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pomocní farmaceutičtí pracovníci

Persons who perform certain functions under the supervision of the pharmacist.
MSH

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heparinový kofaktor II

A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.
MSH

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stereotypizace

An oversimplified perception or conception especially of persons, social groups, etc.
MSH

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motocykly

Two-wheeled, engine-driven vehicles.
MSH

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chlorzoxazon

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
MSH

A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity.
NCI

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fenindion

An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
MSH

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virová hepatitida u lidí

INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
MSH

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žaludek – dilatace

Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.
MSH

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mukopolysacharidóza IV

Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.
MSH

genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate.
CSP

A rare autosomal recessive lysosomal storage disease characterized by abnormal skeletal developments, dwarfism, heart disorders, and central nervous system deficits.
NCI

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cholestáza

Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
MSH

intrahepatic impairment of bile flow; usually due to liver cell damage, but may be due to obstruction of intrahepatic bile ducts.
CSP

stoppage or suppression of bile by intrahepatic or extrahepatic causes.
CSP

Impairment of the bile flow caused by obstruction within the liver, or outside the liver in the bile duct system.
NCI

Any condition in which the release of bile from the liver is blocked. The blockage can occur in the liver (intrahepatic cholestasis) or in the bile ducts (extrahepatic cholestasis).
NCI

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fenylmethylsulfonylfluorid

An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
MSH

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herpesvirus 2 lidský

A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.
MSH

similiar to herpes simplex 1 except that it is usually transmitted sexually; causes genital lesions and may cause carcinoma of the cervix.
CSP

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Streptomyces griseus

An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.
MSH

A species of aerobic, Gram positive, filamentous bacteria in the phylum Actinobacteria. This species is spore forming, yellow to orange colored, elastase and hydrolase positive and produces streptomycin. S. griseus is not a known pathogen.
NCI

Any bacterial organism that can be assigned to the species Streptomyces griseus.
NCI

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virus encefalitidy Murray Valley

A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), found in Australia and New Guinea. It causes a fulminating viremia resembling Japanese encephalitis (ENCEPHALITIS, JAPANESE).
MSH

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chondroitinsulfáty

Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
MSH

A form contains glucuronic acid, B and C forms contain L-iduronic acid; all are sulfated on their galactosamine residues, B and C differing by the position of sulfation.
CSP

The major glycosaminoglycan (a type of sugar molecule) in cartilage.
NCI

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fonace

The process of producing vocal sounds by means of VOCAL CORDS vibrating in an expiratory blast of air.
MSH

The process of producing vocal sounds by vibration of the vocal cords during an expiration of air.
NCI

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hexetidin

A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
MSH

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zběhnutí ze studií

individuals who leave school, secondary or college, prior to completion of specified curriculum requirements.
CSP

Individuals who have withdrawn from school.
NCI

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yperit

Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
MSH

A pale yellow, oily, highly toxic, volatile, liquid alkylating compound with a sweet to garlic-like odor that evaporates to a poisonous gas. Mustard gas is a vesicant that was first used in chemical warfare in World War I, but is now only used in small amounts in research studies involving alkylating agents. Exposure to this substance is corrosive to the eyes, skin and lungs and leads to blindness and blistering of the skin and can cause severe and sometimes fatal respiratory damage. Mustard gas is a mutagen and is a known carcinogen that is associated with an increased risk of developing lung and other respiratory tract cancers. (NCI05)
NCI

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chromafinní systém

The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
MSH

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fosfoenolpyruvátkarboxylasa

An enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloacetate from phosphoenolpyruvate and carbon dioxide. This fixation of carbon dioxide in several bacteria and some plants is the first step in the biosynthesis of glucose. EC 4.1.1.31.
MSH

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kyčelní kloub

A ball-and-socket joint between the head of the femur and the acetabulum. (NCI)
NCI

A ball-and-socket joint between the head of the femur and the acetabulum.
NCI

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podjazyková slinná žláza – nádory

Neoplasms of the sublingual glands.
MSH

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Mycoplasmatales – infekce

Infections with bacteria of the order MYCOPLASMATALES.
MSH

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chromozomální poruchy

clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material, either a whole chromosome or a chromosome segment.
CSP

Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
MSH

A disorder that results from a chromosomal abnormality.
NCI

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fosfor – radioisotopy

Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.
MSH

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histokompatibilita – antigeny třídy I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
MSH

large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin; in humans, three structural genes on chromosome 6 code for the HLA-A, HLA-B and HLA-C antigens, and in mice three genes on chromosome 17 code for the H-2 antigens; class I antigens are found on most nucleated cells, are recognized during graft rejection, restrict cell-mediated lysis of virus infected cells, and are associated with rheumatologic diseases and certain malignant disorders.
CSP

Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens) Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein and nonpolymorphic 12-kDa b2-microglobulin. The HLA antigens are encoded by closely linked multiallelic genes of the HLA (MHC) complex, a region containing several genetic loci (HLA-A, -B, -C, -DP, -DQ, -DR, -MB, -MT, and -Te).
NCI

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sacharosa

A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.
MSH

nonreducing disaccharide, composed of glucose and fructose linked via their anomeric carbons.
CSP

A disaccharide consisting of glucose and fructose. The linkage is alpha with respect to the glucose and beta with respect to the fructose.
NCI

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myoepiteliální nádor

A usually benign tumor made up predominantly of myoepithelial cells.
MSH

A benign or malignant epithelial neoplasm characterized by the presence of cells that show myoepithelial differentiation. Based on its morphologic features, it is classified as benign or malignant. A representative example of benign myoepithelioma is benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma or myoepithelial carcinoma are malignant breast myoepithelioma and salivary gland myoepithelial carcinoma.
NCI

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chromozómy lidské, pár 4

A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.
MSH

The designation for each member of the fourth largest human autosomal chromosome pair. Chromosome 4 spans more than 186 million base pairs and represents between 6 and 6.5% of the total DNA in normal diploid cells.
NCI

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