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steroid-17-alfa-hydroxylasa

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
MSH

Encoded by human CYP17A1 Gene (Cytochrome P450 Family), 508-aa 57-kDa Cytochrome P450 XVIIA1 is a cAMP-regulated endoplasmic reticulum P450 heme-thiolate monooxygenase with 17alpha-hydroxylase and 17,20-lyase activity and a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Involved in fetal and adult sexual development, CYP17A1 converts pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 mutations are associated with steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia type V (AH-V). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
NCI

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defenzivní medicína

The alterations of modes of medical practice, induced by the threat of liability, for the principal purposes of forestalling lawsuits by patients as well as providing good legal defense in the event that such lawsuits are instituted.
MSH

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IMP-dehydrogenasa

An enzyme that catalyzes the dehydrogenation of inosine 5`-phosphate to xanthosine 5`-phosphate in the presence of NAD. EC 1.1.1.205.
MSH

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fenotyp

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
MSH

the entire physical, biochemical, and physiological makeup of an individual as determined both genetically and environmentally; also, any one or any group of such traits.
CSP

The observable characteristics in an individual resulting from the expression of genes; the clinical presentation of an individual with a particular genotype.
NCI

Description:A genomic phenomenon that is expressed externally in the organism.


HL7V3.0

The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and the environment.
NCI

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argininsukcinátsynthasa

An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
MSH

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stomatitida herpetická

Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.
MSH

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bludy

A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one`s associates.
MSH

false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one`s associates.
CSP

A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
NCI

False personal beliefs held contrary to reality, despite contradictory evidence and common sense.
NCI

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ostrovy Indického oceánu

Numerous islands in the Indian Ocean situated east of Madagascar, north to the Arabian Sea and east to Sri Lanka. Included are COMOROS (republic), MADAGASCAR (republic), Maldives (republic), MAURITIUS (parliamentary democracy), Pemba (administered by Tanzania), REUNION (a department of France), and SEYCHELLES (republic).
MSH

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Phialophora

A mitosporic fungal genus. Phialophora verrucosa is a cause of chromomycosis (CHROMOBLASTOMYCOSIS). Ophiobolus is the teleomorph of Phialophora.
MSH

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arterioarteriální píštěl

Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.
MSH

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stresové poruchy traumatické

Anxiety disorders manifested by the development of characteristic symptoms following a psychologically traumatic event that is outside the normal range of usual human experience. Symptoms include re-experiencing the traumatic event, increased arousal, and numbing of responsiveness to or reduced involvement with the external world. Traumatic stress disorders can be further classified by the time of onset and the duration of these symptoms.
MSH

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zubní kavita – podložka

An inner coating, as of varnish or other protective substance, to cover the dental cavity wall. It is usually a resinous film-forming agent dissolved in a volatile solvent, or a suspension of calcium hydroxide in a solution of a synthetic resin. The lining seals the dentinal tubules and protects the pulp before a restoration is inserted. (Jablonski, Illustrated Dictionary of Dentistry, 1982)
MSH

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kojenci – potrava

Food processed and manufactured for the nutritional health of children in their first year of life.
MSH

anything which, when taken into the infant body, serves to nourish or build up the tissues or to supply body heat; typically liquids or pureed food until the baby develops teeth; includes baby formula.
CSP

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fosfamidon

An organophosphate cholinesterase inhibitor that is used as an insecticide.
MSH

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aromatické hydroxylasy

A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
MSH

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epidemiologický výzkum – projekt

The form and structure of analytic studies in epidemiologic and clinical research.
MSH

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zubní čepy

Small cylindrical pieces of metal used to enhance retention.
MSH

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informační střediska

Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.
MSH

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fosfolipasa D

An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.
MSH

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aspartátaminotransferasy

Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
MSH

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substance P

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
MSH

neuropeptide composed of 11 amino acids, present in nerve cells scattered throughout the body and in special endocrine cells in the gut; increases the contractions of gastrointestinal smooth muscle, causes vasodilation, and appears to be a sensory neurotransmitter mediating pain, touch, and temperature.
CSP

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of pain, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
NCI

Encoded by human TAC1 Gene (Tachykinin Family) as alternative alpha, beta, delta, and gamma isoforms, Preprotachykinin 1 generates by proteolytic processing the secreted tachykinins: Substance P, Substance K, Neurokinin A, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, and Neuropeptide Gamma. Tachykinins are amidated neuropeptides/neurotransmitters that share C-terminal Phe-X-Gly-Leu-Met sequence; interact with nerve receptors to excite neurons and evoke behavioral responses; are potent vasodilators and secretagogues; and directly or indirectly contract many smooth muscles. Substance P is produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling. (NCI)
NCI

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dentin – rozpustnost

The susceptibility of the DENTIN to dissolution.
MSH

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injekce páteřní

Injection, intraspinal


HL7V3.0

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kyselina fosfowolframová

Tungsten hydroxide oxide phosphate. A white or slightly yellowish-green, slightly efflorescent crystal or crystalline powder. It is used as a reagent for alkaloids and many other nitrogen bases, for phenols, albumin, peptone, amino acids, uric acid, urea, blood, and carbohydrates. (From Merck Index, 11th ed)
MSH

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astma z námahy

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
MSH

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sulbenicilin

Semisynthetic penicillin-type antibiotic.
MSH

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kyselina deoxycholová

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
MSH

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inseminace

The deposit of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.
MSH

The introduction of semen or sperm into the genital tract of a female. [ISBN:0582227089]
GO

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fyzikální vyšetření

Systematic and thorough inspection of the patient for physical signs of disease or abnormality.
MSH

see:http://www.nlm.nih.gov/mesh/MBrowser.html
AOT

An exam of the body to check for general signs of disease.
NCI

A systemic evaluation of the body and it`s functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual`s health assessment.
NCI

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atrioventrikulární blokáda

Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
MSH

A delay or failure in the conduction of a cardiac impulse from the atria to the ventricles at the level of the atrioventricular node.
NCI

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