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hypotyreóza

A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
MSH

deficiency of thyroid gland activity; characterized by decreased basal metabolic rate, fatigue and lethargy, sensitivity to cold, and menstrual disturbances; untreated it progresses to myxedema; in infants severe hypothyroidism leads to cretinism.
CSP

A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.
NCI

Too little thyroid hormone. Symptoms include weight gain, constipation, dry skin, and sensitivity to the cold.
NCI

A condition in which the production of thyroid hormone by the thyroid gland is diminished. Signs and symptoms of hypothyroidism include low metabolic rate, tendency to weight gain, somnolence and sometimes myxedema. In the United States, the most common cause of hypothyroidism is Hashimoto`s thyroiditis, an autoimmune disorder.
NCI

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sodíkové kanály

Cell membrane glycoproteins selective for sodium ions. Fast sodium current is associated with the action potential in neural membranes.
MSH

cell membrane glycoproteins selective for sodium ions; fast sodium current is associated with the action potential in neural membranes.
CSP

An ion channel with selective permeability for sodium.
NCI

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buňky – inhibice migrace

Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
MSH

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dusíkaté sloučeniny

Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.
MSH

compound containing the chemical group N02.
CSP

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patologie klinická

A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)
MSH

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idarubicin

An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
MSH

An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
NCI

A semisynthetic anthracycline antineoplastic antibiotic derived from daunorubicin. Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes better than other anthracycline antibiotics. Idarubicin hydrochloride is the therapeutic form of this drug. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39753&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39753&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C562″ NCI Thesaurus)
PDQ

A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.
NCI

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Softwareontwikkeling

The application of a systematic, disciplined, quantifiable approach to the development, operation, and maintenance of computer software.
NCI

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látky ovlivňující centrální nervový systém

A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into “specific” agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and “nonspecific” agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman`s The Pharmacological Basis of Therapeutics, 8th ed, p252)
MSH

class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
CSP

NOTE: Includes all single-entity and combination analgesic products containing an opioid agonist or partial agonist (CN101); non-opioid single-entity and combination analgesic products containing acetaminophen and/or salicylates (CN103); single-entity monocyclic, bicyclic, or tetracyclic antidepressants (CN609); and single-entity products containing a phenothiazine or thioxanthene (CN701). Excludes antitussive products containing an agonist or partial agonist opioid (RE301); antidiarrheal products containing tincture of opium or paregoric (GA400); single- entity anticholinergic products and dopamine agonists (AU350); pargyline (CV490); procarbazine (AN900); anesthetics, local topical (DE700).
NDFRT

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kyselina dusitá

Nitrous acid (HNO2). A weak acid that exists only in solution. It can form water-soluble nitrites and stable esters. (From Merck Index, 11th ed)
MSH

the weak acid HNO.
CSP

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pektiny

High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.
MSH

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obrazy – zpracování pomocí počítače

A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
MSH

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sotalol

An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
MSH

An ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties. Sotalol is a nonselective beta-adrenergic receptor and potassium channel antagonist. In the heart, this agent inhibits chronotropic and inotropic effects thereby slowing the heart rate and decreasing myocardial contractility. This agent also reduces sinus rate, slows conduction in the atria and in the atrioventricular (AV) node and increases the functional refractory period of the AV node.
NCI

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cerebelární ataxie

Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
MSH

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noradrenalin

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
MSH

precursor of epinephrine; widespread central and autonomic neurotransmitter, principal transmitter of most postganglionic sympathetic fibers; secreted by the adrenal medulla; used pharmacologically as a sympathomimetic.
CSP

A synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.
NCI

A naturally occurring catecholamine hormone that functions as a neurotransmitter in the sympathetic nervous system. Norepinephrine directly stimulates adrenergic receptors. Stimulation of alpha-adrenergic receptors causes vasoconstriction of the radial smooth muscle of the iris, arteries, arterioles, veins, urinary bladder, and the sphincter of the gastrointestinal tract. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation.
NCI

A chemical made by some nerve cells and in the adrenal gland. It can act as both a neurotransmitter (a chemical messenger used by nerve cells) and a hormone (a chemical that travels in the blood and controls the actions of other cells or organs). Noradrenaline is released from the adrenal gland in response to stress and low blood pressure.
NCI

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penfluridol

One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.
MSH

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imunoblastická lymfadenopatie

A disorder characterized by proliferation of arborizing small vessels, prominent immunoblastic proliferations and amorphous acidophilic interstitial material. Clinical manifestations include fever, sweats, weight loss, generalized lymphadenopathy and frequently hepatosplenomegaly.
MSH

An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma marked by enlarged lymph nodes and hypergammaglobulinemia (increased antibodies in the blood). Other symptoms may include a skin rash, fever, weight loss, or night sweats.
NCI

A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes. It occurs in the middle aged and elderly, with an equal incidence in males and females. The clinical course is typically aggressive. (WHO, 2001)
NCI

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specializační komise

Organizations which certify physicians and dentists as specialists in various fields of medical and dental practice.
MSH

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In Cerebrospinal Fluid

Used for the presence or analysis of substances in the cerebrospinal fluid; also for examination of or changes in cerebrospinal fluid in disease states.
MSH

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polyester pentosanu kyseliny sírové

A sulfated pentosyl polysaccharide with heparin-like properties.
MSH

anhydride or polymerized form of any pentose.
CSP

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imunologický capping

An energy dependent process following the crosslinking of B CELL ANTIGEN RECEPTORS by multivalent ligands (bivalent anti-antibodies, LECTINS or ANTIGENS), on the B-cell surface. The crosslinked ligand-antigen receptor complexes collect in patches which flow to and aggregate at one pole of the cell to form a large mass – the cap. The caps may then be endocytosed or shed into the environment.
MSH

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spermie – aglutinace

Agglutination of spermatozoa by antibodies or autoantibodies.
MSH

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cesium – radioisotopy

Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.
MSH

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Peptococcaceae

A family of bacteria found in the mouth and intestinal and respiratory tracts of man and other animals as well as in the human female urogenital tract. Its organisms are also found in soil and on cereal grains.
MSH

A taxonomic family of bacterium in the phylum Firmicutes that includes the genera Dehalobacter, Peptococcus and Thermincola, among others.
NCI

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Motieven

A benefit, consideration, or positive motivational influence, financial or otherwise, given to induce a specific action.
NCI

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sféroplasty

Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round.
MSH

Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round. (MeSH)
NCI

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chemická válka

Tactical warfare using incendiary mixtures, smokes, or irritant, burning, or asphyxiating gases.
MSH

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perikarditida

Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.
MSH

A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).
NCI

An inflammatory process affecting the pericardium.
NCI

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individualita

Those psychological characteristics which differentiate individuals from one another.
MSH

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lamina spiralis ossea

The bony plate which extends outwards from the modiolus into the spiral canal of the cochlea, forming part of the structure that divides the upper SCALA VESTIBULI and the lower SCALA TYMPANI.
MSH

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kuřecí embryo

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
MSH

domestic chicken or any other bird at any stage of development prior to hatching.
CSP

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