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epoprostenol

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
MSH

prostaglandin synthesized by the vascular endothelium; potent inhibitor of platelet aggregation and powerful vasodilator.
CSP

An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to prostacyclin receptors on platelet surfaces, subsequently activating platelet membrane adenyl cyclase and resulting in increased cAMP levels. The elevated cAMP triggers signal transduction that leads to vasodilations. In addition, this agent also functions as an antagonist of thromboxane A2, thereby resulting in direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.
NCI

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cholecystografie

Radiography of the gallbladder after ingestion of a contrast medium.
MSH

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leukémie radiační

Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.
MSH

radiation induced progressive, malignant disease of the blood forming organs.
CSP

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acetyl-CoA-karboxylasa

A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
MSH

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tekutiny a sekrety tělesné

Liquid substances produced by living organisms to fulfill specific functions or excreted as waste.
MSH

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proteinmethyltransferasy

Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.
MSH

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cholestyraminová pryskyřice

strongly basic anion exchange resin used to extract bile salts and cholesterol, to treat diarrhea and biliary obstruction, and as an antipruritic.
CSP

A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.
MSH

An anion exchange resin. Cholestyramine resin adsorbs and combines with bile acids in the intestine to form an insoluble complex, which is then excreted in the feces. As a result, the absorption of bile acids from the enterohepatic circulation is partially prevented, resulting in an increased oxidation of cholesterol to bile acids, a decrease in low density lipoprotein in the plasma, and a decrease in serum cholesterol levels. Cholestyramine also increases the elimination of methotrexate and leflunomide, thereby potentially decreasing related toxicities. (NCI04)
NCI

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levonorgestrel

A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
MSH

The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.
NCI

a synthetic progestational hormone; can be delivered through different routes including capsules inserted under the skin as in Norplant.
CSP

A form of the hormone progesterone that is made in the laboratory and used to prevent pregnancy. It is being studied in the prevention of ovarian and endometrial cancer, and in the treatment of other conditions. Levonorgestrel is a type of oral contraceptive.
NCI

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kyselá fosfatasa

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.
MSH

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fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
MSH

pyrimidine analog that is an antineoplastic antimetabolite.
CSP

A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.
NCI

An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2`-deoxyuridine-5`-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), a necessary constituent of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C505″ NCI Thesaurus)
PDQ

An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2`-deoxyuridine-5`-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.
NCI

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protozoální infekce zvířat

Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.
MSH

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chorion

The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.
MSH

The outermost layer of the membranous sac enclosing the embryo in higher vertebrates.
NCI

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lišejníky

Any of a group of plants formed by a symbiotic combination of a fungus with an algae or CYANOBACTERIA, and sometimes both. The fungal component makes up the bulk of the lichen and forms the basis for its name.
MSH

a kind of fungus
CHV

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akriflavin

3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.
MSH

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Wereld Voedsel- en Landbouworganisatie, Verenigde Naties

Founded in 1945, FAO leads international efforts to defeat hunger. FAO acts as a neutral forum where all nations meet as equals to negotiate agreements and debate policy. FAO is also a source of knowledge and information. FAO`s activities comprise four main areas: putting information within reach, sharing policy expertise, providing a meeting place for nations, bringing knowledge to the field. (from FAO)
NCI

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pseudopodia

A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.
MSH

A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

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chromatografie vysokotlaká kapalinová

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
MSH

type of liquid chromotography in which the liquid (mobile) phase can be readily changed to affect resolution and time of analysis.
CSP

Frequently referred to simply as HPLC, this form of column chromatography is used frequently in biochemistry. The analyte is forced through a column by liquid at high pressure, which decreases the time the separated components remain on the stationary phase. Less time on the column then translates to narrower peaks in the resulting chromatogram and thence to better selectivity and sensitivity.
NCI

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linitis plastica

A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a “leather bottle” shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.
MSH

A cancer-related condition in which the gastric wall becomes thickened and rubbery (leather-bottle stomach). It is most often associated with diffuse gastric adenocarcinomas.
NCI

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aktivační analýza

A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
MSH

chemical analytic method based on the detection of characteristic radionuclides following a nuclear bombardment.
CSP

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Aphthovirus

A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.
MSH

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psychologie

The science dealing with the study of mental processes and behavior in man and animals.
MSH

study of mental and behavioral phenomena in individuals and groups; human and nonhuman species are included.
CSP

The science dealing with the study of mental processes and behavior in man and animals. (MeSH)
NCI

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chromozómy lidské, 4-5

The large, submetacentric human chromosomes, called group B in the human chromosome classification. This group consists of chromosome pairs 4 and 5.
MSH

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lipomatóza mnohočetná symetrická

A condition characterized by the growth of unencapsulated masses of ADIPOSE TISSUE symmetrically deposited around the neck, shoulders, or other sites around the body.
MSH

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viry adenoasociované

A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
MSH

replication is dependent on a helper adenovirus; multiplies in cells which support adenovirus replication in many species of host.
CSP

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receptáře jako téma

Lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
MSH

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psychoterapie racionálně emotivní

The replacement of illogical and unrealistic ideas with more realistic and adaptive ones through direct intervention and confrontation by the therapist.
MSH

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Churgův-Straussové syndrom

Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.
MSH

An autoimmune necrotizing vasculitis with the formation of granulomas. It is a pulmonary and systemic vasculitis associated with eosinophilia.
NCI

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vrh – velikost

The number of offspring produced at one birth by a viviparous animal.
MSH

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Adenoviridae – infekce

Virus diseases caused by the ADENOVIRIDAE.
MSH

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Francisella

The lone genus of bacteria in the family Francisellaceae, frequently found in natural waters. It can be parasitic in humans, other MAMMALS; BIRDS; and ARTHROPODS.
MSH

A genus of aerobic, Gram negative, rod and cocci shaped bacterium assigned to the phylum Proteobacteria and the family Franciscellaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Francisella genus level.
NCI

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