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epirubicin

An anthracycline which is the 4`-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
MSH

A 4`-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
NCI

A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.
NCI

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biomedicínské a zubní materiály

Substances used in biomedicine or dentistry predominantly for their physical, as opposed to chemical, properties.
MSH

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retrospektivní studie

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
MSH

A study in which known outcomes are examined in hindsight using existing records.
NCI

A study that compares two groups of people: those with the disease or condition under study (cases) and a very similar group of people who do not have the disease or condition (controls). Researchers study the medical and lifestyle histories of the people in each group to learn what factors may be associated with the disease or condition. For example, one group may have been exposed to a particular substance that the other was not.
NCI

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meziobratlová ploténka

plates of fibrocartilage found between the bodies of adjacent vertebrae in the spine, each consisting of a fibrous ring enclosing a pulpy center.
CSP

Spongy discs located between the vertebrae of the spinal column; composed of the outer annulus fibrosus and inner nucleus pulposus.
NCI

Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
MSH

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Donor person

One that contributes something.
NCI

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erbium

Erbium. An element of the rare earth family of metals. It has the atomic symbol Er, atomic number 68, and atomic weight 167.26.
MSH

An element with atomic symbol Er, atomic number 68, and atomic weight 167.259.
NCI

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porodní hmotnost

The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
MSH

In humans, the weight of a neonate measured within one hour after birth. The factors influencing the birth weight include but not limited to infant sex, racial and ethnic group, maternal size and health status, concurrent diseases, parity, and nutrition, pregnancy environment and conditions, e.g. altitude of geographic area.
NCI

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rinitida

Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
MSH

inflammation of the mucous membrane of the nose.
CSP

an inflammation of the nasal mucous membrane
CHV

An inflammation of the mucous membrane lining the nose, usually associated with nasal discharge.
NCI

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nitroděložní antikoncepční prostředky – vypuzení

Spontaneous loss of INTRAUTERINE DEVICES from the UTERUS.
MSH

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spotřeba vody

A measurement of a subject`s water intake.
NCI

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erytroblasty

Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.
MSH

Red blood cells that are at the last stage of development, still containing a nucleus, that are found in the bone marrow and occasionally in the peripheral blood.
NCI

An immature, nucleated erythrocyte occupying the stage of erythropoiesis that follows formation of erythroid progenitor cells and precedes formation of reticulocytes.
NCI

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Blastomyces

A genus of onygenacetous mitosporic fungi whose perfect state is Ajellomyces (see ONYGENALES). The species Blastomyces dermatitidis (perfect state Ajellomyces dermatitidis) causes blastomycosis.
MSH

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ribavirin

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
MSH

1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS.
CSP

A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
NCI

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C807″ NCI Thesaurus)
PDQ

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. (NCI04)
NCI

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jodofory

Complexes of iodine and non-ionic SURFACE-ACTIVE AGENTS acting as carrier and solubilizing agent for the iodine in water. Iodophors usually enhance bactericidal activity of iodine, reduce vapor pressure and odor, minimize staining, and allow wide dilution with water. (From Merck Index, 11th ed)
MSH

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léky – rezidua

Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.
MSH

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divertikly jícnu

Saccular protrusion beyond the wall of the ESOPHAGUS.
MSH

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transkutánní měření krevních plynů

The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.
MSH

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Orientia tsutsugamushi

A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
MSH

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nukleární rodina

A family composed of spouses and their children.
MSH

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iridoviry

A family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus; Megalocytivirus; and Lymphocystivirus.
MSH

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duodenum – obstrukce

Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.
MSH

Blockage of the normal flow of stomach contents through the duodenum.
NCI

A disorder characterized by blockage of the normal flow of stomach contents through the duodenum.
NCI

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estrany

A group of compounds forming the nucleus of the estrogenic steroid family.
MSH

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hematoencefalická bariéra

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
MSH

a physical barrier and a system of cellular transport mechanisms which maintain homeostasis in the brain by restricting the entrance of potentially harmful chemicals from the blood and by allowing the entrance of essential nutrients.
CSP

A network of blood vessels and tissue that is made up of closely spaced cells and helps keep harmful substances from reaching the brain. The blood-brain barrier lets some substances, such as water, oxygen, carbon dioxide, and general anesthetics, pass into the brain. It also keeps out bacteria and other substances, such as many anticancer drugs.
NCI

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RNA-polymerasa II

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
MSH

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nukleotidasy

A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.
MSH

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isoenzymy

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
MSH

different form of the same enzyme, such as from another tissue or species, membrane-bound vs. soluble, secreted vs. intracellular, or oligomerized to a different degree.
CSP

The term “isoenzyme” or “isozyme” refers to variants of the same enzyme which can be separated on special conducting media using electrophoresis. It should apply only to those multiple forms of enzymes arising from genetically determined differences in primary structure and not to those derived by modification of the same primary sequence.
NCI

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dyslexie získaná

A receptive visual aphasia characterized by the loss of a previously possessed ability to comprehend the meaning or significance of handwritten words, despite intact vision. This condition may be associated with posterior cerebral artery infarction (INFARCTION, POSTERIOR CEREBRAL ARTERY) and other BRAIN DISEASES.
MSH

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etika stomatologická

The principles of proper professional conduct concerning the rights and duties of the dentist, relations with patients and fellow practitioners, as well as actions of the dentist in patient care and interpersonal relations with patient families. (From Stedman, 25th ed)
MSH

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Bolívie

A country in Central South America, southwest of Brazil. (NCI)
NCI

A country in Central South America, southwest of Brazil. (CIA World Factbook 2002)
NCI

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RNA transferová Gln

A transfer RNA which is specific for carrying glutamine to sites on the ribosomes in preparation for protein synthesis.
MSH

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