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promedol

A narcotic analgesic similar to MEPERIDINE; it exists in four stereoisomers, two of which, the beta (isopromedol) and the gamma (trimeperidine) are active.
MSH

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fibrinolýza

The natural enzymatic dissolution of FIBRIN.
MSH

natural enzymatic dissolution of fibrin.
CSP

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. [GOC:jl, PMID:15842654]
GO

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enoyl-CoA-hydratasa

An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.
MSH

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kapitační platba

A method of payment for health services in which an individual or institutional provider is paid a fixed, per capita amount without regard to the actual number or nature of services provided to each patient.
MSH

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potrat hrozící

UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.
MSH

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volný čas – činnosti

Voluntary use of free time for activities outside the daily routine.
MSH

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Propionibacterium

genus of gram positive, rod shaped bacteria whose cells occur singly, in pairs or short chains, in V or Y configurations, or in clumps resembling letters of the Chinese alphabet; organisms are found in cheese and dairy products as well as on human skin and can occasionally cause soft tissue infections.
CSP

A genus of gram-positive, rod-shaped bacteria whose cells occur singly, in pairs or short chains, in V or Y configurations, or in clumps resembling letters of the Chinese alphabet. Its organisms are found in cheese and dairy products as well as on human skin and can occasionally cause soft tissue infections.
MSH

A genus of gram-positive, anaerobic, rod-shaped bacteria in the Propionibacteriaceae family that is a normal skin saprophyte but that can cause chronic infections and abscesses.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Propionibacterium genus level.
NCI

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filipin

A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.
MSH

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životní prostředí – expozice

The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
MSH

exposure to chemical, physical or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, toxic chemicals, dust, lead, or pollution; do not confuse with DOSAGE.
CSP

Exposure to potentially harmful chemical, physical or biological agents via the environment.
NCI

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sacharidy – sekvence

The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
MSH

sequence of carbohydrates within polysaccharides, glycoproteins, and glycolipids.
CSP

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úrazy v domácnosti

An accident taking place within a home.
NCI

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Leschův-Nyhanův syndrom

An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
MSH

rare x-linked disorder of purine metabolism, due to deficiency of hypoxanthine phosphoribosyltransferase; affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures; self-destructive behaviors such as biting of fingers and lips are seen frequently; intellectual impairment may also occur but is typically not severe; elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis.
CSP

An X-linked inherited syndrome caused by mutations in the gene that encodes the enzyme hypoxanthine-guanine phosphoribosyltransferase, resulting in accumulation of uric acid in the body. It affects males and is characterized by neurologic defects, moderate mental retardation, muscle hypotonia, and a tendency for self-mutilation (self-biting of lips, tongue, and fingertips).
NCI

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prostaglandiny A syntetické

Analogs or derivatives of prostaglandin A that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGA.
MSH

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fixativa

Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
MSH

A compound that fixes tissues and cells for microscopic study.
NCI

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karcinoembryonální antigen

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
MSH

cancer specific antigen of colon carcinoma, also present in adenocarinomas of endodermal origin and in human embryonic gastrointestinal tissue.
CSP

a substance often found in a person with cancer
CHV

A substance that is sometimes found in an increased amount in the blood of people who have certain cancers, other diseases, or who smoke. It is used as a tumor marker for colorectal cancer.
NCI

A cancer-specific antigen associated with both tumors and the developing fetus. The main use of this antigen is as a tumor marker, especially with respect to intestinal cancers. Production of the antigen ceases shortly before birth, but may reappear in people who develop certain types of cancer.
NCI

An antigen that is secreted onto the luminal surface of gastrointestinal epithelia and is found in pancreaticobiliary secretions. The antigen has been implicated as a facilitator of hepatic metastasis and is a cancer specific antigen of colon carcinoma. It is present in adenocarcinomas of endodermal origin and is localized in human embryonic gastrointestinal tissue.
NCI

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acetoin

A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.
MSH

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leukémie myeloidní chronická BCR-ABL pozitivní

chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.
CSP

A slowly progressing disease in which too many white blood cells are made in the bone marrow.
NCI

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
MSH

A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival.
NCI

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia (CML), there are too many of a specific type of white blood cell called a granulocyte.

Sometimes CML does not cause any symptoms at all. If you have symptoms, they may include:

  • Feeling very tired
  • Weight loss
  • Night sweats
  • Fever
  • Pain or a feeling of fullness below the ribs on the left side

Tests that examine the blood and bone marrow diagnose CML. Treatments include chemotherapy, radiation therapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, immune therapy, or surgery to remove the spleen.

NIH: National Cancer Institute


MEDLINEPLUS

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proteiny – konformace

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
MSH

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Stroomschema`s (computer)

A diagram that shows step-by-step progression through a procedure or system especially using connecting lines and a set of conventional symbols.
NCI

A diagram that shows the order of steps in a complex process.
NCI

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kardenolidy

C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.
MSH

C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17; they are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule; the class includes cardadienolides and cardatrienolides.
CSP

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Achillova šlacha

The tendon that connects the heel bone to the calf muscles at the back of the lower leg.
NCI

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leukoplakie orální

A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).
MSH

white patch seen on the oral mucosa; considered a premalignant condition and is often tobacco-induced.
CSP

A white patch or plaque on oral mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition.
NCI

A white patch or plaque on oral cavity mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition. –2004
NCI

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protokatechuát-3,4-dioxygenasa

An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.
MSH

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fluorokarbony

Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
MSH

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karmustin

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
MSH

cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers.
CSP

An anticancer drug that belongs to the family of drugs called alkylating agents.
NCI

a kind of cancer treatment drug
CHV

An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43027&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43027&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C349″ NCI Thesaurus)
PDQ

An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
NCI

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akustické impedanční testy

Objective tests of middle ear function based on the difficulty (impedance) or ease (admittance) of sound flow through the middle ear. These include static impedance and dynamic impedance (i.e., tympanometry and impedance tests in conjunction with intra-aural muscle reflex elicitation). This term is used also for various components of impedance and admittance (e.g., compliance, conductance, reactance, resistance, susceptance).
MSH

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licence

The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.
MSH

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Pseudomonas

genus of gram negative, aerobic, rod shaped bacteria widely distributed in nature; some species are pathogenic for humans, animals, and plants.
CSP

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
MSH

A genus of gram-negative, motile, non-spore-forming, rod-shaped bacteria in the phylum Proteobacteria.
NCI

A genus of aerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria and the family Pseudomonadaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Pseudomonas genus level.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Chryseomonas genus level.
NCI

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folklór

The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.
MSH

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kazuistiky

Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis.
MSH

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