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náhodné rozdělení

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
MSH

When referring to an experiment or clinical trial, the process by which animal or human subjects are assigned by chance to separate groups that compare different treatments or other interventions. Randomization gives each participant an equal chance of being assigned to any of the groups.
NCI

The process of assigning trial subjects to treatment or control groups using an element of chance to determine the assignments in order to reduce bias. NOTE: Unequal randomization is used to allocate subjects into groups at a differential rate; for example, three subjects may be assigned to a treatment group for every one assigned to the control group. [ICH E6 1.48] See also balanced study. (CDISC glossary)
NCI

The allocation of individuals to groups by chance, especially in order to control the variables in an experiment.
NCI

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mopidamol

A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic.
MSH

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poruchy vylučování

Excretory-related psychiatric disorders usually diagnosed in infancy or childhood.
MSH

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alternativní sestřih

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
MSH

Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
NCI

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hemosideróza

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
MSH

conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage.
CSP

Accumulation of iron in internal organs.
NCI

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buspiron

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to DIAZEPAM.
MSH

8-(4-(2-pyrimidinyl)-1-piperazinyl) butyl-8-azaspirodecane-7,9- dione; serotonergic tranquilizer frequently contrasted with benzodiazepine-type, GABAergic tranquilizers.
CSP

An anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects.
NCI

A drug that is used to treat certain anxiety disorders. It belongs to the family of drugs called antianxiety agents.
NCI

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Raynaudův fenomén

WHAT: Raynaud`s phenomenon.
AIR

A set of symptoms characteristic of peripheral vascular disease, namely caused by an inappropriate response of the peripheral arteries in reaction to environmental stimuli, usually to the cold. The term is used when an underlying disease (mostly connective tissue/autoimmune disorders such as lupus, scleroderma, rheumatoid arthritis, etc.) is primarily causative and a range of symptoms including the peripheral vascular spasm is secondary. The term does not refer to the primary Raynaud`s or Raynaud`s disease.
NCI

Intermittent bilateral attacks of ischemia of the fingers or toes and sometimes of the ears or nose, marked by severe pallor, and often accompanied by paresthesia and pain.
NCI

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film jako téma

The art, technique, or business of producing motion pictures for entertainment, propaganda, or instruction.
MSH

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náhlé příhody – terapie

First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
MSH

Description:Provision of emergency healthcare .


HL7V3.0

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Ambystoma mexicanum

A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
MSH

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virus hepatitidy B kachen

A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
MSH

DNA virus that closely resembles human hepatitis B virus; it has been recovered from naturally infected ducks; do not confuse with Duck Hepatitis Virus 1 or 2, which is a picornavirus.
CSP

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mrtvola

A dead body, usually a human body.
MSH

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receptory opiátové

Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
MSH

family of cell surface receptors which mediate opiate drug effects on neurons, lymphocytes, macrophages, and other cells; may or may not coincide with neuropeptide receptors; some are G protein coupled to calcium channel inhibition.
CSP

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mRNA Precursor

newly transcribed RNA fully complementary to the DNA sequence of structural genes; this component of the spliceosome and hnRNA is spliced, 5` capped, 3` polyadenylated, transported to the cytoplasm as mature mRNA, and translated.
CSP

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viry encefalitidy

A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.
MSH

collection of single stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.
CSP

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aminy

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

group of compounds derived from ammonia by substituting organic radicals for the hydrogens.
CSP

A class of organic compounds that contain nitrogen as the pivotal atom for functional groups. There are several different types of amines and the class is extensive.
NCI

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hernie femorální

A groin hernia occurring inferior to the inguinal ligament and medial to the FEMORAL VEIN and FEMORAL ARTERY. The femoral hernia sac has a small neck but may enlarge considerably when it enters the subcutaneous tissue of the thigh. It is caused by defects in the ABDOMINAL WALL.
MSH

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šťavelan vápenatý

The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.
MSH

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receptory somatotropinu

Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
MSH

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multivariační analýza

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
MSH

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endokrinní žlázy – nádory

Tumors or cancer of the ENDOCRINE GLANDS.
MSH

new abnormal endocrine gland tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. –2003
NCI

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porfobilinogensynthasa

An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.
MSH

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heterosexualita

The sexual attraction or relationship between members of the opposite SEX.
MSH

A sexual attraction to members of the opposite sex. (WordNet)
NCI

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kalsequestrin

Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.
MSH

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Reduviidae

A family of winged insects of the suborder HETEROPTERA, called assassin bugs, because most prey on other insects. However one subfamily, TRIATOMINAE, attacks humans and other vertebrates and transmits Chagas disease.
MSH

family of winged insects of the suborder Heteroptera, called assassin bugs, because most prey on other insects; however one subfamily, Triatominae, attacks humans and other vertebrates and transmits Chagas disease.
CSP

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svalové dystrofie

A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
MSH

general term for a group of inherited disorders which are characterized by progressive degeneration of skeletal muscles.
CSP

Muscular dystrophy (MD) refers to a group of more than 30 inherited diseases that cause muscle weakness and muscle loss. Some forms of MD appear in infancy or childhood, while others may not appear until middle age or later. The different muscular dystrophies vary in who they affect and the symptoms. All forms of MD grow worse as the person`s muscles get weaker. Most people with MD eventually lose the ability to walk.

There is no cure for muscular dystrophy. Treatments include physical and speech therapy, orthopedic devices, surgery and medications. Some people with muscular dystrophy have mild cases that worsen slowly. Other cases are disabling and severe.

NIH: National Institute of Neurological Disorders and Stroke


MEDLINEPLUS

A group of inherited progressive muscle disorders characterized by muscle weakness and eventual death of the muscle tissues. Examples include Duchenne muscular dystrophy, Becker`s muscular dystrophy, Emery-Dreifuss muscular dystrophy, facioscapulohumeral muscular dystrophy, and limb-girdle muscular dystrophy.
NCI

an inherited disease where skeletal muscles are progressively weakened and wasted.
CHV

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endotel cévní

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen; this function has been most intensively studied in the blood capillaries.
MSH

single pavement layer of cells which line the luminal surface of the cardiovascular system and regulate the transport of macromolecules and blood components from interstitium to lumen.
CSP

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen. (MeSH)
NCI

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Amoeba

A genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several lodopodia, one of which is dominant at a given time. Reproduction occurs asexually by binary fission.
MSH

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vysokofrekvenční proudová ventilace

Respiratory support system used primarily with rates of about 100 to 200/min with volumes of from about one to three times predicted anatomic dead space. Used to treat respiratory failure and maintain ventilation under severe circumstances.
MSH

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kanibalismus

Eating other individuals of one`s own species.
MSH

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