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guanylthiomočovina

May protect against hypoxic damage; proposed for treatment of shock due to trauma or blood loss; also stimulates paretic gastrointestinal system.
MSH

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čepelková implantace

Insertion of an endosseous implant with a narrow wedge-shaped infrastructure extending through the oral mucosa into the mouth and bearing openings or vents through which tissue grows to obtain retention.
MSH

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polyribonukleotidy

A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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methopren

Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.
MSH

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léky implantované

Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
MSH

A device placed in tissue to deliver therapeutic agents at a controlled, constant release rate.
NCI

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tetragastrin

L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
MSH

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Haemophilus influenzae, biotype III

Any bacterial organism that can be assigned to the species Haemophilus aegyptius.
NCI

A species of facultatively anaerobic, Gram negative, coccobacilli shaped bacteria assigned to the phylum Proteobacteria. This species is urease, catalase and oxidase positive, nonhemolytic and indole negative. H. aegyptius is a pathogen and the causative agent of conjunctivitis and Brazilian purpuric fever.
NCI

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koagulopatie

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
MSH

condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
CSP

A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
NCI

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porfiromycin

Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.
MSH

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.
NCI

An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39610&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39610&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C763″ NCI Thesaurus)
PDQ

An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)
NCI

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kyselina methylmalonová

A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
MSH

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ductus arteriosus

A fetal blood vessel connecting the pulmonary artery with the descending aorta.
MSH

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thanatoforická dysplazie

A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.
MSH

A severe autosomal dominant inherited disorder caused by mutations in the FGFR3 gene. It is characterized by multiple skeletal abnormalities, including extremely short limbs. It results in the death of the neonate.
NCI

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Cricetinae

any of a subfamily (Cricetinae) of small Old World rodents having very large cheek pouches.
CSP

Any member of four genera of the rodent family Cricetidae; short-tailed Old World burrowing rodents with large cheek pouches.
NCI

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
MSH

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krev – dusík močoviny

The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
MSH

A quantitative measurement of the amount of urea nitrogen present in a serum sample.
NCI

A measurement of the urea nitrogen in a blood specimen.
NCI

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postflebitický syndrom

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.
MSH

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metyrapon

An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
MSH

USP lists as a diagnostc aid for determination of pituitary function.
CSP

A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness.
NCI

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dyzentérie

Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.
MSH

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thiacetazon

A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)
MSH

A thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.
NCI

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hlava a krk – nádory

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
MSH

new abnormal tissue from head or neck areas of the body that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm affecting one of the following areas: base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
NCI

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tělesná teplota

The measure of the level of heat of a human or animal.
MSH

degree of heat in the body of a living organism, temperature is measure of the average kinetic energy of the particles in a sample of matter, expressed in terms of units or degrees designated on a standard scale.
CSP

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prajmalin

A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.
MSH

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mikroklima

The climate of a very small area.
MSH

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zemětřesení

Sudden slips on a fault, and the resulting ground shaking and radiated seismic energy caused by the slips, or by volcanic or magmatic activity, or other sudden stress changes in the earth. Faults are fractures along which the blocks of EARTH crust on either side have moved relative to one another parallel to the fracture.
MSH

An earthquake happens when two blocks of the earth suddenly slip past one another. Earthquakes strike suddenly, violently, and without warning at any time of the day or night. If an earthquake occurs in a populated area, it may cause property damage, injuries, and even deaths. If you live in a coastal area, there is the possibility of a tsunami. Damage from earthquakes can also lead to floods or fires.

Although there are no guarantees of safety during an earthquake, you can take actions to protect yourself. You should have a disaster plan. Being prepared can help reduce fear, anxiety and losses.

Federal Emergency Management Agency


MEDLINEPLUS

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thioguanin

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
MSH

thioguanine is USP.
CSP

An anticancer drug that belongs to the family of drugs called antimetabolites.
NCI

a kind of cancer treatment drug
CHV

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C876″ NCI Thesaurus)
PDQ

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
NCI

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zdravotnické plánování – organizace

Organizations involved in all aspects of health planning activities.
MSH

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kosti – regenerace

Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
MSH

renewal or repair of lost bone tissue.
CSP

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těhotenství při diabetu

Diabetes is a disease in which your blood glucose, or sugar, levels are too high. When you are pregnant, too much glucose is not good for your baby. Out of every 100 pregnant women in the United States, between three and eight get gestational diabetes. Gestational diabetes is diabetes that happens for the first time when a woman is pregnant. Gestational diabetes goes away when you have your baby, but it does increase your risk for having diabetes later.

If you already have diabetes before you get pregnant, you need to monitor and control your blood sugar levels.

Either type of diabetes during pregnancy raises the risk of problems for the baby and the mother. To help reduce these risks, you should follow your meal plan, exercise, test your blood sugar and take your medicine.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.
MSH

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mikrozómy

Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
MSH

vesicular fragments of endoplasmic reticulum formed when cells are disrupted.
CSP

Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

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echoviry

A group of enteroviruses isolated from man and originally thought not to be associated with disease, whence the name Enteric Cytopathic Human Orphan; however, several serotypes have been found to cause meningitis, diarrhea, and respiratory disease.
MSH

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torakoplastika

Surgical removal of ribs, allowing the chest wall to move inward and collapse a diseased lung. (Dorland, 28th ed)
MSH

Surgical removal of a rib to gain access during surgery or to collapse the chest wall and a diseased lung.
NCI

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