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deprese bipolární

severe disorder characterized by one or more manic episodes; although diagnosis does not require a major depressive episode, virtually all cases eventually develop one.
CSP

The depressive stage of bipolar disorder.
NCI

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noha – deformity vrozené

Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
MSH

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doxorubicin

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
MSH

antineoplastic antibiotic obtained from Streptomyces peucetius; a hydroxy derivative of daunorubicin.
CSP

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.
NCI

a kind of cancer treatment drug
CHV

An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
NCI

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Urbachův-Wietheho syndrom

An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.
MSH

A rare, autosomal recessive metabolic disorder characterized by hoarseness of voice, eyelid beading, skin lesions, and seizures.
NCI

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rhodopsin

A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
MSH

photoreceptor protein found in retinal rods; it is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain.
CSP

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močový měchýř – obstrukce

Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.
MSH

Blockage of the opening between the bladder and the urethra resulting in the reduction or prevention of the urine flow from the bladder into the urethra.
NCI

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formiáty

caustic acid or its derivatives containing the HCOO- radical.
CSP

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léky – modelování struktury

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
MSH

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lithium

An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
MSH

white metal, symbol Li, atomic number 3; lithium salts are used in treating the manic phase of bipolar disorder.
CSP

A monovalent cation that is metabolized much like sodium and is important in many cellular functions inside or on the surface of cells.
NCI

An element with atomic symbol Li, atomic number 3, and atomic weight 6.941.
NCI

A soft metal. Lithium salts are used to treat certain mental disorders, especially bipolar (manic depressive) disorder. Lithium salts include lithium carbonate and lithium citrate.
NCI

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ricin

A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.
MSH

proteinaceous phytotoxin from the castor oil plant, Ricinus communis; A chain has glycosidase activity which cleaves 28S rRNA, halting protein synthesis; extreme cytotoxicity makes ricin an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins.
CSP

A highly toxic protein phytotoxin lectin and hemagglutin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally. It has N-glycosidase activity that cleaves 28S rRNA, halting protein synthesis; extreme cytotoxicity makes ricin an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins.
NCI

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krevní oběh

The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
MSH

general term for blood supply and flow through tissues and organs.
CSP

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825]
GO

In the body, the flow of blood through the heart and blood vessels, and the flow of lymph through the lymph vessels.
NCI

The movement of blood to and from the heart and to the rest of the body`s organs, tissues, and cells through the network of arteries, veins, and capillaries. (NCI)
NCI

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fraktury nespojené

A fracture in which union fails to occur, the ends of the bone becoming rounded and eburnated, and a false joint occurs. (Stedman, 25th ed)
MSH

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nos – nádory

Tumors or cancer of the NOSE.
MSH

new abnormal nasal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; includes neoplasm of the external structure, through the nasal cavity, sinuses and up to the nasopharynx.
CSP

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Duaneův retrakční syndrom

A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.
MSH

A rare disorder affecting the muscles of the eye. It is characterized by an abnormal contraction of some eye muscles and failure of contraction of other eye muscles. It leads to limited abduction and adduction of the affected eye.
NCI

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Nephropidae

Family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.
MSH

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rizikové řízení

The process of minimizing risk to an organization by developing systems to identify and analyze potential hazards to prevent accidents, injuries, and other adverse occurrences, and by attempting to handle events and incidents which do occur in such a manner that their effect and cost are minimized. Effective risk management has its greatest benefits in application to insurance in order to avert or minimize financial liability. (From Slee & Slee: Health care terms, 2d ed)
MSH

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krevní transfúze

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
MSH

introduction of whole blood or blood component directly into the blood stream.
CSP

The injection of whole blood or a blood component directly into the bloodstream.
NCI

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fruktany

Polysaccharides composed of D-fructose units.
MSH

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jadérko – oblast organizátoru

The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.
MSH

A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed. [PMID:14504406]
GO

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dysartrie

Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition. (From Adams et al., Principles of Neurology, 6th ed, p489)
MSH

imperfect speech articulation due to disturbances of muscular control.
CSP

Slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes.
NCI

A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.
NCI

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dolní část těla – negativní tlak

External decompression applied to the lower body. It is used to study orthostatic intolerance and the effects of gravitation and acceleration, to produce simulated hemorrhage in physiologic research, to assess cardiovascular function, and to reduce abdominal stress during childbirth.
MSH

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RNA ribozomální 5S

Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.
MSH

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tělní krajiny

Anatomical areas of the body.
MSH

a general term for grouping regions of the body; preference is to use NTs.
CSP

Named areas of the body.
NCI

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hrudník vpáčený

A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.
MSH

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řízení ošetřovatelství – výzkum

Research concerned with establishing costs of nursing care, examining the relationships between nursing services and quality patient care, and viewing problems of nursing service delivery within the broader context of policy analysis and delivery of health services (from a national study, presented at the 1985 Council on Graduate Education for Administration in Nursing (CGEAN) meeting).
MSH

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ucho střední

The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.
MSH

portion of the ear between the tympanic membrane and the cochlea, containing the tympanic cavity and its bones, the malleus, incus, and stapes.
CSP

The part of the ear including the eardrum and ossicles. The middle ear leads to the inner ear. (NCI)
NCI

The part of the ear including the eardrum and ossicles. The middle ear leads to the inner ear.
NCI

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lupus vulgaris

A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the NASAL MUCOSA; BUCCAL MUCOSA; and conjunctival mucosa.
MSH

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horečka Skalistých hor

An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.
MSH

acute, infectious, sometimes fatal disease caused by Rickettsia rickettsii usually transmitted by ixodid ticks; occurs only in North and South America; manifestations include chills, fever, rash, headache, myalgia, and prostration.
CSP

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transplantace kostní dřeně

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
MSH

transference of bone marrow within an individual, between individuals of the same species, or between individuals of different species.
CSP

procedure to replace bone marrow that has been destroyed by treatment with high doses of anticancer drugs or radiation. Transplantation may be autologous (an individual`s own marrow saved before treatment), allogeneic (marrow donated by someone else), or syngeneic (marrow donated by an identical twin).
NCI

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.

If there is a problem with your bone marrow, a transplant can give you healthy new marrow. You could need a transplant because of a disease, such as bone marrow diseases or cancers like leukemia or lymphoma. Or you might need one if a strong cancer treatment kills your healthy blood cells.

People with cancer sometimes donate bone marrow before treatment to be transplanted later. But often the new marrow comes from a donor, either a close family member or someone unrelated.


MEDLINEPLUS

A procedure to replace diseased or pathologic bone marrow with transplanted healthy bone marrow cells.
NCI

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galaktokinasa

An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. Galactosamine can also act as the acceptor. A deficiency of this enzyme results in GALACTOSEMIA. EC 2.7.1.6.
MSH

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