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Hodgkinova nemoc

A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin`s and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
MSH

malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells) of unknown origin.
CSP

A lymphoma, previously known as Hodgkin`s disease, characterized by the presence of Reed-Sternberg cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma has a bimodal age distribution, and involves primarily lymph nodes. Current therapy for Hodgkin lymphoma has resulted in an excellent outcome and cure for the majority of patients.
NCI

Hodgkin disease is a type of lymphoma. Lymphoma is cancer of lymph tissue found in the lymph nodes, spleen, liver, and bone marrow. The first sign of Hodgkin disease is often an enlarged lymph node. The disease can spread to nearby lymph nodes. Later it may spread to the lungs, liver or bone marrow. The cause is unknown.

Hodgkin disease is rare. Symptoms include

  • Painless swelling of the lymph nodes in the neck, armpits, or groin
  • Fever and chills
  • Night sweats
  • Weight loss
  • Loss of appetite
  • Itchy skin

Doctors can diagnose Hodgkin disease with a biopsy. This involves removing and examining a piece of tissue under a microscope. Treatment varies depending on how far the disease has spread and often includes radiation therapy or chemotherapy.

The earlier the disease is diagnosed, the more effective the treatment. In most cases, Hodgkin disease can be cured.

NIH: National Cancer Institute


MEDLINEPLUS

A cancer of the immune system that is marked by the presence of a type of cell called the Reed-Sternberg cell. The two major types of Hodgkin lymphoma are classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Symptoms include the painless enlargement of lymph nodes, spleen, or other immune tissue. Other symptoms include fever, weight loss, fatigue, or night sweats.
NCI

An obsolete term referring to Hodgkin lymphma.
NCI

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chemoreceptory

sensory nerve endings capable of transducing chemical stimuli into neuronal impulses; do not confuse with receptor molecules, which are covered under RECEPTOR.
CSP

Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
MSH

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Onemocnění pulmonální chlopně

A heart disorder characterized by a defect in pulmonary valve structure or function.
NCI

A disorder characterized by a defect in pulmonary valve function or structure.
NCI

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nehty – nemoci

Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.
MSH

Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. Your nails` health can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can signal various lung, heart, kidney and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless.

Nail problems that sometimes require treatment include bacterial and fungal infections, ingrown nails, tumors and warts. Keeping nails clean, dry and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.


MEDLINEPLUS

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insuficience nadledvin

abnormally diminished activity of the adrenal gland.
CSP

A disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison`s disease or primary adrenal insufficiency.
NCI

Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
MSH

An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison`s disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).
NCI

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Hormone Receptor

postcoordinate with specific hormone terms if needed.
CSP

A cell protein that binds a specific hormone. The hormone receptor may be on the surface of the cell or inside the cell. Many changes take place in a cell after a hormone binds to its receptor.
NCI

Ligand binding proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell. The hormone receptor can be cytoplasmic/nuclear, or associated with the cell membrane in the case of receptors whose ligands cannot penetrate the membrane.
NCI

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dítě – zařízení denní péče

Facilities which provide care for pre-school and school-age children.
MSH

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purpura

Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).
MSH

small hemorrhage in the skin, mucous membrane or serosal surface, or a group of hemorrhagic diseases characterized by purpuric lesions.
CSP

A hemorrhagic area of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.
NCI

A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.
NCI

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narkolepsie

A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
MSH

recurrent, uncontrollable brief episodes of sleep and lapses in consciousness, often associated with hypnagogic hallucinations, cataplexy, automatic behaviors and sleep paralysis.
CSP

A sleep disorder characterized by a tendency for excessive sleepiness during the day which occurs even after adequate sleep in the nighttime. The persons who suffer from this condition experience fatigue and may fall asleep at inappropriate times during the day.
NCI

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Aerococcus

A genus of gram-positive cocci in the family AEROCOCCACEAE, occurring as airborne saprophytes.
MSH

A genus of aerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Aerococcaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Aerococcus genus level.
NCI

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nemocnice pro chronická onemocnění

Hospitals which provide care to patients with long-term illnesses.
MSH

(1) A hospital including a physical plant and personnel that provides multidisciplinary diagnosis and treatment for diseases that have one or more of the following characteristics: is permanent; leaves residual disability; is caused by nonreversible pathological alteration; requires special training of the patient for rehabilitation; and/or may be expected to require a long period of supervision or care. In addition, patients require the safety, security, and shelter of these specialized inpatient or partial hospitalization settings. (2) A hospital that provides medical and skilled nursing services to patients with long-term illnesses who are not in an acute phase but who require an intensity of services not available in nursing homes. Source: (1) Expanded from Rhea, Ott, and Shafritz, The Facts On File Dictionary of Health Care Management, New York: Facts On File Publications, 1988.


HL7V3.0

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Chiroptera

order of mammals whose members are adapted for flight; it includes bats, flying foxes, and fruit bats.
CSP

Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
MSH

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pyreny

A group of condensed ring hydrocarbons.
MSH

polycyclic hydrocarbon, C16H10.
CSP

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přirozený porod

Labor and delivery without medical intervention, usually involving RELAXATION THERAPY.
MSH

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Agaricus

A basidiomycetous fungal genus of the family Agaricaceae, order Agaricales, which includes the field mushroom (A. campestris) and the commercial mushroom (A. bisporus).
MSH

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potřeby pro domácnost

Various material objects and items in the home. It includes temporary or permanent machinery and appliances. It does not include furniture or interior furnishings (FURNITURE see INTERIOR DESIGN AND FURNISHINGS; INTERIOR FURNISHINGS see INTERIOR DESIGN AND FURNISHINGS).
MSH

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chloracetofenon

A potent eye, throat, and skin irritant. One of its uses is as a riot control agent.
MSH

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pyrroly

Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
MSH

5-membered aromatic ring structure with one nitrogen heteroatom.
CSP

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sousedství

A surrounding or nearby region.
NCI

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vzduch – ionizace

The dissociation of molecules in the air into positive and negative ions under the influence of an electric field.
MSH

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hyalin

clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
CSP

A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
MSH

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výběrové chování

The act of making a selection among two or more alternatives, usually after a period of deliberation.
MSH

act of making a selection among two or more alternatives, usually after a period of deliberation.
CSP

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kvantová teorie

The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck`s constant and v is the frequency of the radiation.
MSH

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Embryonal Neoplasm

new abnormal embryonic tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. –2003
NCI

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alciánová modř

A copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
MSH

Dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.
SPN

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hydrokodon

Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
MSH

A semisynthetic hydrogenated codeine derivative and opioid agonist with analgesic and antitussive effects. Hydrocodone primarily binds to and activates the mu-opioid receptor in the central nervous system (CNS). This leads to analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal motility, cough suppression and physical dependence. Hydrocodone is converted to hydromorphone by the cytochrome P450 enzyme CYP2D6.
NCI

a kind of pain relieving drug
CHV

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cholesteatom

A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.
MSH

non-neoplastic keratinizing mass with stratified squamous epithelium, frequently occurring in the meninges, central nervous system, bones of the skull, and most commonly in the middle ear and mastoid region.
CSP

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rasy – vztahy mezi nimi

Cultural contacts between people of different races.
MSH

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nefróza

Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.
MSH

diseases of the kidney characterized by purely degenerative lesions of the renal tubules without an inflammatory component.
CSP

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alfentanil

A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
MSH

An ultra short-acting, synthetic, opioid agonist with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to and stimulates the opiate receptors in the central nervous system (CNS), thereby mimicking the actions of endogenous opioids. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of various neurotransmitters. The analgesic effect of alfentanil is likely due to the actions of its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.
NCI

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