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hematologické látky

Drugs that act on blood and blood-forming organs and those that affect the hemostatic system.
MSH

biologically active substance intended for use in diagnosis, treatment, or prevention of blood disorders.
CSP

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nadledviny – nádory

Tumors or cancer of the ADRENAL GLANDS.
MSH

new abnormal adrenal gland tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant (primary or metastatic) neoplasm affecting the adrenal glands.
NCI

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purpura hyperglobulinemická

Purplish or brownish red discoloration of the skin associated with increase in circulating polyclonal globulins, usually GAMMA-GLOBULINS. This syndrome often occurs on the legs of women aged 20 to 40 years.
MSH

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Molecullaire neurobiologie

The branch of neurobiology that tries to understand the anatomy, physiology, and pathology of the nervous system by understanding the way that genes, proteins, and molecules interact.
NCI

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klofazimin

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
MSH

A phenazine dye with anti-mycobacterial and anti-inflammatory activities. The exact mechanism through which clofazimine exerts its effect is unknown. However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
NCI

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Hemodialýza

therapy for the insufficient cleansing of the blood by the kidneys based on dialysis.
CSP

Removal of certain elements from the blood based on the difference in their rates of diffusion through a semipermeable membrane.
MSH

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Aeromonas

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs singly, in pairs, or in short chains. Its organisms are found in fresh water and sewage and are pathogenic to humans, frogs, and fish.
MSH

A genus of Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria and the family Aeromonadaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Aeromonas genus level.
NCI

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pyrethriny

The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester.
MSH

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monoaminoxidasa – inhibitory

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman`s The Pharmacological Basis of Therapeutics, 8th ed, p414)
MSH

chemically heterogeneous group of antidepressant drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines.
CSP

A type of drug used to treat depression. It stops the breakdown of certain chemicals in the brain that help improve a person`s mood. A MAO inhibitor is a type of antidepressant.
NCI

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kloxacilin

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
MSH

A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.
NCI

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hemopexin

a blood glycoprotein found in the beta globulin fraction which binds free heme and other porphyrins.
CSP

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Age

How long something has existed; elapsed time since birth.
NCI

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pyrrolidinony

A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)
MSH

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morfin – deriváty

Analogs or derivatives of morphine.
MSH

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nervus cochlearis

The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.
MSH

cochlear part of the 8th cranial nerve (vestibulocochlear nerve); cochlear nerve fibers originate from neurons of the spiral ganglion and project peripherally to cochlear hair cells and centrally to the cochlear nuclei of the brain stem; mediates the sense of hearing.
CSP

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heparitinsulfát

A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.
MSH

similar to heparin but with some L-iduronic acid residues.
CSP

Heparitin Sulfate. A glycosaminoglycan, structurally similar to heparin but with more N-acetyl groups and fewer O- and N-sulfate groups. Occurs in the liver, aorta, and lung. Accumulates in several mucopolysaccharidoses.
NCI

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vzduch – mikrobiologie

The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.
MSH

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karanténa

Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed & Black`s Veterinary Dictionary, 17th ed)
MSH

Place into enforced isolation.
NCI

restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; detention or isolation on account of suspected contagion; it includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country.
CSP

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virus myší leukémie

Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
MSH

species of gammaretrovirus, containing many well defined strains, producing leukemia in mice; latent viruses whose properties differ after they have become fixed viruses; can be split into 2 types, thymic and splenic.
CSP

Type C retroviruses that cause leukemia in mice. Includes the Abelson, AKR, Friend, Moloney, Gross, and other leukemia viruses.
NCI

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kolchicin

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
MSH

inhibits tubulin-tubulin binding and thus destabilizes microtubules; used to block mitosis, axonal transport, and other microtubule dependent cellular functions in vitro, and clinically to treat gout.
CSP

A general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers.
SPN

a drug used to prevent or treat attacks of gout
CHV

A drug used to treat gout (inflamed joints caused by a buildup of uric acid). It comes from the crocus plant Colchicum autumnale. Colchicine blocks cell division and the movement of certain immune cells to areas that are inflamed. It is a type of alkaloid and a type of mitotic inhibitor.
NCI

An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activity. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39188&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39188&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C385″ NCI Thesaurus)
PDQ

An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.
NCI

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HEPATOMEGALIA

Enlargement of the liver.
MSH

Enlarged liver.
NCI

Abnormal enlargement of the liver.
NCI

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alkoholismus – poruchy amnestické

A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)
MSH

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Racial group

In the United States, federal standards for classifying data on race determine the categories used by federal agencies and exert a strong influence on categorization by state and local agencies and private sector organizations. The federal standards do not conceptually define race, and they recognize the absence of an anthropological or scientific basis for racial classification. Instead, the federal standards acknowledge that race is a social-political construct in which an individual`s own identification with one more race categories is preferred to observer identification. The standards use a variety of features to define five minimum race categories. Among these features are descent from “the original peoples” of a specified region or nation. The minimum race categories are American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Other Pacific Islander, and White. The federal standards stipulate that race data need not be limited to the five minimum categories, but any expansion must be collapsible to those categories.


HL7V3.0

In the United States, federal standards for classifying data on race determine the categories used by federal agencies and exert a strong influence on categorization by state and local agencies and private sector organizations. The federal standards do not conceptually define race, and they recognize the absence of an anthropological or scientific basis for racial classification. Instead, the federal standards acknowledge that race is a social-political construct in which an individual`s own identification with one more race categories is preferred to observer identification. The standards use a variety of features to define five minimum race categories. Among these features are descent from “the original peoples” of a specified region or nation. The minimum race categories are American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Other Pacific Islander, and White. The federal standards stipulate that race data need not be limited to the five minimum categories, but any expansion must be collapsible to those categories.

OpenIssue:This concept domain definition does not align with current vocabulary practices and is much too US-centric to be appropriate as a “universal” domain.


HL7V3.0

In the United States, federal standards for classifying data on race determine the categories used by federal agencies and exert a strong influence on categorization by state and local agencies and private sector organizations. The federal standards do not conceptually define race, and they recognize the absence of an anthropological or scientific basis for racial classification. Instead, the federal standards acknowledge that race is a social-political construct in which an individual`s own identification with one more race categories is preferred to observer identification. The standards use a variety of features to define five minimum race categories. Among these features are descent from “the original peoples” of a specified region or nation. The minimum race categories are American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Other Pacific Islander, and White. The federal standards stipulate that race data need not be limited to the five minimum categories, but any expansion must be collapsible to those categories.


HL7V3.0

An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.
NCI

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mukoproteiny

Conjugated proteins in which mucopolysaccharides are combined with proteins. The mucopolysaccharide moiety is the predominant group with the protein making up only a small percentage of the total weight.
MSH

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Collesova fraktura

Fracture of the lower end of the radius in which the lower fragment is displaced posteriorly.
MSH

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ZOSTER HERPESA

An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
MSH

acute infectious, usually self-limited, disease believed to represent activation of latent varicella zoster virus in those who have been rendered partially immune after a previous attack of chickenpox; it involves the sensory ganglia and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.
CSP

A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient`s initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.
NCI

Shingles is a disease caused by the varicella-zoster virus – the same virus that causes chickenpox. After you have chickenpox, the virus stays in your body. It may not cause problems for many years. As you get older, the virus may reappear as shingles. Unlike chickenpox, you can`t catch shingles from someone who has it.

Early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. The pain can be mild to severe. Blisters then form and last from one to 14 days. If shingles appears on your face, it may affect your vision or hearing. The pain of shingles may last for weeks, months or even years after the blisters have healed.

There is no cure for shingles. Early treatment with medicines that fight the virus may help. These medicines may also help prevent lingering pain. A vaccine may prevent shingles or lessen its effects. The vaccine is for people 60 or over.

NIH: National Institute of Allergy and Infectious Diseases


MEDLINEPLUS

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Algae

major group of lower freshwater, marine, terrestrial or subterranean photosynthetic plants of extremely varied morphology and physiology, and that is commonly considered to be a heterogeneous assemblage.
CSP

Chlorophyll-containing, mainly aquatic eukaryotic organisms lacking true stems and roots and leaves.
NCI

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radiochemie

The study of the chemical and physical phenomena of radioactive substances.
MSH

branch of chemistry concerned with the interactions of molecules and subatomic particles.
CSP

The science concerned with the effects of radioactivity on health. (from On-line Medical Dictionary)
NCI

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Muscidae

includes many common flies, some of which are important pests; larvae breed in filth or decaying vegetation.
CSP

A family of the order DIPTERA with over 700 species. Important species that may be mechanical vectors of disease include Musca domesticus (HOUSEFLIES), Musca autumnalis (face fly), Stomoxys calcitrans (stable fly), Haematobia irritans (horn fly) and Fannia spp.
MSH

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kolpotomie

An incision in the vagina.
MSH

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