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ATP-fosforibosyltransferasa

An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typhimurium. ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5`-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17.
MSH

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acetoacetáty

salts and derivatives of acetoacetic acid.
CSP

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závislost (psychologie)

The tendency of an individual or individuals to rely on others for advice, guidance, or support.
MSH

tendency of an individual or individuals to rely on others for advice, guidance, or support.
CSP

Related so that change in one leads to change in the other.
NCI

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inzulin Lente

An insulin, zinc chloride preparation in the form of a suspension of crystals and amorphous material in a ratio of approximately 7:3. Typically, lente insulin has a duration of activity that lasts between 13-20 hours after dosage.
MSH

A long-acting crystalline insulin often used in combination with a short-acting insulin in the treatment of diabetes mellitus. This type of insulin may be derived from porcine or recombinant sources. Administered once daily, insulin Lente starts to lower blood glucose within 1 to 3 hours after injection and exerts its peak effect 7 to 15 hours after injection. Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
NCI

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proteinarginin-N-methyltransferasa

Enzymes that catalyze the methylation of arginine residues of proteins to yield N-mono- and N,N-dimethylarginine. This enzyme is found in many organs, primarily brain and spleen.
MSH

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sluchové dráhy

cochlear nuclei give rise to two bundles, the trapezoid body and dorsal acoustic stria, which rejoin as the lateral lemniscus and continue via the inferior colliculus to the auditory cortex.
CSP

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acetylthiocholin

An agent used as a substrate in assays for cholinesterases, especially to discriminate among enzyme types.
MSH

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pouštní klima

A type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
MSH

climate lacking moisture, especially having insufficient rainfall to support trees or woody plants.
CSP

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jednotky intenzivní péče o novorozence

Hospital units providing continuing surveillance and care to acutely ill newborn infants.
MSH

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prothrombinový čas

Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
MSH

clotting time of plasma recalcified in the presence of excess tissue thromboplastin; used for monitoring anticoagulant therapy with coumarins.
CSP

A measurement of the clotting time of plasma recalcified in the presence of excess tissue thromboplastin; it is a measure of the extrinsic pathway of coagulation. It is used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage and vitamin K status. Factors measured are fibrinogen, prothrombin, and factors V, VII, and X.
NCI

A blood clotting measurement that evaluates the extrinsic pathway of coagulation and is expressed in units of time or percent activity.
NCI

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blokáda autonomních nervů

Interruption of sympathetic pathways, by local injection of an anesthetic agent, at any of four levels: peripheral nerve block, sympathetic ganglion block, extradural block, and subarachnoid block.
MSH

interruption of autonomic pathways, by local injection of an anesthetic agent.
CSP

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epididymis

The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
MSH

convoluted tubule connecting the vas efferens, that comes from the seminiferous tubules of the mammalian testis, to the vas deferens; maturation and storage of sperm occur in the epididymis.
CSP

A narrow, tightly-coiled tube that is attached to each of the testicles (the male sex glands that produce sperm). Sperm cells (male reproductive cells) move from the testicles into the epididymis, where they finish maturing and are stored.
NCI

A crescent-like structure located in the upper and posterior surfaces of the testis. It consists of the efferent ductules and the duct of the epididymis. It facilitates the maturation of sperm that is produced in the testis.
NCI

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akonitáthydratasa

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.
MSH

catalyzes the conversion of citrate to isocitrate.
CSP

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dextromethorfan

Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
MSH

A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
NCI

d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
CSP

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ventilace umělá s přerušovaným přetlakem

Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.
MSH

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pseudohypoaldosteronismus

A heterogeneous group of disorders characterized by renal electrolyte transport dysfunctions. Congenital forms are rare autosomal disorders characterized by neonatal hypertension, HYPERKALEMIA, increased RENIN activity and ALDOSTERONE concentration. The Type I features HYPERKALEMIA with sodium wasting; Type II, HYPERKALEMIA without sodium wasting. Pseudohypoaldosteronism can be the result of a defective renal electrolyte transport protein or acquired after KIDNEY TRANSPLANTATION.
MSH

An inherited or acquired disorder of electrolyte metabolism, characterized by the inability of the renal tubules to respond to aldosterone. It is manifested by hyperkalemic metabolic acidosis, urinary salt wasting, normal or increased aldosterone secretion and normal glomerular filtration rate.
NCI

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azaguanin

One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
MSH

A purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine transglycosylase). Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation. 8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis. This agent inhibits tumor cell growth and stimulates cell differentiation. (NCI04)
NCI

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epsilon-globiny

A member of the beta-globin family. In humans, epsilon-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two epsilon-globin chains combine with two ZETA-GLOBIN chains to form the embryonic hemoglobin Gower I or two epsilon-globin chains combine with two ALPHA-2 GLOBIN chains to form the embryonic hemoglobin Gower II.
MSH

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Actinobacillus – infekce

Infections with bacteria of the genus ACTINOBACILLUS.
MSH

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diagnostické techniky – dýchací systém

determination of disorder(s) of the respiratory system based on symptoms, medical history, risk factors, and clinical tests.
CSP

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.
MSH

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střeva – perforace

Opening or penetration through the wall of the INTESTINES.
MSH

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psychoanalytická teorie

Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.
MSH

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Bacillaceae

family of bacteria which produce endospores; they are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
CSP

A family of bacteria which produce endospores. They are mostly saprophytes from soil, but a few are insect or animal parasites or pathogens.
MSH

A taxonomic family of bacterium in the phylum Firmicutes that contains the notable genus Bacillus.
NCI

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erotická literatura

Literary or artistic items having an erotic theme. It refers especially to books treating sexual love in a sensuous or voluptuous manner. (Webster, 3d ed)
MSH

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N-acylneuraminátcytidylyltransferasa

An enzyme that forms CMP-acylneuraminic acids, which donate the N-acylneuraminic acid residues to the terminal sugar residue of a ganglioside or glycoprotein. EC 2.7.7.43.
MSH

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diazoniové sloučeniny

The salt form of diazo compounds, compounds containing the N2 nitrogen attached to only one hydrocarbon, formulated by replacing three hydrogen atoms of the salt of an aryl primary amine by nitrogen having the general structure represented as R-N2X.
NCI

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Body part inversion

a turning inside-out positioning of a body part
CHV

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psychózy toxické

Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
MSH

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bakteriofágy

Viruses whose hosts are bacterial cells.
MSH

capable of producing transmissible lysis of bacteria; virus particle attaches to bacterial cell wall and viral nucleoprotein enters the cell, resulting in viral synthesis and liberation on bacterial cell lysis.
CSP

A virus that infects and lyses certain bacteria.
NCI

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erythromycin

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
MSH

bacteriostatic antibiotic macrolide produced by Streptomyces erythreus; in sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits; this binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
CSP

a kind of antibiotics
CHV

A broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39234&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39234&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C476″ NCI Thesaurus)
PDQ

A broad-spectrum, macrolide antibiotic with antibacterial activity. Erythromycin diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.
NCI

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