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elastin

collagen-like, elastic protein found in yellow connective tissue.
CSP

Elastin (786 aa, ~68 kDa) is encoded by the human ELN gene. This protein is involved in the elasticity of the extracellular matrix.
NCI

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nucleus ruber

A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.
MSH

pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum receiving a large projection from the contralateral half of the cerebellum via the superior cerebellar peduncle and a projection from the ipsilateral motor cortex.
CSP

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interleukin-1

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
MSH

macrophage produced interleukin that induces the production of interleukin 2 by T cells that have been stimulated by antigen or mitogen; at least two types, alpha and beta, exist; interleukin 1 or a similar protein is also produced by epithelial cells and stimulates fibroblast proliferation and release of proteolytic enzymes and prostaglandins in inflammatory processes.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1 is made mainly by one type of white blood cell, the macrophage, and helps another type of white blood cell, the lymphocyte, fight infections. It also helps leukocytes pass through blood vessel walls to sites of infection and causes fever by affecting areas of the brain that control body temperature. There are two forms of IL-1, alpha and beta, which act the same. IL-1 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. IL-1 is a type of cytokine.
NCI

Human interleukin-1 protein (271 aa, 31 kD precursor) is encoded by the human interleukin-1 (IL1) gene. This soluble protein is produced primarily by monocytes and macrophages. It activates and potentiates T-lymphocyte responses to mitogens or antigens. This protein is also capable of replacing macrophage requirements for T-cell activation
NCI

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bronchopulmonální sekvestrace

A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.
MSH

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epirubicin

An anthracycline which is the 4`-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
MSH

A 4`-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
NCI

A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.
NCI

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amodiachin

A 4-aminoquinoline compound with anti-inflammatory properties.
MSH

An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.
NCI

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mikroanalýza elektronovou sondou

Identification and measurement of ELEMENTS and their location based on the fact that X-RAYS emitted by an element excited by an electron beam have a wavelength characteristic of that element and an intensity related to its concentration. It is performed with an electron microscope fitted with an x-ray spectrometer, in scanning or transmission mode.
MSH

identification and measurement of concentration of elements based on the fact that primary-emission x-rays emitted by an element excited by an electron beam have a wavelength characteristic of that element and an intensity related to its concentration; may be performed by an electron probe microanalyzer, an electron microscope microanalyzer, or by an electron microscope, or scanning electron microscope, fitted with an x-ray spectrometer.
CSP

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regresní analýza

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
MSH

Regression analysis provides a “best-fit” mathematical equation for the relationship between the dependent variable (response) and independent variable(s) (covariates). There are two major classes of regression – parametric and non-parametric. Parametric regression requires choice of the regression equation with one or a greater number of unknown parameters. Linear regression, in which a linear relationship between the dependent variable and independent variables is posited, is an example. The aim of parametric regression is to find the values of these parameters which provide the best fit to the data. The number of parameters is usually much smaller than the number of data points. In contrast, the non-parametric regression requires no such a choice of the regression equation. (Statistics.com Glossary)
NCI

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meziobratlová ploténka

plates of fibrocartilage found between the bodies of adjacent vertebrae in the spine, each consisting of a fibrous ring enclosing a pulpy center.
CSP

Spongy discs located between the vertebrae of the spinal column; composed of the outer annulus fibrosus and inner nucleus pulposus.
NCI

Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.
MSH

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bulimia

Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as “ox hunger”.
MSH

A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image.
NCI

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erbium

Erbium. An element of the rare earth family of metals. It has the atomic symbol Er, atomic number 68, and atomic weight 167.26.
MSH

An element with atomic symbol Er, atomic number 68, and atomic weight 167.259.
NCI

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amyloidóza

A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
MSH

any disease manifested by the pathogenic accumulation of amyloid in organs and tissues.
CSP

A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.
NCI

A group of diseases in which protein is deposited in specific organs or throughout the body.
CHV

Amyloidosis occurs when abnormal proteins build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

There are three main types of amyloidosis:

  • Primary – with no known cause
  • Secondary – caused by another disease, including some types of cancer
  • Familial – passed down through genes

Treatment depends on the type of amyloidosis you have.


MEDLINEPLUS

A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
NCI

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určení vhodnosti pacienta

Criteria to determine eligibility of patients for medical care programs and services.
MSH

The act of determining if a subject is suitable for enrollment in a study according specific protocol criteria and procedures.
NCI

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nemocnice náboženských organizací

Private hospitals that are owned or sponsored by religious organizations.
MSH

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nitroděložní antikoncepční prostředky – vypuzení

Spontaneous loss of INTRAUTERINE DEVICES from the UTERUS.
MSH

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buserelin

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.
MSH

An anticancer drug that belongs to the family of drugs called gonadotropin-releasing hormones. In prostate cancer therapy, buserelin blocks the production of testosterone in the testicles.
NCI

A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39170&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39170&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C320″ NCI Thesaurus)
PDQ

A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)
NCI

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erytroblasty

Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.
MSH

Red blood cells that are at the last stage of development, still containing a nucleus, that are found in the bone marrow and occasionally in the peripheral blood.
NCI

An immature, nucleated erythrocyte occupying the stage of erythropoiesis that follows formation of erythroid progenitor cells and precedes formation of reticulocytes.
NCI

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anatomy & histology (qualifier)

Used with organs, regions, and tissues for normal descriptive anatomy and histology, and for the normal anatomy and structure of animals and plants.
MSH

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urgentní služby psychiatrické

Organized services to provide immediate psychiatric care to patients with acute psychological disturbances.
MSH

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reprodukce nepohlavní

Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from “parent” cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).
MSH

The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process. [ISBN:0387520546]
GO

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jodofory

Complexes of iodine and non-ionic SURFACE-ACTIVE AGENTS acting as carrier and solubilizing agent for the iodine in water. Iodophors usually enhance bactericidal activity of iodine, reduce vapor pressure and odor, minimize staining, and allow wide dilution with water. (From Merck Index, 11th ed)
MSH

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kyselina kakodylová

An arsenical that has been used as a dermatologic agent and as an herbicide.
MSH

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divertikly jícnu

Saccular protrusion beyond the wall of the ESOPHAGUS.
MSH

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virus západní encefalitidy koňské

A species of ALPHAVIRUS that is the etiologic agent of encephalomyelitis in humans and equines in the United States, southern Canada, and parts of South America.
MSH

species of Alphavirus that is the etiologic agent of encephalomyelitis in humans and equines in the United States, southern Canada, and parts of South America.
CSP

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dýchání – mechanika

The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
MSH

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iridoviry

A family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus; Megalocytivirus; and Lymphocystivirus.
MSH

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vápník – poruchy metabolismu

Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
MSH

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estrany

A group of compounds forming the nucleus of the estrogenic steroid family.
MSH

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endokrinní systém – nemoci

impairment of health or a condition of abnormal functioning of the system of glands that release their secretions (hormones) directly into the circulatory system.
CSP

Any deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs. (NCI)
NCI

Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include

  • Growth and development
  • Metabolism – digestion, elimination, breathing, blood circulation and maintaining body temperature
  • Sexual function
  • Reproduction
  • Mood

If your hormone levels are too high or too low, you may have a hormone disorder. Hormone diseases also occur if your body does not respond to hormones the way it is supposed to. Stress, infection and changes in your blood`s fluid and electrolyte balance can also influence hormone levels.

In the United States, the most common endocrine disease is diabetes. There are many others. They are usually treated by controlling how much hormone your body makes. Hormone supplements can help if the problem is too little of a hormone.


MEDLINEPLUS

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
MSH

Any deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs.
NCI

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arteria retinalis

Central retinal artery and its branches. It arises from the ophthalmic artery, pierces the optic nerve and runs through its center, enters the eye through the porus opticus and branches to supply the retina.
MSH

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