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galaktosylceramidy

Cerebrosides which contain as their polar head group a galactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in beta-galactosidase, is the cause of galactosylceramide lipidosis or globoid cell leukodystrophy.
MSH

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musculus stapedius

A tiny muscle that arises from the posterior wall of the TYMPANIC CAVITY of MIDDLE EAR with its tendon inserted onto the neck of the STAPES. Stapedius pulls the stapes posteriorly and controls its movement.
MSH

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kyanatany

organic salts of cyanic acid containing the -OCN radical.
CSP

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fagocyty – baktericidní dysfunkce

disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.
CSP

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protilátky – rozmanitost

The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
MSH

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virus lymfocytární choriomeningitidy

The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.
MSH

type species of Arenavirus, part of the Old World Arenaviruses etiologic agent of lymphocytic choriomeningitis; occurs naturally in mice, dogs and monkeys.
CSP

A species of single-stranded, negative-sense RNA viruses in the genus arenavirus and family arenaviridae. It is spread by rodents and causes meningitis and encephalitis.
NCI

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gamma1-MSH

The 11-residue peptide that is fully amidated.
MSH

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stearyl-CoA desaturasa

An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor.
MSH

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cyclopropane

C3H6; a flammable moderately toxic narcotic colorless gas used in organic synthesis and as an anesthetic.
CSP

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fenazocin

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)
MSH

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antigeny diferenciační B-lymfocytární

Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
MSH

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Macaca

large genus of Old World monkeys (family Cercopithecidae) that includes the macaque and rhesus monkeys, and the Barbary apes; Macaca mulatta, the rhesus monkey, is used as a research animal.
CSP

A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.
MSH

Any of several species of short-tailed monkeys of the genus Macacus.
NCI

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žaludek – píštěl

Abnormal passage communicating with the STOMACH.
MSH

abnormal passage communicating with the stomach; often applied to an artificially created opening through the abdominal wall into the stomach (gastrostoma).
CSP

An abnormal communication between the stomach and another organ or anatomic site.
NCI

A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.
NCI

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Stevensův-Johnsonův syndrom

A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.
MSH

A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. The lesions may appear anywhere in the body but they occur more commonly in the palms, soles, dorsum of the hands, and extensor surfaces. The lesions are vesicular or necrotic in the center, surrounded by an erythematous zone and occupy less than 10% of the body surfaces. The appearance of the mucocutaneous lesions is preceded by an upper respiratory tract infection. It is an immune complex hypersensitivity reaction usually caused by drugs (e.g., sulfa, phenytoin, penicillin), viruses (e.g., herpes simplex, influenza, hepatitis), and malignancies (e.g., carcinoma and lymphoma).
NCI

A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
NCI

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cysteinproteinasy – inhibitory

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
MSH

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fenylbutyráty

cytostatic, apoptosis inducing agent; effects cell differentiation.
CSP

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antitumorózní kombinovaná chemoterapie – protokoly

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
MSH

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magnetická rezonanční tomografie

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
MSH

non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images; concept includes proton spin tomographic techniques.
CSP

A procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and diseased tissue. NMRI makes better images of organs and soft tissue than other scanning techniques, such as computed tomography (CT) or x-ray. NMRI is especially useful for imaging the brain, the spine, the soft tissue of joints, and the inside of bones.
NCI

Magnetic resonance imaging (MRI) uses a large magnet and radio waves to look at organs and structures inside your body. Health care professionals use MRI scans to diagnose a variety of conditions, from torn ligaments to tumors. MRIs are very useful for examining the brain and spinal cord.

During the scan, you lie on a table that slides inside a tunnel-shaped machine. Doing the scan can take a long time, and you must stay still. The scan is painless. The MRI machine makes a lot of noise. The technician may offer you earplugs.

Before you get a scan, tell your doctor if you

  • Are pregnant
  • Have pieces of metal in your body. You might have metal in your body if you have a shrapnel or bullet injury or if you are a welder
  • Have electronic devices in your body, such as a cardiac pacemaker


MEDLINEPLUS

Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.
NCI

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Gaucherova nemoc

An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
MSH

autosomal recessive disorder caused by deficiency of the enzyme glucocerebrosidase featuring the pathological storage of glycosylceramide in mononuclear phagocytes; the most common subtype is the non-neuronopathic form, a slowly progressive condition characterized by hepatosplenomegaly and skeletal deformities; the neuronopathic forms are divided into infantile and juvenile forms; the infantile form presents at 4-5 months of age with anemia, loss of cognitive gains, neck retraction, dysphagia, and hepatosplenomegaly; the juvenile form features a slowly progressive loss of intellect, hepatosplenomegaly, ataxia, myoclonic seizures, and spasticity; the neuronopathic forms are characterized by neuronal loss with neuronophagia, and accumulation of glucocerebroside in neurons.
CSP

An inherited lysosomal storage disease caused by deficiency of the enzyme glucocerebrosidase. It results in the accumulation of a fatty substance called glucocerebroside in mononuclear cells in the bone marrow, liver, spleen, brain, and kidneys. Signs and symptoms include hepatomegaly, splenomegaly, neurologic disorders, lymphadenopathy, skeletal disorders, anemia and thrombocytopenia.
NCI

Gaucher`s disease is a rare, inherited disorder that causes too much of a substance called glucocerebroside to build up in your spleen, liver, lungs, bones and sometimes in your brain. The buildup prevents these organs from working properly.

There are three types:

  • Type 1, the most common form, causes liver and spleen enlargement, bone pain and broken bones, and, sometimes, lung and kidney problems. It does not involve the brain. It can occur at any age.
  • Type 2, which causes severe brain damage, appears in infants. Most children who have it die by age 2.
  • In type 3, there may be liver and spleen enlargement, and signs of brain involvement appear gradually.

Gaucher`s disease has no cure. Treatment options for types 1 and 3 include medicine and enzyme replacement therapy, which is usually very effective. There is no good treatment for the brain damage of type 2.

NIH: National Institute of Neurological Disorders and Stroke


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Lactococcus lactis

A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.
MSH

A species of Gram positive, cocci shaped, lactic acid bacteria assigned to the phylum Firmicutes. This species is nonmotile, catalase negative, nonsporulating and produces lactic acid from lactose fermentation. L lactis may be an opportunistic pathogen in humans and animals. Most significantly this microorganism is used commercially in the production of buttermilk and cheese.
NCI

Any bacterial organism that can be assigned to the species Lactococcus lactis.
NCI

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cytochromy b

cytochromes of the b group that have alpha-band absorption of 563-564 nm and occur as subunits in mitochondrial electron transport complex III.
CSP

Cytochromes of the b group that have alpha-band absorption of 563-564 nm. They occur as subunits in MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III.
MSH

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flebitida

Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).
MSH

A disorder characterized by inflammation of the wall of a vein.
NCI

Inflammation (redness, swelling, pain, and heat) of a vein, usually in the legs. Phlebitis may be caused by infection, injury, or irritation.
NCI

Inflammation of a vein.
NCI

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anus – nemoci

The anus is the opening of the rectum through which stool passes out of your body. Problems with the anus are common. They include hemorrhoids, abscesses, fissures (cracks), and cancer.

Many people are embarrassed to talk about anal troubles. But seeing your doctor about problems in this area is important. This is especially true if you have pain or bleeding. Treatments vary widely depending on the particular problem.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

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maligní hypertermie

Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.
MSH

usually inherited reaction to general anesthesia manifested as a sudden, rapid rise in temperature, hypermetabolism, and skeletal muscle rigidity; mutation is in the calcium release channel of skeletal muscle sarcoplasmic reticulum.
CSP

A rare disorder characterized by rapid rise of the body temperature, accompanied by rhabdomyolysis and, if untreated, by collapse and death. It occurs in susceptible individuals who receive certain drugs for general anesthesia, gas anesthetics, or succinylcholine. It may be inherited in an autosomal dominant pattern.
NCI

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genová přestavba

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
MSH

covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.
CSP

Any DNA sequence rearrangement that results in the creation of a novel protein-coding capacity. Within certain genes, gene rearrangement is a normal part of development, facilitating the affinity maturation of B and T lymphocytes as well as class switching of immunoglobulins.
NCI

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Strongyloides

A genus of parasitic nematodes widely distributed as intestinal parasites of mammals.
MSH

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cytoplazma

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
MSH

protoplasm of a cell exclusive of that of the nucleus; it consists of a continuous aqueous solution (cytosol) and the organelles and inclusions suspended in it (phaneroplasm), and is the site of most of the chemical activities of the cell.
CSP

The fluid inside a cell but outside the cell`s nucleus. Most chemical reactions in a cell take place in the cytoplasm.
NCI

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO

Cell component which has as its direct parts a portion of cytosol and one or more organelles. Examples: cytoplasm of hepatocyte, cytoplasm of erythrocyte, cytoplasm of thrombocyte, cytoplasm of neuron.
FMA

Cell substance which consists of cytosol and cytoplasmic organelles.
UWDA

That portion of the cell contained within the plasma membrane but excluding the nucleus.
NCI

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fosfatidylseriny

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
MSH

derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety.
CSP

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afázie

A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.
MSH

cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form; caused by diseases which affect the language areas of the dominant hemisphere; general categories include receptive, expressive, and mixed forms of aphasia.
CSP

Aphasia is a disorder caused by damage to the parts of the brain that control language. It can make it hard for you to read, write and say what you mean to say. It is most common in adults who have had a stroke. Brain tumors, infections, injuries and dementia can also cause it. The type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is.

There are four main types:

  • Expressive aphasia – you know what you want to say, but you have trouble saying or writing what you mean
  • Receptive aphasia – you hear the voice or see the print, but you can`t make sense of the words
  • Anomic aphasia – you have trouble using the correct word for objects, places or events
  • Global aphasia – you can`t speak, understand speech, read or write

Some people recover from aphasia without treatment. Most, however, need language therapy as soon as possible.

NIH: National Institute of Neurological Disorders and Stroke


MEDLINEPLUS

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mandibula – poranění

Injuries to the lower jaw bone.
MSH

Your jaw is a set of bones that holds your teeth. It consists of two main parts. The upper part is the maxilla. It doesn`t move. The moveable lower part is called the mandible. You move it when you talk or chew. The two halves of the mandible meet at your chin. The joint where the mandible meets your skull is the temporomandibular joint.

Jaw problems include

Treatment of jaw problems depends on the cause.


MEDLINEPLUS

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