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legionelóza

Infections with bacteria of the genus LEGIONELLA.
MSH

gram negative bacterial infection by any species of Legionella including Legionnaire`s disease, which is characterized by high fever, malaise, muscle aches, respiratory disorders and headache.
CSP

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chiasma opticum

The X-shaped structure formed by the meeting of the two optic nerves. At the optic chiasm the fibers from the medial part of each retina cross to project to the other side of the brain while the lateral retinal fibers continue on the same side. As a result each half of the brain receives information about the contralateral visual field from both eyes.
MSH

hypothalamic structure formed by the crossing of optic nerve fibers from the medial half of each retina.
CSP

An anatomy term for an X-shaped crossing (for example, of nerves or tendons).
NCI

Nerve trunk which is continuous with right and left optic nerves and right and left optic tracts.
FMA

An anatomic structure formed by the crossing of the two optic nerves under the hypothalamus.
NCI

The place in the brain where some of the optic nerve fibers coming from one eye cross optic nerve fibers from the other eye.
NCI

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fibroblasty

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
MSH

connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
CSP

A connective tissue cell that makes and secretes collagen proteins.
NCI

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tanec

Rhythmic and patterned body movements which are usually performed to music.
MSH

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Schizophyllum

A genus of fleshy shelf basidiomycetous fungi, family Schizophyllaceae, order POLYPORALES, growing on woody substrata. It is pathogenic in humans.
MSH

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apendektomie

Surgical removal of the vermiform appendix. (Dorland, 28th ed)
MSH

Surgical removal of the vermiform appendix.
NCI

Surgery to remove the appendix (small finger-shaped pouch at the end of the first part of the large intestine).
NCI

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čočka oční – nemoci

pathologic condition of the transparent biconvex body of the eye situated between the posterior chamber and the vitreous body or lens.
CSP

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orgánová specificita

Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
MSH

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finanční řízení nemocnic

The obtaining and management of funds for hospital needs and responsibility for fiscal affairs.
MSH

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smrt náhlá

The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
MSH

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sklerodermie lokalizovaná

A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding tissue; there can be muscle and underlying tissue involvement as well as occasional joint complications. The affected areas of skin can be restrictive and disfiguring. The shape, depth and location of the affected area is used to classify one of the four types of local scleroderma. An individual can have a combination of localized scleroderma types.
NCI

A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
MSH

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arachidonát-15-lipoxygenasa

An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
MSH

Encoded by human ALOX15 Gene, a putative mutator gene regulated by tumor-suppressor TP53, 661-amino acid 74.7 kD cytoplasmic Arachidonate 15-Lipoxygenase (Lipoxygenase Family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis. It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid. (OMIM, Swiss-Prot, and NCI)
NCI

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antigeny CD11c

An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
MSH

Part of the integrin CR4, aka Complement Receptor 4, the CD11c/CD18 heterodimer. (Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 927)
NCI

Leukocyte Surface Antigen p150,95 has a unique alpha chain (CD11c) and shares a beta subunit (CD18) with two other members of the leukocyte adhesion molecule family. The alpha subunit has an extracellular domain containing ten potential glycosylation sites, a transmembrane domain, and a short cytoplasmic tail. It shows homology to alpha subunits of Platelet Glycoprotein IIb/IIIa, Vitronectin Receptor, and Fibronectin Receptor. Receptors involved in cell-cell and cell-matrix interactions belong to a superfamily of integrin genes. (from OMIM 151510 and NCI)
NCI

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ornithinkarbamoyltransferasa

A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
MSH

Ornithine carbamoyltransferase, mitochondrial (354 aa, ~40 kDa) is encoded by the human OTC gene. This protein plays a role in the metabolism of ornithine.
NCI

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plamínková ionizace

Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography.
MSH

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defenzivní medicína

The alterations of modes of medical practice, induced by the threat of liability, for the principal purposes of forestalling lawsuits by patients as well as providing good legal defense in the event that such lawsuits are instituted.
MSH

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mazové žlázy – nádory

new abnormal sebaceous gland tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

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argininsukcinátsynthasa

An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
MSH

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leukémie plazmocytární

rare type of acute leukemia in which the predominating cell in the peripheral blood is the plasma cell; it is often seen in conjunction with multiple myeloma and may be a variant form of that disease.
CSP

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.
MSH

An aggressive plasma cell neoplasm with usually short survival. It is characterized by the presence of neoplastic plasma cells in the peripheral blood. The peripheral blood plasma cells comprise more than 20% of the peripheral blood white cells. It may be the initial presentation of a plasma cell neoplasm or manifest as a terminal complication of plasma cell myeloma. Lymphadenopathy and organomegaly are frequent clinical signs, whereas bone pain and osteolytic lesions are less frequently present.
NCI

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oscilometrie

The measurement of frequency or oscillation changes.
MSH

study of the records of oscillations in electric current waveform.
CSP

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flucytosin

A fluorinated cytosine analog that is used as an antifungal agent.
MSH

fluorinated cytosine analog that is used as an antifungal agent.
CSP

A drug that treats infections caused by fungi.
NCI

A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C501″ NCI Thesaurus)
PDQ

A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
NCI

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bludy

A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one`s associates.
MSH

false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one`s associates.
CSP

A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
NCI

False personal beliefs held contrary to reality, despite contradictory evidence and common sense.
NCI

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autostimulace

Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.
MSH

stimulation which is self-administered; the stimulation may result in negative or positive reinforcement.
CSP

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arterioarteriální píštěl

Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.
MSH

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leukotrien B4

The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
MSH

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osteomalacie

A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (Dorland, 27th ed)
MSH

inadequate or delayed mineralization of osteoid in mature cortical and spongy bone.
CSP

A condition in adults in which bones become soft and deformed because they don`t have enough calcium and phosphorus. It is usually caused by not having enough vitamin D in the diet, not getting enough sunlight, or a problem with the way the body uses vitamin D. Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets.
NCI

A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) –2003
NCI

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fluorometholon

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
MSH

A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone exerts its effects by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
NCI

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zubní kavita – podložka

An inner coating, as of varnish or other protective substance, to cover the dental cavity wall. It is usually a resinous film-forming agent dissolved in a volatile solvent, or a suspension of calcium hydroxide in a solution of a synthetic resin. The lining seals the dentinal tubules and protects the pulp before a restoration is inserted. (Jablonski, Illustrated Dictionary of Dentistry, 1982)
MSH

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septum pellucidum – jádra

Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
MSH

Subdivision of the septum which contains the dorsal septal nucleus, the lateral septal nucleus, medial septal nucleus, triangular septal nucleus, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure and nucleus of stria terminalis.
FMA

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aromatické hydroxylasy

A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
MSH

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