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piroxikam

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
MSH

4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2- benzothiazine-3-carboxamide- 1,1-dioxide; nonsteroidal antiinflammatory drug (NSAID) which functions by inhibiting prostaglandin synthesis; effective against colon cancer.
CSP

A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C751″ NCI Thesaurus)
PDQ

A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.
NCI

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vyšší nervová činnost

A term used in Eastern European research literature on brain and behavior physiology for cortical functions. It refers to the highest level of integrative function of the brain, centered in the CEREBRAL CORTEX, regulating language, thought, and behavior via sensory, motor, and cognitive processes.
MSH

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mozeček – nemoci

Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
MSH

condition in which there is a deviation from or interruption of the normal structure or function of the cerebellum; manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia.
CSP

When you play the piano or hit a tennis ball you are activating the cerebellum. The cerebellum is the area of the brain that controls coordination and balance. Problems with the cerebellum include

  • Cancer
  • Genetic disorders
  • Ataxias – failure of muscle control in the arms and legs that result in movement disorders
  • Degeneration – disorders caused by brain cells decreasing in size or wasting away

Treatment of cerebellar disorders depends on the cause.

NIH: National Institute of Neurological Disorders and Stroke


MEDLINEPLUS

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otorinolaryngologické chirurgické výkony

Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
MSH

surgery performed on the ear and its parts, nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
CSP

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Mycobacterium tuberculosis

species of gram positive, aerobic bacteria that produces tuberculosis in man, other primates, dogs, and some animals which have contact with man; growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
CSP

A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
MSH

An obligate anaerobic, weakly Gram-positive species of mycobacterium that is the cause of most cases of tuberculosis.
NCI

Any bacterial organism that can be assigned to the species Mycobacterium tuberculosis.
NCI

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placentární hormony

Hormones produced by the placenta include CHORIONIC GONADOTROPIN, and PLACENTAL LACTOGEN as well as steroids (ESTROGENS; PROGESTERONE), and neuropeptide hormones similar to those found in the hypothalamus (HYPOTHALAMIC HORMONES).
MSH

hormones produced by the placenta; includes chorionic gonadotropin and somatomammotropin as well as gonadal steroids and neuropeptide hormones similar to those found in the hypothalamus.
CSP

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histiocyty

Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).
MSH

A macrophage present in connective tissue.
NCI

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mozkomíšní mok – proteiny

Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister`s Clinical Neurology, 7th ed, p221)
MSH

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potní žlázy – nádory

A benign or malignant neoplasm arising from the sweat glands.
NCI

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myokard – kontrakce

contractile activity of the myocardium.
CSP

The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph]
GO

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plazmocytom

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
MSH

A type of cancer that begins in plasma cells (white blood cells that produce antibodies). A plasmacytoma may turn into multiple myeloma.
NCI

A malignant (clonal) proliferation of plasma cells that are cytologically and immunophenotypically identical to those of plasma cell myeloma, but manifest a localized osseous or extraosseous growth pattern. (WHO, 2001)
NCI

A single focus of clonal (malignant) plasma cells either in the bone or in another anatomic site without peripheral blood involvement. –2003
NCI

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HIV protilátky

Antibodies reactive with HIV ANTIGENS.
MSH

A substance produced by certain white blood cells in reaction to contact with HIV, the human immunodeficiency virus.
NCI

Produced by B-cells, human immunodeficiency virus (HIV) antibodies reacts with HIV antigens. HIV is a virus which affects white blood cells and eventually destroys the body`s natural ability to fight infections.
NCI

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Cetacea

order of marine mammals; like other mammals they breathe by means of lungs, and bring forth living young which they suckle for some time; the anterior limbs are changed to paddles; the tail flukes are horizontal.
CSP

An order of wholly aquatic MAMMALS occurring in all the OCEANS and adjoining seas of the world, as well as in certain river systems. They feed generally on FISHES, cephalopods, and crustaceans. Most are gregarious and most have a relatively long period of parental care and maturation. Included are DOLPHINS; PORPOISES; and WHALES. (From Walker`s Mammals of the World, 5th ed, pp969-70)
MSH

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synefrin

Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
MSH

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Myoxidae

A family of nocturnal rodents, similar in appearance to SQUIRRELS, but smaller. There are 28 species, half of which are found in Africa.
MSH

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trombocytoferéza

The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
MSH

preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
CSP

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HLA-DR5 antigen

A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles.
MSH

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farmakologické jevy

The properties and processes of drug metabolism and drug interactions.
MSH

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junkční ektopická tachykardie

A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.
MSH

An automatic tachycardia originating in the atrioventricular junction, typically arising in the conduction tissues surrounding the atrioventricular node. A junctional tachycardia tends to be a regular, narrow complex tachycardia and usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication. The rate may range from 140 to 250 beats per minute. (NCI)
NCI

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NADP-transhydrogenasa

Enzymes that catalyze the reversible reduction of NAD by NADPH to yield NADP and NADH. This reaction permits the utilization of the reducing properties of NADPH by the respiratory chain and in the reverse direction it allows the reduction of NADP for biosynthetic purposes.
MSH

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pneumomediastinum diagnostické

Deliberate introduction of air or gas into the mediastinum as an aid to examination and diagnosis.
MSH

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homocystinurie

Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
MSH

autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of cystathionine beta-synthase and associated with elevations of homocysteine in plasma and urine; clinical features include a tall, slender habitus, scoliosis, arachnodactyly, muscle weakness, genu varis, thin blond hair, malar flush, lens dislocations, an increased incidence of mental retardation, and a tendency to develop fibrosis of arteries, frequently complicated by cerebrovascular accidents and myocardial infarction.
CSP

An autosomal recessive inherited metabolic disorder caused by mutations in the CBS, MTHFR, MTR, and MTRR genes. It is characterized by abnormalities in the methionine metabolism and is associated with deficiency of cystathionine synthase. It results in the accumulation of homocysteine in the serum. It may affect the cardiovascular, musculoskeletal and the central nervous systems.
NCI

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kur domácí

Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
MSH

common name for the species Gallus gallus, the domestic fowl; descended from the red jungle fowl of Southeast Asia.
CSP

The common domestic fowl, Gallus gallus.
NCI

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tartrazin

An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain.
MSH

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Naphthalene

A white, volatile, solid polycyclic hydrocarbon with a strong mothball odor. Naphthalene is obtained from either coal tar or petroleum distillation and is primarily used to manufacture phthalic anhydride, but is also used in moth repellents. Exposure to naphthalene is associated with hemolytic anemia, damage to the liver and neurological system, cataracts and retinal hemorrhage. Naphthalene is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing laryngeal and colorectal cancer. (NCI05)
NCI

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mitogeny líčidla amerického

Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells.
MSH

A group of proteins isolated from the roots of pokeweed, Phytolacca americana, with hemagglutinating and mitogenic properties. Pokeweed mitogen is particularly mitogenic for lymphocytes and also agglutinates erythrocytes.
NCI

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nemocnice – plánování

Areawide planning for hospitals or planning of a particular hospital unit on the basis of projected consumer need. This does not include hospital design and construction or architectural plans.
MSH

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předškolní dítě

A child between the ages of 2 and 5.
MSH

a human child aged 1 through 5 years of age; may include kindergarten age group; also index with appropriate human and clinical research terms.
CSP

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technologie lékařská

The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.
MSH

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Národní centrum pro technologii zdravotní péče (USA)

A center in the PUBLIC HEALTH SERVICE which coordinates and administers a program of research, demonstrations, and evaluations of medical technologies and assessments of health care technology.
MSH

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