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sfingolipidózy

A group of inherited metabolic disorders characterized by the intralysosomal accumulation of SPHINGOLIPIDS primarily in the CENTRAL NERVOUS SYSTEM and to a variable degree in the visceral organs. They are classified by the enzyme defect in the degradation pathway and the substrate accumulation (or storage). Clinical features vary in subtypes but neurodegeneration is a common sign.
MSH

lysosomal storage diseases characterized by abnormal storage of spingolipids.
CSP

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farmakologické jevy

The properties and processes of drug metabolism and drug interactions.
MSH

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pojištění lékařské hlavní

Insurance providing a broad range of medical services and supplies, when prescribed by a physician, whether or not the patient is hospitalized. It frequently is an extension of a basic policy and benefits will not begin until the basic policy is exhausted.
MSH

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perikarditida tuberkulózní

INFLAMMATION of the sac surrounding the heart (PERICARDIUM) due to MYCOBACTERIUM TUBERCULOSIS infection. Pericarditis can lead to swelling (PERICARDIAL EFFUSION), compression of the heart (CARDIAC TAMPONADE), and preventing normal beating of the heart.
MSH

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epidemiologická měření

Statistical calculations on the occurrence of disease or other health-related conditions in defined populations.
MSH

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Spirillaceae

A family of gram-negative bacteria in the order Nitrosomonadales. It formerly included the genera CAMPYLOBACTER and SPIRILLUM, then was abandoned, and is now reinstated as a family with a single genus SPIRILLUM.
MSH

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kur domácí

Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
MSH

common name for the species Gallus gallus, the domestic fowl; descended from the red jungle fowl of Southeast Asia.
CSP

The common domestic fowl, Gallus gallus.
NCI

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interleukin-4

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
MSH

lymphokine produced by antigen or mitogen activated T lymphocytes that enhances the ability of B lymphocytes to present antigen, primes B lymphocytes to proliferate in response to anti-Ig and lipopolysaccharide, and regulates the production of IgG and IgE by B lymphocytes; it also acts as a growth factor for T lymphocytes and as a maturation factor for mast cells.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-4 is made by a type of T lymphocyte. It causes B lymphocytes to increase and to make antibodies and also increases the production of T lymphocytes. Interleukin-4 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-4 is a type of cytokine.
NCI

Human interleukin-4 protein (153 aa, 17.5 kDa precursor) is encoded by the human interleukin-4 (IL4) gene. Two isoforms of this protein are expressed by activated T cells. This protein is a pleiotropic soluble cytokine that is a ligand for the interleukin 4 receptor. This receptor-ligand interaction induces expression of MHC II and Fc receptors on B-cells, causing proliferation and differentiation of these cells.
NCI

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Periplaneta

A genus in the family Blattidae containing several species, the most common being P. americana, the American cockroach.
MSH

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epistáze genetická

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
MSH

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spondylosis deformans

A form of spondylosis involving the INTERVERTEBRAL DISK, including both the annulus and the nucleus of the disk. It is usually the consequence of normal aging.
MSH

chronic inflammation of the spine and the low back bone joint
CHV

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předškolní dítě

A child between the ages of 2 and 5.
MSH

a human child aged 1 through 5 years of age; may include kindergarten age group; also index with appropriate human and clinical research terms.
CSP

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interview psychologický

A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.
MSH

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osobnost – testy

standardized objective tests designed to facilitate the evaluation of personality.
CSP

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ergokalciferoly

Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
MSH

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stapes – mobilizace

An operation to remobilize the footplate of the stapes to relieve conductive hearing impairment caused by its immobilization through otosclerosis or middle ear disease. (Stedman, 26th ed)
MSH

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Chlorella

Nonmotile unicellular green algae potentially valuable as a source of high-grade protein and B-complex vitamins.
MSH

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nitroděložní antikoncepční prostředky léčebné

Intrauterine devices that release contraceptive agents.
MSH

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fagocytóza

The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
MSH

engulfing of microorganisms, other cells, and foreign particles by phagocytic cells (phagocytes).
CSP

An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

The process by which a phagocyte (a type of white blood cell) surrounds and destroys foreign substances (such as bacteria) and removes dead cells.
NCI

The process by which phagocytes engulf and digest microorganisms and cellular debris; an important defense against infection.
NCI

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erytrocyty – agregace

The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
MSH

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steatorea

excessive amounts of fats in the feces, as in malabsorption syndromes.
CSP

A finding of an excessive amount of fat in the stool.
NCI

A condition that is characterized by chronic fatty DIARRHEA, a result of abnormal DIGESTION and/or INTESTINAL ABSORPTION of FATS.
MSH

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chlorfeniramin

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
MSH

histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, asthma and in veterinary applications; one of the most widely used of the classical antihistamines.
CSP

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monojodtyrosin

A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.
MSH

product from the iodination of tyrosine; in the biosynthesis of thyroid hormones, tyrosine is first iodized to monoiodotyrosine.
CSP

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fencyklidin

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
MSH

this drug is both a legitimate prescription anesthetic and a notoriously abused street drug also known as “angel dust.”
CSP

Developed as an anesthetic for humans in 1959. Its use was discontinued due to extreme side effects that included delirium, confusion, visual disturbances, hallucinations and violence; some evidence of long-term memory disorders and schizophrenia-like syndrome has been observed. Phencyclidine, a substance of abuse also know as `angel dust`, can cause physical and psychological distresses, such as coma, seizures, convulsions, respiratory depression, and cardiac problems.
NCI

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nádory jícnu

Tumors or cancer of the ESOPHAGUS.
MSH

new abnormal esophageal tissue, the portion of the digestive canal between the pharynx and stomach, that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm involving the esophagus.
NCI

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stigmasterol

Phytosterol with a double bond at the 22nd carbon.
NCI

A steroid derivative characterized by the hydroxyl group in position C-3 of the steroid skeleton, and unsaturated bonds in position 5-6 of the B ring, and position 22-23 in the alkyl substituent. Stigmasterol is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized milk.
NCI

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Choleragenoid

The nontoxic, pentameric B protomer of cholera toxin. The cell membrane binding component of cholera toxin.
MSH

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iris – nádory

Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
MSH

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Phenylephrine Hydrochloride

The hydrochloride salt form of phenylephrine, a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.
NCI

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estrogeny – antagonisté

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
MSH

substances or agents which suppress, prevent or oppose the action of estrogen.
CSP

A substance that keeps cells from making or using estrogen (a hormone that plays a role in female sex characteristics, the menstrual cycle, and pregnancy). Estrogen blockers may stop some cancer cells from growing and are used to prevent and treat breast cancer. They are also being studied in the treatment of other types of cancer. An estrogen blocker is a type of hormone antagonist.
NCI

Substances that inhibit or antagonize the biosynthesis or biologic effects of estrogens by either antagonizing the responsiveness of estrogen sensitive tissues or competing with their binding sites.
NCI

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