective root canal filling.
MSH

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autolýza

The spontaneous disintegration of tissues or cells by the action of their own autogenous enzymes.
MSH

disintegration of cells by the action of their own autogenous enzymes or destruction of cells of the body by its own serum.
CSP

The spontaneous death by lysis of bacteria in response to environmental conditions. [GOC:add]
GO

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plodné dny

The period in the MENSTRUAL CYCLE that is optimal for FERTILIZATION of the OVUM and yielding PREGNANCY. The duration of fertile period depends on the life span of male GAMETES within the female reproductive tract and the time of OVULATION. It usually begins a few days before ovulation and ends on the day of ovulation.
MSH

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alkylace

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
MSH

substitution of an alkyl group for an active hydrogen atom in an organic compound.
CSP

Alkylating Activity in biological systems is typically a process of covalent bonding in which a chemical substance replaces hydrogen atom(s) in biologically active molecules with alkyl radical(s), hindering proper function. DNA alkylation results in strand cross-linking and can inhibit DNA replication.
NCI

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vývojová porucha koordinace

A disorder characterized by an impairment in the development of an individual`s motor coordination skills; this impairment in motor development is not due to a medical condition.
NCI

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analýza metodou nejmenších čtverců

A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.
MSH

A popular criterion used for a cost function, namely minimizing the sum of the squares of the differences between the data points and the analytical function (often a straight line) desired as a best fit. (Dr. Joseph A. Thie)
NCI

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radiologie

A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.
MSH

branch of medicine that deals with the use of radiant energy including X rays, gamma rays, radiowaves, high frequency sound waves in the diagnosis and treatment of disease; for thorough searching see RT`s.
CSP

The use of radiation (such as x-rays) or other imaging technologies (such as ultrasound and magnetic resonance imaging) to diagnose or treat disease.
NCI

The branch of medical science dealing with the medical use of X-rays or other penetrating radiation.
NCI

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Awards

A prize given for achievement in a specific area, including monies given on the basis of merit.
NCI

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fétomaternální transfúze

Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)
MSH

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alfa-1-antichymotrypsin

Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
MSH

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diagnostické techniky kardiovaskulární

determination of a cardiovascular disorder based on symptoms, medical history, risk factors, and clinical tests.
CSP

Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.
MSH

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Leighova nemoc

A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
MSH

An inherited disorder affecting the nervous system, caused by genetic mutations in the mitochondrial DNA or deficiency of pyruvate dehydrogenase. Signs and symptoms appear in infancy and include loss of the motor abilities, poor sucking abilities, irritability, lack of muscle tone, and seizures.
NCI

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