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nogalamycin

An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.
MSH

An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
NCI

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karubicin

A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.
MSH

An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39175&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39175&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C352″ NCI Thesaurus)
PDQ

An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
NCI

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promazin

A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
MSH

phenothiazine derivative used as an antipsychotic, an antiemetic, and as a analgesic/anesthetic potentiating agent.
CSP

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imobilizace

The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.
MSH

render a part of the body incapable of being moved, as by a cast or splint.
CSP

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potrat léčebný

Abortion induced to save the life or health of a pregnant woman. (From Dorland, 28th ed)
MSH

Intentional end of pregnancy by the removal or expulsion of a fetus or embryo from the uterus to preserve the health of the gravida (pregnant female).
NCI

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norpregneny

Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..
MSH

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kathepsin D

An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
MSH

Cathepsin D, encoded by the CTSD Gene, is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It has a specificity similar to but narrower than that of pepsin A, decomposing cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. Cathepsin D takes part in angiogenesis and activates osteoclasts, and plays a major role in the destruction of bone tissue by cholesteatoma. Transcription of the CTSD gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast and ovarian cancer, and possibly Alzheimer disease. (From LocusLink, PMID 12185597 and NCI)
NCI

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Propionibacteriaceae

family of gram positive bacteria found in dairy products or in the intestinal tracts of animals.
CSP

A family of gram-positive bacteria found in dairy products or in the intestinal tracts of animals.
MSH

A taxonomic family of Gram positive, anaerobic bacterium, which are found in dairy products and in the intestines of animals, in the phylum Actinobacteria that includes the genera Brooklawnia, Microlunatus, Propionibacterium and Ponticoccus, among others.
NCI

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imunoglobuliny – vazebný region

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
MSH

The portion of the light and heavy chains of immunoglobulin molecules where the variable and constant regions meet.
NCI

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nehody letecké

An accident taking place aboard, or involving, any type of aircraft.
NCI

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cékum – nemoci

Pathological developments in the CECUM.
MSH

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prostaglandiny A

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.
MSH

a kind of hormone
CHV

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imunosorbenty

An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.
MSH

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acetohexamid

A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.
MSH

A sulfonylurea with oral hypoglycemic properties that is used in the treatment of Type II diabetes mellitus. Acetohexamide lowers blood sugar by stimulating insulin release from the pancreas and increases the sensitivity of beta cells to glucose stimulus. This drug also increases the sensitivity of insulin receptors in muscle, liver, and adipose tissue thereby promoting glucose transport across cell membranes. This results in better controlled blood glucose levels. (NCI05)
NCI

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buňky – počet

The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
MSH

A procedure to determine the number of cells in a sample. Also used to mean the result of such a procedure.
NCI

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protein C

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
MSH

vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
CSP

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indapamid

A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable.
MSH

An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.
NCI

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úspěšnost

Success in bringing an effort to the desired end; the degree or level of success attained in some specified area (esp. scholastic) or in general.
MSH

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buňky kultivované

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
MSH

Cells adapted to culture, but with finite division potential. (On-line Medical Dictionary)
NCI

A human, plant, or animal cell that has been adapted to grow in the laboratory. Cultured cells may be used to diagnose infections, to test new drugs, and in research.
NCI

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protoonkogeny

Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
MSH

normal, nonpathogenic genes which, when mutated or otherwise altered, become oncogenes; many code for growth factors, growth factor receptors, genetic regulatory proteins, or other signal transduction molecules; compare with TUMOR SUPPRESSOR GENE and ONCOGENE.
CSP

A gene involved in normal cell growth. Mutations (changes) in a proto-oncogene may cause it to become an oncogene, which can cause the growth of cancer cells.
NCI

Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in the control of cell proliferation or differentiation. Mutations, amplifications or rearrangements of proto-oncogenes lead to upregulated or deregulated cell growth and allow them to function as oncogenes.
NCI

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průmyslový odpad

Worthless, damaged, defective, superfluous or effluent material from industrial operations. It represents an ecological problem and health hazard.
MSH

unwanted materials from an industrial operation; may be liquid, sludge, gas, solid, or hazardous waste.
CSP

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akonitin

A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates voltage-gated SODIUM CHANNELS. It has been used to induce arhythmias in experimental animals and it has antiinflammatory and antineuralgic properties.
MSH

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cefacetril

A derivative of 7-aminocephalosporanic acid.
MSH

A broad-spectrum first-generation cephalosporin with antibacterial activity. Cephacetrile binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
NCI

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Pseudomonadaceae

family of gram negative bacteria usually found in soil or water and including many plant pathogens and a few animal pathogens.
CSP

A family of gram-negative bacteria usually found in soil or water and including many plant pathogens and a few animal pathogens.
MSH

A taxonomic family of Gram negative, generally motile bacterium in the phylum Proteobacteria that includes the genera Pseudomonas and Rhizobacter, among others.
NCI

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infertilita mužská

The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
MSH

Infertility is a term doctors use if a man hasn`t been able to get a woman pregnant after at least one year of trying. Male infertility can result from physical problems, hormone problems, and lifestyle or environmental factors.

About a third of the time, infertility is because of a problem with the man. One third of the time, it is a problem with the woman. Sometimes no cause can be found.

If you suspect you are infertile, see your doctor. There are tests that may tell if you have fertility problems. When it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. Happily, two-thirds of couples treated for infertility are able to have babies.

National Women`s Health Information Center


MEDLINEPLUS

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Actinomyces israelii (bacteria)

A species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Actinobacteria. This bacteria hydrolyzes esculin, produces acid from xylose and is urease and catalase negative. A. israelii is found in the flora of the human oral and nasopharyngeal tract and in animals and is the most frequent cause of actinomycosis in humans.
NCI

Any bacterial organism that can be assigned to the species Actinomyces israelii.
NCI

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mozková kůra

The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri. It reaches its highest development in man and is responsible for intellectual faculties and higher mental functions.
MSH

thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri; it reaches its highest development in man and is responsible for intellectual faculties and higher mental functions.
CSP

The outer layer of the cerebrum composed of neurons and unmyelinated nerve fibers. It is responsible for memory, attention, consciousness and other higher levels of mental function.
NCI

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Psychodidae

small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms; important disease-related genera are Phlebotomus, Lutzomyia, and Sergentomyia; moth flies occur near drains and sewers and do not bite; sandflies occur in warm climates near water and do bite.
CSP

Small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms. Important disease-related genera are PHLEBOTOMUS, Lutzomyia, and Sergentomyia.
MSH

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injekce intralymfatické

Injections into the lymph nodes or the lymphatic system.
MSH

Injection, intralymphatic


HL7V3.0

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adamantan

A tricyclo bridged hydrocarbon.
MSH

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