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kraniální nervy – nemoci

Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
MSH

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komise pro péči o zvířata

Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
MSH

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ledviny – nekróza kůry

Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.
MSH

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přijímací oddělení nemocnice

Hospital department responsible for the flow of patients and the processing of admissions, discharges, transfers, and also most procedures to be carried out in the event of a patient`s death.
MSH

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oči – pohyby

Voluntary or reflex-controlled movements of the eye.
MSH

voluntary or reflex-controlled motion of the eye.
CSP

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pulzní radiolýza

use of a pulse of X-rays or fast electrons to generate free radicals for spectroscopic examination.
CSP

Pulse Radiolysis is a technique of exposing a sample of material to a beam of highly accelerated electrons to initiate fast reaction events occurring between 10-11 and 102 s after energy absorption. The technique is used to study fast reactions of biologically important molecules, e.g. the kinetics and thermodynamics of redox processes and electron-transfer reactions, enzymatic processes and structural effects which are revealed by physical or kinetic properties.
NCI

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kriminologie

The study of crime and criminals with special reference to the personality factors and social conditions leading toward, or away from crime.
MSH

scientific study of crime as a social phenomenon, of criminals, and of penal treatment.
CSP

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anomie

A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)
MSH

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kininy

A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman`s The Pharmacologic Basis of Therapeutics, 8th ed, p588)
MSH

any of a group of endogenous peptides which cause vasodilation and other changes associated with hypotension.
CSP

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beta-1-adrenergní receptory

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
MSH

Beta 1 adrenergic receptor protein (477 aa, 51 kD) is a cell communication process protein that is encoded by the human ADRB1 gene and has a role in signal transduction.
NCI

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faktor VII

Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.
MSH

A clotting factor found in the serum. It combines with tissue factor (factor III) to activate factor X in the clotting pathway.
NCI

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pyelonefritida xantogranulomatózní

A chronic inflammatory condition of the KIDNEY resulting in diffuse renal destruction, a grossly enlarged and nonfunctioning kidney associated with NEPHROLITHIASIS and KIDNEY STONES.
MSH

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kryoglobuliny

Cryoglobulin: immunoglobulin which precipitates from serum when it is cooled below 37 degrees C.
AIR

Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
MSH

aberrant plasma proteins seen in multiple myeloma that precipitate, gel or crystallize at low temperatures and redissolve upon reaching body temperature.
CSP

An abnormal plasma protein that precipitates within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis.
NCI

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kyseliny anthranilové

Benzoic acids which are substituted with an amino group in the C-2 position.
MSH

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Kuvajt

A country in the Middle East, bordering the Persian Gulf, between Iraq and Saudi Arabia. (NCI)
NCI

A country in the Middle East, bordering the Persian Gulf, between Iraq and Saudi Arabia. (CIA World Factbook 2002)
NCI

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Afghánistán

A country in Southern Asia, north and west of Pakistan, east of Iran. (NCI)
NCI

A country in Southern Asia, north and west of Pakistan, east of Iran. (CIA World Factbook 2002)
NCI

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politika plánování rodičovství

A course or method of action selected, usually by a government, to guide and determine present and future decisions on population control by limiting the number of children or controlling fertility, notably through family planning and contraception within the nuclear family.
MSH

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pyridoxin

The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
MSH

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pyridoxine helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly. Pyridoxine is a group of related compounds (pyridoxine, pyridoxal, and pyridoxamine) found in cereals, beans, peas, nuts, meat, poultry, fish, eggs, and bananas. It is water-soluble (can dissolve in water). Not enough pyridoxine can cause mouth and tongue sores and nervous disorders. Pyridoxine is being studied in the prevention of hand-foot syndrome (a disorder caused by certain anticancer drugs and marked by pain, swelling, numbness, tingling, or redness of the hands or feet).
NCI

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kurikulum

A course of study offered by an educational institution.
MSH

regular and established course of study; courses offered by an educational institution; a set of courses constituting an area of specialization.
CSP

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protilátky heterofilní

Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens–i.e., the phenomenon of heterophile antibody response–is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
MSH

antibody produced by the introduction of heterophile antigen into a species which does not carry it.
CSP

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lac operon

The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.
MSH

prokaryotic genetic unit consisting of three structural genes, an operator and a regulatory gene; the regulatory gene controls the synthesis of the three structural genes: beta-galactosidase and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.
CSP

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stárnutí

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
MSH

the gradual physiological changes that occur with the passage of time; includes from birth to death; may be used for any species.
CSP

The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. [GOC:dph, GOC:ems]
GO

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
NCI

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tuky

The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

ester of glycerol with fatty acids; generally odorless, colorless, and tasteless if pure; fats are insoluble in water, soluble in most organic solvents; they occur in animal and vegetable tissue.
CSP

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pyruvátdehydrogenasofosfatasa

(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.
MSH

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cykloleucin

An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
MSH

a kind of amino acid
CHV

A synthetic amino acid derivative of cyclopentanecarboxylic acid, cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C404″ NCI Thesaurus)
PDQ

A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.
NCI

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antigenní variace

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
MSH

Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism`s immune system. [GOC:mb]
GO

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Laminaria

A genus of BROWN ALGAE in the family Laminariaceae. Dried pencil-like pieces may be inserted in the cervix where they swell as they absorb moisture, serving as osmotic dilators.
MSH

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ajmalin

An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.
MSH

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virus leukémie koček

A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).
MSH

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Quinidine Sulfate

The sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart.
NCI

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