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Romanův-Wardův syndrom

A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.
MSH

An autosomal dominant form of long QT syndrome caused by mutations in the KCNE1, KCNE2, KCNH2, KCNQ1, SCN5A, and ANK2 genes. It is manifested with arrhythmias.
NCI

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nálada

A relatively temporary state of feeling.
NCI

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obezita

A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
MSH

excessively high accumulation of body fat or adipose tissue in relation to lean body mass; the amount of body fat (or adiposity) includes concern for both the distribution of fat throughout the body and the size of the adipose tissue deposits; individuals are usually at high clinical risk because of excess amount of body fat (BMI greater than 30).
CSP

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat and/or body water. Both terms mean that a person`s weight is greater than what`s considered healthy for his or her height.

Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might tip the balance include your genetic makeup, overeating, eating high-fat foods and not being physically active.

Being obese increases your risk of diabetes, heart disease, stroke, arthritis and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

A disorder characterized by having a high amount of body fat.
NCI

A condition marked by an abnormally high, unhealthy amount of body fat.
NCI

Having a high amount of body fat (body mass index [BMI] of 30 or more).
NCI

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určení vhodnosti pacienta

Criteria to determine eligibility of patients for medical care programs and services.
MSH

The act of determining if a subject is suitable for enrollment in a study according specific protocol criteria and procedures.
NCI

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HEMORROIDEAK

Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.
MSH

An enlarged or swollen blood vessel, usually located near the anus or the rectum.
NCI

Hemorrhoids are swollen, inflamed veins around the anus or lower rectum. They are either inside the anus or under the skin around the anus. They often result from straining to have a bowel movement. Other factors include pregnancy, aging and chronic constipation or diarrhea.

Hemorrhoids are very common in both men and women. About half of all people have hemorrhoids by age 50. The most common symptom of hemorrhoids inside the anus is bright red blood covering the stool, on toilet paper or in the toilet bowl. Symptoms usually go away within a few days.

If you have rectal bleeding you should see a doctor. You need to make sure bleeding is not from a more serious condition such as colorectal or anal cancer. Treatment may include warm baths and a cream or other medicine. If you have large hemorrhoids, you may need surgery and other treatments.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

A disorder characterized by the presence of dilated veins in the rectum and surrounding area.
NCI

Dilated veins in the rectum and anal area.
NCI

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buserelin

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.
MSH

An anticancer drug that belongs to the family of drugs called gonadotropin-releasing hormones. In prostate cancer therapy, buserelin blocks the production of testosterone in the testicles.
NCI

A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39170&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39170&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C320″ NCI Thesaurus)
PDQ

A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)
NCI

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Rubinsteinův-Taybiův syndrom

A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).
MSH

A rare genetic syndrome mapped to chromosome 16p13.3 and associated with mutations in the CREBBP gene. It is characterized by mental and growth retardation, distinctive facial features (prominent nose, low-set ears, microcephaly, and small mouth), and broad thumbs and great toes. Patients are at an increased risk of developing benign and malignant neoplasms, including nervous system neoplasms and malignant lymphoproliferative disorders.
NCI

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pohyb – percepce

The real or apparent movement of objects through the visual field.
MSH

sensory interpretation of the movement of objects or persons.
CSP

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Octodon

A genus of diurnal rats in the family Octodonidae, found in South America. The species Octodon degus is frequently used for research.
MSH

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urgentní služby psychiatrické

Organized services to provide immediate psychiatric care to patients with acute psychological disturbances.
MSH

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virus hepatitidy B

A virus that causes hepatitis (inflammation of the liver). It is carried and passed to others through blood or sexual contact. Also, infants born to infected mothers may become infected with the virus.
NCI

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
MSH

Hepatitis B Virus (HBV) is the prototype of the Hepadnavirus Family. Included in the family are the Woodchuck Hepatitis Virus (WHV) and the Duck Hepatitis B Virus (DHBV) which provide animal models of infection. The HBV genome is a partially double stranded circular DNA. A viral reverse transcriptase is bound to the 5` extremity of the long strand. (from http://www.genetique.uvsq.fr/RC/virologie/hepatiteB_2_uk.html)
NCI

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kyselina kakodylová

An arsenical that has been used as a dermatologic agent and as an herbicide.
MSH

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bezpečnost

Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
MSH

The state of being certain that adverse effects will not be caused by some agent under defined conditions.
NCI

Relative freedom from harm. In clinical trials, this refers to an absence of harmful side effects resulting from use of the product and may be assessed by laboratory testing of biological samples, special tests and procedures, psychiatric evaluation, and/or physical examination of subjects.
NCI

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Mosambik

A republic in southern Africa, south of TANZANIA, east of ZAMBIA and ZIMBABWE, bordered on the west by the Indian Ocean. Its capital is Maputo. It was formerly called Portuguese East Africa.
MSH

A country in Southern Africa, bordering the Mozambique Channel, between South Africa and Tanzania. (NCI)
NCI

A country in Southern Africa, bordering the Mozambique Channel, between South Africa and Tanzania. (CIA World Factbook 2002)
NCI

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oleje prchavé

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
MSH

The scented liquid taken from certain plants using steam or pressure. Essential oils contain the natural chemicals that give the plant its “essence” (specific odor and flavor). Essential oils are used in perfumes, food flavorings, medicine, and aromatherapy.
NCI

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virus západní encefalitidy koňské

A species of ALPHAVIRUS that is the etiologic agent of encephalomyelitis in humans and equines in the United States, southern Canada, and parts of South America.
MSH

species of Alphavirus that is the etiologic agent of encephalomyelitis in humans and equines in the United States, southern Canada, and parts of South America.
CSP

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hernie brániční traumatická

The type of DIAPHRAGMATIC HERNIA caused by TRAUMA or injury, usually to the ABDOMEN.
MSH

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vápník – poruchy metabolismu

Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
MSH

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Salmonella arizonae

Gram-negative rods widely distributed in LIZARDS and SNAKES, and implicated in enteric, bone (BONE DISEASES), and joint infections (JOINT DISEASES) in humans.
MSH

A subspecies of aerobic, Gram negative, rod shaped bacteria assigned to the phylum Proteobacteria and the species Salmonella enterica. S. enterica subsp. arizonae is an inhabitant of the gut of reptiles and is pathogenic in humans, although is rarely isolated from clinical specimens.
NCI

Any bacterial organism that can be assigned to the species Salmonella enterica subspecies arizonae.
NCI

a kind of bacteria found it in some reptiles that causes bone and joint diseases in human
CHV

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osobnost – poruchy mnohočetné

A dissociative disorder in which the individual adopts two or more distinct personalities. Each personality is a fully integrated and complex unit with memories, behavior patterns and social friendships. Transition from one personality to another is sudden.
MSH

A disorder characterized by the presence of two or more identities with distinct patterns of perception and personality which recurrently take control of the person`s behavior; this is accompanied by a retrospective gap in memory of important personal information that far exceeds ordinary forgetfulness. The changes in identity are not due to substance use or to a general medical condition.
NCI

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omeprazol

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.
MSH

substituted benzimidazole used as a gastric acid secretion inhibitor.
CSP

A drug that inhibits gastric acid secretion.
NCI

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716″ NCI Thesaurus)
PDQ

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
NCI

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endokrinní systém – nemoci

impairment of health or a condition of abnormal functioning of the system of glands that release their secretions (hormones) directly into the circulatory system.
CSP

Any deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs. (NCI)
NCI

Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include

  • Growth and development
  • Metabolism – digestion, elimination, breathing, blood circulation and maintaining body temperature
  • Sexual function
  • Reproduction
  • Mood

If your hormone levels are too high or too low, you may have a hormone disorder. Hormone diseases also occur if your body does not respond to hormones the way it is supposed to. Stress, infection and changes in your blood`s fluid and electrolyte balance can also influence hormone levels.

In the United States, the most common endocrine disease is diabetes. There are many others. They are usually treated by controlling how much hormone your body makes. Hormone supplements can help if the problem is too little of a hormone.


MEDLINEPLUS

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
MSH

Any deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs.
NCI

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Heterophyidae

A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.
MSH

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kalpain

Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
MSH

an intracellular, non-lysosomal enzyme.
CSP

A class of calcium-dependent thiol-proteases that proteolytically cleave a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two main isoforms of the protein, which differ in their calcium requirement for activation. These enzymes have been linked to both acute and chronic neurodegenerative processes, such as: ischemia, trauma, and Alzheimer`s disease.
NCI

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sarkoidóza

WHAT: Sarcoidosis:
AIR

An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
MSH

inflammatory disease characterized by small lumps or granulomas in lymph nodes and other organs.
CSP

Sarcoidosis is an inflammatory disease. It starts as tiny, grain-like lumps called granulomas, which most often appear in your lungs or lymph nodes. They can clump together and form larger lumps that attack other organs. Sarcoidosis often affects your skin, eyes or liver.

Sarcoidosis may be mild, or it can be severe and do lasting damage. It does not always cause symptoms, so you can have it without knowing it. Symptoms vary, depending on which organs are affected.

No one is sure what causes sarcoidosis. It affects men and women of all ages and races worldwide. However, it occurs mostly in people ages 20 to 40, African Americans, especially women, and people of Asian, German, Irish, Puerto Rican and Scandinavian origin.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

a disease that produces messes especially in the liver, lungs, skin, and lymph nodes
CHV

An inflammatory disease marked by the formation of granulomas (small nodules of immune cells) in the lungs, lymph nodes, and other organs. Sarcoidosis may be acute and go away by itself, or it may be chronic and progressive.
NCI

An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.
NCI

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svaly – nemoci

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
MSH

impairment of health or a condition of abnormal functioning of the muscle.
CSP

Your muscles help you move and help your body work. Different types of muscles have different jobs. There are many problems that can affect muscles. Muscle disorders can cause weakness, pain or even paralysis.

There may be no known cause for a muscle disorder. Some known causes include


MEDLINEPLUS

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operon

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
MSH

group of contiguous genes coordinately regulated by a promoter and an operator element; found in prokaryotes.
CSP

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endotel lymfatický

Unbroken cellular lining (intima) of the lymph vessels (e.g., the high endothelial lymphatic venules). It is more permeable than vascular endothelium, lacking selective absorption and functioning mainly to remove plasma proteins that have filtered through the capillaries into the tissue spaces.
MSH

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hypertenzní neurologický syndrom

A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and SEIZURES. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.
MSH

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kanabinol

A physiologically inactive constituent of Cannabis sativa L.
MSH

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