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cyklické N-oxidy

Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.
MSH

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zeměpisné pojmy

header term for any geographic location; for D43 grants, and R03 TW grants (Fogarty International Center awards), index specific country when possible.
CSP

All of the continents and every country situated within, the UNITED STATES and each of the constituent states arranged by region, CANADA and each of its provinces, AUSTRALIA and each of its states, the major bodies of water and major islands on both hemispheres, and selected major cities. Although the geographic locations are not printed in INDEX MEDICUS as main headings, in indexing they are significant in epidemiologic studies and historical articles and for locating administrative units in education and the delivery of health care.
MSH

Any demarcated area of the Earth; may be determined by both natural and human boundaries.
NCI

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obstipancia

Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.
MSH

A substance used to treat diarrhea (frequent and watery bowel movements).
NCI

Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (MeSH)
NCI

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sterilizace

The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
MSH

The process that effectively kills or eliminates transmissible agents.
NCI

The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means
CHV

Any substance or process that is used primarily on non-living objects to kill germs, such as viruses, bacteria, and other microorganisms that can cause infection and disease. Most disinfectants are harsh chemicals but sometimes heat or radiation may be used.
NCI

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mastektomie segmentální

Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.
MSH

Surgery to remove abnormal tissue or cancer from the breast and a small amount of normal tissue around it. It is a type of breast-sparing surgery.
NCI

The removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out.
NCI

The removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out. Also called partial mastectomy. (Cancer.gov)
NCI

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fenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
MSH

barbituric acid derivative that acts as a nonselective central nervous system depressant.
CSP

A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.
NCI

a drug used for epilepsy and anxiety
CHV

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C739″ NCI Thesaurus)
PDQ

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.
NCI

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cyproheptadin

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
MSH

serotonin antagonist and histamine H1 blocker used as an antipruritic, appetite stimulant, antiallergic, and to treat the post-gastrectomy dumping syndrome.
CSP

A drug that is used to treat asthma, allergies, and colds, and to relieve itching caused by certain skin disorders. It has also been used to stimulate appetite and weight gain, and is being studied in the treatment of weight loss caused by cancer and its treatment. Cyproheptadine belongs to the family of drugs called antihistamines.
NCI

The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=315774&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=315774&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28949″ NCI Thesaurus)
PDQ

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obrovské buňky s cizími tělesy

Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm.
MSH

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antigeny virové nádorové

Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
MSH

Proteins encoded by the genomes of specific DNA tumor viruses that are associated with the neoplastic transformation of infected cells. T-antigens stimulate the production of antibodies and are immunogenic.
NCI

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nádory žaludku

Tumors or cancer of the STOMACH.
MSH

new abnormal gastric tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm involving the stomach.
NCI

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Mauritánie

A republic in western Africa, southwest of ALGERIA and west of MALI. Its capital is Nouakchott.
MSH

A country in Northern Africa, bordering the North Atlantic Ocean, between Senegal and Western Sahara. (NCI)
NCI

A country in Northern Africa, bordering the North Atlantic Ocean, between Senegal and Western Sahara. (CIA World Factbook 2002)
NCI

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fenylthiazolylthiomočovina

A dopamine-beta-hydroxylase inhibitor.
MSH

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cystosarcoma phyllodes

A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known.
MSH

A type of tumor found in breast or prostate tissue. It is often large and bulky and grows quickly. It may be benign (not cancer) or malignant (cancer) and may spread to other parts of the body.
NCI

A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors.
NCI

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GLAUKOMA

An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
MSH

group of diseases characterized by increased intraocular pressure resulting in damage to the optic nerve and retinal nerve fibers.
CSP

Glaucoma damages the eye`s optic nerve. It is a leading cause of blindness in the United States. It usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. Often there are no symptoms at first, but a comprehensive eye exam can detect it.

People at risk should get eye exams at least every two years. They include

  • African Americans over age 40
  • People over age 60, especially Mexican Americans
  • People with a family history of glaucoma

Early treatment can help protect your eyes against vision loss. Treatments usually include prescription eyedrops and/or surgery.

NIH: National Eye Institute


MEDLINEPLUS

A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.
NCI

A condition in which there is a build-up of fluid in the eye, which presses on the retina and the optic nerve. The retina is the layer of nerve tissue inside the eye that senses light and sends images along the optic nerve to the brain. Glaucoma can damage the optic nerve and cause loss of vision or blindness.
NCI

Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
NCI

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asociální osobnost

A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)
MSH

personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others through aggressive, antisocial behavior, without remorse or loyalty to anyone.
CSP

A disorder characterized by a pervasive pattern of disregard for and violation of the rights of others that is manifested in childhood or early adolescence. (adapted from DSM-IV)
NCI

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Streptomycin Sulfate

The sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death.
NCI

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mechlorethamin

A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin`s disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
MSH

antineoplastic cytotoxic alkylating agent of the nitrogen mustard group.
CSP

group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen; formerly used as toxicants and vesicants, but now used therapeutically as antineoplastic agents; they are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
CSP

A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
NCI

A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell`s DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent.
NCI

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fonoforéza

Use of ultrasound to increase the percutaneous adsorption of drugs.
MSH

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keratin-18

A type I keratin found associated with KERATIN-8 in simple, or predominately single layered, internal epithelia.
MSH

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nervus glossopharyngeus

The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and CHEMORECEPTOR CELLS of the carotid sinus.
MSH

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aorta – ruptura

The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.
MSH

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studenti stomatologie

Individuals enrolled a school of dentistry or a formal educational program in leading to a degree in dentistry.
MSH

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lékařská onkologie

A subspecialty of internal medicine concerned with the study of neoplasms.
MSH

The study and treatment of cancers with chemicals, biological products or immunotherapy.
NCI

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fosfoglukomutasa

An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.
MSH

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dakryocystitida

Inflammation of the lacrimal sac. (Dorland, 27th ed)
MSH

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glukosyltransferasy

Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
MSH

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apolipoproteiny B

Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.
MSH

structural proteins of chylomicrons, VLDL, and LDL; important in secretion and transport of lipoproteins; binding proteins for LDL receptor pathway.
CSP

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submitochondriální částice

The various filaments, granules, tubules or other inclusions within mitochondria.
MSH

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mefrusid

A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level.
MSH

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fosforylasokinasa

An enzyme that catalyzes the conversion of ATP and PHOSPHORYLASE B to ADP and PHOSPHORYLASE A.
MSH

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