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konzervovaná sekvence

A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
MSH

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postižení

persons with physical or mental disabilities that affect or limit their activities of daily living and that may require special accommodations.
CSP

Indication of disability.


HL7V3.0

Groups with similar restrictions or lack or ability to perform physical or mental activities in a manner or within the range considered normal for a human being.
NCI

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sarkoidóza plicní

Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
MSH

Sarcoidosis affecting the lung parenchyma. It is characterized by the presence of non-necrotizing granulomas in the lung tissues. It is manifested with dyspnea, cough, fever, night sweats, fatigue, and weight loss.
NCI

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myši inbrední BALB C

Derived from albino mice stocks originally disseminated by Bagg (1913) to Snell in 1932 that has an albino coat with genotype A,b,c. The BALB/c mouse develops plasmacytomas upon injection with mineral oil, which form the mouse cell component of the mouse-human hybrid cells that are used in the production of monoclonal antibodies. This strain exhibits excellent breeding performance and a long life span which contribute to its being one of the most highly utilized of all available mouse strains.
NCI

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ophthalmia neonatorum

Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby`s eyes are contaminated during passage through the birth canal.
MSH

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antikoncepční látky orální hormonální

Oral contraceptives which owe their effectiveness to hormonal preparations.
MSH

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zdravotní péče – koalice

Voluntary groups of people representing diverse interests in the community such as hospitals, businesses, physicians, and insurers, with the principal objective to improve health care cost effectiveness.
MSH

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Schistosoma

genus of digenetic trematodes, including the important blood flukes of humans and domestic animals, that cause schistosomiasis; characterized by elongate shape, by separate sexes with marked sexual dimorphism, by their unusual location in the smaller blood vessels of their host, and by utilization of water snails as intermediate hosts.
CSP

A genus of trematode flukes belonging to the family Schistosomatidae. There are over a dozen species. These parasites are found in man and other mammals. Snails are the intermediate hosts.
MSH

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mikrofilamenta

submicroscopic filaments composed chiefly of actin, found in the cytoplasmic matrix of most cells, often in close association with the microtubules; may play a role in cell and organelle movement and in supportive and cytoskeletal function.
CSP

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
GO

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. [GOC:mah, ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”, PMID:10666339]
GO

Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.
MSH

The finest filamentous element of the cytoskeleton, having a diameter of about 5 nm and consisting primarily of actin.
NCI

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optika oční

The professional practice of primary eye and vision care that includes the measurement of visual refractive power and the correction of visual defects with lenses or glasses.
MSH

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koproporfyriny

Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
MSH

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zdravotnické služby

Services for the diagnosis and treatment of disease and the maintenance of health.
MSH

providing services for the diagnosis, prevention and treatment of disease and the maintenance of health.
CSP

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školy lékařské

Educational institutions for individuals specializing in the field of medicine.
MSH

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mikrotubulární proteiny

Proteins found in the microtubules.
MSH

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organizační kultura

Beliefs and values shared by all members of the organization. These shared values are reflected in the day to day operations of the organization.
MSH

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corpora allata

Paired or fused ganglion-like bodies in the head of insects. The bodies secrete hormones important in the regulation of metamorphosis and the development of some adult tissues.
MSH

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srdce – převodní systém

An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
MSH

impulse conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
CSP

Conducting tissue of heart which consists of specialized cardiac myocyte in the myocardium.
FMA

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anémie sideroblastická

Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.
MSH

acquired or hereditary anemia marked by sideroblasts: bone marrow cells with large mitochondrial deposits of insoluble iron due to defective heme synthesis, leading to ineffective erythropoiesis.
CSP

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skopoletin

Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.
MSH

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mimosin

3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
MSH

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Orphenadrine Citrate

The citrate salt form of orphenadrine with a muscle relaxant property. Although the mechanism of action has not been fully elucidated, orphenadrine citrate appears to block cholinergic receptors, thereby interfering with the transmission of nerve impulses from the spinal cord to the muscles. It does not produce myoneural block, nor does it affect crossed extensor reflexes.
NCI

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kotinin

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
MSH

The major metabolite of nicotine.
NCI

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vyčerpání z tepla

A clinical syndrome caused by heat stress, such as over-exertion in a hot environment or excessive exposure to sun. It is characterized by SWEATING, water (volume) depletion, salt depletion, cool clammy skin, NAUSEA, and HEADACHE.
MSH

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angiografie

radiography of blood vessels after injection of a contrast medium.
CSP

A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray.
NCI

An x-ray of blood vessels. The person receives an injection of dye to outline the vessels on the x-ray.
NCI

The X-ray examination of the blood vessels or chambers of the heart.
NCI

An X-ray representation of blood vessels made after the injection of a radiopaque substance.
NCI

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tělo – sekrety

Endogenous substances produced through the activity of intact cells of glands, tissues, or organs.
MSH

Body substance in a liquid or semisolid state produced by an exocrine gland. Example: saliva, sebum, blood, plasma, semen, urine.
FMA

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mithramycin

A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
MSH

tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors; also used to reduce hypercalcemia, especially that due to malignancies.
CSP

A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Mithracin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.
NCI

An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41738&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41738&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C658″ NCI Thesaurus)
PDQ

An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)
NCI

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osteitis fibrosa cystica

A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
MSH

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kraniologie

The scientific study of variations in size, shape, and proportion of the cranium.
MSH

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hemaglutininy

Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
MSH

group of agents that cause agglutination of red blood cells; they include antibodies, blood group antigens, lectins, autoimmune factors, and bacterial, viral, or parasitic blood agglutinins.
CSP

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práva zvířat

The moral and ethical bases of the protection of animals from cruelty and abuse. The rights are extended to domestic animals, laboratory animals, and wild animals.
MSH

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