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nafazolin

An adrenergic vasoconstrictor agent used as a decongestant.
MSH

An imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness.
NCI

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choroidea

The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
MSH

A thin layer of tissue that is part of the middle layer of the wall of the eye, between the sclera (white outer layer of the eye) and the retina (the inner layer of nerve tissue at the back of the eye). The choriod is filled with blood vessels that bring oxygen and nutrients to the eye.
NCI

A blood vessel-containing membrane of the eye that lies between the retina and the sclera.
NCI

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radioligandová zkouška

Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
MSH

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nemocniční informační systémy

Integrated, computer-assisted systems designed to store, manipulate, and retrieve information concerned with the administrative and clinical aspects of providing medical services within the hospital.
MSH

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mucinóza folikulární

A disease of the pilosebaceous unit, presenting clinically as grouped follicular papules or plaques with associated hair loss. It is caused by mucinous infiltration of tissues, and usually involving the scalp, face, and neck. It may be primary (idiopathic) or secondary to mycosis fungoides or reticulosis.
MSH

A rare dermatologic disorder characterized by the accumulation of mucinous material in the hair follicles. In some cases it is associated with lymphoproliferative disorders, most often mycosis fungoides and Hodgkin lymphoma.
NCI

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natamycin

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.
MSH

A polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.
NCI

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chrom – slitiny

Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
MSH

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náhodné rozdělení

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
MSH

When referring to an experiment or clinical trial, the process by which animal or human subjects are assigned by chance to separate groups that compare different treatments or other interventions. Randomization gives each participant an equal chance of being assigned to any of the groups.
NCI

The process of assigning trial subjects to treatment or control groups using an element of chance to determine the assignments in order to reduce bias. NOTE: Unequal randomization is used to allocate subjects into groups at a differential rate; for example, three subjects may be assigned to a treatment group for every one assigned to the control group. [ICH E6 1.48] See also balanced study. (CDISC glossary)
NCI

The allocation of individuals to groups by chance, especially in order to control the variables in an experiment.
NCI

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nemocnice speciální

Hospitals which provide care for a single category of illness with facilities and staff directed toward a specific service.
MSH

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alternativní sestřih

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
MSH

Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
NCI

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krční svaly

Muscle (organ) which is a part of the neck. Examples: platysma, sternocleidomastoid, cricothyroid muscle.
UWDA

The neck muscles consist of the platysma, splenius cervicis, sternocleidomastoid(eus), longus colli, the anterior, medius, and posterior scalenes, digastric(us), stylohyoid(eus), mylohyoid(eus), geniohyoid(eus), sternohyoid(eus), omohyoid(eus), sternothyroid(eus), and thyrohyoid(eus).
MSH

Muscle organ which is a part of the neck. Examples: platysma, sternocleidomastoid, cricothyroid muscle.
FMA

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chromozómy lidské, pár 14

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
MSH

The designation for each member of the fourteenth largest human autosomal chromosome pair. Chromosome 14 spans about 105 million base pairs and represents between 3 and 3.5% of the total DNA in normal diploid cells.
NCI

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Raynaudův fenomén

WHAT: Raynaud`s phenomenon.
AIR

A set of symptoms characteristic of peripheral vascular disease, namely caused by an inappropriate response of the peripheral arteries in reaction to environmental stimuli, usually to the cold. The term is used when an underlying disease (mostly connective tissue/autoimmune disorders such as lupus, scleroderma, rheumatoid arthritis, etc.) is primarily causative and a range of symptoms including the peripheral vascular spasm is secondary. The term does not refer to the primary Raynaud`s or Raynaud`s disease.
NCI

Intermittent bilateral attacks of ischemia of the fingers or toes and sometimes of the ears or nose, marked by severe pallor, and often accompanied by paresthesia and pain.
NCI

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experimenty na lidech

The use of humans as investigational subjects.
MSH

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Ambystoma mexicanum

A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
MSH

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neonatologie

A subspecialty of Pediatrics concerned with the newborn infant.
MSH

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cialit

Tissue preservative.
MSH

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receptory opiátové

Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
MSH

family of cell surface receptors which mediate opiate drug effects on neurons, lymphocytes, macrophages, and other cells; may or may not coincide with neuropeptide receptors; some are G protein coupled to calcium channel inhibition.
CSP

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hydroa vacciniforme

A vesicular and bullous eruption having a tendency to recur in summer during childhood and commonly appearing on sun-exposed skin. The lesions are surrounded by an erythematous zone and resemble a vaccination. (From Dorland, 27th ed)
MSH

A rare skin disorder of unknown etiology affecting children. It is a photodermatitis, characterized by the formation of vesicles and scarring on sun exposed areas.
NCI

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aminy

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

group of compounds derived from ammonia by substituting organic radicals for the hydrogens.
CSP

A class of organic compounds that contain nitrogen as the pivotal atom for functional groups. There are several different types of amines and the class is extensive.
NCI

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neovaskularizace patologická

A pathologic process consisting in proliferation of blood vessels in abnormal tissues or in abnormal positions.
MSH

The formation of new or recent blood vessels. The vasculature network is critical to the development of neoplasms. As the tumor burden grows, vascular endothial cells are recruited to form new blood vessels as an increased demand for blood and nourishment is required.
NCI

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citráty

citric acid, its salts or esters; found in citrus fruits; an intermediate in the Krebs cycle; used as an anticoagulant for stored blood specimens.
CSP

A salt or ester of citric acid.
NCI

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receptory somatotropinu

Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
MSH

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hydroquinone

1,4-dihydroxybenzene.
CSP

Produced as an inhibitor, an antioxidant, and an intermediate in the synthesis of dyes, motor fuels, and oils; in photographic processing; and naturally in certain plant species, Hydroquinone is a phenol derivative with antioxidant properties that can cause toxicity in several organs, notably the kidney. Used as a topical treatment for skin hyperpigmentation and in various cosmetic products, it is metabolized mainly to glutathione conjugates and forms mutagenic DNA adducts in in-vitro systems. (NCI04)
NCI

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porfobilinogensynthasa

An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.
MSH

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nervový systém – nemoci

Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
MSH

Any deviation from the normal structure or function of the nervous system that is manifested by a characteristic set of symptoms and signs. (NCI)
NCI

impairment of health or a condition of abnormal functioning of the nervous system.
CSP

Any deviation from the normal structure or function of the nervous system that is manifested by a characteristic set of symptoms and signs.
NCI

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klinické praxe

Undergraduate education programs for second- , third- , and fourth-year students in health sciences in which the students receive clinical training and experience in teaching hospitals or affiliated health centers.
MSH

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Reduviidae

A family of winged insects of the suborder HETEROPTERA, called assassin bugs, because most prey on other insects. However one subfamily, TRIATOMINAE, attacks humans and other vertebrates and transmits Chagas disease.
MSH

family of winged insects of the suborder Heteroptera, called assassin bugs, because most prey on other insects; however one subfamily, Triatominae, attacks humans and other vertebrates and transmits Chagas disease.
CSP

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hydroxyprolin

A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
MSH

C5H9NO3; amino acid derived from proline, found in collagen and gelatin.
CSP

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Amoeba

A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.
MSH

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