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protein-tyrosinkinasy

Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
MSH

Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (Dictionary of Cell and Molecular Biology Online)
NCI

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Gaucherova nemoc

An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
MSH

autosomal recessive disorder caused by deficiency of the enzyme glucocerebrosidase featuring the pathological storage of glycosylceramide in mononuclear phagocytes; the most common subtype is the non-neuronopathic form, a slowly progressive condition characterized by hepatosplenomegaly and skeletal deformities; the neuronopathic forms are divided into infantile and juvenile forms; the infantile form presents at 4-5 months of age with anemia, loss of cognitive gains, neck retraction, dysphagia, and hepatosplenomegaly; the juvenile form features a slowly progressive loss of intellect, hepatosplenomegaly, ataxia, myoclonic seizures, and spasticity; the neuronopathic forms are characterized by neuronal loss with neuronophagia, and accumulation of glucocerebroside in neurons.
CSP

An inherited lysosomal storage disease caused by deficiency of the enzyme glucocerebrosidase. It results in the accumulation of a fatty substance called glucocerebroside in mononuclear cells in the bone marrow, liver, spleen, brain, and kidneys. Signs and symptoms include hepatomegaly, splenomegaly, neurologic disorders, lymphadenopathy, skeletal disorders, anemia and thrombocytopenia.
NCI

Gaucher`s disease is a rare, inherited disorder that causes too much of a substance called glucocerebroside to build up in your spleen, liver, lungs, bones and sometimes in your brain. The buildup prevents these organs from working properly.

There are three types:

  • Type 1, the most common form, causes liver and spleen enlargement, bone pain and broken bones, and, sometimes, lung and kidney problems. It does not involve the brain. It can occur at any age.
  • Type 2, which causes severe brain damage, appears in infants. Most children who have it die by age 2.
  • In type 3, there may be liver and spleen enlargement, and signs of brain involvement appear gradually.

Gaucher`s disease has no cure. Treatment options for types 1 and 3 include medicine and enzyme replacement therapy, which is usually very effective. There is no good treatment for the brain damage of type 2.

NIH: National Institute of Neurological Disorders and Stroke


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respirační acidóza

Respiratory retention of carbon dioxide. It may be chronic or acute.
MSH

excess retention of carbon dioxide in the body resulting from ventilatory impairment.
CSP

Acid base imbalance resulting from an accumulation of carbon dioxide secondary to hypoventilation.
NCI

A state due to excess retention of carbon dioxide in the body.
NCI

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kuřecí embryo

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
MSH

domestic chicken or any other bird at any stage of development prior to hatching.
CSP

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maligní hypertermie

Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.
MSH

usually inherited reaction to general anesthesia manifested as a sudden, rapid rise in temperature, hypermetabolism, and skeletal muscle rigidity; mutation is in the calcium release channel of skeletal muscle sarcoplasmic reticulum.
CSP

A rare disorder characterized by rapid rise of the body temperature, accompanied by rhabdomyolysis and, if untreated, by collapse and death. It occurs in susceptible individuals who receive certain drugs for general anesthesia, gas anesthetics, or succinylcholine. It may be inherited in an autosomal dominant pattern.
NCI

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prurigo

A name applied to several itchy skin eruptions of unknown cause. The characteristic course is the formation of a dome-shaped papule with a small transient vesicle on top, followed by crusting over or lichenification. (From Dorland, 27th ed)
MSH

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genová přestavba

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
MSH

covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.
CSP

Any DNA sequence rearrangement that results in the creation of a novel protein-coding capacity. Within certain genes, gene rearrangement is a normal part of development, facilitating the affinity maturation of B and T lymphocytes as well as class switching of immunoglobulins.
NCI

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akronin

A pyrano-acridone alkaloid found in RUTACEAE plants.
MSH

A natural alkaloid with an acridine structure isolated from the bark of the plant Acronychia baueri (Australian scrub ash) with antineoplastic properties. Acronycine appears to alkylate DNA and interfere with DNA replication. (NCI04)
NCI

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dítě hospitalizované

Child hospitalized for short term care.
MSH

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mandibula – poranění

Injuries to the lower jaw bone.
MSH

Your jaw is a set of bones that holds your teeth. It consists of two main parts. The upper part is the maxilla. It doesn`t move. The moveable lower part is called the mandible. You move it when you talk or chew. The two halves of the mandible meet at your chin. The joint where the mandible meets your skull is the temporomandibular joint.

Jaw problems include

Treatment of jaw problems depends on the cause.


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psilocybin

The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)
MSH

A tryptamine alkaloid, isolated from various genera of fungi including the genus Psilocybe, with hallucinogenic, anxiolytic, and psychoactive activities. In vivo, psilocybine is rapidly dephosphorylated into the active compound psilocin, which activates serotonin 2A (5-HT2A) receptors in the central nervous system (CNS), mimicking the effects of serotonin.
NCI

A substance being studied in the treatment of anxiety or depression in patients with advanced cancer. It is taken from the mushroom Psilocybe mexicana. Psilocybin acts on the brain to cause hallucinations (sights, sounds, smells, tastes, or touches that a person believes to be real but are not real).
NCI

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geny nef

DNA sequences that form the coding region for a protein that down-regulates the expression of human immunodeficiency virus (HIV). nef is short for negative factor.
MSH

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akupunktura

The occupational discipline of the traditional Chinese methods of ACUPUNCTURE THERAPY for treating disease by inserting needles along specific pathways or meridians.
MSH

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chlordan

A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)
MSH

highly poisonous organochlorine insecticide; the EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants.
CSP

Chlordane is a chlorinated hydrocarbon used as a non-systemic contact insecticide for lawns and crops. Actually a complex mixture of isomers, other chlorinated hydrocarbons, and by-products, chlordane is used in termite and ant control, and as a protective treatment for underground cables. Chlordane may be irritant and toxic by ingestion, inhalation, or skin absorption; toxic effects may be cumulative. When heated to decomposition, chlordane emits toxic fumes of carbon monoxide, hydrogen chloride, chlorine, and phosgene. Chlordane is very persistent in the environment, surviving in soils for more than 20 years. U.S. production of chlordane was stopped in 1976. (NCI04)
NCI

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manuály jako téma

A small handbook.
NCI

Books designed to give factual information or instructions.
MSH

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psychologie lékařská

A branch of psychology in which there is collaboration between psychologists and physicians in the management of medical problems. It differs from clinical psychology, which is concerned with the diagnosis and treatment of behavior disorders.
MSH

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pohlavní orgány mužské – nemoci

Pathological processes involving the male reproductive tract (GENITALIA, MALE).
MSH

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adenom

A benign epithelial tumor with a glandular organization.
MSH

benign epithelial tumor in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium.
CSP

A tumor that is not cancer. It starts in gland-like cells of the epithelial tissue (thin layer of tissue that covers organs, glands, and other structures within the body).
NCI

A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.
NCI

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chlorfenamidin

An acaricide used against many organophosphate and carbamate resistant pests. It acts as an uncoupling agent and monoamine oxidase inhibitor.
MSH

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Masonův-Pfizerův virus opic

A species of BETARETROVIRUS isolated from mammary carcinoma in rhesus monkeys. It appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus. Several serologically distinct strains exist. MPMV induces SIMIAN AIDS.
MSH

species of beta retrovirus isolated from mammary carcinoma in rhesus monkeys; it appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus; several serologically distinct strains exist; MPMV induces simian AIDS (SAIDS).
CSP

Mason-Pfizer Monkey Virus; causes AIDS-like disease (NCI)
NCI

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kyseliny pteroylpolyglutamové

Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.
MSH

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germanium

A rare metal element with a blue-gray appearance and atomic symbol Ge, atomic number 32, and atomic weight 72.63.
MSH

rare metal element with a blue-gray appearance, atomic symbol Ge, atomic number 32, and atomic weight 72.59.
CSP

a kind of chemical element
CHV

An element with atomic symbol Ge, atomic number 32, and atomic weight 72.64.
NCI

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adenylsukcinátlyasa

An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5`-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5`-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
MSH

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cholera

An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
MSH

acute diarrheal disease endemic in India and southeast Asia whose causative agent is Vibrio cholerae; can lead to severe dehydration in a matter of hours unless quickly treated.
CSP

Cholera is a bacterial infection that causes diarrhea. The cholera bacterium is usually found in water or food contaminated by feces (poop). Cholera is rare in the US. You may get it if you travel to parts of the world with inadequate water treatment and poor sanitation, and lack of sewage treatment. Outbreaks can also happen after disasters. The disease is not likely to spread directly from one person to another.

Often the infection is mild or without symptoms, but sometimes it can be severe. Severe symptoms include profuse watery diarrhea, vomiting, and leg cramps. In severe cases, rapid loss of body fluids leads to dehydration and shock. Without treatment, death can occur within hours.

Doctors diagnose cholera with a stool sample or rectal swab. Treatment includes replacing fluid and salts and sometimes antibiotics.

Anyone who thinks they may have cholera should seek medical attention immediately. Dehydration can be rapid so fluid replacement is essential.

Centers for Disease Control and Prevention


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vyrobené materiály

Substances and materials manufactured for use in various technologies and industries and for domestic use.
MSH

Corresponds to the ManufacturedMaterial class


HL7V3.0

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pneumologie

A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
MSH

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dásně – hyperplazie

Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski`s Dictionary of Dentistry, 1992, p400)
MSH

abnormal multiplication of otherwise normal gingival cells, leading to tissue enlargement.
CSP

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dorostové lékařství

A branch of medicine pertaining to the diagnosis and treatment of diseases occurring during the period beginning with puberty until the cessation of somatic growth.
MSH

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cholinergní vlákna

Nerve fibers liberating acetylcholine at the synapse after an impulse.
MSH

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Mayotte

A country in Southern Africa, occupying an island in the Mozambique Channel, about one-half of the way from northern Madagascar to northern Mozambique. (NCI)
NCI

A country in Southern Africa, occupying an island in the Mozambique Channel, about one-half of the way from northern Madagascar to northern Mozambique. (CIA World Factbook 2002)
NCI

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