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perylen

A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.
MSH

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leishmanióza kožní

An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
MSH

Leishmaniasis affecting the skin. It is the most common form of leishmaniasis. It presents with erythematous macules and papules, and nodules which may eventually ulcerate. The lesions appear in the bite site in the exposed skin areas.
NCI

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Filarioidea

A superfamily of nematodes of the suborder SPIRURINA. Its organisms possess a filiform body and a mouth surrounded by papillae.
MSH

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komplement C5a desargininový

A derivative of complement C5a, generated when the carboxy-terminal ARGININE is removed by CARBOXYPEPTIDASE B present in normal human serum. C5a des-Arg shows complete loss of spasmogenic activity though it retains some chemotactic ability (CHEMOATTRACTANTS).
MSH

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synthasa škrobu

An enzyme that catalyzes the transfer of glucose from ADPglucose to glucose-containing polysaccharides in 1,4-alpha-linkages. EC 2.4.1.21.
MSH

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farmakokinetika

Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.
MSH

distribution and effectiveness of a drug throughout the body as a function of route, schedule, vehicle, chemical isomer, metabolism, and other factors.
CSP

The activity of drugs in the body over a period of time, including the processes by which drugs are absorbed, distributed in the body, localized in the tissues, and excreted.
NCI

how a drug is absorbed, distributed, metabolized, and eliminated by the body
CHV

The characteristic movements of drugs within biological systems, as affected by absorption, distribution, binding, elimination, biotransformation, and excretion; particularly the rates of such movements.
NCI

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Leptothrix

A genus of gram-negative, sheathed, rod-shaped bacteria in the family COMAMONADACEAE.
MSH

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píštěl

Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
MSH

A fistula is an abnormal connection between two parts inside of the body. Fistulas can happen because of injury, infection or inflammation. They may develop between different organs such as between the esophagus and the windpipe, or the bowel and the vagina. They can also develop between two blood vessels such as between an artery and a vein, or between two arteries.


MEDLINEPLUS

An abnormal opening or passage between two organs or between an organ and the surface of the body. Fistulas may be caused by injury, infection, or inflammation, or may be created during surgery.
NCI

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výuka práce s počítačem

Process of teaching a person to interact and communicate with a computer.
MSH

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sterilizace

The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
MSH

The process that effectively kills or eliminates transmissible agents.
NCI

The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means
CHV

Any substance or process that is used primarily on non-living objects to kill germs, such as viruses, bacteria, and other microorganisms that can cause infection and disease. Most disinfectants are harsh chemicals but sometimes heat or radiation may be used.
NCI

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fenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
MSH

barbituric acid derivative that acts as a nonselective central nervous system depressant.
CSP

A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.
NCI

a drug used for epilepsy and anxiety
CHV

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C739″ NCI Thesaurus)
PDQ

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.
NCI

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leukémie myeloidní

Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
MSH

leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.
CSP

A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.
NCI

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flundra

Common name for two families of FLATFISHES belonging to the order Pleuronectiformes: left-eye flounders (Bothidae) and right-eye flounders (Pleuronectidae). The latter is more commonly used in research.
MSH

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konjunktiva – nádory

Tumors or cancer of the CONJUNCTIVA.
MSH

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nádory žaludku

Tumors or cancer of the STOMACH.
MSH

new abnormal gastric tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm involving the stomach.
NCI

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fenylthiazolylthiomočovina

A dopamine-beta-hydroxylase inhibitor.
MSH

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leukopenie

reduction in the number of leukocytes in the blood, the count being 5000 per cubic millimeter or less.
CSP

A condition in which there is a lower-than-normal number of leukocytes (white blood cells) in the blood.
NCI

A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
NCI

an abnormally low white blood cell count
CHV

A laboratory test result indicating a decreased number of white blood cells in the peripheral blood.
NCI

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fluoracetáty

Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall`s Dictionary of Chemistry, 5th ed)
MSH

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kontaktní inhibice

arrest of cell locomotion or cell division when two cells come into contact.
CSP

The cellular process in which cells stop growing or dividing in response to increased cell density. [GOC:dph, PMID:17376520]
GO

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Streptomycin Sulfate

The sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death.
NCI

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fonoforéza

Use of ultrasound to increase the percutaneous adsorption of drugs.
MSH

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Phthiraptera

An order of small, wingless parasitic insects, commonly known as lice. The suborders include ANOPLURA (sucking lice); AMBLYCERA; ISCHNOCERA; and Rhynchophthirina (elephant and warthog lice).
MSH

small, wingless, parasitic insects; though exact taxonomy is still controversial, they can be grouped in the orders Anoplura (sucking lice), Mallophaga (biting lice), and Rhynchophthirina (elephant-lice).
CSP

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nedostatek kyseliny listové

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
MSH

state in which folate is absent or in diminished amount relative to the normal requirement of an organism or a biologic system.
CSP

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rekonvalescence

The period of recovery following an illness.
MSH

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studenti stomatologie

Individuals enrolled a school of dentistry or a formal educational program in leading to a degree in dentistry.
MSH

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fosfoglukomutasa

An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.
MSH

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poranění bleskem

Accidental injuries caused by brief high-voltage electrical discharges during thunderstorms. Cardiopulmonary arrest, coma and other neurologic symptoms, myocardial necrosis, and dermal burns are common. Prompt treatment of the acute sequelae, including cardiopulmonary resuscitation, is indicated for survival.
MSH

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potrava fortifikovaná

Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the fortified food. The supplementation of cereals with iron and vitamins is an example of fortified food. Fortified food includes also enriched food to which various nutrients have been added to compensate for those essential nutrients removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
MSH

A food that has nutrients added back that were lost during processing. Examples are bread, pasta, and other products made from white flour that have B vitamins added back.
NCI

A food that has extra nutrients added to it or has nutrients added that are not normally there. Examples are milk with vitamin D added and salt with iodine added.
NCI

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rohovka – zákal

Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
MSH

clouding that can occur in the transparent part of the coat of the eyeball or cornea, secondary to inflammation, infection or irritant exposure by a foreign body or chemical.
CSP

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submitochondriální částice

The various filaments, granules, tubules or other inclusions within mitochondria.
MSH

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