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komplement C1s

A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
MSH

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Leontopithecus

The genus of lion tamarins in the subfamily CALLITRICHINAE. The common name refers to the mane on the shoulders.
MSH

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Finsko

A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Sweden and Russia. (NCI)
NCI

Description:Realm code for use of Finland


HL7V3.0

A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Sweden and Russia. (CIA World Factbook 2002)
NCI

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ribavirin

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
MSH

1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS.
CSP

A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
NCI

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C807″ NCI Thesaurus)
PDQ

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. (NCI04)
NCI

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poddajnost

Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
MSH

An index reflecting distensibility of elastic organ(s) defined as the change in volume per unit change in pressure (dV/dP).
NCI

testing the extent to which the structure of a organ or a chemical substance can be easily changed
CHV

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leukémie P388

An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
MSH

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flavony

A group of 4-keto-FLAVONOIDS.
MSH

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Orientia tsutsugamushi

A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
MSH

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kondomy

A sheath that is worn over the penis during sexual behavior in order to prevent pregnancy or spread of sexually transmitted disease.
MSH

A condom is a sheath which completely covers the penis with a closely fitting membrane. The condom is used for contraceptive and for prophylactic purposes (preventing transmission of venereal disease). The device may also be used to collect semen to aid in the diagnosis of infertility.
SPN

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test inhibice adherence leukocytů

Test for cell-mediated antitumor immunity and related serum blocking factors based on the finding that leukocytes from cancer patients, but not from controls, when mixed in vitro with antigenic extracts of tumors of the same histological type, undergo a diminution in their normal adherence to glass surfaces. Sera from tumor-bearing patients block the LAI reaction of their own leukocytes or those of other patients with the same type of tumor.
MSH

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nukleární rodina

A family composed of spouses and their children.
MSH

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fluocinonid

A topical glucocorticoid used in the treatment of ECZEMA.
MSH

A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.
NCI

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RNA-polymerasa II

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
MSH

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zachování přírodních zdrojů

The protection, preservation, restoration, and rational use of all resources in the total environment.
MSH

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nádor z Leydigových buněk

Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.
MSH

A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course.
NCI

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nukleotidasy

A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.
MSH

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flurandrenolon

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
MSH

A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
NCI

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RNA transferová Gln

A transfer RNA which is specific for carrying glutamine to sites on the ribosomes in preparation for protein synthesis.
MSH

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antikoncepční látky orální kombinované

Fixed drug combinations administered orally for contraceptive purposes.
MSH

A pill used to prevent pregnancy. It contains hormones that block the release of eggs from the ovaries. Most birth control pills include estrogen and progestin.
NCI

Orally administered synthetic sex hormones with contraceptive activity. The oral contraceptive preparation contains a combination of an estrogen, such as ethinyl estradiol, and a progestagen, such as levonorgestrel or norethidrone. The oral contraceptive prevents pregnancy by preventing ovulation and by inducing endometrial and cervical changes undesirable for fertilization and implantation.
NCI

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pravděpodobná délka života

Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.
MSH

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ošetřovatelský proces

The sum total of nursing activities which includes assessment (identifying needs), intervention (ministering to needs), and evaluation (validating the effectiveness of the help given).
MSH

sum total of nursing activities which includes assessment (identifying needs), intervention (ministering to needs), and evaluation (validating the effectiveness of the help given).
CSP

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potraviny – manipulace

Any aspect of the operations in the preparation, transport, storage, packaging, wrapping, exposure for sale, service, or delivery of food.
MSH

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Romanův-Wardův syndrom

A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.
MSH

An autosomal dominant form of long QT syndrome caused by mutations in the KCNE1, KCNE2, KCNH2, KCNQ1, SCN5A, and ANK2 genes. It is manifested with arrhythmias.
NCI

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koproporfyrinogeny

Porphyrinogens which are intermediates in the heme biosynthesis. They have four methyl and four propionic acid side chains attached to the pyrrole rings. Coproporphyrinogens I and III are formed in the presence of uroporphyrinogen decarboxylase from the corresponding uroporphyrinogen. They can yield coproporphyrins by autooxidation or protoporphyrin by oxidative decarboxylation.
MSH

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len

A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
MSH

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obezita

A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
MSH

excessively high accumulation of body fat or adipose tissue in relation to lean body mass; the amount of body fat (or adiposity) includes concern for both the distribution of fat throughout the body and the size of the adipose tissue deposits; individuals are usually at high clinical risk because of excess amount of body fat (BMI greater than 30).
CSP

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat and/or body water. Both terms mean that a person`s weight is greater than what`s considered healthy for his or her height.

Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might tip the balance include your genetic makeup, overeating, eating high-fat foods and not being physically active.

Being obese increases your risk of diabetes, heart disease, stroke, arthritis and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

A disorder characterized by having a high amount of body fat.
NCI

A condition marked by an abnormally high, unhealthy amount of body fat.
NCI

Having a high amount of body fat (body mass index [BMI] of 30 or more).
NCI

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lipidy – mobilizace

LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.
MSH

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Obstrukce

Blockage of a passageway.
NCI

Blockage of the normal flow of the contents of an anatomical passageway.
NCI

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androstendion

A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
MSH

delta-4 C19 steroid that is produced in the testes, ovaries and adrenal cortex and can serve as a precursor to testosterone as well as estrone and estradiol.
CSP

a kind of male sex hormone
CHV

A steroid hormone synthesized by the adrenal glands and the gonads from either 17-alpha-hydroxyprogesterone or dehydroepiandrosterone and is a precursor of testosterone.
NCI

A potent androgenic prohormone that is a direct precursor of testosterone and used as a supplement to increase plasma testosterone levels and muscle anabolism. (NCI)
NCI

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zahraniční odborný personál

Persons who have acquired academic or specialized training in countries other than that in which they are working. The concept excludes physicians for which FOREIGN MEDICAL GRADUATES is the likely heading.
MSH

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