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Heinzova tělíska

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.
MSH

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virus chřipky A

A negative-strand linear single-strand RNA virus with an 8 segment genome. Virions are enveloped and usually spherical or pleomorphic, 80-120 nm in diameter. Subtyping is based on the antigenic properties of the hemagglutinin and neuraminidase proteins. Influenza type A viruses can infect people, birds, pigs, horses, and other animals, but wild birds are the natural hosts for these viruses.
NCI

One of three types of virus that cause the illness called influenza (flu). The influenza A virus can infect people, birds, pigs, horses, and other animals. It is the main cause of most influenza epidemics.
NCI

The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.
MSH

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encefalomalacie

Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
MSH

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mitomyciny

A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
MSH

group of methylazirinopyrroloindolediones obtained from Streptomyces strains; very toxic antibiotics used as antineoplastics in some solid tumors.
CSP

An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
NCI

Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.
NCI

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selen – radioisotopy

Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
MSH

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proteiny vážící vápník

Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.
MSH

proteins which bind calcium ions; can act as transport proteins, regulator proteins, or activator proteins.
CSP

Calcium Binding Proteins typically belong to the same evolutionary family and often share an EF-hand calcium-binding domain that consists of a 12 residue loop flanked on both sides by a 12 residue alpha-helical domain; the calcium ion is coordinated with oxygen of Glu or Asp residues in a pentagonal bipyramidal configuration. Reversible binding of calcium with proteins often supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades. Calcium is essential for maintenance of a normal heartbeat and for normal cell functions. It also plays a role in blood coagulation and in many enzymatic processes.
NCI

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hematokela

Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.
MSH

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osteochondrodysplazie

Abnormal development of cartilage and bone.
MSH

A term referring to disorders characterized by abnormalities in the development of bones and cartilage.
NCI

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endolymfa

The lymph fluid found in the membranous labyrinth of the ear. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
MSH

Transudate contained within the membranous labyrinth.
UWDA

lymph fluid found in the membranous labyrinth of the ear.
CSP

Transudate contained within the membranous labyrinth.
FMA

The bodily fluid that fills the membranous labyrinth of the inner ear.
NCI

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sirup

The syrup remaining after sugar is crystallized out of SUGARCANE or sugar beet juice. It is also used in ANIMAL FEED, and in a fermented form, is used to make industrial ETHYL ALCOHOL and ALCOHOLIC BEVERAGES.
MSH

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Senecio

A species of toxic plants of the Compositae. The poisonous compounds are alkaloids which cause cattle diseases, neoplasms, and liver damage and are used to produce cancers in experimental animals.
MSH

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kamptothecin

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
MSH

alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata; this compound selectively inhibits the nuclear enzyme DNA topoisomerase type I; several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
CSP

An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
NCI

An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
NCI

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hemobilie

Hemorrhage in or through the BILIARY TRACT due to trauma, inflammation, CHOLELITHIASIS, vascular disease, or neoplasms.
MSH

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otitis media hnisavá

Inflammation of the middle ear with purulent discharge.
MSH

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zesilovače transkripce

cis-acting DNA sequences which can increase transcription of genes; enhancers can usually function in either orientation and at various distances from a promoter.
CSP

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
MSH

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Cercopithecus aethiops

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannas of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
MSH

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receptory serotoninové 5-HT2

A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to the GQ-G11 G-PROTEINS resulting in increased intracellular levels of INOSITOL PHOSPHATES and free CALCIUM.
MSH

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kapilární permeabilita

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
MSH

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hemolytická plaková technika

A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
MSH

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ovum – transport

Transport of the OVUM or fertilized ovum (ZYGOTE) from the mammalian oviduct (FALLOPIAN TUBES) to the site of EMBRYO IMPLANTATION in the UTERUS.
MSH

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enuréza

Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytime (DIURNAL ENURESIS) while one is awake or during sleep (NOCTURNAL ENURESIS). Enuresis can be in children or in adults (as persistent primary enuresis and secondary adult-onset enuresis).
MSH

inability to control the flow of urine and involuntary urination.
CSP

An elimination disorder characterized by urinary incontinence, whether involuntary or intentional, which is not due to a medical condition and which occurs at or beyond an age at which continence is expected (usually 5 years).
NCI

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Maroko

A country located in north Africa, bordering the Atlantic Ocean and the Mediterranean Sea, with a southern border with Western Sahara, eastern border with Algeria. The capital is Rabat.
MSH

A country in Northern Africa, bordering the North Atlantic Ocean and the Mediterranean Sea, between Algeria and Western Sahara. (NCI)
NCI

A country in Northern Africa, bordering the North Atlantic Ocean and the Mediterranean Sea, between Algeria and Western Sahara. (CIA World Factbook 2002)
NCI

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sexuální poradenství

Advice and support given to individuals to help them understand and resolve their sexual adjustment problems. It excludes treatment for PSYCHOSEXUAL DISORDERS or PSYCHOSEXUAL DYSFUNCTION.
MSH

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karbocystein

A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action.
MSH

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heparin – antagonisté

Coagulant substances inhibiting the anticoagulant action of heparin.
MSH

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kyslík – isotopy

Stable oxygen atoms that have the same atomic number as the element oxygen, but differ in atomic weight. O-17 and 18 are stable oxygen isotopes.
MSH

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motorické dovednosti – poruchy

Marked impairments in the development of motor coordination such that the impairment interferes with activities of daily living. (From DSM-IV, 1994)
MSH

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Shigella

genus of gram negative, facultatively anaerobic, rod shaped bacteria that ferments sugar without gas production; its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery.
CSP

A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).
MSH

A genus of Gram-negative, non-spore forming rod-shaped bacteria in the phylum Proteobacteria.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Shigella genus level.
NCI

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karboxylesterhydrolasy

Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
MSH

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hepatitida virová zvířat

INFLAMMATION of the LIVER in animals due to viral infection.
MSH

not restricted to hepatitis caused by hepatitis viruses; use also for hepatitis caused by other viruses in animals.
CSP

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