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ribavirin

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
MSH

1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS.
CSP

A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
NCI

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C807″ NCI Thesaurus)
PDQ

A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. (NCI04)
NCI

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srpkovitá anémie

A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
MSH

disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs; the clinical expression of homozygosity for hemoglobin S.
CSP

Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. The cells are shaped like a crescent or sickle. They don`t last as long as normal, round red blood cells, which leads to anemia. The sickle cells also get stuck in blood vessels, blocking blood flow. This can cause pain and organ damage.

A genetic problem causes sickle cell anemia. People with the disease are born with two sickle cell genes, one from each parent. If you only have one sickle cell gene, it`s called sickle cell trait. About 1 in 12 African Americans has sickle cell trait. A blood test can show if you have the trait or anemia. Most states test newborn babies as part of their newborn screening programs.


MEDLINEPLUS

An inherited disease in which the red blood cells have an abnormal crescent shape, block small blood vessels, and do not last as long as normal red blood cells. Sickle cell anemia is caused by a mutation (change) in one of the genes for hemoglobin (the substance inside red blood cells that binds to oxygen and carries it from the lungs to the tissues). It is most common in people of West and Central African descent.
NCI

A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.
NCI

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novorozenci – screening

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
MSH

Newborn screening tests take place before your newborn leaves the hospital. Babies are tested to identify serious or life-threatening conditions before symptoms begin. Such diseases are usually rare. However, they can affect a baby`s normal physical and mental development.

Most tests use a few drops of blood from pricking the baby`s heel. A hearing test involves placing a tiny earphone in the baby`s ear and measuring his or her response to sound.

If a screening test suggests a problem, your baby`s doctor will follow up with further testing. If those tests confirm a problem, the doctor may refer you to a specialist for treatment. Following your doctor`s treatment plan can save your baby from lifelong health and developmental problems.


MEDLINEPLUS

A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s).
NCI

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cosyntropin

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.
MSH

A synthetically-derived subunit of the endogenous peptide pituitary hormone adrenocorticotropic hormone (ACTH). Consisting of the first 24 amino acids from the amino terminal of ACTH, Cortrosyn is usually prepared for injection and intended for diagnostic and not therapeutic use. Similar to endogenous ACTH, this agent stimulates the adrenal secretion of specific adrenal steroids that can be measured in the plasma. (NCI04)
NCI

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hydrolyasy

Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
MSH

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Orientia tsutsugamushi

A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
MSH

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Angiogenesis Factor

group of agents that induce or stimulate the physiologic angiogenesis process.
CSP

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nukleární rodina

A family composed of spouses and their children.
MSH

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neostigmin

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
MSH

anticholinesterase used in symptomatic treatment of myasthenia gravis, prevention and treatment of postoperative stasis of the gastrointestinal tract or urinary bladder, and as an antidote for neuromuscular blocking agents after surgery.
CSP

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kraniofaciální dysostóza

Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.
MSH

autosomal dominant disorder characterized by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla with relative mandibular prognathism.
CSP

A syndrome inherited in an autosomal dominant pattern. It is characterized by early fusion of the bones of the skull and face. Patients have a distinctive facial appearance which includes low-set ears, brachycephaly, hypertelorism, exophthalmos, and mandibular prognathism.
NCI

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hydrops fetalis

Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
MSH

A condition characterized by fluid accumulation in two or more anatomic compartments in the fetus. Causes include Rh incompatibility, congenital heart defects, and chromosomal abnormalities.
NCI

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RNA-polymerasa II

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
MSH

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zvířata – identifikační systémy

Procedures for recognizing individual animals and certain identifiable characteristics pertaining to them; includes computerized methods, ear tags, etc.
MSH

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nukleotidasy

A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.
MSH

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nervový systém

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
MSH

entire nerve apparatus; in higher animals it is composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
CSP

The organized network of nerve tissue in the body. It includes the central nervous system (the brain and spinal cord), the peripheral nervous system (nerves that extend from the spinal cord to the rest of the body), and other nerve tissue.
NCI

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
NCI

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kritické období (psychologie)

A specific stage in animal and human development during which certain types of behavior normally are shaped and molded for life.
MSH

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hydroxyprogesterony

Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
MSH

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RNA transferová Gln

A transfer RNA which is specific for carrying glutamine to sites on the ribosomes in preparation for protein synthesis.
MSH

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Anoplura

An order of insects comprising the sucking lice, which are blood-sucking ectoparasites of mammals. Recognized families include: Echinphthiriidae, Haematopinidae, and Pediculidae. The latter contains the medically important genera affecting humans: PEDICULUS and PHTHIRUS.
MSH

A taxonomic order of wingless insects that are obligate ectoparasites of birds and mammals. Lice attach tightly to hair, fur, and feathers of the host organism and feed on blood, skin, and sebaceous secretions.
NCI

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ošetřovatelský proces

The sum total of nursing activities which includes assessment (identifying needs), intervention (ministering to needs), and evaluation (validating the effectiveness of the help given).
MSH

sum total of nursing activities which includes assessment (identifying needs), intervention (ministering to needs), and evaluation (validating the effectiveness of the help given).
CSP

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neuroefektorové spoje

The synapse between a neuron (presynaptic) and an effector cell other than another neuron (postsynaptic). Neuroeffector junctions include synapses onto muscles and onto secretory cells.
MSH

junction between a neuron and the effector organ it innervates.
CSP

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kryptokokóza

infection with a fungus of the species Cryptococcus neoformans.
CSP

An acute or chronic, localized or disseminated infection by Cryptococcus neoformans. Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs.–2004
NCI

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hypergamaglobulinémie

An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.
MSH

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Romanův-Wardův syndrom

A form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the VOLTAGE-GATED POTASSIUM CHANNEL.
MSH

An autosomal dominant form of long QT syndrome caused by mutations in the KCNE1, KCNE2, KCNH2, KCNQ1, SCN5A, and ANK2 genes. It is manifested with arrhythmias.
NCI

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antropologie kulturní

It is the study of social phenomena which characterize the learned, shared, and transmitted social activities of particular ethnic groups with focus on the causes, consequences, and complexities of human social and cultural variability.
MSH

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obezita

A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
MSH

excessively high accumulation of body fat or adipose tissue in relation to lean body mass; the amount of body fat (or adiposity) includes concern for both the distribution of fat throughout the body and the size of the adipose tissue deposits; individuals are usually at high clinical risk because of excess amount of body fat (BMI greater than 30).
CSP

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat and/or body water. Both terms mean that a person`s weight is greater than what`s considered healthy for his or her height.

Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might tip the balance include your genetic makeup, overeating, eating high-fat foods and not being physically active.

Being obese increases your risk of diabetes, heart disease, stroke, arthritis and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

A disorder characterized by having a high amount of body fat.
NCI

A condition marked by an abnormally high, unhealthy amount of body fat.
NCI

Having a high amount of body fat (body mass index [BMI] of 30 or more).
NCI

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neuropeptid Y

A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
MSH

36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons; has vasoconstrictor and natriuretic activity.
CSP

Encoded by single copy human NPY Gene (NPY Family), 97-aa 11-kDa (precursor) secreted Neuropeptide Y is a 36-aa peptide neuromodulator with sequence homology to peptide YY and PNP. One of the most abundant widespread peptides in the nervous system and found in some adrenal medulla chromaffin cells, NPY is one of the most highly conserved peptides known; only 3 amino acid differences exist between human and shark. Implicated in control of feeding, energy balance, and secretion of GNRH, NPY may also regulate angiogenesis. NPY regulates proliferation of multipotent postnatal neuronal precursor or basal cells by PKC-dependent rapid and transient activation of ERK1/2 MAP kinases (via NPY Y1 receptor subtype). (NCI)
NCI

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kyanamid

A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.
MSH

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hypertelorismus

Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.
MSH

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Rubinsteinův-Taybiův syndrom

A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).
MSH

A rare genetic syndrome mapped to chromosome 16p13.3 and associated with mutations in the CREBBP gene. It is characterized by mental and growth retardation, distinctive facial features (prominent nose, low-set ears, microcephaly, and small mouth), and broad thumbs and great toes. Patients are at an increased risk of developing benign and malignant neoplasms, including nervous system neoplasms and malignant lymphoproliferative disorders.
NCI

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