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kalcimycin

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
MSH

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micely

Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
MSH

aggregate of lipids in which the polar head groups face outward and the hydrophobic tails face inward.
CSP

A tiny particle made of substances that are soluble in water and that come together to form a ball-like shape. These particles can carry other substances inside them. In medicine, micelles are made in the laboratory and are used to carry drugs to body tissues and cells.
NCI

A multimolecular colloid particle, usually formed by amphipathic molecules in solution with the polar group toward the solution and the hydrophobic group toward the interior.
NCI

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prolaps

The protrusion of an organ or part of an organ into a natural or artificial orifice.
MSH

abnormal lowering of an organ or a part
CHV

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kontrolní skupiny

Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.
MSH

In a clinical trial, the group that does not receive the new treatment being studied. This group is compared to the group that receives the new treatment, to see if the new treatment works.
NCI

A group used as a standard of comparison in a control experiment.
NCI

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zdravotnická zařízení – plánování

Areawide planning for health care institutions on the basis of projected consumer need.
MSH

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potrat neúplný

Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.
MSH

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mikroporézní filtry

A membrane or barrier with micrometer sized pores used for separation purification processes.
MSH

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Propidium Iodide

A fluorescent nucleic acid dye which binds only to double-stranded nucleic acids. It has a molecular weight of 668.4, an absorbance maximum of 535nm, and an emission maximum of 617 nm. It is commonly used to determine the DNA content of a cell or to discriminate viable from non-viable cells.
NCI

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rohovka – nemoci

Diseases of the cornea.
MSH

pathological process affecting the transparent anterior portion of the fibrous coat of the eye.
CSP

Your cornea is the outermost layer of your eye. It is clear and shaped like a dome. The cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. It also helps your eye to focus. If you wear contact lenses, they float on top of your corneas.

Problems with the cornea include

  • Refractive errors
  • Allergies
  • Infections
  • Injuries
  • Dystrophies – conditions in which parts of the cornea lose clarity due to a buildup of cloudy material

Treatments of corneal disorders include medicines, corneal transplantation and corneal laser surgery.

NIH National Eye Institute


MEDLINEPLUS

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agentury pro zdravotnické systémy

Health planning and resources development agencies which function in each health service area of the United States (PL 93-641).
MSH

a department of government concerned with administering those agencies and offices having programs pertaining to health and health services.
CSP

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androsteny

Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.
MSH

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úrazy – dispozice

Tendency toward involvement in accidents. Implies certain personality characteristics which predispose to accidents.
MSH

tendency toward involvement in accidents; implies certain personality or other characteristics which predispose to accidents.
CSP

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midodrin

An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
MSH

A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
NCI

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prostaglandinové endoperoxidy syntetické

Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
MSH

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kortison

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
MSH

naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol.
CSP

A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses.
NCI

A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat.
NCI

A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation.
NCI

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srdeční frekvence fetální

The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
MSH

The number of fetal cardiac beats per minute.
NCI

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anestézie inhalační

Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
MSH

state characterized by loss of feeling or sensation caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
CSP

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kyseliny octové

Acetic acid and its derivatives which may be formed by substitution reactions. Mono- and di-substituted, as well as halogenated compounds have been synthesized.
MSH

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Minocycline Hydrochloride

The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline`s neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.
NCI

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ochranné látky

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
MSH

A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs. Protective agents belong to various chemical classes, acting through various pharmacological mechanisms. They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04)
NCI

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Professional counsellor

A provider who is trained and educated in the performance of behavior health services through interpersonal communications and analysis. Training and education at the specialty level usually requires a master`s degree and clinical experience and supervision for licensure or certification. Sources: Abridged from definitions provided by the National Board of Certified Counselors and the American Association of Pastoral Counselors.


HL7V3.0

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Hela buňky

first continuously cultured human malignant cell line, derived from a cervical carcinoma; used for virus cultivation and antitumor drug screening assays.
CSP

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
MSH

HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences. P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported. M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5. M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns.
NCI

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Angiostrongylus

A genus of parasitic nematodes of the superfamily METASTRONGYLOIDEA. Two species, ANGIOSTRONGYLUS CANTONENSIS and A. vasorum, infest the lungs of rats and dogs, respectively. A. cantonensis is transmissible to man where it causes frequently fatal infection of the central nervous system.
MSH

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acetylprokainamid

A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
MSH

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mitóza

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
MSH

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division. [GOC:dph, GOC:mah, ISBN:0815316194]
GO

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
GO

The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. It is divided into Prophase, Metaphase, Anaphase, and Telophase.
NCI

The process by which a single parent cell divides to make two new daughter cells. Each daughter cell receives a complete set of chromosomes from the parent cell. This process allows the body to grow and replace cells.
NCI

The usual process of somatic reproduction of cells consisting of a sequence of modifications of the nucleus that result in the formation of two daughter cells with exactly the same chromosome and DNA content as that of the original cell. It is the process by which the body grows and replaces cells and is divided into four phases. In Prophase, paired chromosomes form, nuclear membrane disappears, the achromatic spindle appears, and polar bodies form. In Metaphase, chromosomes are arranged in the equatorial plane of the central spindle to form the monaster and chromosomes separate into exactly similar halves. In Anaphase, the two groups of daughter chromosomes separate and move along the fibers of the central spindle, each toward one of the asters, forming the diaster. In Telophase, the daughter chromosomes resolve themselves into a reticulum, the daughter nuclei are formed, and the cytoplasm divides forming two complete daughter cells.
NCI

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prothionamid

Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.
MSH

A thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.
NCI

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kreatinkinasa – forma MM

An isoenzyme of creatine kinase found in the MUSCLE.
MSH

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hematochezie

The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.
MSH

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zvířata divoká

Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.
MSH

animals considered to be wild or feral or not adapted for domestic use; prefer indexing specific animal, treed elsewhere, when possible.
CSP

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acne vulgaris

A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
MSH

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