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neuroleptický maligní syndrom

A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
MSH

A life-threatening condition that may be caused by certain drugs used to treat mental illness, nausea, or vomiting. Symptoms include high fever, sweating, unstable blood pressure, confusion, and stiffness.
NCI

A rare, life-threatening disorder that is caused by neuroleptic medications. It is characterized by fever, muscular cramps and rigidity, autonomic nervous system dysfunction, and changes in the mental status that may lead to coma.
NCI

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aquaeductus cerebri

Narrow channel in the mesencephalon that connects the third and fourth ventricles.
MSH

A channel that connects the third and fourth ventricles of the brain.
NCI

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hyperlipoproteinémie typ V

A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .
MSH

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alfa částice

Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
MSH

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sazby – stanovení a přezkoumání

A method of examining and setting levels of payments.
MSH

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neurosekreční systémy

A system of neurons that has the specialized function to produce and secrete hormones, and that constitutes, in whole or in part, an endocrine organ or system.
MSH

organs, structures, or transmitter/receptor systems involved in communication between the nervous and endocrine systems.
CSP

Having to do with the interactions between the nervous system and the endocrine system. Neuroendocrine describes certain cells that release hormones into the blood in response to stimulation of the nervous system.
NCI

A system of neurosecretory neurons that release hormones to the circulatory system.
NCI

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cer – isotopy

Stable cerium atoms that have the same atomic number as the element cerium, but differ in atomic weight. Ce-136, 138, and 142 are stable cerium isotopes.
MSH

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hypertrichóza

Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.
MSH

Generalized or localized hair growth of abnormal length and density. It may be congenital or acquired (e.g., drug-induced).
NCI

A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.
NCI

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hliník – silikáty

Any of the numerous types of clay which contain varying proportions of Al2O3 and SiO2. They are made synthetically by heating aluminum fluoride at 1000-2000 degrees C with silica and water vapor. (From Hawley`s Condensed Chemical Dictionary, 11th ed)
MSH

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terapie realitou

Method of psychotherapeutic treatment based on assumption of patients` personal responsibility for their own behavior. The therapist actively guides patients to accurate self-perception for fulfillment of needs of self-worth and respect for others. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)
MSH

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Newfoundland

An island in the Atlantic Ocean, off the east coast of Canada, constituting with Labrador on the mainland, a province of Canada. The name describing a land just discovered was recorded by John Cabot in 1497. (From Webster`s New Geographical Dictionary, 1988, p831 & Room, Brewer`s Dictionary of Names, 1992, p376)
MSH

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chalazion

A non-neoplastic cyst of the MEIBOMIAN GLANDS of the eyelid.
MSH

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hypofosfatázie

A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
MSH

genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia; manifestations include severe skeletal defects resembling vitamin D resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes.
CSP

A rare, serious metabolic disorder caused by mutations in the gene encoding tissue non-specific alkaline phosphatase (TNSALP) activity. It is characterized by low activity of TNSALP in the serum. The signs and symptoms vary significantly and include death in utero, failure to thrive, premature loss of deciduous teeth, early loss of the adult dentition, hypercalcemia, osteomalacia, skeletal defects, renal stones, and movement disorders.
NCI

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amenorea

Absence of menstruation.
MSH

absence of menses for three months or more.
CSP

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receptory gonadotropinů

Those protein complexes or molecular sites on the surfaces of gonadal and other sensitive cells that bind gonadotropins and thereby modify the functions of those cells; hCG, LH, and FOLLICLE STIMULATING HORMONE are the major specific gonadotropins.
MSH

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nimodipin

A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
MSH

1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery.
CSP

Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.
NCI

A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C692″ NCI Thesaurus)
PDQ

A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.
NCI

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chemie organická

The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

A branch of chemistry that deals specifically with the structures, synthesis and reactions of carbon-containing compounds.
NCI

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hysterie

Historical term for a chronic, but fluctuating, disorder beginning in early life and characterized by recurrent and multiple somatic complaints not apparently due to physical illness. This diagnosis is not used in contemporary practice.
MSH

behavior exhibiting excessive or uncontrollable emotion, such as fear or panic; mental disorder characterized by emotional excitability and sometimes by amnesia or a physical deficit, such as paralysis, or a sensory deficit, without an organic cause.
CSP

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aminokyseliny diaminové

dibasic amino acids.
CSP

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rekombinantní proteiny

Proteins prepared by recombinant DNA technology.
MSH

peptides or proteins produced by genes which have been artificially inserted into living cells or cell-free expression systems; index with or without RECOMBINANT DNA and the following RTs as needed.
CSP

Proteins produced by genes or recombinant DNA that has been artificially engineered and inserted into a heterologous host. Recombinant proteins are used extensively by investigators of disease pathways to identify protein targets for potential drug therapies.
NCI

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dusík – sloučeniny

Inorganic compounds that contain nitrogen as an integral part of the molecule.
MSH

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poruchy chování u dětí

Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.
MSH

child behavior disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression.
CSP

All kids misbehave some times, but behavior disorders go beyond mischief and rebellion. With behavior disorders, your child or teen has a pattern of hostile, aggressive or disruptive behaviors for more than 6 months.

Warning signs can include

  • Harming or threatening themselves, other people or pets
  • Damaging or destroying property
  • Lying or stealing
  • Not doing well in school, skipping school
  • Early smoking, drinking or drug use
  • Early sexual activity
  • Frequent tantrums and arguments
  • Consistent hostility towards authority figures

If you see signs of a problem, ask for help. Poor choices can become habits. Kids who have behavior problems are at higher risk for school failure, mental health problems and even suicide. Classes or family therapy may help parents learn to set and enforce limits.

Substance Abuse and Mental Health Services Administration


MEDLINEPLUS

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imunoglobulin A sekreční

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).
MSH

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aminochinoliny

Quinolines substituted in any position by one or more amino groups.
MSH

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reflex akustický

Intra-aural contraction of tensor tympani and stapedius in response to sound.
MSH

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Nocardiaceae

A family of gram-positive, aerobic actinomycetes found in soil and animal tissue. Some species are the cause of infection in man and animals.
MSH

A taxonomic family of Gram positive, aerobic bacterium in the phylum Actinobacteria that includes the genera Nocardia, Rhodococcus and Smaragdicoccus, among others.
NCI

family of gram positive, aerobic actinomycetes found in soil and animal tissue; some species are the cause of infection in man and animals.
CSP

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Amerikanen van Chinese komaf

any person with Chinese ethnic background whose home or birthplace is in the Americas.
CSP

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imipramin

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
MSH

dibenzazepine tricyclic antidepressant.
CSP

A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)
NCI

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ampicilin

semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
CSP

A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.
NCI

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dávkové mechanismy

Processes or methods of reimbursement for services rendered or equipment.
MSH

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