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karmustin

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
MSH

cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers.
CSP

An anticancer drug that belongs to the family of drugs called alkylating agents.
NCI

a kind of cancer treatment drug
CHV

An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43027&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43027&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C349″ NCI Thesaurus)
PDQ

An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
NCI

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akustické impedanční testy

Objective tests of middle ear function based on the difficulty (impedance) or ease (admittance) of sound flow through the middle ear. These include static impedance and dynamic impedance (i.e., tympanometry and impedance tests in conjunction with intra-aural muscle reflex elicitation). This term is used also for various components of impedance and admittance (e.g., compliance, conductance, reactance, resistance, susceptance).
MSH

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legální poručníci

A legal concept for individuals who are designated to act on behalf of persons who are considered incapable of acting in their own behalf, e.g., minors and persons found to be not mentally competent.
MSH

An individual who is authorized under applicable State or local law to consent on behalf of a child or incapable person to general medical care including participation in clinical research.
NCI

An individual who is authorized under applicable State or local law to consent on behalf of a child or incapable person to general medical care including participation in clinical research. (NCI)
NCI

The role played by a person or institution legally empowered with responsibility for the care of a ward.


HL7V3.0

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Pseudomonas

genus of gram negative, aerobic, rod shaped bacteria widely distributed in nature; some species are pathogenic for humans, animals, and plants.
CSP

A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
MSH

A genus of gram-negative, motile, non-spore-forming, rod-shaped bacteria in the phylum Proteobacteria.
NCI

A genus of aerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria and the family Pseudomonadaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Pseudomonas genus level.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Chryseomonas genus level.
NCI

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fibrinolýza

The natural enzymatic dissolution of FIBRIN.
MSH

natural enzymatic dissolution of fibrin.
CSP

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. [GOC:jl, PMID:15842654]
GO

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kazuistiky

Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis.
MSH

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Actinomycetaceae

A family of bacteria including numerous parasitic and pathogenic forms.
MSH

A taxonomic family of filamentous or rod shaped bacterium in the phylum Actinobacteria with type genus actinomyces.
NCI

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volný čas – činnosti

Voluntary use of free time for activities outside the daily routine.
MSH

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psychodrama

Primarily a technique of group psychotherapy which involves a structured, directed, and dramatized acting out of the patient`s personal and emotional problems.
MSH

technique of group psychotherapy which involves a structured, directed, and dramatized acting out of the patients personal and emotional problems.
CSP

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filipin

A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.
MSH

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kathepsiny

A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
MSH

Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer`s disease, several types of cancer, arthritis, and osteoporosis.
NCI

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Adamsův-Stokesův syndrom

A condition of fainting spells caused by heart block, often an atrioventricular block, that leads to BRADYCARDIA and drop in CARDIAC OUTPUT. When the cardiac output becomes too low, the patient faints (SYNCOPE). In some cases, the syncope attacks are transient and in others cases repetitive and persistent.
MSH

An episode of sudden and transient loss of consciousness sometimes associated with seizures. It is caused by a sudden decrease of the cardiac output that results from a sudden cardiac dysrhythmia. Typically patients develop an initial pallor, followed by facial flush during recovery.
NCI

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Leschův-Nyhanův syndrom

An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
MSH

rare x-linked disorder of purine metabolism, due to deficiency of hypoxanthine phosphoribosyltransferase; affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures; self-destructive behaviors such as biting of fingers and lips are seen frequently; intellectual impairment may also occur but is typically not severe; elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis.
CSP

An X-linked inherited syndrome caused by mutations in the gene that encodes the enzyme hypoxanthine-guanine phosphoribosyltransferase, resulting in accumulation of uric acid in the body. It affects males and is characterized by neurologic defects, moderate mental retardation, muscle hypotonia, and a tendency for self-mutilation (self-biting of lips, tongue, and fingertips).
NCI

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psychosin

An intermediate in the biosynthesis of cerebrosides. It is formed by reaction of sphingosine with UDP-galactose and then itself reacts with fatty acid-Coenzyme A to form the cerebroside.
MSH

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fixativa

Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
MSH

A compound that fixes tissues and cells for microscopic study.
NCI

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cékum – nádory

Tumors or cancer of the CECUM.
MSH

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adenosinfosfosulfát

5`-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.
MSH

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leukémie myeloidní chronická BCR-ABL pozitivní

chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.
CSP

A slowly progressing disease in which too many white blood cells are made in the bone marrow.
NCI

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
MSH

A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival.
NCI

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic myeloid leukemia (CML), there are too many of a specific type of white blood cell called a granulocyte.

Sometimes CML does not cause any symptoms at all. If you have symptoms, they may include:

  • Feeling very tired
  • Weight loss
  • Night sweats
  • Fever
  • Pain or a feeling of fullness below the ribs on the left side

Tests that examine the blood and bone marrow diagnose CML. Treatments include chemotherapy, radiation therapy, stem cell transplants, infusion of donated white blood cells following stem cell transplants, immune therapy, or surgery to remove the spleen.

NIH: National Cancer Institute


MEDLINEPLUS

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veřejná politika

A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions.
MSH

The basic policy or set of policies forming the foundation of public laws, especially such policy not yet formally enunciated. (dictionary.com)
NCI

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Stroomschema`s (computer)

A diagram that shows step-by-step progression through a procedure or system especially using connecting lines and a set of conventional symbols.
NCI

A diagram that shows the order of steps in a complex process.
NCI

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buněčné kultury – kultivační techniky

Methods for maintaining or growing CELLS in vitro.
MSH

General term referring to the maintenance of cell strains or lines in the laboratory. (On-line Medical Dictionary)
NCI

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kožní aplikace

The application of suitable drug dosage forms to the skin for either local or systemic effects.
MSH

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leukoplakie orální

A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).
MSH

white patch seen on the oral mucosa; considered a premalignant condition and is often tobacco-induced.
CSP

A white patch or plaque on oral mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition.
NCI

A white patch or plaque on oral cavity mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition. –2004
NCI

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venae pulmonales

The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
MSH

large vein carrying oxygenated blood from lungs to left atrium.
CSP

Vein in the pulmonary vemnous system.
FMA

One of four veins that carries oxygen-rich blood from the lungs to the cardiac left atrium.
NCI

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fluorokarbony

Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
MSH

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buněčné inkluze

A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)
MSH

generic term for any circumscribed mass of foreign (for example, lead or viruses) or metabolically inactive materials (for example, ceroid or Mallory bodies), within the cytoplasm or nucleus of a cell; inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells.
CSP

A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744]
GO

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nadledviny – hyperplazie kongenitální

A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
MSH

group of syndromes caused by inherited defects in cortisol and/or aldosterone biosynthesis; ACTH elevation is caused by low levels of cortisol, whose production is impaired by absence or deficiency of one of the five enzymes necessary for its synthesis from cholesterol.
CSP

A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells.
NCI

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licence

The legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of institutions as well as individuals.
MSH

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Products Used to Treat Thrombocytopenic Purpura

a condition where platelets are used to form blood clots within the circulation thus causes low platelets and high bleeding tendency
CHV

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folklór

The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.
MSH

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