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fenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
MSH

barbituric acid derivative that acts as a nonselective central nervous system depressant.
CSP

A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.
NCI

a drug used for epilepsy and anxiety
CHV

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C739″ NCI Thesaurus)
PDQ

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.
NCI

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bretyliumtosylát

An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.
MSH

The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia.
NCI

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mukoproteiny

Conjugated proteins in which mucopolysaccharides are combined with proteins. The mucopolysaccharide moiety is the predominant group with the protein making up only a small percentage of the total weight.
MSH

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nádory žaludku

Tumors or cancer of the STOMACH.
MSH

new abnormal gastric tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm involving the stomach.
NCI

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Ehrlichia

genus in the order Rickettsiales, family Anaplasmataceae which produces disease in dogs, cattle, sheep, and humans.
CSP

Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating LYMPHOCYTES. They are the etiologic agents of tick-borne diseases of humans; DOGS; CATTLE; SHEEP; GOATS; and HORSES.
MSH

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ZOSTER HERPESA

An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
MSH

acute infectious, usually self-limited, disease believed to represent activation of latent varicella zoster virus in those who have been rendered partially immune after a previous attack of chickenpox; it involves the sensory ganglia and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.
CSP

A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient`s initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.
NCI

Shingles is a disease caused by the varicella-zoster virus – the same virus that causes chickenpox. After you have chickenpox, the virus stays in your body. It may not cause problems for many years. As you get older, the virus may reappear as shingles. Unlike chickenpox, you can`t catch shingles from someone who has it.

Early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. The pain can be mild to severe. Blisters then form and last from one to 14 days. If shingles appears on your face, it may affect your vision or hearing. The pain of shingles may last for weeks, months or even years after the blisters have healed.

There is no cure for shingles. Early treatment with medicines that fight the virus may help. These medicines may also help prevent lingering pain. A vaccine may prevent shingles or lessen its effects. The vaccine is for people 60 or over.

NIH: National Institute of Allergy and Infectious Diseases


MEDLINEPLUS

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fenylthiazolylthiomočovina

A dopamine-beta-hydroxylase inhibitor.
MSH

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bronchy – nemoci

condition in which there is a deviation from or interruption of the normal structure or function of the bronchi.
CSP

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Muscidae

includes many common flies, some of which are important pests; larvae breed in filth or decaying vegetation.
CSP

A family of the order DIPTERA with over 700 species. Important species that may be mechanical vectors of disease include Musca domesticus (HOUSEFLIES), Musca autumnalis (face fly), Stomoxys calcitrans (stable fly), Haematobia irritans (horn fly) and Fannia spp.
MSH

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Streptomycin Sulfate

The sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death.
NCI

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Holter

An ambulatory electrocardiography technique that records a continuous electrocardiographic rhythm pattern for 24 hours or more to detect heart arrhythmias.
NCI

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hexokinasa

An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
MSH

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fonoforéza

Use of ultrasound to increase the percutaneous adsorption of drugs.
MSH

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bukrylát

Cyanoacrylate tissue adhesive also used to occlude blood vessels supplying neoplastic or other diseased tissue.
MSH

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mutace

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
MSH

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studenti stomatologie

Individuals enrolled a school of dentistry or a formal educational program in leading to a degree in dentistry.
MSH

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elektroforéza na papíru

Electrophoresis in which paper is used as the diffusion medium. This technique is confined almost entirely to separations of small molecules such as amino acids, peptides, and nucleotides, and relatively high voltages are nearly always used.
MSH

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hipokampus

A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle. The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
MSH

a layer of gray matter lying along the floor of the lateral ventricle of the brain, comprised of cholinergic and possibly glutamatergic fibers, believed to be the critical brain structure underlying learning and memory.
CSP

a kind of brain structure
CHV

A curved gray matter structure of the temporal lobe lying on the floor of the lateral ventricle of the brain.
NCI

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fosfoglukomutasa

An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.
MSH

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buprenorfin

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
MSH

21-cyclopropyl-7-alpha-(2-hydroxy-3, 3-dimethyl-2-butyl)-6,14-endo-ethano -6,7,8,14-tetrahydro oripavine, a narcotic analgesic with mixed agonist-antagonist opiate properties; potential efficacy in heroin withdrawal.
CSP

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mykotoxikóza

Poisoning caused by the ingestion of mycotoxins (toxins of fungal origin).
MSH

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submitochondriální částice

The various filaments, granules, tubules or other inclusions within mitochondria.
MSH

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embolie nádorová

A tumor embolism involves sudden blockage of an artery by a clot or by other material from tumor fragments transported by the blood stream.
NCI

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histocytochemie

Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
MSH

The study of cells and tissues using chemical staining techniques.
NCI

study of chemical changes and chemical constitution of tissues and cells.
CSP

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fosforylasokinasa

An enzyme that catalyzes the conversion of ATP and PHOSPHORYLASE B to ADP and PHOSPHORYLASE A.
MSH

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butylskopolamoniumbromid

Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.
MSH

An orally available bromide salt form of butylscopolamine, a quaternary ammonium derivative of the alkaloid scopolamine, with anticholinergic property. Upon oral administration, hyoscine butylbromide binds to and blocks muscarinic receptors located on postganglionic parasympathetic nerve endings and on smooth muscle cells. This blocks the activity of acetylcholine (Ach) and causes its antispasmodic effect in the gastrointestinal (GI), urinary, uterine, and biliary tracts. This agent may also facilitate radiologic visualization of the GI tract.
NCI

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myoglobin

A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
MSH

conjugated protein which is the oxygen-transporting pigment of muscle, made up of one globin polypeptide chain and one heme group.
CSP

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náhlá smrt kojenců

The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)
MSH

sudden and unexpected death of an apparently healthy infant, typically occurring between 3 weeks and 5 months of age, most infants dying at night, and not explained by postmortem data.
CSP

Sudden infant death syndrome (SIDS) is the sudden, unexplained death of an infant younger than one year old. Some people call SIDS “crib death” because many babies who die of SIDS are found in their cribs.

SIDS is the leading cause of death in children between one month and one year old. Most SIDS deaths occur when babies are between two months and four months old. Although health care professionals don`t know what causes SIDS, they do know ways to reduce the risk. These include

  • Placing babies on their backs to sleep, even for short naps – “tummy time” is for when babies are awake and someone is watching
  • Using a firm sleep surface, such as a crib mattress covered with a fitted sheet
  • Keeping soft objects and loose bedding away from sleep area
  • Making sure babies don`t get too hot – keep the room at a comfortable temperature for an adult

NIH: National Institute of Child Health and Human Development


MEDLINEPLUS

Unexpected death in infancy which remains unexplained following autopsy, review of the medical history, and investigation of the death circumstances and death scene.
NCI

The sudden and unexpected death of a healthy child who is younger than one year old, usually during sleep. The cause of SIDS is not known.
NCI

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zaměstnanost

The state of being engaged in an activity or service for wages or salary.
MSH

The state of being engaged in an activity or service for wages or salary; the occupation for which you are paid.
NCI

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HLA-A antigeny

Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
MSH

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