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nemocnice městské

Hospitals located in metropolitan areas.
MSH

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africká choroba koní

An insect-borne reovirus infection of horses, mules and donkeys in Africa and the Middle East; characterized by pulmonary edema, cardiac involvement, and edema of the head and neck.
MSH

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chromoblastomykóza

Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew`s Diseases of the Skin, 8th ed, p362)
MSH

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pyrogalol

A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.
MSH

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Necturus

A genus of the Proteidae family with five recognized species, which inhabit the Atlantic and Gulf drainages.
MSH

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humanismus

An ethical system which emphasizes human values and the personal worth of each individual, as well as concern for the dignity and freedom of humankind.
MSH

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zemědělství

The science of soil cultivation, crop production, and livestock raising.
MSH

the science, art, or practice of cultivating the soil, producing crops, and raising livestock and in varying degrees the preparation and marketing of the resulting products.
CSP

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chromozómy lidské, pár 18

A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
MSH

The designation for each member of the eighteenth largest human autosomal chromosome pair. Chromosome 18 spans about 76 million base pairs and represents about 2.5% of the total DNA in normal diploid cells.
NCI

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šarlatánství

The fraudulent misrepresentation of the diagnosis and treatment of disease.
MSH

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nádorové proteiny

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (TUMOR MARKERS, BIOLOGICAL) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
MSH

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uhlovodíky aromatické

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.
MSH

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Aljaška

constituent state of the United States of America; it lies at the extreme northwest of the North American continent and is the largest peninsula in the Western Hemisphere.
CSP

A state in the far northwestern United States. Its capital is Juneau.
NCI

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ciguatoxiny

Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.
MSH

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chinuklidinylbenzilan

A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.
MSH

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nefrektomie

Excision of a kidney. (Dorland, 28th ed)
MSH

surgical removal of a kidney.
CSP

Surgery to remove a kidney or part of a kidney. In a partial nephrectomy, part of one kidney or a tumor is removed, but not an entire kidney. In a simple nephrectomy, one kidney is removed. In a radical nephrectomy, an entire kidney, nearby adrenal gland and lymph nodes, and other surrounding tissue are removed. In a bilateral nephrectomy, both kidneys are removed.
NCI

A surgical procedure to completely or partially remove a kidney. With a complete nephrectomy, the attached adrenal gland, perinephric fat, and regional lymph nodes are often removed as well. With a partial nephrectomy, the removed tissue contains the tumor and a rim of normal renal parenchyma only.
NCI

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kyseliny hydroxamové

A class of weak acids with the general formula R-CONHOH.
MSH

A group of weak acids with the general chemical formula RC(=O)N(R`)OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
NCI

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aldehydy

organic compounds containing a carbonyl group in the form -CHO.
CSP

A type of chemical substance made from alcohol. Aldehydes are found in essential oils (scented liquid taken from plants).
NCI

Any organic compound containing a formyl (-CHO) group. Its functional group, with the structure R-CHO, consists of a carbonyl center bonded to hydrogen and an R group. Traces of various aldehydes are found in essential oils and often contribute to their odors.
NCI

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citrulin

amino acid, C6H13N3O3, originally isolated from watermelon, that is produced as an intermediate in the conversion of ornithine to arginine during urea formation in the liver; chemical name L-ornithine, N5-(aminocarbonyl).
CSP

A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product . Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=464795&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=464795&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53406″ NCI Thesaurus)
PDQ

A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product.
NCI

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radiestézie

Therapeutic cult concerned with intangible energies surrounding the living body and based on the detection of these intrinsic radiations by dowsing, or divining, or the use of more elaborate instruments (radionics).
MSH

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nezidioblastóza

A sporadic or inherited disorder characterized by the focal or diffuse proliferation of Langerhans cells in the pancreas. It results in hyperinsulinemia and hypoglycemia.
NCI

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.
MSH

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hydroxysteroidy

steroids in which one or more hydroxy groups have been substituted for hydrogen atoms either within the ring skeleton or on any of the side chains.
CSP

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alkyny

Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
MSH

unsaturated hydrocarbon containing a triple bond between two carbon atoms; the alkynes are members of the acetylene series.
CSP

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klinické lékařství

The study and practice of medicine by direct examination of the patient.
MSH

The practice of medicine based on direct observation of patients.
NCI

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radiologické informační systémy

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
MSH

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neurofibromatóza 2

An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
MSH

A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance. Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow.
NCI

An autosomal dominant disorder caused by mutations in the NF2 tumor suppressor gene. It is characterized by the development of peripheral and central nervous system tumors including acoustic schwannomas, neurofibromas, gliomas, and meningiomas.
NCI

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hyperkalémie

Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
MSH

abnormally high potassium concentration in the blood, most often due to defective renal excretion; characterized clinically by electrocardiographic abnormalities; in severe cases, weakness and flaccid paralysis may occur.
CSP

A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.
NCI

Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs.
NCI

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interferon alfa

One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
MSH

major interferon produced by virus-exposed leukocytes; has antiviral activity and activates NK cells; used in the treatment of hairy cell leukemia and other neoplasms.
CSP

a protein produced by the body in response to an infection
CHV

A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C225″ NCI Thesaurus)
PDQ

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mikrobiální kolagenasa

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
MSH

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znásilnění

unlawful sexual intercourse without consent of the victim.
CSP

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neuropsychologické testy

Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
MSH

tests designed to assess neurological function associated with certain behaviors; used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
CSP

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