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emodin

Purgative anthraquinone found in several plants, especially Rhamnus frangula. It was formerly used as a laxative, but is now used mainly as tool in toxicity studies.
MSH

A substance found in certain plants, including rhubarb. It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects.
NCI

A substance found in certain plants, including aloe vera. It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects.
NCI

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HIV obalový protein gp120

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
MSH

glycoprotein encoded by HIV envelope gene (env) with a molecular weight of 120,000; interaction between gp120 and CD4 on T-helper cells is involved in the recognition of the cells by HIV and the binding of HIV to those cells.
CSP

A protein produced by the human immunodeficiency virus that functions as a viral anti-receptor attachment protein. The protein is localized to the viral envelope and mediates fusion between viral and cellular membranes.
NCI

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kadmium – otrava

Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.
MSH

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19-jodcholesterol

19-Iodocholest-5-en-3 beta-ol. A cholesterol derivative usually substituted with radioactive iodine in the 19 position. The compound is an adrenal cortex scanning agent used in the assessment of patients suspected of having Cushing`s syndrome, hyperaldosteronism, pheochromocytoma and adrenal remnants following total adrenalectomy.
MSH

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myristany

Salts and esters of the 14-carbon saturated monocarboxylic acid–myristic acid.
MSH

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priony

small proteinaceous infectious particle that lacks nucleic acids; pathogen of animals, and apparently man.
CSP

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
MSH

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encefalitida japonská

A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)
MSH

Viral encephalitis caused by the mosquito-born Japanese encephalitis virus. Signs and symptoms include an initial period of fever, headaches, and malaise, followed by neck rigidity, hemiparesis, and convulsions. It may lead to coma.
NCI

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HLA-DR7 antigen

A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.
MSH

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pyrofosforečnan vápenatý

An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
MSH

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kyselina 3-hydroxy-3-methylglutarová

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
MSH

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NADPH-dehydrogenasa

A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.
MSH

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prodigiosin

4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)- 2,2`-bi-1H-pyrrole. A toxic, bright red tripyrrole pigment from Serratia marcescens and others. It has antibacterial, anticoccidial, antimalarial, and antifungal activities, but is used mainly as a biochemical tool.
MSH

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endocytóza

Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
MSH

the uptake by a cell of material from the environment by invagination of its plasma membrane.
CSP

A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. [GOC:mah, ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”, ISBN:0716731363]
GO

Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. Endosomes play a central role in endocytosis.
NCI

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homosexualita

The sexual attraction or relationship between members of the same SEX.
MSH

sexual attraction or relationship between members of the same sex.
CSP

A sexual attraction to members of the same sex. (WordNet)
NCI

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kambendazol

A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.
MSH

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7S Collagen

A stable peptide fragment originating from the N-terminal domain of collagen type IV.
MSH

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naftaleny

Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
MSH

two-ring crystalline aromatic hydrocarbons isolated from coal tar; used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, and preservatives.
CSP

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proinsulin

A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
MSH

precursor of insulin; it has minimum hormonal activity and is converted to insulin by removal of the connecting C peptide, leaving the two chain, active insulin molecule.
CSP

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energetický metabolismus

The chemical reactions involved in the production and utilization of various forms of energy in cells.
MSH

Any subcellular or molecular event, process, or condition concerned with storing and generating metabolic energy.
NCI

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nemocnice – restrukturalizace

Reorganization of the hospital corporate structure.
MSH

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Christmas Island

An Australian-administered island in the eastern Indian Ocean south of Java, Indonesia. (American Heritage Dictionary)
NCI

An Australian-administered island in the eastern Indian Ocean south of Java, Indonesia. (NCI)
NCI

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abortiva nesteroidní

Non-steroidal chemical compounds with abortifacient activity.
MSH

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Informační centrum pro národní zdravotnické plánování (USA)

A center in the HEALTH RESOURCES ADMINISTRATION Division of Planning Methods and Technology which provides access to current information on health planning and resources development.
MSH

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Propantheline Bromide

The bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. An aspartic acid residue present in the N-terminal portion of the third trans-membrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax bronchial muscle and reduce tone and motility of intestinal smooth muscle.
NCI

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enterotoxiny

Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.
MSH

substances that are toxic to the intestinal tract, causing vomiting, diarrhea, etc; most common enterotoxins are produced by bacteria.
CSP

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nemocnice městské

Hospitals located in metropolitan areas.
MSH

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karbazoly

Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
MSH

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akantocyty

Erythrocytes with protoplasmic projections giving the cell a thorny appearance.
MSH

Erythrocytes with protoplasmic projections giving the cell a thorny appearance. (MeSH)
NCI

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Necturus

A genus of the Proteidae family with five recognized species, which inhabit the Atlantic and Gulf drainages.
MSH

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prospektivní platební výměrová komise

The commission charged with evaluating issues and factors which affect the implementation of the PROSPECTIVE PAYMENT SYSTEM.
MSH

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