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thromboxan A2

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
MSH

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ATP-fosforibosyltransferasa

An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typhimurium. ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5`-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17.
MSH

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kepon

A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.
MSH

A very stable, colorless, odorless, synthetic chlorinated polycyclic hydrocarbon that is a degradation product of Mirex. Chlordecone has been used as an insecticide on bananas, non-bearing citrus trees, tobacco, lawns and flowers. Exposure to this substance causes neurological symptoms, such as tremors and slurred speech. Chlordecone is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
NCI

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konzervační prostředky farmaceutické

Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.
MSH

Chemicals that are added to drug products to prolong shelf life and maintain sterility. Protection of formulations, especially aqueous solutions, against microbial growth requires use of either antibacterial or antifungal preservatives. Generally, such agents are active against either bacteria or fungi but a few are active against both. The antimicrobials include but not limited to chlorobutanol, benzyl alcohol, sodium benzoate, sorbic acid, and phenol. The antioxidizing agents include butylated hydroxytolune, hydroxyanisole, propyl gallate, and sulfites. The necessary addition of preservatives for both safety and economy sometimes has been associated with significant adverse effects in certain patient populations.
NCI

A substance (player) added to a mixture (scoper) to prevent microorganisms (fungi, bacteria) to spoil the mixture.


HL7V3.0

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expedice

Usually refers to planned scientific data-gathering excursions.
MSH

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závislost (psychologie)

The tendency of an individual or individuals to rely on others for advice, guidance, or support.
MSH

tendency of an individual or individuals to rely on others for advice, guidance, or support.
CSP

Related so that change in one leads to change in the other.
NCI

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2-acetylaminofluoren

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
MSH

A synthetic, light tan crystalline solid that is insoluble in water and soluble in alcohols, glycols, ether, acetic acid, and fat solvents. It is used as a positive control by toxicologists to study the carcinogenicity and mutagenicity of aromatic amines. When heated to decomposition, 2-acetylaminofluorene emits toxic fumes of nitrogen oxides. The primary routes of potential human exposure to 2-acetylaminofluorene are inhalation and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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sluchové dráhy

cochlear nuclei give rise to two bundles, the trapezoid body and dorsal acoustic stria, which rejoin as the lateral lemniscus and continue via the inferior colliculus to the auditory cortex.
CSP

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ketonoxidoreduktasy

Oxidoreductases that are specific for KETONES.
MSH

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proadifen

An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
MSH

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oči – barva

Color of the iris.
MSH

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pouštní klima

A type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
MSH

climate lacking moisture, especially having insufficient rainfall to support trees or woody plants.
CSP

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4-butyrolakton

One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
MSH

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blokáda autonomních nervů

Interruption of sympathetic pathways, by local injection of an anesthetic agent, at any of four levels: peripheral nerve block, sympathetic ganglion block, extradural block, and subarachnoid block.
MSH

interruption of autonomic pathways, by local injection of an anesthetic agent.
CSP

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Kienbockova choroba

Osteonecrosis of the lunate.
MSH

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profesionální společnosti

Legally authorized corporations owned and managed by one or more professionals (medical, dental, legal) in which the income is ascribed primarily to the professional activities of the owners or stockholders.
MSH

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neuralgie lícního nervu

Neuralgic syndromes and other conditions which feature chronic or recurrent FACIAL PAIN as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.
MSH

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dextromethorfan

Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
MSH

A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
NCI

d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
CSP

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abat

An organothiophosphate insecticide.
MSH

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azaguanin

One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
MSH

A purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine transglycosylase). Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation. 8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis. This agent inhibits tumor cell growth and stimulates cell differentiation. (NCI04)
NCI

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zdraví – znalosti, postoje, praxe

Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
MSH

The consideration of knowledge, attitude, or behavior as variables in disease processes such as incident, transmission, and control.
NCI

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prolinhydroxylasa

A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
MSH

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fakulta lékařská

The teaching staff and members of the administrative staff having academic rank in a medical school.
MSH

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diagnostické techniky – dýchací systém

determination of disorder(s) of the respiratory system based on symptoms, medical history, risk factors, and clinical tests.
CSP

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.
MSH

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potrat zamlklý

The retention in the UTERUS of a dead FETUS two months or more after its DEATH.
MSH

Retention in uterus of an abortus that has been dead at least 4 weeks.
NCI

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Bacillaceae

family of bacteria which produce endospores; they are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
CSP

A family of bacteria which produce endospores. They are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
MSH

A taxonomic family of bacterium in the phylum Firmicutes that contains the notable genus Bacillus.
NCI

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odbory

Organizations comprising wage and salary workers in health-related fields for the purpose of improving their status and conditions. The concept includes labor union activities toward providing health services to members.
MSH

organization of workers formed for the purpose of serving the members` interests with respect to wages, status and working conditions.
CSP

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propiomazine

A phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine H1 receptors; Its antipsychotic effect is attributed to antagonistic activities at dopamine and 5-HT2 receptors.
NCI

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fascioliáza

Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.
MSH

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diazoniové sloučeniny

The salt form of diazo compounds, compounds containing the N2 nitrogen attached to only one hydrocarbon, formulated by replacing three hydrogen atoms of the salt of an aryl primary amine by nitrogen having the general structure represented as R-N2X.
NCI

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