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mopidamol

A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic.
MSH

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alternativní sestřih

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
MSH

Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
NCI

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hemosideróza

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
MSH

conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage.
CSP

Accumulation of iron in internal organs.
NCI

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corpora allata

Paired or fused ganglion-like bodies in the head of insects. The bodies secrete hormones important in the regulation of metamorphosis and the development of some adult tissues.
MSH

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Raynaudův fenomén

WHAT: Raynaud`s phenomenon.
AIR

A set of symptoms characteristic of peripheral vascular disease, namely caused by an inappropriate response of the peripheral arteries in reaction to environmental stimuli, usually to the cold. The term is used when an underlying disease (mostly connective tissue/autoimmune disorders such as lupus, scleroderma, rheumatoid arthritis, etc.) is primarily causative and a range of symptoms including the peripheral vascular spasm is secondary. The term does not refer to the primary Raynaud`s or Raynaud`s disease.
NCI

Intermittent bilateral attacks of ischemia of the fingers or toes and sometimes of the ears or nose, marked by severe pallor, and often accompanied by paresthesia and pain.
NCI

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anémie sideroblastická

Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.
MSH

acquired or hereditary anemia marked by sideroblasts: bone marrow cells with large mitochondrial deposits of insoluble iron due to defective heme synthesis, leading to ineffective erythropoiesis.
CSP

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film jako téma

The art, technique, or business of producing motion pictures for entertainment, propaganda, or instruction.
MSH

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Ambystoma mexicanum

A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
MSH

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virus hepatitidy B kachen

A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
MSH

DNA virus that closely resembles human hepatitis B virus; it has been recovered from naturally infected ducks; do not confuse with Duck Hepatitis Virus 1 or 2, which is a picornavirus.
CSP

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kotinin

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
MSH

The major metabolite of nicotine.
NCI

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receptory opiátové

Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
MSH

family of cell surface receptors which mediate opiate drug effects on neurons, lymphocytes, macrophages, and other cells; may or may not coincide with neuropeptide receptors; some are G protein coupled to calcium channel inhibition.
CSP

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angiografie

radiography of blood vessels after injection of a contrast medium.
CSP

A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray.
NCI

An x-ray of blood vessels. The person receives an injection of dye to outline the vessels on the x-ray.
NCI

The X-ray examination of the blood vessels or chambers of the heart.
NCI

An X-ray representation of blood vessels made after the injection of a radiopaque substance.
NCI

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mRNA Precursor

newly transcribed RNA fully complementary to the DNA sequence of structural genes; this component of the spliceosome and hnRNA is spliced, 5` capped, 3` polyadenylated, transported to the cytoplasm as mature mRNA, and translated.
CSP

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aminy

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

group of compounds derived from ammonia by substituting organic radicals for the hydrogens.
CSP

A class of organic compounds that contain nitrogen as the pivotal atom for functional groups. There are several different types of amines and the class is extensive.
NCI

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hernie femorální

A groin hernia occurring inferior to the inguinal ligament and medial to the FEMORAL VEIN and FEMORAL ARTERY. The femoral hernia sac has a small neck but may enlarge considerably when it enters the subcutaneous tissue of the thigh. It is caused by defects in the ABDOMINAL WALL.
MSH

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kraniologie

The scientific study of variations in size, shape, and proportion of the cranium.
MSH

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receptory somatotropinu

Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
MSH

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práva zvířat

The moral and ethical bases of the protection of animals from cruelty and abuse. The rights are extended to domestic animals, laboratory animals, and wild animals.
MSH

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multivariační analýza

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
MSH

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porfobilinogensynthasa

An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.
MSH

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heterosexualita

The sexual attraction or relationship between members of the opposite SEX.
MSH

A sexual attraction to members of the opposite sex. (WordNet)
NCI

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kritický stav

A disease or state in which death is possible or imminent.
MSH

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Reduviidae

A family of winged insects of the suborder HETEROPTERA, called assassin bugs, because most prey on other insects. However one subfamily, TRIATOMINAE, attacks humans and other vertebrates and transmits Chagas disease.
MSH

family of winged insects of the suborder Heteroptera, called assassin bugs, because most prey on other insects; however one subfamily, Triatominae, attacks humans and other vertebrates and transmits Chagas disease.
CSP

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anorexie

The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
MSH

clinical manifestation consisting of a physiopathological lack or loss of appetite accompanied by an aversion to food and the inability to eat.
CSP

An abnormal loss of the appetite for food. Anorexia can be caused by cancer, AIDS, a mental disorder (i.e., anorexia nervosa), or other diseases.
NCI

A disorder characterized by a loss of appetite.
NCI

Loss of appetite.
NCI

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svalové dystrofie

A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
MSH

general term for a group of inherited disorders which are characterized by progressive degeneration of skeletal muscles.
CSP

Muscular dystrophy (MD) refers to a group of more than 30 inherited diseases that cause muscle weakness and muscle loss. Some forms of MD appear in infancy or childhood, while others may not appear until middle age or later. The different muscular dystrophies vary in who they affect and the symptoms. All forms of MD grow worse as the person`s muscles get weaker. Most people with MD eventually lose the ability to walk.

There is no cure for muscular dystrophy. Treatments include physical and speech therapy, orthopedic devices, surgery and medications. Some people with muscular dystrophy have mild cases that worsen slowly. Other cases are disabling and severe.

NIH: National Institute of Neurological Disorders and Stroke


MEDLINEPLUS

A group of inherited progressive muscle disorders characterized by muscle weakness and eventual death of the muscle tissues. Examples include Duchenne muscular dystrophy, Becker`s muscular dystrophy, Emery-Dreifuss muscular dystrophy, facioscapulohumeral muscular dystrophy, and limb-girdle muscular dystrophy.
NCI

an inherited disease where skeletal muscles are progressively weakened and wasted.
CHV

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Amoeba

A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.
MSH

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vysokofrekvenční proudová ventilace

Respiratory support system used primarily with rates of about 100 to 200/min with volumes of from about one to three times predicted anatomic dead space. Used to treat respiratory failure and maintain ventilation under severe circumstances.
MSH

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Cryptococcus

mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium.
CSP

A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
MSH

A genus of fungi in the phylum Basidiomycota that grows in culture as an encapsulated yeast. Its sexual form is called Filobasidiella and its asexual form is called Cryptococcus.
NCI

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vládní regulace

Exercise of governmental authority to control conduct.
MSH

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antropologie fyzická

The comparative science dealing with the physical characteristics of humans as related to their origin, evolution, and development in the total environment.
MSH

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