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Schizophyllum

A genus of fleshy shelf basidiomycetous fungi, family Schizophyllaceae, order POLYPORALES, growing on woody substrata. It is pathogenic in humans.
MSH

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mozková obrna

A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
MSH

heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life; the four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common; the motor disorder may range from difficulties with fine motor control to severe spasticity in all limbs; spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms.
CSP

Cerebral palsy is a group of disorders that affect a person`s ability to move and to maintain balance and posture. The disorders appear in the first few years of life. Usually they do not get worse over time. People with cerebral palsy may have difficulty walking. They may also have trouble with tasks such as writing or using scissors. Some have other medical conditions, including seizure disorders or mental impairment.

Cerebral palsy happens when the areas of the brain that control movement and posture do not develop correctly or get damaged. Early signs of cerebral palsy usually appear before 3 years of age. Babies with cerebral palsy are often slow to roll over, sit, crawl, smile or walk. Some babies are born with cerebral palsy; others get it after they are born.

There is no cure for cerebral palsy, but treatment can improve the lives of those who have it. Treatment includes medicines, braces, and physical, occupational and speech therapy.

NIH: National Institute of Neurological Disorders and Stroke


MEDLINEPLUS

birth injury of the brain nerve that controls body movement
CHV

A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.
NCI

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čočka oční – nemoci

pathologic condition of the transparent biconvex body of the eye situated between the posterior chamber and the vitreous body or lens.
CSP

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orgánová specificita

Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
MSH

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finanční řízení nemocnic

The obtaining and management of funds for hospital needs and responsibility for fiscal affairs.
MSH

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sklerodermie lokalizovaná

A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding tissue; there can be muscle and underlying tissue involvement as well as occasional joint complications. The affected areas of skin can be restrictive and disfiguring. The shape, depth and location of the affected area is used to classify one of the four types of local scleroderma. An individual can have a combination of localized scleroderma types.
NCI

A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
MSH

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uterus – cervicitida

Inflammation of the UTERINE CERVIX.
MSH

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antigeny CD11c

An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
MSH

Part of the integrin CR4, aka Complement Receptor 4, the CD11c/CD18 heterodimer. (Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 927)
NCI

Leukocyte Surface Antigen p150,95 has a unique alpha chain (CD11c) and shares a beta subunit (CD18) with two other members of the leukocyte adhesion molecule family. The alpha subunit has an extracellular domain containing ten potential glycosylation sites, a transmembrane domain, and a short cytoplasmic tail. It shows homology to alpha subunits of Platelet Glycoprotein IIb/IIIa, Vitronectin Receptor, and Fibronectin Receptor. Receptors involved in cell-cell and cell-matrix interactions belong to a superfamily of integrin genes. (from OMIM 151510 and NCI)
NCI

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ornithinkarbamoyltransferasa

A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
MSH

Ornithine carbamoyltransferase, mitochondrial (354 aa, ~40 kDa) is encoded by the human OTC gene. This protein plays a role in the metabolism of ornithine.
NCI

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plamínková ionizace

Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography.
MSH

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mazové žlázy – nádory

new abnormal sebaceous gland tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

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tvář

The fleshy part of the face bounded by the eyes, nose, ear, and jaw line.
NCI

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leukémie plazmocytární

rare type of acute leukemia in which the predominating cell in the peripheral blood is the plasma cell; it is often seen in conjunction with multiple myeloma and may be a variant form of that disease.
CSP

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.
MSH

An aggressive plasma cell neoplasm with usually short survival. It is characterized by the presence of neoplastic plasma cells in the peripheral blood. The peripheral blood plasma cells comprise more than 20% of the peripheral blood white cells. It may be the initial presentation of a plasma cell neoplasm or manifest as a terminal complication of plasma cell myeloma. Lymphadenopathy and organomegaly are frequent clinical signs, whereas bone pain and osteolytic lesions are less frequently present.
NCI

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oscilometrie

The measurement of frequency or oscillation changes.
MSH

study of the records of oscillations in electric current waveform.
CSP

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flucytosin

A fluorinated cytosine analog that is used as an antifungal agent.
MSH

fluorinated cytosine analog that is used as an antifungal agent.
CSP

A drug that treats infections caused by fungi.
NCI

A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41023&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C501″ NCI Thesaurus)
PDQ

A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
NCI

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autostimulace

Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.
MSH

stimulation which is self-administered; the stimulation may result in negative or positive reinforcement.
CSP

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cherubismus

A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.
MSH

A rare disorder usually caused by mutations in the SH3BP2 gene. It is characterized by prominence of the lower part of the face due to bilateral replacement of the mandible or maxilla bones by excessive fibrous tissue.
NCI

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leukotrien B4

The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
MSH

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osteomalacie

A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (Dorland, 27th ed)
MSH

inadequate or delayed mineralization of osteoid in mature cortical and spongy bone.
CSP

A condition in adults in which bones become soft and deformed because they don`t have enough calcium and phosphorus. It is usually caused by not having enough vitamin D in the diet, not getting enough sunlight, or a problem with the way the body uses vitamin D. Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets.
NCI

A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) –2003
NCI

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fluorometholon

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
MSH

A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone exerts its effects by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
NCI

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septum pellucidum – jádra

Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
MSH

Subdivision of the septum which contains the dorsal septal nucleus, the lateral septal nucleus, medial septal nucleus, triangular septal nucleus, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure and nucleus of stria terminalis.
FMA

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dětská řeč

The language and sounds expressed by a child at a particular maturational stage in development.
MSH

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licence farmaceutická

The granting of a license to practice pharmacy.
MSH

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ambulantní kliniky nemocniční

Organized services in a hospital which provide medical care on an outpatient basis.
MSH

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folikulitida

Inflammation of follicles, primarily hair follicles.
MSH

Inflammation of a follicle (a sac or pouch-like cavity), usually a hair follicle.
NCI

Inflammation of the hair follicles. Causes include excessive perspiration, skin infections, and skin wounds.
NCI

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Alkalická fosfatáza v séru NOS

A quantitative measurement of the amount of alkaline phosphatase present in a sample of serum.
NCI

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Chlamydiaceae – infekce

Infections with bacteria of the family CHLAMYDIACEAE.
MSH

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lineární modely

Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
MSH

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oxazoly

Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.
MSH

five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position.
CSP

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noha – deformity vrozené

Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
MSH

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