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Loxipine Succinate

The succinate salt form of loxapine, a tricyclic dibenzoxazepine antipsychotic agent with antiemetic, sedative, anticholinergic, and antiadrenergic actions. Loxapine succinate exerts its actions by blocking the dopamine receptors at postsynaptic receptor sites in the limbic system, cortical system and basal ganglia, thereby reducing the hallucinations and delusions that are associated with schizophrenia. This agent also exerts extrapyramidal side effects.
NCI

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piperonylbutoxid

An insecticide synergist, especially for pyrethroids and ROTENONE.
MSH

A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity. It is toxic and suspected of causing anorexia, carcinogenesis, convulsions, and dermal irritation, as well as hepatic and renal damage. (NCI04)
NCI

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zubní usazeniny

Accumulations of microflora that lead to pathological plaque and calculus which cause PERIODONTAL DISEASES. It can be considered a type of BIOFILMS. It is subtly distinguished from the protective DENTAL PELLICLE.
MSH

hard or soft material deposited on a tooth surface, such as dental calculus or plaque and materia alba.
CSP

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Furocoumarins

linear furanocoumarins found in many plants; they can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate pyrimidines, resulting in photosensitivity.
CSP

The most prominent linear type of furocoumarin is PSORALEN. An example of the angular type of furocoumarin is angelicin. In plants, they derive from mevalonic acid addition to umbelliferone and subsequent cyclization.
MSH

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arylsulfotransferasa

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3`-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3`,5`-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.
MSH

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otologické chirurgické výkony

procedures performed on the ear, used in the treatment of disease, injuries, or deformities; includes surgeries on the external and internal ear.
CSP

Surgery performed on the external, middle, or internal ear.
MSH

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nefritida při lupus erythematosus

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I – normal glomeruli, class II – pure mesangial alterations, class III – focal segmental glomerulonephritis, class IV – diffuse glomerulonephritis, class V – diffuse membranous glomerulonephritis, and class VI – advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
MSH

glomerulonephritis associated with systemic lupus erythematosus; classified into four histologic types: mesangial, focal, diffuse, and membranous.
CSP

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pizotylin

Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.
MSH

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zubní porcelán

A type of porcelain used in dental restorations, either jacket crowns or inlays, artificial teeth, or metal-ceramic crowns. It is essentially a mixture of particles of feldspar and quartz, the feldspar melting first and providing a glass matrix for the quartz. Dental porcelain is produced by mixing ceramic powder (a mixture of quartz, kaolin, pigments, opacifiers, a suitable flux, and other substances) with distilled water. (From Jablonski`s Dictionary of Dentistry, 1992)
MSH

white translucent dense ceramic material produced by fusing under high temperature a mixture of feldspar, kaolin, quartz, whiting and other substances; dental porcelain is used in dental restorations, either jacket crowns or inlays, artificial teeth, or metal-ceramic crowns and is essentially a mixture of particles of feldspar and quartz.
CSP

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galaktosaoxidasa

An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It is a copper protein. EC 1.1.3.9.
MSH

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aspartátsemialdehyddehydrogenasa

An enzyme that catalyzes the conversion of L-aspartate 4-semialdehyde, orthophosphate, and NADP+ to yield L-4-aspartyl phosphate and NADPH. EC 1.2.1.11.
MSH

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Suspending Agents

Therapeutically inactive ingredient of pharmaceutical dosage form used to prevent aggregation of the active drug in liquid form, allowing uniform concentrations to be maintained for accurate dosing.
NCI

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lymfokela

Cystic mass containing lymph from diseased lymphatic channels or following surgical trauma or other injury.
MSH

A cystic lesion containing lymph. It usually results from injury, gynecologic surgery, or urologic surgery.
NCI

A disorder characterized by a cystic lesion containing lymph.
NCI

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rostliny léčivé

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
MSH

plant considered to possess healing properties.
CSP

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zubní lékař a pacient – vztahy

The psychological relations between the dentist and patient.
MSH

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glutamátcysteinligasa

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
MSH

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink)
NCI

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astrocytom

Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
MSH

neoplasms composed of astrocytes of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.
CSP

A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.
NCI

A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.
NCI

a kind of brain tumor
CHV

A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.
NCI

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patologické stavy – příznaky a symptomy

see:http://www.nlm.nih.gov/mesh/MBrowser.html
AOT

Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.
MSH

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lysofosfatidylcholiny

derivatives of phosphatidylcholines obtained by their partial hydrolysis which removes one of the fatty acid moieties.
CSP

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trombocyty – agregace

The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
MSH

attachment of platelets to one another; part of the mechanism leading to the formation of a thrombus.
CSP

The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
GO

Any cell adhesion process that involves the association of platelets via adhesion molecules.
NCI

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DCMP-deaminasa

An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.
MSH

Deoxycytidylate deaminase (178 aa, ~20 kDa) is encoded by the human DCTD gene. This protein plays a role in the conversion of deoxycytidine to deoxyuridine.
NCI

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benzin

Volative flammable fuel (liquid hydrocarbons) derived from crude petroleum by processes such as distillation reforming, polymerization, etc.
MSH

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Hyoscyamine Sulfate

The sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
NCI

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T-fágy

A series of 7 virulent phages which infect E. coli. The T-even phages T2, T4; (BACTERIOPHAGE T4), and T6, and the phage T5 are called “autonomously virulent” because they cause cessation of all bacterial metabolism on infection. Phages T1, T3; (BACTERIOPHAGE T3), and T7; (BACTERIOPHAGE T7) are called “dependent virulent” because they depend on continued bacterial metabolism during the lytic cycle. The T-even phages contain 5-hydroxymethylcytosine in place of ordinary cytosine in their DNA.
MSH

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hořčík

A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
MSH

light, silvery metallic element, symbol Mg, atomic number 12; its salts are essential in nutrition, being required for the activity of many enzymes especially those concerned with oxidative phosphorylation.
CSP

In medicine, a mineral used by the body to help maintain muscles, nerves, and bones. It is also used in energy metabolism and protein synthesis.
NCI

An alkaline earth metal, Magnesium is important for many biochemical functions and reactions; for bone and muscle function, protein and fatty acid formation, activation of B vitamins, blood clotting, insulin secretion, and ATP formation. More than 300 enzymes require magnesium for catalytic action. The adult daily requirement is about 300 mg/day. Magnesium is found in many green plants, vegetables, and seeds; chlorophyll is a magnesium-centered porphyrin compound. Magnesium salts are used for magnesium deficiency supplementation. (NCI04)
NCI

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ploidie

The degree of replication of the chromosome set in the karyotype.
MSH

the whole set of chromosomes for the species.
CSP

The number of sets of chromosomes in a cell or an organism. For example, haploid means one set and diploid means two sets.
NCI

The number of chromosome set per cell.
NCI

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dermabraze

The mechanical planing of the SKIN with sand paper, emery paper, or wire brushes, to promote reepithelialization and smoothing of skin disfigured by ACNE scars or dermal NEVI.
MSH

A type of surgery used to make the skin smooth and to improve the way deep scars, pits, and wrinkles look. After numbing the skin, a doctor removes the top layer of skin using sandpaper or a brush or burr (small file) that spins at a high speed.
NCI

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gastrointestinální trakt

The upper gastrointestinal (GI) tract is comprised of mouth, pharynx, esophagus and stomach while the lower GI tract consists of intestines and anus. The primary function of the GI tract is to ingest, digest, absorb and ultimately excrete food stuff. (NCI)
NCI

Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
MSH

The upper gastrointestinal (GI) tract is comprised of mouth, pharynx, esophagus and stomach while the lower GI tract consists of intestines and anus. The primary function of the GI tract is to ingest, digest, absorb and ultimately excrete food stuff.
NCI

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autoritářství

The personality pattern or syndrome consisting of behavioral and attitudinal characteristics reflecting a preoccupation with the factors of power and authority in interpersonal relationships.
MSH

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taniny

Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
MSH

lustrous powder, yellow to light-brown in color, that is found in tree bark (particularly oak), fruits, leaves, and tea; used medicinally as an astringent, commercially in tanning hides, as a dye mordant, and as a histological fixative and stain.
CSP

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