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nemocnice krajské

Hospitals controlled by the county government.
MSH

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kazuistiky

Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis.
MSH

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pyridiny

Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
MSH

6-membered aromatic ring structure with one nitrogen heteroatom.
CSP

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naturopatie

A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage. Treatments are often diet- and nutrition-oriented with attention given to the patient`s personal history and lifestyle. (From Cassileth, Alternative Medicine Handbook, 1998, p329)
MSH

A system of therapy based on preventative care, and on the use of heat, water, light, air, and massage as primary therapies for disease. Some naturopaths use no medications, either pharmaceutical or herbal. Some recommend herbal remedies only. A few who are licensed to prescribe may recommend pharmaceuticals in those cases where they feel their use is warranted. (MedicineNet.com)
NCI

A system of disease prevention and treatment that avoids drugs and surgery. Naturopathy is based on the use of natural agents such as air, water, light, heat, and massage to help the body heal itself. It also uses herbal products, nutrition, acupuncture, and aromatherapy as forms of treatment.
NCI

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věkové rozložení

The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
MSH

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správcovství

The care and management of property.
MSH

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kathepsiny

A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
MSH

Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer`s disease, several types of cancer, arthritis, and osteoporosis.
NCI

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pyrrolinkarboxylátreduktasy

A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.
MSH

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Neisseria meningitidis

gram-negative, aerobic bacteria; a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx; when found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis; also found in venereal discharges and blood; there are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135; each serogroup can be further classifed by serotype, serosubtype, and immunotype.
CSP

A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
MSH

A gram negative diplococcal bacterium that is a causative agent for meningitis and other meningococcal diseases.
NCI

Any bacterial organism that can be assigned to the species Neisseria meningitidis.
NCI

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látky znečišťující vzduch

Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
MSH

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hyaluronoglukosaminidasa

An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.
MSH

Enzyme preparations are products that are used in the histopathology laboratory for the following purposes: (1) To disaggregate tissues and cells already in established cultures for preparation into subsequent cultures (e.g., trypsin); (2) To disaggregate fluid specimens for cytological examination (e.g., papain for gastric lavage or trypsin for sputum liquefaction); (3) To aid in the selective staining of tissue specimens (e.g., diastase for glycogen determination).
SPN

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cékum – nádory

Tumors or cancer of the CECUM.
MSH

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Quebec

A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster`s New Geographical Dictionary, 1988, p993 & Room, Brewer`s Dictionary of Names, 1992, p440)
MSH

A province of eastern Canada. Its capital is Quebec.
NCI

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nádory experimentální

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
MSH

Laboratory tumor models used to study tumor development and treatment.
NCI

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alkohol – odvykací prostředky

Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
MSH

group of agents used as alcoholism deterrents, either by causing unpleasant symptoms when ethanol is ingested or as aids in withdrawal or maintenance of abstinence.
CSP

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hydroflumethiazid

A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
MSH

A thiazide diuretic with antihypertensive activity. Hydroflumethiazide directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment of the distal convoluted tubule in the kidney. This results in an increase in water, sodium, chloride, potassium and bicarbonate excretion and a decrease in calcium and uric acid secretion. (NCI05)
NCI

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buněčné kultury – kultivační techniky

Methods for maintaining or growing CELLS in vitro.
MSH

General term referring to the maintenance of cell strains or lines in the laboratory. (On-line Medical Dictionary)
NCI

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radar

A system using beamed and reflected radio signals to and from an object in such a way that range, bearing, and other characteristics of the object may be determined.
MSH

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Ureteronefrektomie

Surgical removal of a kidney and its ureter.
NCI

Surgery to remove a kidney and its ureter.
NCI

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Chlorophyta

green algae; in this division of algae, the green pigment of chlorophyll is not masked by other pigments; there are over 7000 species; most live in freshwater, about ten percent are marine.
CSP

A phylum of photosynthetic EUKARYOTA bearing double membrane-bound plastids containing chlorophyll a and b. They comprise the classical green algae, and represent over 7000 species that live in a variety of primarily aquatic habitats. Only about ten percent are marine species, most live in freshwater.
MSH

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hydroxydopaminy

Dopamines with a hydroxy group substituted in one or more positions.
MSH

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buněčné inkluze

A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)
MSH

generic term for any circumscribed mass of foreign (for example, lead or viruses) or metabolically inactive materials (for example, ceroid or Mallory bodies), within the cytoplasm or nucleus of a cell; inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells.
CSP

A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744]
GO

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rentgenový obraz – zesílení

Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.
MSH

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nervový přenos

The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
MSH

communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
CSP

The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. [GOC:curators, ISBN:0815316194]
GO

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:jl, MeSH:D009435]
GO

Any process in which a presynaptic cell transfers a signal to a postsynaptic cell, by either release of a neurotransmitter or by passage of an electrical current via specialized channels. This process is essential to all neuronal functions.
NCI

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Allomyces

A genus of aquatic fungi in the phylum BLASTOCLADIOMYCOTA. It is abundant in warmer climates and exhibits true alternation of generations.
MSH

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os hyoideum

A mobile U-shaped bone that lies in the anterior part of the neck at the level of the third CERVICAL VERTEBRAE. The hyoid bone is suspended from the processes of the TEMPORAL BONES by ligaments, and is firmly bound to the THYROID CARTILAGE by muscles.
MSH

A U-shaped bone supporting the tongue. This bone is located at the base of the tongue and is suspended from the tips of the styloid processes of the temporal bones by the stylohyoid ligaments. (NCI)
NCI

A U-shaped bone supporting the tongue. This bone is located at the base of the tongue and is suspended from the tips of the styloid processes of the temporal bones by the stylohyoid ligaments.
NCI

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cefalexin

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
MSH

An antibiotic drug that belongs to the family of drugs called cephalosporins.
NCI

an antibiotic drug
CHV

A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C356″ NCI Thesaurus)
PDQ

A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms.
NCI

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radioterapie vysokoenergetická

Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.
MSH

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nervosvalové látky

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.
MSH

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eflornithin

An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
MSH

A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
NCI

A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)
NCI

A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39754&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C226″ NCI Thesaurus)
PDQ

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