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pneumokonióza

A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
MSH

any of a group of lung diseases resulting from inhalation of particles of industrial substances.
CSP

An occupational lung disorder caused by inhalation of dust particles. It is characterized by bilateral interstitial lung infiltrates. Representative examples include asbestosis, silicosis, anthracosis, and talc pneumoconiosis.
NCI

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indium – radioisotopy

Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
MSH

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Chiariho-Frommelův syndrom

A POSTPARTUM condition consists of persistent lactation (GALACTORRHEA) and AMENORRHEA in patients not BREAST FEEDING.
MSH

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tarzální kosti

The seven bones which form the tarsus – namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
MSH

Any one of the seven bones forming the instep of the foot. (NCI)
NCI

The seven bones which form the tarsus; namely the calcaneus, talus, cuboid, navicular, and first, second and third cuneiforms. The tarsus is a skeletal part of the foot.
NCI

Any one of the seven bones forming the instep of the foot.
NCI

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Poisoning aspects

Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.
MSH

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novorozenec nedonošený

A human infant born before 37 weeks of GESTATION.
MSH

human born before the normal gestation period has elapsed, before 32 weeks of gestation.
CSP

A premature baby, or preemie, is born before the 37th week of pregnancy. Premature birth occurs in between 8 percent to 10 percent of all pregnancies in the United States. Because they are born too early, preemies weigh much less than full-term babies. They may have health problems because their organs did not have enough time to develop. Preemies need special medical care in a neonatal intensive care unit, or NICU. They stay there until their organ systems can work on their own.


MEDLINEPLUS

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dítě nadané

A child or adolescent who, when compared to others of the same age or experience, exhibits capability of high performance in intellectual, creative, or artistic areas, possesses an unusual capacity for leadership or excels in specific academic fields. (From PL 100-297, Sec. 4103, Definitions)
MSH

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technologie v biomedicíně – hodnocení

Evaluation of biomedical technology in relation to cost, efficacy, utilization, etc., and its future impact on social, ethical, and legal systems.
MSH

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polybrombifenylové sloučeniny

Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.
MSH

A mixture of synthetic solids, containing three or more bromine atoms, that is virtually insoluble in water but is soluble in fat and various organic solvents. There are 209 different molecular combinations, or congeners, that are possible for polybrominated biphenyls. These mixtures are no longer used or produced in commercial quantities in the United States. Residues remaining in and around plants that formerly manufactured, processed or produced products using polybrominated biphenyls are the current sources for human exposure. The primary routes of potential human exposure to polybrominated biphenyls are ingestion, inhalation, and dermal contact. A commercial mixture of these compounds is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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infúzní pumpy

Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
MSH

An infusion pump is a device used in a health care facility to pump fluids into a patient in a controlled manner. The device may use a piston pump, a roller pump, or a peristaltic pump and may be powered electrically or mechanically. The device may also operate using a constant force to propel the fluid through a narrow tube which determines the flow rate. The device may include means to detect a fault condition, such as air in, or blockage of, the infusion line and to activate an alarm.
SPN

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chlorečnany

Inorganic salts of chloric acid that contain the ClO3- ion.
MSH

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temporomandibulární kloub

An articulation between the condyle of the mandible and the articular tubercle of the temporal bone.
MSH

temporomandibular articulation: a bicondylar joint formed by the head of the mandible and the mandibular fossa, and the articular tubercle of the temporal bone.
CSP

The joint between the head of the lower mandible and the temporal bone. (NCI)
NCI

The joint between the head of the lower mandible and the temporal bone.
NCI

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polymerázová řetězová reakce

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
MSH

method for reproducing specific DNA sequences based on elongation of complementary primers by DNA polymerase; primarily used to increase quantities for analytical detection of, e.g., virus genome.
CSP

A laboratory method used to make many copies of a specific DNA sequence.
NCI

laboratory procedure for producing large amounts of specific DNA or RNA fragments
CHV

Description:Polymerase Chain Reaction


HL7V3.0

A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample.
NCI

Molecular, Polymerase chain reaction


HL7V3.0

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inosin cyklický monofosfát

Inosine cyclic 3`,5`-(hydrogen phosphate). An inosine nucleotide which acts as a mild inhibitor of the hydrolysis of cyclic AMP and cyclic GMP and as an inhibitor of cat heart cyclic AMP phosphodiesterase.
MSH

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chlortrianisen

A powerful synthetic, non-steroidal estrogen.
MSH

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testis – nemoci

Pathological processes of the TESTIS.
MSH

deviation from or interruption of the normal structure or function of the testis.
CSP

Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It`s easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports.

You should examine your testicles monthly and seek medical attention for lumps, redness, pain or other changes. Testicles can get inflamed or infected. They can also develop cancer. Testicular cancer is rare and highly treatable. It usually happens between the ages of 15 and 40.


MEDLINEPLUS

A disorder characterized by involvement of the testis.
NCI

A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.
NCI

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polytetrafluoroethylen

Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
MSH

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institut lékařství (USA)

Identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.
MSH

As part of the National Academy of Science, identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.
NCI

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choleny

Unsaturated derivatives of cholane with methyl groups at C-10 and C-13 and a branched five-carbon chain at C-17. They must have at least one double bond in the ring system.
MSH

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tetrahydrouridin

An inhibitor of nucleotide metabolism.
MSH

A substance that makes tumor cells more sensitive to radiation therapy and is being studied in the treatment of cancer. It belongs to the families of drugs called cytidine deaminase inhibitors, multidrug resistance modulators, and radiosensitizers.
NCI

A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2`-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2`-deoxycytidine monophosphate (CldCMP) to 5-chloro-2`-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2`-deoxyuridine). Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39710&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39710&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C868″ NCI Thesaurus)
PDQ

A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2`-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2`-deoxycytidine monophosphate (CldCMP) to 5-chloro-2`-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2`-deoxyuridine). (NCI04)
NCI

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sviňuchy

Mammals of the family Phocoenidae comprising four genera found in the North Pacific Ocean and both sides of the North Atlantic Ocean and in various other seas. They differ from DOLPHINS in that porpoises have a blunt snout and a rather stocky body while dolphins have a beak-like snout and a slender, streamlined body. They usually travel in small groups. (From Walker`s Mammals of the World, 5th ed, pp1003-4)
MSH

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pojištění zákonné odpovědnosti

Insurance against loss resulting from liability for injury or damage to the persons or property of others.
MSH

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epichlorhydrin

A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.
MSH

A volatile and flammable, clear, colorless, liquid, chlorinated cyclic ether with an irritating, chloroform-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Epichlorohydrin is used in the manufacture of epoxy resins, synthetic glycerin and elastomers. Exposure to epichlorohydrin irritates the eyes, skin and respiratory tract, and can cause chemical pneumonitis, pulmonary edema, and renal lesions. This substance also affects the blood. Epichlorohydrin is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing respiratory cancer. (NCI05)
NCI

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cholinfosfotransferasa

An enzyme that catalyzes the synthesis of phosphatidylcholines from CDPcholine and 1,2-diacylglycerols. EC 2.7.8.2.
MSH

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tematická apercepce – test

A projective technique which focuses primarily on the dynamics of interpersonal relationships. It consists of a series of 31 pictures that depict various social situations and interpersonal relations. A subset is selected by the examiner and presented to the subject who is asked to tell a story about each picture. The stories are interpreted in terms of the subject`s relations to authority figures, to contemporaries of both sexes, and in terms of the compromises between external demands and the needs of the id, the ego, and the superego. (From Campbell, Psychiatric Dictionary, 1996)
MSH

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dvojchroman draselný

Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.
MSH

An orange to red colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Potassium dichromate is highly corrosive and is a strong oxidizing agent. This substance is used in wood preservatives, in the manufacture of pigments and in photomechanical processes, but is mainly replaced by sodium dichromate. Potassium dichromate primarily affects the respiratory tract causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
NCI

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interleukin-1

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
MSH

macrophage produced interleukin that induces the production of interleukin 2 by T cells that have been stimulated by antigen or mitogen; at least two types, alpha and beta, exist; interleukin 1 or a similar protein is also produced by epithelial cells and stimulates fibroblast proliferation and release of proteolytic enzymes and prostaglandins in inflammatory processes.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1 is made mainly by one type of white blood cell, the macrophage, and helps another type of white blood cell, the lymphocyte, fight infections. It also helps leukocytes pass through blood vessel walls to sites of infection and causes fever by affecting areas of the brain that control body temperature. There are two forms of IL-1, alpha and beta, which act the same. IL-1 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. IL-1 is a type of cytokine.
NCI

Human interleukin-1 protein (271 aa, 31 kD precursor) is encoded by the human interleukin-1 (IL1) gene. This soluble protein is produced primarily by monocytes and macrophages. It activates and potentiates T-lymphocyte responses to mitogens or antigens. This protein is also capable of replacing macrophage requirements for T-cell activation
NCI

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epirubicin

An anthracycline which is the 4`-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
MSH

A 4`-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
NCI

A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.
NCI

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choristom

A mass of histologically normal tissue present in an abnormal location.
MSH

Proliferation of normal tissue in an anatomic site in which this particular type of tissue is not normally present.
NCI

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thiaminpyrofosfokinasa

An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2.
MSH

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