Shopping Page. Buy or upgrade website.

misonidazol

A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
MSH

1-(alpha-methoxymethyl ethanol)-2-nitroimidazole; trichimonicide and experimental mutagen and radiosensitizer, probably due to its ability to form DNA-attacking free radical under hypoxic conditions.
CSP

A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39504&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39504&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C657″ NCI Thesaurus)
PDQ

A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04)
NCI

Price: $1.00

Loading Updating cart…

acetyl-CoA-hydrolasa

An enzyme that catalyzes reversibly the hydrolysis of acetyl-CoA to yield CoA and acetate. The enzyme is involved in the oxidation of fatty acids. EC 3.1.2.1.
MSH

Price: $1.00

Loading Updating cart…

Helsinská deklarace

An international agreement of the World Medical Association which offers guidelines for conducting experiments using human subjects. It was adopted in 1962 and revised by the 18th World Medical Assembly at Helsinki, Finland in 1964. Subsequent revisions were made in 1975, 1983, 1989, and 1996. (From Encyclopedia of Bioethics, rev ed, 1995)
MSH

Price: $1.00

Loading Updating cart…

kraniální nervy – nemoci

Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
MSH

Price: $1.00

Loading Updating cart…

protein-O-methyltransferasa

An enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine to free carboxyl groups of a protein molecule forming methyl esters. EC 2.1.1.-.
MSH

Price: $1.00

Loading Updating cart…

komise pro péči o zvířata

Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
MSH

Price: $1.00

Loading Updating cart…

mobilní zdravotnické jednotky

movable facilities in which diagnostic and therapeutic services are provided to the community.
CSP

Price: $1.00

Loading Updating cart…

kyselý déšť

Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.
MSH

Price: $1.00

Loading Updating cart…

hematoporfyriny

Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.
MSH

Price: $1.00

Loading Updating cart…

kriminologie

The study of crime and criminals with special reference to the personality factors and social conditions leading toward, or away from crime.
MSH

scientific study of crime as a social phenomenon, of criminals, and of penal treatment.
CSP

Price: $1.00

Loading Updating cart…

protozoální proteiny

Proteins found in any species of protozoan.
MSH

Price: $1.00

Loading Updating cart…

anomie

A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)
MSH

Price: $1.00

Loading Updating cart…

měkkýši – jedy

Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.
MSH

Price: $1.00

Loading Updating cart…

akrodermatitida

Inflammation involving the skin of the extremities, especially the hands and feet. Several forms are known, some idiopathic and some hereditary. The infantile form is called Gianotti-Crosti syndrome.
MSH

An inflammatory skin condition affecting children. It is often associated with Epstein-Barr virus infection, hepatitis B infection or cytomegalovirus infection. It is characterized by the presence of cutaneous rashes and patches on the palms and soles. The trunk is not affected.
NCI

Price: $1.00

Loading Updating cart…

hemoglobin E

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.
MSH

Price: $1.00

Loading Updating cart…

kryoglobuliny

Cryoglobulin: immunoglobulin which precipitates from serum when it is cooled below 37 degrees C.
AIR

Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
MSH

aberrant plasma proteins seen in multiple myeloma that precipitate, gel or crystallize at low temperatures and redissolve upon reaching body temperature.
CSP

An abnormal plasma protein that precipitates within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis.
NCI

Price: $1.00

Loading Updating cart…

pseudogravidita

An acyclic state that resembles PREGNANCY in that there is no ovarian cycle, ESTROUS CYCLE, or MENSTRUAL CYCLE. Unlike pregnancy, there is no EMBRYO IMPLANTATION. Pseudopregnancy can be experimentally induced to form DECIDUOMA in the UTERUS.
MSH

absence of menses accompanied by other signs of pregnancy without conception; may be due to psychogenic factors, abdominal neoplasia, or a hormonal disorder.
CSP

Price: $1.00

Loading Updating cart…

kyseliny anthranilové

Benzoic acids which are substituted with an amino group in the C-2 position.
MSH

Price: $1.00

Loading Updating cart…

Montana

A state in the northern midwest United States. Its capital is Helena.
NCI

Price: $1.00

Loading Updating cart…

aktivátorové přístroje

Loose-fitting removable orthodontic appliances which redirect the pressures of the facial and masticatory muscles onto the teeth and their supporting structures to produce improvements in tooth arrangements and occlusal relations.
MSH

Price: $1.00

Loading Updating cart…

hemoragická horečka krymská

A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).
MSH

Price: $1.00

Loading Updating cart…

kurikulum

A course of study offered by an educational institution.
MSH

regular and established course of study; courses offered by an educational institution; a set of courses constituting an area of specialization.
CSP

Price: $1.00

Loading Updating cart…

psychologie aplikovaná

The science which utilizes psychologic principles to derive more effective means in dealing with practical problems.
MSH

Price: $1.00

Loading Updating cart…

protilátky heterofilní

Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens–i.e., the phenomenon of heterophile antibody response–is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
MSH

antibody produced by the introduction of heterophile antigen into a species which does not carry it.
CSP

Price: $1.00

Loading Updating cart…

matka a dítě – vztahy

Interaction between the mother and the child.
MSH

relationships and behaviors between mother and child; including biological, adopted or step children.
CSP

Price: $1.00

Loading Updating cart…

adenokarcinom

A malignant epithelial tumor with a glandular organization.
MSH

carcinoma derived from glandular tissue or in which tumor cells form recognizable glandular structures.
CSP

Cancer that begins in cells that line certain internal organs and that have gland-like (secretory) properties.
NCI

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma.
NCI

Price: $1.00

Loading Updating cart…

hepatitida B – protilátky

Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the “e” antigens.
MSH

An antibody produced by B lymphocytes in response to hepatitis B hepadnaviral infection.
NCI

Price: $1.00

Loading Updating cart…

cykloleucin

An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
MSH

a kind of amino acid
CHV

A synthetic amino acid derivative of cyclopentanecarboxylic acid, cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C404″ NCI Thesaurus)
PDQ

A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.
NCI

Price: $1.00

Loading Updating cart…

psychotické poruchy

WHAT: Psychosis.
AIR

Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
MSH

severest class of psychological disorders, characterized by one or more of severe affective disturbances, profound introspection, withdrawal from reality, hallucinations, or regression.
CSP

Psychotic disorders are severe mental disorders that cause abnormal thinking and perceptions. People with psychoses lose touch with reality. Two of the main symptoms are delusions and hallucinations. Delusions are false beliefs, such as thinking that someone is plotting against you or that the TV is sending you secret messages. Hallucinations are false perceptions, such as hearing, seeing or feeling something that is not there. Schizophrenia is one type of psychotic disorder.

Treatment for psychotic disorders varies by disorder. It might involve drugs to control symptoms, and talk therapy. Hospitalization is an option for serious cases where a person might be dangerous to himself or others.


MEDLINEPLUS

A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder, or brain tumor.
NCI

A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.
NCI

A severe mental disorder in which a person loses the ability to recognize reality or relate to others. The person is not able to cope with the demands of everyday life. Symptoms include being paranoid, having false ideas about what is taking place or who one is, and seeing, hearing, or feeling things that are not there.
NCI

Price: $1.00

Loading Updating cart…

antigenní variace

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
MSH

Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism`s immune system. [GOC:mb]
GO

Price: $1.00

Loading Updating cart…

Comments are closed