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peptidyl-dipeptidasa A

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
MSH

Cl- dependent, zinc glycoprotein that is generally membrane bound.
CSP

Angiotensin-converting enzyme (1306 aa, ~150 kDa) is encoded by the human ACE gene. This protein plays a role in the hydrolysis of angiotensin I to form angiotensin II and the solubilization of glycophophoinositol-anchored proteins from the plasma membrane.
NCI

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sekvenční homologie nukleových kyselin

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
MSH

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faktor V – nedostatek

A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren`s disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)
MSH

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cysta choledochu, typ I

Characterized by the fusiform or saccular dilatation of the COMMON BILE DUCT.
MSH

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ovarium – cysty

General term for CYSTS and cystic diseases of the OVARY.
MSH

fluid-filled closed cavity or sac in the ovary that is lined by epithelium; can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
CSP

A cyst is a fluid-filled sac. In most cases a cyst on the ovary does no harm and goes away by itself. Most women have them sometime during their lives. Cysts are rarely cancerous in women under 50. Cysts sometimes hurt – but not always. Often, a woman finds out about a cyst when she has a pelvic exam.

If you`re in your childbearing years or past menopause, have no symptoms, and have a fluid-filled cyst, you may choose to monitor the cyst. You may need surgery if you have pain, are past menopause or if the cyst does not go away. Birth control pills can help prevent new cysts.

A health problem that may involve ovarian cysts is polycystic ovary syndrome (PCOS). Women with PCOS can have high levels of male hormones, irregular or no periods and small ovarian cysts.

National Women`s Health Information Center


MEDLINEPLUS

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Kupfferovy buňky

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
MSH

specialized phagocytic cells of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids; they filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
CSP

Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system.
NCI

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sérové proteiny

Dissolved proteins of blood plasma. These mainly consist of albumins and globulins and include antibodies and blood-clotting proteins.
NCI

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rodina

A social group consisting of parents or parent substitutes and children.
MSH

group of individuals related by blood or marriage or other arrangements, including parents or parent substitutes and children, however, the specific members differ from culture to culture.
CSP

A phenotype or trait that occurs with greater frequency in a given family than in the general population; familial traits may have a genetic and/or nongenetic etiology.
NCI

Living with family. Maps to PD1-2 Living arrangement (IS) 00742 [F]


HL7V3.0

A domestic group, or a number of domestic groups linked through descent (demonstrated or stipulated) from a common ancestor, marriage, or adoption.
NCI

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kompetitivní chování

The direct struggle between individuals for environmental necessities or for a common goal.
MSH

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oxidancia fotochemická

Compounds that accept electrons in an oxidation-reduction reaction. The reaction is induced by or accelerated by exposure to electromagnetic radiation in the spectrum of visible or ultraviolet light.
MSH

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labyrint – tekutiny

Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray`s Anatomy, 30th American ed, p1328, 1332)
MSH

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sexuální abstinence

Refraining from SEXUAL INTERCOURSE.
MSH

Prevention of contraception by not engaging in sexual intercourse.
NCI

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syndrom chronické únavy

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
MSH

distinctive syndrome characterized by chronic fatigue, mild fever, lymphadenopathy, headache, myalgia, arthralgia, depression, and memory loss; candidate etiologic agents include Epstein-Barr and other herpesviruses.
CSP

Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

Symptoms of CFS include fatigue for 6 months or more and experiencing other problems such as muscle pain, memory problems, headaches, pain in multiple joints, sleep problems, sore throat and tender lymph nodes. Since other illnesses can cause similar symptoms, CFS is hard to diagnose.

No one knows what causes CFS. It is most common in women in their 40s and 50s, but anyone can have it. It can last for years. There is no cure for CFS, so the goal of treatment is to improve symptoms. Medicines may treat pain, sleep disorders and other problems.

Centers for Disease Control and Prevention


MEDLINEPLUS

A condition lasting for more than 6 months in which a person feels tired most of the time and may have trouble concentrating and carrying out daily activities. Other symptoms include sore throat, fever, muscle weakness, headache, and joint pain.
NCI

A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months` duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis.
NCI

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membranolytický komplex

A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the “membrane attack complex” or MAC.
MSH

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oxythiamin

Thiamine antagonist, antimetabolite.
MSH

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Lambertův-Eatonův myastenický syndrom

An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
MSH

A rare autoimmune presynaptic disorder characterized by impairment of the impulse transmission at the neuromuscular junction. It affects predominantly the proximal muscles of the lower extremities, resulting in muscle weakness and fatigability. It has been associated with small cell lung carcinoma.
NCI

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šok traumatický

Shock produced as a result of trauma.
MSH

Any shock produced by trauma.
NCI

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viry sarkomu koček

Species of GAMMARETROVIRUS isolated from fibrosarcoma in cats. The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. It is unique to individuals and not transmitted naturally to other cats. FeSVs are replication defective and require FeLV to reproduce.
MSH

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početí

In biology, the beginning of pregnancy, marked by fertilization of an egg by a sperm.
NCI

Fertilization of an ovum by a spermatozoon resulting in formation of a viable zygote.
NCI

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nesnesitelná bolest

Persistent pain that is refractory to some or all forms of treatment.
MSH

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laryngální nervy

Branches of the VAGUS NERVE. The superior laryngeal nerves originate near the nodose ganglion and separate into external branches, which supply motor fibers to the cricothyroid muscles, and internal branches, which carry sensory fibers. The RECURRENT LARYNGEAL NERVE originates more caudally and carries efferents to all muscles of the larynx except the cricothyroid. The laryngeal nerves and their various branches also carry sensory and autonomic fibers to the laryngeal, pharyngeal, tracheal, and cardiac regions.
MSH

branches of the vagus nerve (the tenth cranial nerve); superior laryngeal nerves originate near the nodose ganglion and separate into external branches, which supply motor fibers to the cricothyroid muscles, and internal branches, which carry sensory fibers; the recurrent (inferior) laryngeal nerve originates more caudally and carries efferents to all muscles of the larynx except the cricothyroid; laryngeal nerves and their various branches also carry sensory and autonomic fibers to the laryngeal, pharyngeal, tracheal, and cardiac regions.
CSP

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sigmoidoskopie

Endoscopic examination, therapy or surgery of the sigmoid flexure.
MSH

Examination of the lower colon using a sigmoidoscope, inserted into the rectum. A sigmoidoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue to be checked under a microscope for signs of disease.
NCI

Endoscopic examination of the luminal surface of the sigmoid colon.
NCI

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fretky

Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.
MSH

animal of the weasel family (Mustela or Putorius furo), about fourteen inches in length.
CSP

A small domestic mammal of the type Mustela putorious, with an elongated body and brown, black, white, or mixed fur. The ferret is carnivorous and crepuscular, spending 14-18 hours a day sleeping. This animal is prone to adrenal cancers, insulinoma, and lymphoma. In pre-clinical research, the ferret is used most commonly in toxicological screening and studies involving human influenza virus, as well as studies in reproductive physiology, anatomy, endocrinology and neuroscience.
NCI

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buňky tkáně pojivové

A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
MSH

group of cells that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells, and bone cells.
CSP

A group of cells that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells, and bone cells. (MeSH)
NCI

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pankreatektomie

Surgical removal of the pancreas. (Dorland, 28th ed)
MSH

surgical removal of the pancreas.
CSP

Surgery to remove all or part of the pancreas. In a total pancreatectomy, part of the stomach, part of the small intestine, the common bile duct, gallbladder, spleen, and nearby lymph nodes also are removed.
NCI

Surgical removal of part or all of the pancreas.
NCI

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LDL-2

Low-density lipoprotein particles with density between 1.045 and 1.063 g/ml.
MSH

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Simuliidae

black flies are widely distributed; females are vicious biters and serious pests; larvae live in streams; are the vector for onchocerciasis.
CSP

Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.
MSH

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plodové obaly – předčasné protržení

Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
MSH

The condition when a patient who is beyond 37 weeks gestation presents with rupture of membranes prior to the onset of labor. Rupture of membranes is diagnosed by speculum vaginal examination of the cervix and vaginal cavity, which will show pooling of fluid in the vagina or leakage of fluid from the cervix. Preterm PROM (known as PPROM) refers to a patient who has not yet reached 37 weeks gestation and presents with rupture of membranes.
NCI

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antikoncepční látky

Chemical substances that prevent or reduce the probability of CONCEPTION.
MSH

agent that diminishes the likelihood of or prevents conception; may be chemical, physical, or behavioral.
CSP

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papain

A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.
MSH

Enzyme preparations are products that are used in the histopathology laboratory for the following purposes: (1) To disaggregate tissues and cells already in established cultures for preparation into subsequent cultures (e.g., trypsin); (2) To disaggregate fluid specimens for cytological examination (e.g., papain for gastric lavage or trypsin for sputum liquefaction); (3) To aid in the selective staining of tissue specimens (e.g., diastase for glycogen determination).
SPN

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