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anthranilátfosforibosyltransferasa

An enzyme that catalyzes the formation of N-5`-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.
MSH

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geny gag

DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short for group-specific antigen.
MSH

This gene is involved in retroviral core structure.
NCI

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pivampicilin

Pivalate ester analog of AMPICILLIN.
MSH

A semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
NCI

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curium

A radioactive actinide with atomic symbol Cm, atomic number 96, and atomic weight 247. Thirteen curium isotopes have been produced with mass numbers ranging from 238-250. Its valence can be +3 or +4. It is intensely radioactive and decays by alpha-emission.
MSH

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alfa-mannosidóza

An autosomal recessive lysosomal storage disease characterized by deficient activity of the enzyme alpha-D-mannosidase. There is a wide range of signs and symptoms including hepatomegaly, splenomegaly, hearing loss, respiratory infections, mental retardation, skeletal abnormalities, leveled nasal bridge and protruding forehead.
NCI

An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.
MSH

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přežívající – četnost

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
MSH

The percentage of people in a study or treatment group who are alive for a certain period of time after they were diagnosed with or treated for a disease, such as cancer. The survival rate is often stated as a five-year survival rate, which is the percentage of people in a study or treatment group who are alive five years after diagnosis or treatment.
NCI

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protilátky fungální

Immunoglobulins produced in a response to FUNGAL ANTIGENS.
MSH

immunoglobulins induced by exposure to fungal antigens.
CSP

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Genetics, Biochemical

The science concerned with the chemical and physical nature of genes and the genome.
NCI

A branch of genetics which deals with the chemical structure of the genes and with the mechanisms by which the genes control and regulate the structure and synthesis of proteins.
MSH

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rostliny jedlé

An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.
MSH

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cykloheximid

Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
MSH

antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus; it inhibits protein synthesis in eukaryotic cells by blocking translation of messenger RNA on the ribosome.
CSP

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manželství

The social institution involving legal and/or religious sanction whereby men and women are joined together for the purpose of founding a family unit.
MSH

The social institution involving legal and/or religious sanction whereby men and women are joined together for the purpose of founding a family unit; the state of being a married couple.
NCI

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sympatomimetika

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
MSH

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buňky předkládající antigen

heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor; traditional antigen presenting cells include macrophages, dendritic cells, Langerhans cells, and B-lymphocytes; follicular dendritic cells are also considered to be antigen presenting cells by some.
CSP

A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
MSH

A type of immune cell that boosts immune responses by showing antigens on its surface to other cells of the immune system. An antigen-presenting cell is a type of phagocyte.
NCI

A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen presenting cell. The T-lymphocyte can now recognize and bind with the MHC-linked antigen.
NCI

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geriatrický odhad

Evaluation of the level of physical, physiological, or mental functioning in the older population group.
MSH

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trombocyty – adhezivita

The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other “foreign” surfaces.
MSH

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cystathionin-gama-lyasa

A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.
MSH

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mastocytóza

A heterogenous group of disorders characterized by the abnormal increase of MAST CELLS in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
MSH

rare disease characterized by an abnormal increase in mast cells in the bone marrow, liver, spleen, lymph nodes, gastrointestinal tract, and skin.
CSP

A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival.
NCI

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T-lymfocyty regulační

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
MSH

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antimitotické látky

agent that inhibits or prevents mitosis.
CSP

A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer.
NCI

An agent that inhibits tumor growth by interfering with mitotic processes or the assembly of the mitotic machinery.
NCI

Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.
MSH

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gigantismus

The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
MSH

condition of abnormal overgrowth or excessive size of the whole body or any of its parts.
CSP

A clinical finding indicating abnormal and excessive body growth and height resulting from the overproduction of human growth hormone.
NCI

A condition in which the whole body or any of its parts grow much larger than normal.
NCI

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pleuropneumonie nakažlivá

A pleuropneumonia of cattle and goats caused by species of MYCOPLASMA.
MSH

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cytidindifosfátdiglyceridy

The ester of diacylglycerol with the terminal phosphate of cytidine diphosphate. It serves as an intermediate in the biosynthesis of phosphatidylethanolamine and phosphatidylserine in bacteria.
MSH

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maxilofaciální vývoj

The process of growth and differentiation of the jaws and face.
MSH

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tangierská nemoc

An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.
MSH

autosomal recessive disorder of lipoprotein and lipid metabolism characterized by absence in plasma of normal high-density lipoprotein, deficiency of apolipoproteins AI and AII, low to normal low-density lipoproteins, high triglycerides and accumulation in body tissues of cholesteryl esters.
CSP

A rare, autosomal recessive inherited disorder of cholesterol transport, resulting in severe reduction of the amount of high density lipoprotein in the plasma and accumulation of cholesterol esters in the tissues. Signs and symptoms include large tonsils, hepatosplenomegaly, lymphadenopathy, and hypocholesterolemia.
NCI

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antitusika

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
MSH

Any substance that is capable of relieving or suppressing coughing.
NCI

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gliom

Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
MSH

new abnormal neuroglial tissue in any one of its stages of development that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A general term for tumors of the central nervous system, including astrocytomas, ependymal tumors, glioblastoma multiforme, and primitive neuroectodermal tumors.
NCI

A general term for many types of tumors of the central nervous system
CHV

A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas.
NCI

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Podophyllum

A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.
MSH

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Cytomegalovirus – infekce

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
MSH

A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies.
NCI

Cytomegalovirus (CMV) is a virus found around the world. It is related to the viruses that cause chickenpox and infectious mononucleosis (mono). Between 50 percent and 80 percent of adults in the United States have had a CMV infection by age 40. Once CMV is in a person`s body, it stays there for life.

Most people with CMV don`t get sick. But infection with the virus can be very serious in babies and people with weak immune systems. If a woman gets CMV when she is pregnant, she can pass it on to her baby. CMV does not harm most babies. But some develop lifelong disabilities.

CMV is spread through close contact with body fluids. You should use good hygiene, including proper hand washing, to avoid catching or spreading the virus. Most people with CMV don`t require treatment. If you have a weakened immune system, your doctor may prescribe antiviral medicine.

Centers for Disease Control and Prevention


MEDLINEPLUS

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nervus medianus

A major nerve of the upper extremity. In humans, the fibers of the median nerve originate in the lower cervical and upper thoracic spinal cord (usually C6 to T1), travel via the brachial plexus, and supply sensory and motor innervation to parts of the forearm and hand.
MSH

A branch of the brachial plexus that extends along the anterior aspect of the forearm and the hand.
NCI

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technecium

The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
MSH

first artificially produced element; technetium has the atomic symbol Tc, atomic number 43; all technetium isotopes are radioactive; technetium 99m has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent.
CSP

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