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lineární modely

Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
MSH

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noha – deformity vrozené

Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
MSH

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alfa-MSH

A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
MSH

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potkani inbrední WKY

A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
MSH

An outbred Wistar substrain derived at Kyoto school of medicine and disseminated to the NIH in 1971 and finally to Charles River in 1974. The Wistar Kyoto is a white albino with pink eyes, genotype c. This rat strain is used in cardiac and behavioral research and as a control for studies involving the spontaneous hypertensive rat.
NCI

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nitrofenoly chlorortuťnaté

Mercuriphenols substituted with one or more chlorine atoms and one or more nitro groups. Some of these are sulfhydryl reagents which act as chromophoric probes in enzymes and other proteins.
MSH

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Urbachův-Wietheho syndrom

An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.
MSH

A rare, autosomal recessive metabolic disorder characterized by hoarseness of voice, eyelid beading, skin lesions, and seizures.
NCI

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formiáty

caustic acid or its derivatives containing the HCOO- radical.
CSP

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amaranth – barvivo

A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)
MSH

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receptory antigenů T-buněk

Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
MSH

immunoglobulin like receptor associated with CD3 marker on T lymphocytes which binds specific antigen and thereby participates in T cell activation; recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen receptor structure, composed of either alpha-beta or gamma-delta chains.
CSP

Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins. Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression. Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products. T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands. T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex. TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. (from OMIM and NCI)
NCI

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sklerozující cholangitida

Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
MSH

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lithium

An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
MSH

white metal, symbol Li, atomic number 3; lithium salts are used in treating the manic phase of bipolar disorder.
CSP

A monovalent cation that is metabolized much like sodium and is important in many cellular functions inside or on the surface of cells.
NCI

An element with atomic symbol Li, atomic number 3, and atomic weight 6.941.
NCI

A soft metal. Lithium salts are used to treat certain mental disorders, especially bipolar (manic depressive) disorder. Lithium salts include lithium carbonate and lithium citrate.
NCI

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fraktury nespojené

A fracture in which union fails to occur, the ends of the bone becoming rounded and eburnated, and a false joint occurs. (Stedman, 25th ed)
MSH

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mitomycin

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
MSH

antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis.
CSP

A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42674&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1820″ NCI Thesaurus)
PDQ

A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
NCI

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receptory mitogenů

Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.
MSH

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estery cholesterolu

Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
MSH

fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in human plasma; accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
CSP

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Nephropidae

Family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.
MSH

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fruktany

Polysaccharides composed of D-fructose units.
MSH

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aminobifenylové sloučeniny

Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
MSH

nitrogen substituted aromatic amine formerly used in dyemaking; now used to induce cancer in laboratory animals.
CSP

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rektum – nádory

Tumors or cancer of the RECTUM.
MSH

new abnormal rectal or anal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

Either benign or malignant growth of tissue in rectum, the terminal portion of the digestive tube.
NCI

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chorea

Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.
MSH

ceaseless occurrence of rapid, highly complex jerky movements that appear to be well coordinated but are performed involuntarily.
CSP

A neurological condition affecting the involuntary movements. It is characterized by brief, non-repetitive irregular muscle contractions. It is seen in patients with Huntington`s disease.
NCI

a group of diseases marked by involuntary and jerky movements
CHV

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dolní část těla – negativní tlak

External decompression applied to the lower body. It is used to study orthostatic intolerance and the effects of gravitation and acceleration, to produce simulated hemorrhage in physiologic research, to assess cardiovascular function, and to reduce abdominal stress during childbirth.
MSH

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hrudník vpáčený

A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.
MSH

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síran amonný

Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.
MSH

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refrakterní doba psychologická

A delayed response interval occurring when two stimuli are presented in close succession.
MSH

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chromatografie DEAE-celulózová

A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
MSH

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lupus vulgaris

A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the NASAL MUCOSA; BUCCAL MUCOSA; and conjunctival mucosa.
MSH

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galaktokinasa

An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. Galactosamine can also act as the acceptor. A deficiency of this enzyme results in GALACTOSEMIA. EC 2.7.1.6.
MSH

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amrinon

A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
MSH

A synthetic bipyridine phosphodiesterase inhibitor with inotropic and vasodilator properties. Inamrinone inhibits type III phosphodiesterase, which is abundant in cardiac and vascular tissues, thereby preventing the degradation of cyclic adenosine monophosphate (cAMP) and increasing intracellular concentrations of this secondary messenger. Elevated levels of cAMP increase the contractile force of the cardiac muscle and produce positive inotropic effects. Although the mechanism of action is not fully understood, inamrinone causes smooth muscle relaxation, resulting in peripheral vasodilation (reduced afterload) and a decreased pulmonary vascular resistance (reduced preload).
NCI

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návratná horečka

An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.
MSH

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chromozómy lidské, 13-15

The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
MSH

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