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komise pro péči o zvířata

Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
MSH

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záření – monitorování

The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.
MSH

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interferon gama

activates NK cells, cytotoxic T cells, endothelial cells, and macrophages; stimulates LAK activity; costimulates B cell proliferation; inhibits T cell proliferation; implicated in aberrant expression of MHC II antigens leading to autoimmune disease.
CSP

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
MSH

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C583″ NCI Thesaurus)
PDQ

The gamma or immune IFNs are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized. They are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
NCI

Interferon gamma (IFNg) is produced by activated T cells and is an important immunoregulatory molecule, particularly in allergic diseases.
NCI

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kriminologie

The study of crime and criminals with special reference to the personality factors and social conditions leading toward, or away from crime.
MSH

scientific study of crime as a social phenomenon, of criminals, and of penal treatment.
CSP

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alkaloidy

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

organic nitrogenous bases; many alkaloids of medical importance occur in the animal and vegetable kingdoms.
CSP

A member of a large group of substances found in plants and in some fungi. Alkaloids contain nitrogen and can be made in the laboratory. Nicotine, caffeine, codeine, and vincristine are alkaloids. Some alkaloids, such as vincristine, are used to treat cancer.
NCI

A family or group of nitrogen-containing base compounds primarily derived from plant and animal sources. Many alkaloids are used medicinally, including cancer therapy.
NCI

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epilepsie traumatická

Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
MSH

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anomie

A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)
MSH

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radioimunoprecipitační analýza

Sensitive assay using radiolabeled ANTIGENS to detect specific ANTIBODIES in SERUM. The antigens are allowed to react with the serum and then precipitated using a special reagent such as PROTEIN A sepharose beads. The bound radiolabeled immunoprecipitate is then commonly analyzed by gel electrophoresis.
MSH

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interfáze

The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).
MSH

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. [GOC:dph, GOC:mah, http://www.onelook.com]
GO

The interval between two successive cell divisions during which the chromosomes are not individually distinguishable. Interphase is considered the resting stage of the cell.
NCI

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kryoglobuliny

Cryoglobulin: immunoglobulin which precipitates from serum when it is cooled below 37 degrees C.
AIR

Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
MSH

aberrant plasma proteins seen in multiple myeloma that precipitate, gel or crystallize at low temperatures and redissolve upon reaching body temperature.
CSP

An abnormal plasma protein that precipitates within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis.
NCI

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alylglycin

An inhibitor of glutamate decarboxylase and an antagonist of GAMMA-AMINOBUTYRIC ACID. It is used to induce convulsions in experimental animals.
MSH

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nemocnice – vybavení a zásobování

Any materials used in providing care specifically in the hospital.
MSH

expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures in hospitals.
CSP

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kyseliny anthranilové

Benzoic acids which are substituted with an amino group in the C-2 position.
MSH

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Rana

genus of frog; tailess amphibian with long hind legs adapted for jumping; lives in damp or aquatic environments.
CSP

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peroperační péče

Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
MSH

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kurikulum

A course of study offered by an educational institution.
MSH

regular and established course of study; courses offered by an educational institution; a set of courses constituting an area of specialization.
CSP

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Alphavirus

genus of Togaviridae, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae; viruses are transmitted by mosquitoes.
CSP

A genus of TOGAVIRIDAE, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae. The viruses are transmitted by mosquitoes. The type species is the SINDBIS VIRUS.
MSH

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Erythrina

A genus of leguminous shrubs or trees, mainly tropical, yielding certain alkaloids, lectins, and other useful compounds.
MSH

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protilátky heterofilní

Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens–i.e., the phenomenon of heterophile antibody response–is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
MSH

antibody produced by the introduction of heterophile antigen into a species which does not carry it.
CSP

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potkani Zucker

Two populations of Zucker rats have been cited in research–the “fatty” or obese and the lean. The “fatty” rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
MSH

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jodacetamid

An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
MSH

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cykloleucin

An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
MSH

a kind of amino acid
CHV

A synthetic amino acid derivative of cyclopentanecarboxylic acid, cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C404″ NCI Thesaurus)
PDQ

A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.
NCI

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sanitky

A vehicle equipped for transporting patients in need of emergency care.
MSH

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achalázie jícnu

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).
MSH

failure of normal relaxation of the lower esophageal sphincter associated with uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction and difficulty swallowing.
CSP

A finding indicating the lack of adequate relaxation of the lower esophageal sphincter resulting in difficulty swallowing food.
NCI

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antigenní variace

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
MSH

Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism`s immune system. [GOC:mb]
GO

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Receptors, Corticosteroid

proteins found usually in the cytoplasm or cell nucleus that specifically bind corticosteroids and trigger changes influencing the behavior of cells.
CSP

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Irák

A country in the Middle East, bordering the Persian Gulf, between Iran and Kuwait. (NCI)
NCI

A country in the Middle East, bordering the Persian Gulf, between Iran and Kuwait. (CIA World Factbook 2002)
NCI

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cystatiny

A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.
MSH

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amidofosforibosyltransferasa

An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and phosphoribosylpyrophosphate. EC 2.4.2.14.
MSH

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4. (from Gene)
NCI

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Estradiol 17 beta-Dehydrogenase

Expressed in many peripheral tissues (high in placenta) by human HSD17B2 Gene (SDR Family), 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2 is a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)
NCI

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