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infekční nemoci – vektory

Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
MSH

index also with the most specific vector organism name available; see RTs for specific organisms.
CSP

An invertebrate animal (e.g., tick, mite, mosquito, bloodsucking fly) capable of transmitting an infectious agent among vertebrates.
NCI

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leukémie T-buněčná akutní

aggressive T-cell malignancy with adult onset, caused by human T lymphotropic virus type 1.
CSP

An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver.
NCI

Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.
MSH

A peripheral (mature) T-cell neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa. (WHO, 2001)
NCI

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bibliografie národní

A bibliography which lists all the books and other publications published, or distributed in significant quantity, in a particular country. Sometimes the term is used with respect to the new publications published within a specific period, and sometimes with respect to all those published within a lengthy period of many years. It is also used to indicate a bibliography of publications about a country (whether written by its nationals or not) and those written in the language of the country as well as those published in it. (Harrod`s Librarians` Glossary, 7th ed)
MSH

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flumethason

An anti-inflammatory glucocorticoid used in veterinary practice.
MSH

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25-hydroxyvitamin D 2

9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.
MSH

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Prochlorperazine Maleate

The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension.
NCI

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diuretika

agents that promote the excretion of urine through their effects on kidney function.
CSP

A drug that increases the production of urine.
NCI

a drug that increases urinary elimination
CHV

A class of agents that promotes the formation of urine by the kidney. Via various mechanism of actions, diuretics retain water in urine, thus provides a means of forced diuresis.
NCI

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levodopa

The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
MSH

naturally occuring form of DOPA and precursor of dopamine; used as an antiparkinsonian agent; unlike dopamine it can be administered orally.
CSP

An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson`s disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42622&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42622&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C611″ NCI Thesaurus)
PDQ

An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson`s disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.
NCI

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binomické rozdělení

The probability distribution associated with two mutually exclusive outcomes; used to model cumulative incidence rates and prevalence rates. The Bernoulli distribution is a special case of binomial distribution.
MSH

A family of discreet probability density functions, which models systems that meet the following requirements: 1) the number of trials (n) is fixed; 2) there are only two outcomes for each trial, success or failure; 3) the outcome of each trial is independent; and 4) all trials have the same probability (p) of success. Binomial distributions show the likelihood of the number of successful trials versus the total number of trials.
NCI

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fluoxymesteron

An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.
MSH

A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494707&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494707&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C507″ NCI Thesaurus)
PDQ

A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04)
NCI

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Methylbufotenin

major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin.
CSP

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proglumid

A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
MSH

antiulceric
NCI

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DNA sondy HLA

DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).
MSH

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lidoflazin

Coronary vasodilator with some antiarrhythmic action.
MSH

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biologie

One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
MSH

science concerned with the phenomena of life and living organisms.
CSP

The scientific study of living organisms.
NCI

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potraviny – kontaminace

The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage.
MSH

presence in food of harmful, unpalatable, or otherwise objectionable foreign substances such as chemicals, microorganisms or diluents, before, during, or after processing or storage.
CSP

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abetalipoproteinémie

An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.
MSH

disorder of lipid metabolism inherited as an autosomal recessive trait characterized by the near absence of apolipoprotein B and apoB containing lipoproteins in plasma; microsomal triglyceride transfer protein is deficient or absent in enterocytes; clinical and laboratory findings include acanthocytosis, hypocholesterolemia, peripheral neuropathy, posterior column degeneration, ataxia, and steatorrhea; intellectual abilities may also be impaired.
CSP

An autosomal recessive disorder characterized by defective absorption of dietary fat, cholesterol and fat-soluble vitamins. It results in multiple vitamin deficiencies. Signs and symptoms include failure to thrive, diarrhea, steatorrhea, acanthocytosis and ataxia.
NCI

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propafenon

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
MSH

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dominance-subordinace

Relationship between individuals when one individual threatens or becomes aggressive and the other individual remains passive or attempts to escape.
MSH

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vazebná nerovnováha

Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
MSH

when a specific haplotype is almost always associated with a gene mutation; genetic diagnostic method used to decrease uncertainty in linkage analysis.
CSP

Where alleles (DNA markers) occur together more often than can be accounted for by chance because of their physical proximity on a chromosome.
NCI

Nonrandom association of linked genes; the occurrence of some genes together, more often than would be expected based upon their physical separation, presumably because the combination confers some selective advantage.
NCI

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porodní poranění

Mechanical or anoxic trauma incurred by the infant during labor or delivery.
MSH

mechanical or anoxic trauma incurred by or to the infant during labor or delivery.
CSP

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foramen magnum

A large orifice in the occipital bone through which the spinal cord enters the cranial cavity.
NCI

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referování

The process of creating a summary of the main points of an article, argument, or theory.
NCI

shortening or summarizing of documents.
CSP

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propriocepce

Sensory functions that transduce stimuli received by proprioceptive receptors in joints, tendons, muscles, and the INNER EAR into neural impulses to be transmitted to the CENTRAL NERVOUS SYSTEM. Proprioception provides sense of stationary positions and movements of one`s body parts, and is important in maintaining KINESTHESIA and POSTURAL BALANCE.
MSH

The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. [http://www.onelook.com/, ISBN:072168677X]
GO

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drenáž sanitární

A system of artificial or natural drains, generally used for the disposal of liquid wastes.
MSH

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lipoproteiny HDL3

Intermediate-density subclass of the high-density lipoproteins, with particle sizes between 7 to 8 nm. As the larger lighter HDL2 lipoprotein, HDL3 lipoprotein is lipid-rich.
MSH

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Blastocladiella

A genus of aquatic fungi of the family Blastocladiaceae, order Blastocladiales, used in the study of zoospore formation.
MSH

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formyciny

Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.
MSH

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acedapson

Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.
MSH

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kyseliny prostanové

2-Octylcyclopentaneheptanoic acids. The family of saturated carbon-20 cyclic fatty acids that represent the parent compounds of the prostaglandins.
MSH

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