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kryptokokóza

infection with a fungus of the species Cryptococcus neoformans.
CSP

An acute or chronic, localized or disseminated infection by Cryptococcus neoformans. Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs.–2004
NCI

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laktační zuby

Predeciduous teeth present at birth. They may be well formed and normal or may represent hornified epithelial structures without roots. They are found on the gingivae over the crest of the ridge and arise from accessory buds of the dental lamina ahead of the deciduous buds or from buds of the accessory dental lamina. (From Jablonski, Dictionary of Dentistry, 1992)
MSH

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rozvoj osobnosti

Growth of habitual patterns of behavior in childhood and adolescence.
MSH

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antropologie kulturní

It is the study of social phenomena which characterize the learned, shared, and transmitted social activities of particular ethnic groups with focus on the causes, consequences, and complexities of human social and cultural variability.
MSH

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nemocnice přidružené

Those hospitals which are extensions of a main hospital and are wholly or partly administered by that hospital.
MSH

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stanozolol

A synthetic steroid that has anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1194)
MSH

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kyanamid

A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.
MSH

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krk – poranění

General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
MSH

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bakteriofág phi X 174

The type species of the genus MICROVIRUS. A prototype of the small virulent DNA coliphages, it is composed of a single strand of supercoiled circular DNA, which on infection, is converted to a double-stranded replicative form by a host enzyme.
MSH

Microvisus type species; circular (+)-sense ssDNA; causes lysis of enterobacteria within 25-30 minutes of entry.
CSP

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protilátky – afinita

A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of “avidity,” which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
MSH

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lidské inženýrství

The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.
MSH

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kyseliny stearové

A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)
MSH

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cyklofosfamid

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
MSH

precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent; used in the treatment of lymphomas, leukemias and other cancers, and as an immunosupressive agent to prevent transplant rejection; its side effect, alopecia, has been used for defleecing sheep; may also cause sterility, birth defects, mutations, and cancer.
CSP

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.
NCI

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39748&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39748&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C405″ NCI Thesaurus)
PDQ

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.
NCI

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novorozenci – screening

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
MSH

Newborn screening tests take place before your newborn leaves the hospital. Babies are tested to identify serious or life-threatening conditions before symptoms begin. Such diseases are usually rare. However, they can affect a baby`s normal physical and mental development.

Most tests use a few drops of blood from pricking the baby`s heel. A hearing test involves placing a tiny earphone in the baby`s ear and measuring his or her response to sound.

If a screening test suggests a problem, your baby`s doctor will follow up with further testing. If those tests confirm a problem, the doctor may refer you to a specialist for treatment. Following your doctor`s treatment plan can save your baby from lifelong health and developmental problems.


MEDLINEPLUS

A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s).
NCI

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fenaziny

3 ring aromatic structure consisting of 2 benzene rings bridged by ortho nitrogen heteroatoms; used in dyes and larvicides; do not confuse with Phenazine, the drug trade name.
CSP

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antigeny diferenciační

Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
MSH

antigens normally only seen at particular phases of differentiation of a cell type.
CSP

Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation. (MeSH)
NCI

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hydrolyasy

Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
MSH

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steroly

Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
MSH

steroids with long (8-10 carbon) aliphatic side chains at position 17 and at least one alcoholic hydroxyl group, usually at position 3; they have lipid-like solubility.
CSP

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kaspasy

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
MSH

The caspases are a family of proteases responsible for carrying out the cell death process. In a living cell, these proteases are kept inactive by proteins on the mitochondrial cell surface from the BcL-2 family. When a cell is exposed to cell death signals such as ischemia, chemotherapy or radiation, BcL-2 function is blocked and caspase activators initiate the cell death cascade.
NCI

Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)
NCI

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neostigmin

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
MSH

anticholinesterase used in symptomatic treatment of myasthenia gravis, prevention and treatment of postoperative stasis of the gastrointestinal tract or urinary bladder, and as an antidote for neuromuscular blocking agents after surgery.
CSP

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fenylbutazon

A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
MSH

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antitumorózní látky

Substances that inhibit or prevent the proliferation of NEOPLASMS.
MSH

agent that inhibits or prevents the development or proliferation of neoplasms.
CSP

A drug used to treat cancer.
NCI

NOTE: Includes hormones (AN500) which are exclusively used as antineoplastics (e.g.,tamoxifen). Excludes other hormones (HS000).
NDFRT

A substance that inhibits the maturation, growth or spread of tumor cells.
NCI

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hydrops fetalis

Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
MSH

A condition characterized by fluid accumulation in two or more anatomic compartments in the fetus. Causes include Rh incompatibility, congenital heart defects, and chromosomal abnormalities.
NCI

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Enterococcus faecalis

A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.
MSH

Any bacterial organism that can be assigned to the species Enterococcus faecalis.
NCI

A species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is catalase positive, oxidase negative, ferments citrate, does not ferment arabinose or melibiose, reduces tetrazolium and is a lactic acid bacteria. E. faecalis is a leading agent of nosocomial infections in humans.
NCI

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cytochemie

Branch of histochemistry associated with the localization of cellular components by specific staining methods, as for example the localization of acid phosphatases by the Gomori method.
NCI

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nervový systém

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
MSH

entire nerve apparatus; in higher animals it is composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
CSP

The organized network of nerve tissue in the body. It includes the central nervous system (the brain and spinal cord), the peripheral nervous system (nerves that extend from the spinal cord to the rest of the body), and other nerve tissue.
NCI

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
NCI

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fimóza

A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.
MSH

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anus

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded.
NCI

The opening of the rectum to the outside of the body.
NCI

The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded. (NCI)
NCI

The external outlet of the GASTROINTESTINAL TRACT.
MSH

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hydroxyprogesterony

Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
MSH

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Strongyloidea

A superfamily of strongyles or roundworms which are parasites in the intestinal tract of equines, pigs, rodents, and primates (including man). It includes the genera Cyasthostomum, Ransomus, Globocephalus, OESOPHAGOSTOMUM, and STRONGYLUS.
MSH

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