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vnímání teploty

The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). [GOC:ai, http://www.wikipedia.org/Thermoception]
GO

sensation of temperature.
CSP

The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
MSH

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růst a vývoj

includes normal and pathological, biological and psychological, age-related changes; includes the entire life span and may be used for any species.
CSP

The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.
MSH

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diflubenzuron

An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.
MSH

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Polygonum

A plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE).
MSH

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benzomorfany

Morphine derivatives of the methanobenzazocine family that act as potent analgesics.
MSH

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methadon

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
MSH

synthetic narcotic possessing pharmacologic actions similar to those of morphine and heroin and almost equal addiction liability; used as an analgesic and as a narcotic abstinence syndrome suppressant in the treatment of heroin addition.
CSP

A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between morphine-like agents and methadone differ in that the onset of methadone`s withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe.
NCI

a narcotic drug used to treat drug addiction
CHV

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umírající

Persons with an incurable or irreversible illness at the end stage that will result in death within a short time. (From O`Leary et al., Lexikon: Dictionary of Health Care Terms, Organizations, and Acronyms for the Era of Reform, 1994, p780)
MSH

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guanylthiomočovina

May protect against hypoxic damage; proposed for treatment of shock due to trauma or blood loss; also stimulates paretic gastrointestinal system.
MSH

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difterický toxoid

The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
MSH

formaldehyde inactivated toxin of Corynebacterium diphtheriae; generally used in mixtures with tetanus toxoid and pertussis vaccine; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5 to 10 fold less diphtheria toxoid, for other use); diphtheria toxoid is used for the prevention of diphtheria.
CSP

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polyribonukleotidy

A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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beta-2-mikroglobulin

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
MSH

Beta-2-microglobulin protein (119 aa, ~14 kDa) is encoded by the human B2M gene. This protein plays a role in immune responses and is a key component of major histocompatibility complex class I molecules. The protein is localized to the surface of cells and is utilized as a prognostic marker in persons with cancers that involve white blood cells. The polypeptide is also used as a marker in kidney damage diagnosis and in the detection of viral infection.
NCI

A small protein normally found on the surface of many cells, including lymphocytes, and in small amounts in the blood and urine. An increased amount in the blood or urine may be a sign of certain diseases, including some types of cancer, such as multiple myeloma or lymphoma.
NCI

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methopren

Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.
MSH

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tetragastrin

L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
MSH

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Haemophilus influenzae, biotype III

Any bacterial organism that can be assigned to the species Haemophilus aegyptius.
NCI

A species of facultatively anaerobic, Gram negative, coccobacilli shaped bacteria assigned to the phylum Proteobacteria. This species is urease, catalase and oxidase positive, nonhemolytic and indole negative. H. aegyptius is a pathogen and the causative agent of conjunctivitis and Brazilian purpuric fever.
NCI

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nemoc – propuknutí

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
MSH

sudden increase in the incidence of a disease; the concept includes epidemics.
CSP

An outbreak represents a series of public health cases. The date on which an outbreak starts is the earliest date of onset among the cases assigned to the outbreak, and its ending date is the last date of onset among the cases assigned to the outbreak.


HL7V3.0

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porfiromycin

Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.
MSH

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.
NCI

An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39610&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39610&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C763″ NCI Thesaurus)
PDQ

An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)
NCI

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bibliografie

A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects.
MSH

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kyselina methylmalonová

A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
MSH

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thanatoforická dysplazie

A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.
MSH

A severe autosomal dominant inherited disorder caused by mutations in the FGFR3 gene. It is characterized by multiple skeletal abnormalities, including extremely short limbs. It results in the death of the neonate.
NCI

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Cricetinae

any of a subfamily (Cricetinae) of small Old World rodents having very large cheek pouches.
CSP

Any member of four genera of the rodent family Cricetidae; short-tailed Old World burrowing rodents with large cheek pouches.
NCI

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
MSH

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dithizon

Chelating agent used for heavy metal poisoning and assay. It causes diabetes.
MSH

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postflebitický syndrom

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing.
MSH

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vazebná místa protilátek

Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
MSH

The site at which an antibody makes direct physical contact with a corresponding epitope on an antigen.
NCI

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metyrapon

An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
MSH

USP lists as a diagnostc aid for determination of pituitary function.
CSP

A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness.
NCI

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thiacetazon

A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)
MSH

A thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.
NCI

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hlava a krk – nádory

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
MSH

new abnormal tissue from head or neck areas of the body that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm affecting one of the following areas: base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
NCI

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DNA-polymerasa III

A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3`-5` and 5`-3` exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.
MSH

An enzyme that has dual functionality in DNA synthesis. The protein has the ability to facilitate DNA synthesis by polymerase action and an exonucleolytic activity that degrades single stranded DNA in the 3` to 5` direction. This protein is essential for leading strand synthesis.
NCI

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prajmalin

A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.
MSH

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biologický transport

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
MSH

movement of materials (including biochemical substances and drugs) through a biological system at the cellular level; can be across cell membranes and epithelial layers and also can occur within intracellular compartments and extracellular compartments.
CSP

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. [GOC:dph, GOC:jl, GOC:mah]
GO

The directed movement of substances into, out of, or within a cell
CHV

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mikroklima

The climate of a very small area.
MSH

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