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exprese genu – regulace leukemická

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.
MSH

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biologická odpověď – modifikátory

a diversity of reagents employed for nonspecific active immunization; used to enhance the immune response; 4 major groups: bacterial products, synthetic molecules, cytokines, and hormones.
CSP

Substances that enhance, restore or alter the host`s immune system. Immunomodulating agents can be preventive or therapeutic and can suppress or activate the immune system, either directly or indirectly. For cancer treatment purposes, immunomodulating agents can be used to prevent or inhibit tumorigenesis. Examples of immunomodulators include, but are not limited to, cytokines, monoclonal antibodies and vaccines.
NCI

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řízení lékařské praxe

The organization and operation of the business aspects of a physician`s practice.
MSH

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mamografie

Radiographic examination of the breast.
MSH

radiography of the mammary gland.
CSP

The use of film or a computer to create a picture of the breast.
NCI

An x-ray of the breast.
NCI

A mammogram is a special type of X-ray of the breasts. Mammograms can show tumors long before they are big enough for you or your health care provider to feel. They are recommended for women who have symptoms of breast cancer or who have a high risk of the disease. You and your health care provider should discuss when to start having mammograms and how often to get one.

Mammograms are quick and easy. You stand in front of an X-ray machine. The person who takes the X-rays places your breast between two plastic plates. The plates press your breast and make it flat. This may be uncomfortable, but it helps get a clear picture. You will have an X-ray of each breast. A mammogram takes only a few seconds and it can help save your life.

NIH: National Cancer Institute


MEDLINEPLUS

A type of radiography used specifically to examine breast tissue. The procedure utilizes a low-dose of x-rays or radiation to generate an image. A mammography exam or mammogram, is used as a screening tool to detect early breast cancer in women experiencing no symptoms and to detect and diagnose breast disease.
NCI

A low voltage X-ray photograph of the breast generally done to detect breast cancer. This method is also valuable in diagnosis of benign abnormal conditions of the breast such as fibroadenoma, mastitis, abscess, and cysts.
NCI

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dolichol

Eicosamethyl octacontanonadecasen-1-o1. Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated.
MSH

20-unit isoprenoid found in eukaryotes; serves as membrane anchor for oligosaccharide assembly in rough endoplasmic reticulum during protein glycosylation.
CSP

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Thioethers

any compound of the type R-S-R.
CSP

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geny dominantní

Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
MSH

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deprese bipolární

severe disorder characterized by one or more manic episodes; although diagnosis does not require a major depressive episode, virtually all cases eventually develop one.
CSP

The depressive stage of bipolar disorder.
NCI

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HAURDUNALDIAREKIN IZANKIDE BESTE EGOERA ZOLDURAGARRI BAT(*)

The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
MSH

pregnancy complications caused by microorganism infections; this term applies mainly to the mother and fetus, in contrast to CONGENITAL INFECTION, which applies mainly to the postnatal infant.
CSP

If you are pregnant, an infection can be more than just a problem for you. Some infections can be dangerous to your baby. You can help yourself avoid infections:

  • Don`t eat raw or undercooked meat
  • Don`t share food or drinks with other people
  • Wash your hands frequently
  • Don`t empty cat litter. Cats can transmit toxoplasmosis.

You may need to take medicines or get a vaccine to prevent an infection in your baby. For example, you may need to take antibiotics if you develop an infection with streptococcus, or take medicines if you have genital herpes. Only some medicines and vaccines are safe during pregnancy. Ask your health care provider about how best to protect you and your baby.


MEDLINEPLUS

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mannosafosfáty

Phosphoric acid esters of mannose.
MSH

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doxorubicin

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
MSH

antineoplastic antibiotic obtained from Streptomyces peucetius; a hydroxy derivative of daunorubicin.
CSP

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.
NCI

a kind of cancer treatment drug
CHV

An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
NCI

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rentgendiagnostika hrudníku

X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
MSH

An x-ray of the structures inside the chest. An x-ray is a type of high-energy radiation that can go through the body and onto film, making pictures of areas inside the chest, which can be used to diagnose disease.
NCI

An x-ray examination of the chest.
NCI

X ray visualization of the chest and organs of the thoracic cavity; not restricted to visualization of the lungs.
CSP

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genetika

The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)
MSH

branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance; the study of genes and their heredity.
CSP

The study of genes and heredity. Heredity is the passing of genetic information and traits (such as eye color and an increased chance of getting a certain disease) from parents to offspring.
NCI

The branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms
NCI

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močový měchýř – obstrukce

Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.
MSH

Blockage of the opening between the bladder and the urethra resulting in the reduction or prevention of the urine flow from the bladder into the urethra.
NCI

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pregnenolonkarbonitril

A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
MSH

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marketink zdravotnických služeb

Application of marketing principles and techniques to maximize the use of health care resources.
MSH

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léky – modelování struktury

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
MSH

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enzym větvící alfa-glukan v poloze 1,4

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.
MSH

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Geotrichum

A mitosporic Saccharomycetales fungal genus, various species of which have been isolated from pulmonary lesions. Teleomorphs include Dipodascus and Galactomyces.
MSH

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krevní oběh

The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
MSH

general term for blood supply and flow through tissues and organs.
CSP

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825]
GO

In the body, the flow of blood through the heart and blood vessels, and the flow of lymph through the lymph vessels.
NCI

The movement of blood to and from the heart and to the rest of the body`s organs, tissues, and cells through the network of arteries, veins, and capillaries. (NCI)
NCI

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preventivní psychiatrie

A discipline concerned with the prevention of mental illness and the promotion of mental health.
MSH

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mastitida

INFLAMMATION of the BREAST, or MAMMARY GLAND.
MSH

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Duaneův retrakční syndrom

A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.
MSH

A rare disorder affecting the muscles of the eye. It is characterized by an abnormal contraction of some eye muscles and failure of contraction of other eye muscles. It leads to limited abduction and adduction of the affected eye.
NCI

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mesna

A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
MSH

A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.
NCI

2-mercaptoethanesulfonic acid sodium salt; scavenges glutathione; used as a detoxifying agent for uroprotection (especially in cancer combination chemotherapy), as a prophlylactic for hemorrhagic cystitis, and as an expectorant in treating chronic bronchitis.
CSP

A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39759&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39759&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C192″ NCI Thesaurus)
PDQ

A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)
NCI

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gibereliny

A class of plant growth hormone isolated from cultures of Gibberella fujikuroi, a fungus causing Bakanae disease in rice. There are many different members of the family as well as mixtures of multiple members; all are diterpenoid acids based on the gibberellane skeleton.
MSH

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krevní transfúze

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
MSH

introduction of whole blood or blood component directly into the blood stream.
CSP

The injection of whole blood or a blood component directly into the bloodstream.
NCI

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prokainamid

A derivative of PROCAINE with less CNS action. It also acts as a non-nucleoside inhibitor of DNA METHYLATION and has led to SYSTEMIC LUPUS ERYTHEMATOSUS.
MSH

derivative of procaine, cardiac depressant used in treatment of cardiac arrhythmias.
CSP

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sinus maxillaris

The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
MSH

A pyramidal-shaped, thin-walled, air-filled cavity located in the maxilla. It is lined by mucus membrane and periosteum (mucoperiosteum) which contains cilia. It is adjacent to the nasal cavity and communicates with the middle meatus of the nose. It is the largest paranasal sinus and is composed of three recesses: alveolar, zygomatic, and infraorbital. (NCI)
NCI

A type of paranasal sinus (a hollow space in the bones around the nose). There are two large maxillary sinuses, one in each of the maxillary bones, which are in the cheek area next to the nose. The maxillary sinuses are lined with cells that make mucus to keep the nose from drying out.
NCI

A pyramidal-shaped, thin-walled, air-filled cavity located in the maxilla. It is lined by mucus membrane and periosteum (mucoperiosteum) which contains cilia. It is adjacent to the nasal cavity and communicates with the middle meatus of the nose. It is the largest paranasal sinus and is composed of three recesses: alveolar, zygomatic, and infraorbital.
NCI

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dysartrie

Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition. (From Adams et al., Principles of Neurology, 6th ed, p489)
MSH

imperfect speech articulation due to disturbances of muscular control.
CSP

Slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes.
NCI

A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.
NCI

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5,6-dihydroxytryptamin

Tryptamine substituted with two hydroxyl groups in positions 5 and 6. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacologic research.
MSH

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