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fagocyty – baktericidní dysfunkce

disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.
CSP

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srdce – převodní systém

An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
MSH

impulse conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
CSP

Conducting tissue of heart which consists of specialized cardiac myocyte in the myocardium.
FMA

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karboanhydrasa II

A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-
MSH

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stearyl-CoA desaturasa

An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor.
MSH

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mimosin

3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
MSH

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fenazocin

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)
MSH

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vyčerpání z tepla

A clinical syndrome caused by heat stress, such as over-exertion in a hot environment or excessive exposure to sun. It is characterized by SWEATING, water (volume) depletion, salt depletion, cool clammy skin, NAUSEA, and HEADACHE.
MSH

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karcinom bazocelulární

A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
MSH

malignant skin neoplasm that seldom metastasizes but has potential for local invasion and destruction; clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid); develops on hair-bearing skin, most commonly on sun exposed areas.
CSP

Cancer that begins in the lower part of the epidermis (the outer layer of the skin). It may appear as a small white or flesh-colored bump that grows slowly and may bleed. Basal cell cancers are usually found on areas of the body exposed to the sun. Basal cell cancers rarely metastasize (spread) to other parts of the body. They are the most common form of skin cancer.
NCI

a kind of skin cancer
CHV

The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like.. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.
NCI

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Stevensův-Johnsonův syndrom

A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.
MSH

A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma).
NCI

A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
NCI

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mithramycin

A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
MSH

tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors; also used to reduce hypercalcemia, especially that due to malignancies.
CSP

A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Mithracin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.
NCI

An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41738&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41738&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C658″ NCI Thesaurus)
PDQ

An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)
NCI

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fenylbutyráty

cytostatic, apoptosis inducing agent; effects cell differentiation.
CSP

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hemaglutininy

Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
MSH

group of agents that cause agglutination of red blood cells; they include antibodies, blood group antigens, lectins, autoimmune factors, and bacterial, viral, or parasitic blood agglutinins.
CSP

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kardioplegické roztoky

Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
MSH

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Lactococcus lactis

A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.
MSH

A species of Gram positive, cocci shaped, lactic acid bacteria assigned to the phylum Firmicutes. This species is nonmotile, catalase negative, nonsporulating and produces lactic acid from lactose fermentation. L lactis may be an opportunistic pathogen in humans and animals. Most significantly this microorganism is used commercially in the production of buttermilk and cheese.
NCI

Any bacterial organism that can be assigned to the species Lactococcus lactis.
NCI

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modely genetické

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
MSH

representation of the behavior or activity of genetic processes or systems which can be manipulated to demonstrate the effects that various actions will have on the genetic process or system or organism as a whole.
CSP

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flebitida

Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).
MSH

A disorder characterized by inflammation of the wall of a vein.
NCI

Inflammation (redness, swelling, pain, and heat) of a vein, usually in the legs. Phlebitis may be caused by infection, injury, or irritation.
NCI

Inflammation of a vein.
NCI

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hemeproteiny

Proteins that contain an iron-porphyrin, or heme, prosthetic group resembling that of hemoglobin. (From Lehninger, Principles of Biochemistry, 1982, p480)
MSH

conjugated protein containing heme as the prosthetic group.
CSP

Proteins that contain a metal-containing cofactor that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. One of the main functions of heme proteins is the retention of molecular oxygen to deliver it for enzymatic reactions. As a result, many heme-containing enzymes are located in the mitochondrion.
NCI

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sinus caroticus

The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
MSH

slight dilation in the carotid artery at its bifurcation into the external and internal carotid arteries; it contains baroreceptors (pressure sensors) that when stimulated, will cause a reflex slowing of the heart, vasodilation and a fall in blood pressure.
CSP

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Strongyloides

A genus of parasitic nematodes widely distributed as intestinal parasites of mammals.
MSH

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Monako

A country in Western Europe, bordering the Mediterranean Sea on the southern coast of France, near the border with Italy. (NCI)
NCI

A country in Western Europe, bordering the Mediterranean Sea on the southern coast of France, near the border with Italy. (CIA World Factbook 2002)
NCI

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fosfatidylseriny

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
MSH

derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety.
CSP

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hemoglobinometrie

Measurement of hemoglobin concentration in blood.
MSH

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kataplexie

A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)
MSH

transient attack of weakness precipitated by emotional excitement; patient falls as if struck down.
CSP

A rare disorder characterized by sudden and transient episodes of loss of muscle tone. It often follows an experience of intense emotions. It is seen in patients with narcolepsy.
NCI

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vena subclavia

The continuation of the axillary vein which follows the subclavian artery and then joins the internal jugular vein to form the brachiocephalic vein.
MSH

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mopidamol

A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic.
MSH

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fosforamidové hořčice

A group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. They are usually cytotoxic and used as antineoplastic agents.
MSH

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hemosideróza

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
MSH

conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage.
CSP

Accumulation of iron in internal organs.
NCI

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skot – nemoci

Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
MSH

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sukcinátcytochrom c oxidoreduktasa

An electron transport chain complex that catalyzes the transfer of electrons from SUCCINATE to CYTOCHROME C. It includes ELECTRON TRANSPORT COMPLEX II and ELECTRON TRANSPORT COMPLEX III.
MSH

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film jako téma

The art, technique, or business of producing motion pictures for entertainment, propaganda, or instruction.
MSH

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