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androsteny

Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.
MSH

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psychofyziologie

The study of the physiological basis of human and animal behavior.
MSH

branch of psychology which experimentally investigates the physiological basis of behavior, including anatomical structures, psychological processes, and mental functions.
CSP

The branch of psychology concerned with the physiological basis of behavior.
NCI

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midodrin

An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
MSH

A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
NCI

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srdeční frekvence fetální

The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
MSH

The number of fetal cardiac beats per minute.
NCI

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kortison

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
MSH

naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol.
CSP

A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses.
NCI

A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat.
NCI

A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation.
NCI

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adenosindifosfátglukosa

Serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants.
MSH

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anestézie inhalační

Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
MSH

state characterized by loss of feeling or sensation caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
CSP

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veřejné zubní lékařství

A dental specialty concerned with the prevention of disease and the maintenance of oral health through promoting organized dental health programs at a community, state, or federal level.
MSH

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Minocycline Hydrochloride

The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline`s neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.
NCI

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Hela buňky

first continuously cultured human malignant cell line, derived from a cervical carcinoma; used for virus cultivation and antitumor drug screening assays.
CSP

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
MSH

HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences. P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported. M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5. M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns.
NCI

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Professional counsellor

A provider who is trained and educated in the performance of behavior health services through interpersonal communications and analysis. Training and education at the specialty level usually requires a master`s degree and clinical experience and supervision for licensure or certification. Sources: Abridged from definitions provided by the National Board of Certified Counselors and the American Association of Pastoral Counselors.


HL7V3.0

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adjuvancia imunologická

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund`s adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
MSH

A drug that stimulates the immune system to respond to disease.
NCI

a drug that stimulates the immune system
CHV

A substance that increases the ability of the immune system to fight infection and disease.
NCI

Substances that stimulate the immune system.
NCI

Adjuvants are mostly pharmacological agents of drug or biological origin used to modify the antigenicity of immunization components, i.e., to stimulate, potentiate, or depress the immune response or to inhibit or enhance specific subclasses of immunocytes. Adjuvants augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. Classical agents (Freund`s adjuvant, BCG, Corynebacterium parvum) contain bacterial antigens. Some adjuvants are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a variety of antigens, or antigen-specific, affecting a restricted type of immune response to a narrow group of antigens. Since adjuvants enhance the body`s immune response, they can be considered a type of immune modulator.
NCI

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Angiostrongylus

A genus of parasitic nematodes of the superfamily METASTRONGYLOIDEA. Two species, ANGIOSTRONGYLUS CANTONENSIS and A. vasorum, infest the lungs of rats and dogs, respectively. A. cantonensis is transmissible to man where it causes frequently fatal infection of the central nervous system.
MSH

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plicní surfaktanty

Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
MSH

phospholipids secreted by the great alveolar cells into alveoli and respiratory air passages which contributes to the elastic property of pulmonary tissue.
CSP

Secretion produced by Type 2 pulmonary alveolar cell.
FMA

Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis. (NCI)
NCI

Secretion produced by Type 2 pulmonary alveolar cell.
UWDA

Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis.
NCI

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mitóza

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
MSH

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division. [GOC:dph, GOC:mah, ISBN:0815316194]
GO

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
GO

The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. It is divided into Prophase, Metaphase, Anaphase, and Telophase.
NCI

The process by which a single parent cell divides to make two new daughter cells. Each daughter cell receives a complete set of chromosomes from the parent cell. This process allows the body to grow and replace cells.
NCI

The usual process of somatic reproduction of cells consisting of a sequence of modifications of the nucleus that result in the formation of two daughter cells with exactly the same chromosome and DNA content as that of the original cell. It is the process by which the body grows and replaces cells and is divided into four phases. In Prophase, paired chromosomes form, nuclear membrane disappears, the achromatic spindle appears, and polar bodies form. In Metaphase, chromosomes are arranged in the equatorial plane of the central spindle to form the monaster and chromosomes separate into exactly similar halves. In Anaphase, the two groups of daughter chromosomes separate and move along the fibers of the central spindle, each toward one of the asters, forming the diaster. In Telophase, the daughter chromosomes resolve themselves into a reticulum, the daughter nuclei are formed, and the cytoplasm divides forming two complete daughter cells.
NCI

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hematochezie

The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.
MSH

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kreatinkinasa – forma MM

An isoenzyme of creatine kinase found in the MUSCLE.
MSH

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nadledviny – nemoci

Pathological processes of the ADRENAL GLANDS.
MSH

pathologic condition or abnormal functioning of either or both of the paired glands situated in the retroperitoneal tissues at the superior pole of the kidneys or adrenal glands.
CSP

Your adrenal, or suprarenal, glands are located on the top of each kidney. These glands produce hormones that you can`t live without, including sex hormones and cortisol, which helps you respond to stress and has many other functions.

Adrenal disorders can cause your adrenal glands to make too much or not enough hormones. With Cushing`s syndrome, there`s too much cortisol, while with Addison`s disease, there is too little. Some people are born unable to make enough cortisol. Tumors can also cause disorders in your adrenal glands. Bleeding and infection can cause an adrenal gland problem that can be fatal without quick treatment.

Treatment depends on which problem you have. Surgery or medicines can treat many adrenal gland disorders.


MEDLINEPLUS

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zvířata divoká

Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.
MSH

animals considered to be wild or feral or not adapted for domestic use; prefer indexing specific animal, treed elsewhere, when possible.
CSP

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puromycinaminonukleosid

PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis.
MSH

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Moldavsko

A country in Eastern Europe, northeast of Romania. (NCI)
NCI

A country in Eastern Europe, northeast of Romania. (CIA World Factbook 2002)
NCI

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hemochromatóza

WHAT: Hemochromatosis: Hemochromatosis: a disorder of iron metabolism characterized by excess deposition of iron in the tissues, especially the liver. It is characterized by pigmentation of the skin, hepatic cirrhosis, decreased carbohydrate tolerance, cardiomyopathy and endocrinopathy (especially hypogonadism). Mainly seen in men over the age of 40 years. It has an associated arthropathy distinguished by involvement of the metacarpophalangeal joints (particularly the second and third), wrists, knees, shoulders, and hips. There is often an associated chondrocalcinosis.
AIR

A disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary. Full development of the disease in women is restricted by menstruation, pregnancy, and lower dietary intake of iron. Acquired hemochromatosis may be the result of blood transfusions, excessive dietary iron, or secondary to other disease. Idiopathic or genetic hemochromatosis is an autosomal recessive disorder of metabolism associated with a gene tightly linked to the A locus of the HLA complex on chromosome 6. (From Dorland, 27th ed)
MSH

condition in which there is a deviation or interruption in the storage of iron in the body.
CSP

Hemochromatosis is an inherited disease in which too much iron builds up in your body. It is one of the most common genetic diseases in the United States.

Iron is a mineral found in many foods. Your body normally absorbs about 10 percent of the iron in the food you eat. If you have hemochromatosis, you absorb more iron than you need. Your body has no natural way to get rid of the extra iron. It stores it in body tissues, especially the liver, heart and pancreas. The extra iron can damage your organs. Without treatment, it can cause your organs to fail.

The most common treatment is to remove some blood, just like when you donate blood. This is called therapeutic phlebotomy. Medicines may also help remove the extra iron. Your doctor might suggest some changes in your diet.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

An inherited metabolic disorder characterized by iron accumulation in the tissues.
NCI

A condition in which the body takes up and stores more iron than it needs. The extra iron is stored in the liver, heart, and pancreas, which may cause liver disease, heart problems, organ failure, and cancer. It may also cause bronze skin, diabetes, pain in the joints and abdomen, tiredness, and impotence. Hemochromatosis may be inherited, or it may be caused by blood transfusions.
NCI

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chřestýší jedy

Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
MSH

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aerobik

exercise designed to improve an individual`s cardiovascular condition.
CSP

Physical activity that increases the heart rate and the body`s use of oxygen. It helps improve a person`s physical fitness.
NCI

Sustained exercise that places an increased oxygen demand on the cardiovascular system and promotes an increased efficiency of the body`s use of oxygen.
NCI

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antilopy

Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.
MSH

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pyrazinamid

A pyrazine that is used therapeutically as an antitubercular agent.
MSH

antibacterial derived from nicotinic acid, used as a tuberculostatic.
CSP

A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)
NCI

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opice

Any haplorhine primate not belonging to the family Tarsiidae, Hylobatidae, Pongidae, or Hominidae; this does not correspond to any taxon. This group is divided into Old World monkeys (Cercopithecidae) and New World monkeys (Callitrichidae and Cebidae). Many types are used as an experimental model for human disease and drug testing.
NCI

A non-taxonomic, non-specific term for the smaller longer-tailed PRIMATES.
MSH

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hemolyticko-uremický syndrom

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
MSH

A form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
NCI

A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
NCI

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Culex

A genus of mosquitoes (CULICIDAE) commonly found in tropical regions. Species of this genus are vectors for ST. LOUIS ENCEPHALITIS as well as many other diseases of man and domestic and wild animals.
MSH

genus of mosquitoes commonly found in tropical regions; are vectors for many diseases including St. Louis encephalitis.
CSP

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agar

A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
MSH

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