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dinitrofenoly

Organic compounds that contain two nitro groups attached to a phenol.
MSH

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krk – poranění

General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
MSH

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Alternaria

A mitosporic Loculoascomycetes fungal genus including several plant pathogens and at least one species which produces a highly phytotoxic antibiotic. Its teleomorph is Lewia.
MSH

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benzoylarginin nitroanilid

A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.
MSH

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lidské inženýrství

The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.
MSH

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Raynaudova nemoc

intermittent attacks of ischemia in the fingers, toes, ears, or nose, accompanied by pain, pallor, and prickling; phenomenon applies to secondary symptoms, disease when cause is unknown.
CSP

Raynaud`s disease is a rare disorder of the blood vessels, usually in the fingers and toes. People with this disorder have attacks that cause the blood vessels to narrow. When this happens, blood can`t get to the surface of the skin and the affected areas turn white and blue. When the blood flow returns, the skin turns red and throbs or tingles. In severe cases, loss of blood flow can cause sores or tissue death. Cold weather and stress can trigger attacks. Often the cause of Raynaud`s is not known. People in colder climates are more likely to develop Raynaud`s than people in warmer areas.

Treatment for Raynaud`s may include drugs to keep the blood vessels open. There are also simple things you can do yourself, such as

  • Soaking hands in warm water at the first sign of an attack
  • Keeping your hands and feet warm in cold weather

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

blood vessel disease that causes exaggerated responses to cold and stress with poor blood circulation
CHV

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
MSH

An idiopathic vascular disorder characterized by ischemic attacks in the fingers, toes, ears, or nose, associated with pain and pallor. The attacks occur during exposure to cold temperatures or stress.
NCI

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diprenorfin

A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.
MSH

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novorozenci – screening

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
MSH

Newborn screening tests take place before your newborn leaves the hospital. Babies are tested to identify serious or life-threatening conditions before symptoms begin. Such diseases are usually rare. However, they can affect a baby`s normal physical and mental development.

Most tests use a few drops of blood from pricking the baby`s heel. A hearing test involves placing a tiny earphone in the baby`s ear and measuring his or her response to sound.

If a screening test suggests a problem, your baby`s doctor will follow up with further testing. If those tests confirm a problem, the doctor may refer you to a specialist for treatment. Following your doctor`s treatment plan can save your baby from lifelong health and developmental problems.


MEDLINEPLUS

A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s).
NCI

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Ambystoma

A genus of the Ambystomatidae family. The best known species are the axolotl AMBYSTOMA MEXICANUM and the closely related tiger salamander Ambystoma tigrinum. They may retain gills and remain aquatic without developing all of the adult characteristics. However, under proper changes in the environment they metamorphose.
MSH

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beta-krystaliny – řetězec B

The basic subunit of beta-crystallins.
MSH

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hydrolyasy

Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
MSH

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receptory buněčného povrchu

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
MSH

cell surface proteins that bind signaling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell; not all cell surface receptors are tree`d under this term.
CSP

A receptor protein that is localized to the plasma membrane and may have exposure to the extracellular milieu.
NCI

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LUXAZIOA

Dislocations are joint injuries that force the ends of your bones out of position. The cause is often a fall or a blow, sometimes from playing a contact sport. When a dislocation occurs, you can`t move the joint. You can dislocate your ankles, knees, shoulders, hips and elbows. You can also dislocate your finger and toe joints. Dislocated joints often are swollen, very painful and visibly out of place.

If you dislocate a joint, seek medical attention. Treatment depends on which joint you dislocate and the severity of the injury. It might include manipulations to reposition your bones, medicine, a splint or sling, and rehabilitation. When properly repositioned, a joint will usually function and move normally again in a few weeks. Once you dislocate a shoulder or kneecap, you are more likely to dislocate it again. Wearing protective gear during sports may help prevent dislocations.


MEDLINEPLUS

A displacement of a part (especially a bone) from its normal position. (WordNet)
NCI

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neostigmin

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
MSH

anticholinesterase used in symptomatic treatment of myasthenia gravis, prevention and treatment of postoperative stasis of the gastrointestinal tract or urinary bladder, and as an antidote for neuromuscular blocking agents after surgery.
CSP

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aminace

The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
MSH

creation of an amine by the addition of an amino group to an organic compound or reduction of a nitro group.
CSP

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bikukulin

An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
MSH

plant alkaloid with GABA antagonist properties, used as a probe for GABA function in the nervous system.
CSP

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hydrops fetalis

Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
MSH

A condition characterized by fluid accumulation in two or more anatomic compartments in the fetus. Causes include Rh incompatibility, congenital heart defects, and chromosomal abnormalities.
NCI

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receptory serotoninové

Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
MSH

diverse family of receptors that mediate the effects of serotonin on neurons, lymphocytes, and other cells; in neurons, serotonin can be either excitatory or inhibitory; some serotonin receptors are G protein coupled.
CSP

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kolon – divertikl

A pouch or sac opening from the COLON.
MSH

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nervový systém

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
MSH

entire nerve apparatus; in higher animals it is composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
CSP

The organized network of nerve tissue in the body. It includes the central nervous system (the brain and spinal cord), the peripheral nervous system (nerves that extend from the spinal cord to the rest of the body), and other nerve tissue.
NCI

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
NCI

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kyselina aminolevulová

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
MSH

The active ingredient in a drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.
NCI

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C234″ NCI Thesaurus)
PDQ

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. (NCI04)
NCI

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biokompatibilní materiály

Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
MSH

synthetic or industrial materials intended for use in contact with human tissues.
CSP

Any substance other than pharmacologic substance that can be applied in biomedical research or in constructing artificial organs, devices, or prostheses that can be introduced into the human body.
NCI

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hydroxyprogesterony

Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
MSH

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nucleus ruber

A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.
MSH

pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum receiving a large projection from the contralateral half of the cerebellum via the superior cerebellar peduncle and a projection from the ipsilateral motor cortex.
CSP

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DNA restringující-modifikující enzymy

Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
MSH

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neuroefektorové spoje

The synapse between a neuron (presynaptic) and an effector cell other than another neuron (postsynaptic). Neuroeffector junctions include synapses onto muscles and onto secretory cells.
MSH

junction between a neuron and the effector organ it innervates.
CSP

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amodiachin

A 4-aminoquinoline compound with anti-inflammatory properties.
MSH

An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.
NCI

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biomedicínské a zubní materiály

Substances used in biomedicine or dentistry predominantly for their physical, as opposed to chemical, properties.
MSH

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hypergamaglobulinémie

An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.
MSH

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regresní analýza

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
MSH

Regression analysis provides a “best-fit” mathematical equation for the relationship between the dependent variable (response) and independent variable(s) (covariates). There are two major classes of regression – parametric and non-parametric. Parametric regression requires choice of the regression equation with one or a greater number of unknown parameters. Linear regression, in which a linear relationship between the dependent variable and independent variables is posited, is an example. The aim of parametric regression is to find the values of these parameters which provide the best fit to the data. The number of parameters is usually much smaller than the number of data points. In contrast, the non-parametric regression requires no such a choice of the regression equation. (Statistics.com Glossary)
NCI

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